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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
852 Results for "
hepatically
" in MedChemExpress (MCE) Product Catalog:
Products (852)
852 Results for "hepatically" in MCE Product Catalog:
Cat. No.: HY-10585AR
CAS No.: 1069-66-5
Synonyms: Sodium Valproate (Standard); VPA sodium (Standard); 2-Propylpentanoic acid sodium (Standard)
Cat. No.: HY-10585B
CAS No.: 76584-70-8
Synonyms: Sodium Valproate (2:1); VPA sodium (2:1); 2-Propylpentanoic acid sodium (2:1)
Cat. No.: HY-107133
CAS No.: 1247847-78-4
Target:
Research Areas:
Simmitecan hydrochloride is a potent topoisomerase I (TOP1) inhibitor, which is a 9-substituted lipophilic camptothecin (Camptothecin (HY-16560)) derivative. Simmitecan hydrochloride blocks DNA replication and transcription, thereby inducing tumor cell apoptosis by inhibiting the activity of TOP1. Simmitecan hydrochloride can be used for research on cancers such as liver cancer .
Cat. No.: HY-107133A
CAS No.: 951290-31-6
Target:
Research Areas:
Simmitecan is a potent topoisomerase I (TOP1) inhibitor, which is a 9-substituted lipophilic camptothecin (Camptothecin (HY-16560)) derivative. Simmitecan blocks DNA replication and transcription, thereby inducing tumor cell apoptosis by inhibiting the activity of TOP1. Simmitecan can be used in the research of cancers such as liver cancer .
Cat. No.: HY-179639
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PDE4-IN-30 is a selective PDE4 inhibitor with an IC50 of 2.7 nM for PED4D2, targeting PDE4 through halogen bonding and metal coordination. PDE4-IN-30 exhibits at least 67-fold selectivity for other PDE subfamilies. PDE4-IN-30 can be used for the research of idiopathic pulmonary fibrosis .
Cat. No.: HY-181643
CAS No.: 3075693-57-8
YOK24 is an orally active MetAP2 inhibitor and anti-amoebic agent. YOK24 binds covalently to MetAP2 and inhibits its peptidase activity, where MetAP2 is a protein essential for the proliferation of *Entamoeba histolytica*. YOK24 can be used in the research of amoebiasis .
Cat. No.: HY-183473
CAS No.: 34535-83-6
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Fenalcomine hydrochloride is an orally active phenethylamine derivative with antianginal activity. Fenalcomine hydrochloride reduces myocardial oxygen consumption, and increases cardiac output and coronary blood flow. Fenalcomine hydrochloride is suitable for angina models complicated by hypertension, diabetes, and old myocardial infarction. Fenalcomine hydrochloride can be used in studies related to angina pectoris .
Cat. No.: HY-183473A
CAS No.: 34616-39-2
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Fenalcomine is an orally active phenethylamine derivative with antianginal activity. Fenalcomine reduces myocardial oxygen consumption, and increases cardiac output and coronary blood flow. Fenalcomine is suitable for angina models complicated by hypertension, diabetes, and old myocardial infarction. Fenalcomine can be used in studies related to angina pectoris .
Cat. No.: HY-N21699
CAS No.: 1927024-53-0
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Cat. No.: HY-N7543
CAS No.: 64917-82-4
Category:
Infection Schisandra sphenanthera Rehd. et Wils Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields
Target:
Cat. No.: HY-P11827
Target:
Research Areas:
Cat. No.: HY-W794759
CAS No.: 62959-43-7
Synonyms: Magnesium valproate; VPA magnesium; 2-Propylpentanoic acid magnesium
Research Areas:
Valproic acid magnesium (Magnesium valproate) is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM. Valproic acid magnesium inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid magnesium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid magnesium is used in the epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches .
Cat. No.: HY-114118CP
CAS No.: 910463-68-2
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Cat. No.: HY-114118S
Target:
Isotope-Labeled Compounds GLP Receptor Insulin Receptor α-synuclein Apoptosis p38 MAPK Autophagy Bcl-2 Family
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Cat. No.: HY-114118S1
Target:
Isotope-Labeled Compounds GLP Receptor Insulin Receptor α-synuclein Apoptosis p38 MAPK Autophagy Bcl-2 Family
Research Areas:
Cat. No.: HY-123320S
Synonyms: ADX-629
Target:
Research Areas:
Acloproxalap (ADX-629) is an orally active reactive aldehyde species (RASP) inhibitor. Acloproxalap binds covalently to free aldehydes, sequesters reactive aldehyde species, malondialdehyde, acetaldehyde and preformed malondialdehyde-acetaldehyde adducts, and reduces elevated RASP levels. Acloproxalap decreases the formation of aldehyde adducts, reduces liver and serum triglyceride levels, hepatic fat accumulation, circulating anti-malondialdehyde-acetaldehyde adduct antibody levels, and inhibits the release of IL-6 and MCP-1. Acloproxalap improves cell viability of liver slices exposed to ethanol. Acloproxalap blocks ethanol-induced damage in animal models of alcoholic liver disease. Acloproxalap is applicable to research related to alcoholic liver disease, alcoholic fatty liver disease, non-alcoholic steatohepatitis, chronic cough, rheumatoid arthritis, ulcerative colitis and mild atopic asthma .
Cat. No.: HY-182356
CAS No.: 3125953-25-2
Research Areas:
MTHFD1/2-IN-1 is an orally active dual MTHFD1/MTHFD2 inhibitor, with IC50 values of 0.26 μM and 0.031 μM against human MTHFD1 and MTHFD2, respectively. MTHFD1/2-IN-1 blocks one-carbon metabolism by inhibiting the dehydrogenase activity of MTHFD1 as well as the dehydrogenase and cyclohydrolase activities of MTHFD2, thereby disrupting nucleotide biosynthesis and redox homeostasis in cancer cells. MTHFD1/2-IN-1 exhibits favorable Caco-2 permeability and hepatic microsomal metabolic stability. MTHFD1/2-IN-1 shows significant anti-leukemic activity, which not only reduces the viability of various leukemia cells but also inhibits tumor growth of acute myeloid leukemia (AML) in mouse models .
Cat. No.: HY-N0732R
CAS No.: 37905-08-1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
