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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
136 Results for "
M5
" in MedChemExpress (MCE) Product Catalog:
Products (136)
136 Results for "M5" in MCE Product Catalog:
Cat. No.: HY-107656
CAS No.: 201939-40-4
Target:
Research Areas:
PTAC oxalate is a selective muscarinic receptor ligand. PTAC oxalate is an partial agonist of M2 and M4 but antagonist of M1, M3, and M5 (Ki values of 0.2-2.8 nM for hM1-5 in CHO cells). PTAC oxalate alleviates the mechanical allodynia on the neuropathic pain and has antidepression effects .
Cat. No.: HY-A0030S
CAS No.: 2747918-94-9
Cat. No.: HY-108226
CAS No.: 835621-12-0
Synonyms: N-Desmethyl regorafenib N-oxide
Target:
Research Areas:
Regorafenib N-oxide and N-desmethyl (M5) (N-Desmethyl regorafenib N-oxide) is an active metabolite of Sorafenib (HY-10201) and can be metabolized by CYP3A4 .
Cat. No.: HY-158507
Synonyms: Mannose-5 N-linked oligosaccharide, procainamide labelled; Oligomannose 5 glycan, procainamide labelled
Cat. No.: HY-158503
Synonyms: Mannose-5 N-linked oligosaccharide, 2-AB labelled; Oligomannose 5 glycan, 2-AB labelled
Cat. No.: HY-159578S
CAS No.: 2746406-36-8
Cat. No.: HY-B0406AS
Synonyms: Carbamyl-β-methylcholine-d6 chloride
Target:
Research Areas:
VU0238441 is a pan muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC50s of 3.2 μM, 2.8 μM, 2.2 μM, 2.1 μM, >10 μM for M1, M2, M3, M5 and M4, respectively .
Cat. No.: HY-127022
CAS No.: 52646-92-1
Synonyms: Daturamine; α-Hydroxyscopolamine
Cat. No.: HY-127022A
CAS No.: 76822-34-9
Synonyms: Daturamine hydrobromide; α-Hydroxyscopolamine hydrobromide
Research Areas:
Anisodine (Daturamine) hydrobromide is a neuroprotective compound that reduces exacerbated M1, M2, M4, and M5 receptor expression in brain tissues under hypoxia/reoxygenation conditions. Anisodine hydrobromide inhibits calcium ion influx and reactive oxygen species (ROS)levels. Anisodine hydrobromide leads to decreased aspartate levels during hypoxia .
Cat. No.: HY-108226S1
Cat. No.: HY-108226S
Synonyms: N-Desmethyl regorafenib N-oxide-d3
Cat. No.: HY-W709612
Synonyms: N-Desmethyl regorafenib N-oxide-d3-1
Cat. No.: HY-158505
Synonyms: Mannose-5 N-linked oligosaccharide, APTS labelled; Oligomannose 5 glycan, APTS labelled
Cat. No.: HY-158501
Synonyms: Mannose-5 N-linked oligosaccharide, 2-AA labelled; Oligomannose 5 glycan, 2-AA labelled
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(R)-VU 6008667, the less active (R)-enantiomer to VU 6008667, is devoid of M5 NAM activity (IC50>10 μM) .
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Research Areas:
mAChR antagonist 1 (compound 4a) is a mAChR antagonist with Ki values of 255 nM, 121 nM, 158 nM, and 255 nM for M1, M3, M4, and M5 subtype, respectively .
Cat. No.: HY-12100S1
Synonyms: GSK573719A-d10
Cat. No.: HY-12100R
CAS No.: 869113-09-7
Synonyms: GSK573719A (Standard)
Target:
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Umeclidinium (bromide) (Standard) is the analytical standard of Umeclidinium (bromide). This product is intended for research and analytical applications. Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
