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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
653 Results for "
MYC
" in MedChemExpress (MCE) Product Catalog:
Products (653)
653 Results for "MYC" in MCE Product Catalog:
Cat. No.: HY-P700435
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF9; Homolog Of Mouse 4-1BB-L; TNF Superfamily Member 9; Receptor 4-1BB Ligand; 4-1BBL; CD137 Ligand; 4-1BB-L; 4-1BB Ligand; CD137L; Tumor Necrosis Factor (Ligand) Superfamily, Member 9, Isoform CRA_a; Tumor Necrosis Factor (Ligand) Superfamily, Member
Species:
Human
Source:
HEK293
Cat. No.: HY-P700631
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: FAM3B; ORF9; Prev. C21orf11; Cytokine-Like Protein 2-21; C21orf76; Pancreatic-Derived Factor; PANDER; Protein FAM3B; D21M16SJHU19e; Chromosome 21 Open Reading Frame 11; PRED44; Pancreatic Derived Factor; 2-21; FAM3 Metabolism Regulating Signaling Molecule
Species:
Human
Source:
E. coli
Cat. No.: HY-P702815
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RNF8; Ring Finger Protein 8, E3 Ubiquitin Protein Ligase; Ring Finger Protein 8; UBC13/UEV-Interacting Ring Finger Protein; KIAA0646; Ring Finger Protein (C3HC4 Type) 8; RING-Type E3 Ubiquitin Transferase RNF8; C3HC4-Type Zinc Finger Protein; E3 Ubiquitin
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P704538
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SRXN1; YKL086W; Prev. C20orf139; Sulfiredoxin 1 Homolog (S. Cerevisiae); SRX1; Chromosome 20 Open Reading Frame 139; Npn3; HBV PreS1-Transactivated Protein 5; Srx; CDNA FLJ25552 Fis, Clone JTH02127; Sulfiredoxin-1; PS1TP5; Sulphiredoxin; SRX; DJ850E9.2; S
Species:
Human
Source:
E. coli
Cat. No.: HY-L109
826 compounds
Protein protein interactions (PPI) have pivotal roles in life processes. The studies showed that aberrant PPI are associated with various diseases, including cancer, infectious diseases, and neurodegenerative diseases. The classic drug targets are usually enzymes, ion channels, or receptors, the PPI indicate new potential therapeutic targets. Therefore, targeting PPI is a new direction in treating diseases and an essential strategy for the development of new drugs.
However, the design of modulators targeting PPI still faces tremendous challenges, such the difficult PPI interfaces for the drug design, lack of ligands reference, lack of guidance rules for the PPI modulators development and high-resolution PPI proteins structures.
With the development of high-throughput technology, high-throughput screening is also gradually used for the identification of PPI inhibitors, but the compound library used for conventional target screening is not very effective in screening PPI inhibitors. To improve screening efficiency, MCE carefully selected 826 PPI inhibitors and mainly targeting MDM2-p53, Keap1-Nrf2, PD-1/PD-L1, Myc-Max, etc. MCE Protein-protein Interaction Inhibitor Library is a useful tool for PPI drug discovery and related research.
Cat. No.: HY-170820
CAS No.: 3006788-11-7
Target:
Molecular Glues Eukaryotic Release Factor (eRF) Bcl-2 Family CDK EGFR HSP Androgen Receptor c-Myc
Research Areas:
XYD049 is a CRBN-based molecular glue degrader targeting GSPT1, with a DC50 of 19 nM. XYD049 mediates the formation of a ternary complex between CRBN and GSPT1, thereby triggering CRBN- and proteasome-dependent degradation of GSPT1. By degrading GSPT1, XYD049 downregulates castration-resistant prostate cancer (CRPC)-related oncogenes, including BCL2, CDK2, E2F3, EGFR, HSP90B1, TMPRSS2, AR, AR-V7, PSA and c-Myc. XYD049 inhibits cancer cell growth and suppresses tumor growth in mice. XYD049 can be used for research on castration-resistant prostate cancer. XYD049 consists of a linker (black part) NH2-C5-NH-Boc (HY-W004710), a CRBN-based E3 ligase ligand (blue part) Thalidomide 4-fluoride (HY-41547), and a target protein ligand (red part) GSPT1 ligand-1 (HY-170821), among which the E3 ligase ligand plus linker forms the conjugate E3 Ligase Ligand-linker Conjugate 158 (HY-170822) .
