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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
54 Results for "
CLK1/2/4
" in MedChemExpress (MCE) Product Catalog:
Products (54)
54 Results for "CLK1/2/4" in MCE Product Catalog:
Cat. No.: HY-157995
Target:
Research Areas:
Dyrk1a-in-7 (Compound 29) is a selective DYRK1A kinase inhibitor, and has good kinase selectivity for CLK1 kinase. The IC50 value of DYRK1A is 28 nM. For CLK2, Kd is 17.5 nM. Dyrk1a-in-7 can be used in the research of cancer, type Ⅱ diabetes and neurological diseases [1].
Cat. No.: HY-131909
CAS No.: 2226742-61-4
Target:
Research Areas:
CJ-2360 is a potent and orally active ALK inhibitor with IC50s of 2.2, 4.0, 8.8, 6.3, and 8.9 nM against wild-type ALK and F1197M, G1269A, L1196M, and S1206Y ALK mutants, respectively. CJ-2360 displays potent inhibitory activity against two clinically reported ALK mutants (C1156Y and L1196M) and a few other kinases (LTK, MERTK, CLK1, DAPK1, and DAPK2) among the 468 kinases evaluated [1].
Cat. No.: HY-P705761
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CLK1; Protein Tyrosine Kinase STY; CDC Like Kinase 1; Dual-Specificity Kinase; Dual Specificity Protein Kinase CLK1; CDC28/CDC2-Like Kinase; CDC-Like Kinase 1; CLK/STY; CLK; STY
Species:
Human
Source:
sf9 insect cells
Cat. No.: HY-183831
CAS No.: 3034312-19-8
GPS167 is a CLK kinase inhibitor that potently and selectively inhibits recombinant human CLK1, CLK2 and CLK4. By inhibiting CLK-mediated phosphorylation of SRSF10, GPS167 upregulates the protein-binding ability of CLK1 and CLK4 with SRSF10, downregulates oncogenic BCLAF1-L and upregulates tumor-suppressive BCLAF1-S, regulates alternative splicing of genes such as MDM2 and MDM4, stabilizes p53 protein and induces DNA damage, ultimately triggering tumor cell apoptosis. GPS167 can block the epithelial-mesenchymal transition process of tumors, activate intracellular double-stranded RNA-mediated antiviral immune responses, and produce synergistic cytotoxicity when combined with microtubule-targeting drugs. GPS167 can be used in research related to various cancers including colorectal cancer [1] .
Cat. No.: HY-183068
AP4-43 is an orally active CLK1, CLK4, PI3K, DDR1, EGFR and NEK4 inhibitor. AP4-43 reduces growth of mammalian colorectal cancer organoids. AP4-43 improves survival in a transgenic Drosophila model of KRAS-mutant colorectal cancer. AP4-43 can be used for the research of KRAS-mutant colorectal cancer [1].
Cat. No.: HY-103647R
CAS No.: 443798-47-8
Target:
Research Areas:
K00546 (Standard) is the analytical standard of K00546 (HY-103647). This product is intended for research and analytical applications. K00546 is a potent CDK1 and CDK2 inhibitor with IC50s of 0.6 nM and 0.5 nM for CDK1/cyclin B and CDK2/cyclin A, respectively. K00546 is also a potent CDC2-like kinase 1 (CLK1) and CLK3 inhibitor with IC50s of 8.9 nM and 29.2 nM, respectively [1] .
Cat. No.: HY-P70067
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: COLEC11; Collectin Sub-Family Member 11; Collectin Subfamily Member 11; CL-K1-IIa; CL-K1; CL-K1-IIb; CL-11; CL-K1-II; Collectin Kidney Protein 1; CL-K1-I; Collectin K1; 3MC2; Collectin-11; CLK1; MGC3279
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P70100
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: COLEC11; Collectin Sub-Family Member 11; Collectin Subfamily Member 11; CL-K1-IIa; CL-K1; CL-K1-IIb; CL-11; CL-K1-II; Collectin Kidney Protein 1; CL-K1-I; Collectin K1; 3MC2; Collectin-11; CLK1; MGC3279
Species:
Human
Source:
HEK293
Cat. No.: HY-184447
CAS No.: 3091508-49-2
RN193 is a type II kinase inhibitor with a human PAK1 IC50 of 4.28 μM. RN193 functionally inhibits kinase activity of PAK1, PAK2, and PAK3, and engages with their kinase domains in live cells. RN193 induces thermal shifts in CLK1, GSK3B, ULK1, MELK, MAPK13, BRAF, and STK10, indicating binding and stabilization of these proteins. RN193 induces formation of PAK3:PAK2 heterodimers and displaces PAK2 homodimers in live cells. RN193 acts as a tool compound for studying group I PAK conformational states [1].
Cat. No.: HY-P703552
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: CDK11B; P58 CLK-1; Prev. CDC2L1; CDK11; Galactosyltransferase-Associated Protein Kinase P58/GTA; CLK-1; CDK11-P110; Cell Division Cycle 2-Like Protein Kinase 1; CDK11-P58; CDC-Related Protein Kinase P58; CDK11-P46; Cyclin-Dependent Kinase; Cell Division C
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P706028
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: CDK11B; P58 CLK-1; Prev. CDC2L1; CDK11; Galactosyltransferase-Associated Protein Kinase P58/GTA; CLK-1; CDK11-P110; Cell Division Cycle 2-Like Protein Kinase 1; CDK11-P58; CDC-Related Protein Kinase P58; CDK11-P46; Cyclin-Dependent Kinase; Cell Division C
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P706029
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: CDK11B; P58 CLK-1; Prev. CDC2L1; CDK11; Galactosyltransferase-Associated Protein Kinase P58/GTA; CLK-1; CDK11-P110; Cell Division Cycle 2-Like Protein Kinase 1; CDK11-P58; CDC-Related Protein Kinase P58; CDK11-P46; Cyclin-Dependent Kinase; Cell Division C
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P70096
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: COQ7; Ubiquinone Biosynthesis Protein COQ7 Homolog; Coenzyme Q7, Hydroxylase; Coenzyme Q Biosynthesis Protein 7 Homolog; Ubiquinone Biosynthesis Monooxygenase COQ7; Coenzyme Q7 Homolog, Ubiquinone (Yeast); Timing Protein CLK-1 Homolog; COQ7 Coenzyme Q, 7
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
