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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
79 Results for "
rapamycin
" in MedChemExpress (MCE) Product Catalog:
Products (79)
79 Results for "rapamycin" in MCE Product Catalog:
Cat. No.: HY-122402S
Cat. No.: HY-106979
CAS No.: 186752-78-3
Synonyms: SAR-943
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Olcorolimus (SAR-943) is a Rapamycin (HY-10219) derivative. Olcorolimus can reduce IL-4, IL-5, eosinophil, neutrophil, lymphocyte, cellular fibronectin; lung epithelial cell proliferation and mucus hypersecretory phenotype in Ovalbumin (HY-W250978)-sensitized BALB/c mice. Olcorolimus can be used for the researches of inflammation and immunology, such as asthma .
Cat. No.: HY-10218S1
CAS No.: 1661009-29-5
Synonyms: RAD001-13C2,d4; SDZ-RAD-13C2,d4
CC214-2 is an oral active and selective mTOR kinase inhibitor. CC214-2 targets to both of mTORC1 (pS6) and mTORC2 (pAktS473). CC214-2 induces autophagy, which is a potential target for host-directed therapy (HDT) in tuberculosis. CC214-2 exhibits synergistic bactericidal and sterilizing activity agasinst tuberculosis (TB), and shortens the treatment duration. CC214-2 also inhibits Rapamycin (HY-10219)-resistant signaling and the growth of glioblastomas in vitro and in vivo .
Cat. No.: HY-N15267
CAS No.: 64280-22-4
Cat. No.: HY-133770
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Seco Rapamycin ethyl ester is an open-ring metabolite of Rapamycin derivative. Seco-rapamycin is reported not to affect the mTOR function .
Cat. No.: HY-132003
CAS No.: 1067892-47-0
Wortmannin-Rapamycin Conjugate 1 (compound 7c) is a furan ring-opened derivative of wortmannin-rapamycin conjugate with potent antitumor activities and a fine water solubility. Wortmannin-Rapamycin Conjugate 1 can inhibit the AKT phosphorylation in the tumor and can be used for cancer research .
Cat. No.: HY-W765245
Synonyms: Sirolimus-13C,d3-1; AY-22989-13C,d3-1
Cat. No.: HY-W781875
CAS No.: 150821-39-9
Sirolimus isomer C is an impurity of Rapamycin (Sirolimus) (HY-10219) .
Cat. No.: HY-19555AR
CAS No.: 148554-65-8
Synonyms: Secorapamycin A monosodium (Standard)
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Phenglutarimid (hydrochloride) (Standard) is the analytical standard of Phenglutarimid (hydrochloride). This product is intended for research and analytical applications. Phenglutarimid hydrochloride is an anticholinergic used as an antiparkinsonian agent.
Cat. No.: HY-13766
CAS No.: 179033-51-3
Synonyms: VX-853
Timcodar is a macrolide agent, and studies have shown that during adipogenesis, timcodar can significantly inhibit fat accumulation, with an effect similar to that of rapamycin. However, unlike rapamycin, timcodar does not cause immunosuppression and glucose resistance. In addition, timcodar can effectively inhibit the adipogenic transcriptional regulators PPAR?? and C/EBP??, thereby inhibiting genes involved in fat accumulation. These studies lay the foundation for timcodar as a potential anti-obesity therapy, as obesity is becoming a global epidemic.
Cat. No.: HY-139085A
Purity: ≥95.0%
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XL388-C2-amide-PEG9-NH2 hydrochloride is an intermediate used in the synthesis of C26-linked Rapamycin analog .
Cat. No.: HY-139085B
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XL388-C2-amide-PEG9-NH2 TFA is an intermediate used in the synthesis of C26-linked Rapamycin analog .
Cat. No.: HY-W339757
CAS No.: 321883-54-9
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Dioctanoylphosphatidic acid sodium functions as a modulator of phagocyte respiratory burst, acts as a precursor to diacylglycerol and lysophosphatidic acid, and influences the phosphorylation of the mammalian target of rapamycin (mTOR) while enhancing the viability of gallbladder carcinoma cells treated with histone deacetylase inhibitors (HDACIs); it is derived from glycerophospholipid through the action of phospholipase D.
Cat. No.: HY-149861
CAS No.: 2984599-57-5
Mip-IN-1（S,S-28i）is a new rapamycin-derived macrophage infectivity potentiator (Mip) inhibitor. Mip-IN-1 displays strong anti-enzymatic activity against the Mip proteins of Neisseria meningitidis and Neisseria gonorrhoeae and substantially improved the ability of macrophages to kill the bacteria .
Cat. No.: HY-172789
mTOR inhibitor-27 (Compound 7e) is a mammalian target of rapamycin (mTOR) inhibitor with an IC50 value of 5.47 μM. mTOR inhibitor-27 can induce tumor cell apoptosis and arrest the cell cycle in the S-phase, thereby inhibiting cancer cell growth. mTOR inhibitor-27 is promising for research of cancers, such as skin cancer .
Cat. No.: HY-W003943
CAS No.: 903899-13-8
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6-Hydroxypyridin-3-ylboronic acid is a heterocyclic building block, which can be used in the synthesis of non-nucleoside inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B). 6-Hydroxypyridin-3-ylboronic acid has also been used in the synthesis of mammalian target of rapamycin (mTOR) inhibitors .
Cat. No.: HY-116191
CAS No.: 1309087-83-9
WJD008 is a potent dual phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor with antiproliferative and anticlonogenic activity in tumor cells and transformed cells with PIK3CA mutant. WJD008 inhibits kinase activity of PI3K α and mTOR and abrogates insulin-like growth factor-I-activated PI3K-Akt-mTOR signaling cascade. WJD008 is promising for research of cancers .
Cat. No.: HY-185200
CAS No.: 155589-16-5
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Rapamycin 42-hemisuccinate is a Rapamycin (HY-10219) derivative used in the synthesis of sterolated Rapamycin liposomes .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