Cat. No.: HY-187731
CAS No.: 685141-23-5
BXL0124 is an orally effective CD44 inhibitor and Notch signaling pathway inhibitor. BXL0124 has a vitamin D receptor-dependent mechanism and can downregulate the expression of CD44, Notch1/2/3, HES1, OCT4, LAMA5, JAG1, JAG2, NF-κB and DLL1. BXL0124 inhibits c-Myc expression and the levels of phosphorylated ERK, AKT, ErbB2, reduces the level of activated Notch1 receptor and its nuclear localization, decreases the mRNA and protein levels of Jagged-1 and Jagged-2, and inhibits the STAT3 signaling pathway by reducing the formation of the CD44-STAT3-JAK2 complex, while also inhibiting the transcriptional activity of the CD44 promoter in a p53-dependent manner. BXL0124 can induce myoepithelial differentiation and inhibit the self-renewal of cancer stem cell-like cells, cancer cell proliferation, invasion, and growth. BXL0124 can be used in research related to triple-negative breast cancer, basal-like breast cancer, ErbB2-overexpressing mammary tumorigenesis, and breast cancer .
Cat. No.: HY-P72159
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CXCR4; SDF-1 Receptor; C-X-C Motif Chemokine Receptor 4; CD184 Antigen; LESTR; LAP-3; Fusin; NPYRL; HM89; FB22; C-X-C Chemokine Receptor Type 4; LCR1; D2S201E; Seven-Transmembrane-Segment Receptor, Spleen; NPYY3R; Chemokine (C-X-C Motif), Receptor 4 (Fusi
Species:
Human
Source:
E. coli
Cat. No.: HY-P700543
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CCR8; Chemokine Receptor-Like 1; Prev. CMKBRL2; GPRCY6; Prev. CMKBR8; CCR-8; TER1; CKRL1; C-C Chemokine Receptor Type 8; Chemokine (C-C) Receptor-Like 2; GPR-CY6; CC-Chemokine Receptor Chemr1; CKR-L1; Chemokine (C-C) Receptor 8; CDw198; CC Chemokine Recep
Species:
Human
Source:
P. pastoris
Cat. No.: HY-P700645
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SIRPB1; Signal-Regulatory Protein Beta-1 Isoform 3; Signal Regulatory Protein Beta 1; Signal-Regulatory Protein Beta 1; SIRP-BETA-1; Alternative Protein SIRPB1; CD172b; SIRP-Beta-1 Isoform 3; CD172 Antigen-Like Family Member B; CD172b Antigen; Signal-Regu
Species:
Human
Source:
HEK293
Cat. No.: HY-P71645
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: AK3; AKL3L; Prev. AK3L1; GTP:AMP Phosphotransferase, Mitochondrial; Prev. AK6; Adenylate Kinase 3 Like 1; GTP:AMP Phosphotransferase AK3, Mitochondrial; Adenylate Kinase 6; Adenylate Kinase 3 Alpha-Like 1; AK 3; AKL3L1; FIX; Adenylate Kinase Isozyme 3; Ad
Species:
Human
Source:
E. coli
Cat. No.: HY-178172
Research Areas:
AF9/ENL-DOT1L/AF4 PPI-IN-1 is a potent AF9/ENL and histone methyltransferase DOT1L/AF4 protein-protein interactions (PPI) inhibitor. AF9/ENL-DOT1L/AF4 PPI-IN-1 can inhibit the AF9-DOT1L (IC50 = 1.5 μM), AF9-AF4 (IC50 = 1 μM), ENL-AF4 (IC50 = 1.2 μM) interactions. AF9/ENL-DOT1L/AF4 PPI-IN-1 can suppress the expression of Mixed lineage leukemia (MLL) target genes Myc and Meis1 and selectively block the proliferation of MLL-r and several other leukemia cells. AF9/ENL-DOT1L/AF4 PPI-IN-1 exhibits significant antitumor activities in a mouse model of MLL-r leukemia without overt toxicities. AF9/ENL-DOT1L/AF4 PPI-IN-1 can be used for the study of MLL-r leukemia .
Cat. No.: HY-P705694
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: EIF4G1; EIF-4-Gamma 1; Prev. EIF4F; EIF4GI; Prev. EIF4G; Eucaryotic Translation Initiation Factor 4G; P220; EIF4G1 Protein; PARK18; EIF4-Gamma; Eukaryotic Translation Initiation Factor 4 Gamma, 1; EIF-4G 1; Eukaryotic Translation Initiation Factor 4 Gamma
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
