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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
89 Results for "
STAT6
" in MedChemExpress (MCE) Product Catalog:
Products (89)
89 Results for "STAT6" in MCE Product Catalog:
Cat. No.: HY-185073
CAS No.: 3092076-12-2
Target:
Research Areas:
STAT6-IN-11 is a STAT6 inhibitor with an EC50 of 0.006 μM. STAT6-IN-11 can be used for the research of dermatological condition or respiratory conditions .
Cat. No.: HY-174636
Target:
Research Areas:
Human IL15 mRNA encodes the human interleukin 15 (IL15) protein, a cytokine that regulates T and natural killer cell activation and proliferation. IL15 induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6.
Synonyms: HMS (Standard); 6α-Methyl-11β-hydroxyprogesterone (Standard)
Target:
Research Areas:
Medrysone (Standard) is the analytical standard of Medrysone. This product is intended for research and analytical applications. Medrysone (HMS; 6α-Methyl-11β-hydroxyprogesterone) is a STAT6 modulator and M2 macrophage polarization inducer. Medrysone enhances IL-4-triggered STAT6 activation, upregulates the expression of M2 markers, and promotes the secretion of VEGF and CCL2. Medrysone also enhances the pro-migratory activity of M2-like macrophages toward endothelial cells. By regulating macrophage polarization and related repair pathways, Medrysone significantly promotes corneal wound repair in a rat mechanical injury model. Medrysone can be used for research related to corneal injury .
Cat. No.: HY-P71337
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: STAT6; Transcription Factor IL-4 STAT; Signal Transducer And Activator Of Transcription 6; STAT, Interleukin4-Induced; IL-4-STAT; IL-4 STAT; D12S1644; STAT6B; Signal Transducer And Activator Of Transcription 6, Interleukin-4 Induced; STAT6C; Signal Transd
Species:
Human
Source:
E. coli
Cat. No.: HY-P702835
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: STAT6; Transcription Factor IL-4 STAT; Signal Transducer And Activator Of Transcription 6; STAT, Interleukin4-Induced; IL-4-STAT; IL-4 STAT; D12S1644; STAT6B; Signal Transducer And Activator Of Transcription 6, Interleukin-4 Induced; STAT6C; Signal Transd
Species:
Human
Source:
E. coli
Cat. No.: HY-P702835A
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: STAT6; Transcription Factor IL-4 STAT; Signal Transducer And Activator Of Transcription 6; STAT, Interleukin4-Induced; IL-4-STAT; IL-4 STAT; D12S1644; STAT6B; Signal Transducer And Activator Of Transcription 6, Interleukin-4 Induced; STAT6C; Signal Transd
Species:
Human
Source:
E. coli
Cat. No.: HY-P703579
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: STAT6; Transcription Factor IL-4 STAT; Signal Transducer And Activator Of Transcription 6; STAT, Interleukin4-Induced; IL-4-STAT; IL-4 STAT; D12S1644; STAT6B; Signal Transducer And Activator Of Transcription 6, Interleukin-4 Induced; STAT6C; Signal Transd
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-116474R
CAS No.: 14484-44-7
Cat. No.: HY-188210
CAS No.: 3077478-62-4
Cat. No.: HY-P5763A
Synonyms: PNX-20 TFA
Target:
Epigenetic Reader Domain PGC-1α Toll-like Receptor (TLR) MyD88 NF-κB Sirtuin NOD-like Receptor (NLR) ASCT Caspase Interleukin Related NADPH Oxidase Reactive Oxygen Species (ROS) STAT
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Phoenixin-20 TFA (PNX-20 TFA) is a neuropeptide that activates GPR173. Phoenixin-20 TFA inhibits LPS-induced TLR-4/MyD88/NF-κB signaling, pro-inflammatory cytokines, adhesion molecules, MMPs, and cytotoxicity. Phoenixin-20 TFA increases SIRT1 and inhibits NLRP3/ASC/caspase-1, oxidative stress, and IL-1β/IL-18. Phoenixin-20 TFA alleviates ox-LDL-induced endothelial dysfunction, monocyte adhesion, adhesion molecules, cytokines, NADPH oxidase/NOX-4, and ROS. Phoenixin-20 TFA promotes GPR173/STAT6-mediated anti-inflammatory polarization of microglia and neuroprotection. Phoenixin-20 TFA can be used in research on dental pulp infection, pulmonary arterial hypertension, atherosclerosis, neuroinflammation, anxiety, and neurodegenerative diseases [6] .
Cat. No.: HY-113402B
Synonyms: γ-Glu-Cys ammonium
Target:
Interleukin Related TNF Receptor Endogenous Metabolite AMPK Sirtuin STAT PI3K NF-κB JAK p38 MAPK JNK Akt Apoptosis Ferroptosis
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Gamma-glutamylcysteine ammonium (γ-Glu-Cys ammonium) is an orally active, blood-brain barrier permeable dipeptide . Gamma-glutamylcysteine ammonium activates AMPK, SIRT1, IL-4/STAT6, AC/cAMP/PI3K, IGF-1R/IRS1/PI3K, and Nrf2 signaling pathways; it inhibits NF-κB, JAK1/STAT1/3, MAPKs, cadmium-induced p38 MAPK, JNK, and PI3K/Akt signaling pathways. Gamma-glutamylcysteine ammonium regulates macrophage polarization, modulates the trafficking of CD36 and GLUT4, induces glutathione synthesis, improves metabolic dysfunction, reduces lipid deposition, ameliorates glucose homeostasis, inhibits apoptosis (Apoptosis), stabilizes mitochondria, suppresses lipid peroxidation, iron accumulation and ferroptosis (Ferroptosis), reduces ds-HMGB1 levels, reverses mechanical hyperalgesia, and alleviates hepatic lipid droplet formation. Gamma-glutamylcysteine ammonium is applicable to research related to inflammatory bowel disease, type 2 diabetes, cadmium-induced neurotoxicity, Alzheimer's disease, cerebral ischemia/reperfusion injury, neuropathy, and alcoholic liver disease [6] .
Cat. No.: HY-N0566R
CAS No.: 85999-40-2
Synonyms: Anemosapogenin (Standard)
Category:
Cat. No.: HY-100614R
CAS No.: 919486-40-1
Target:
Research Areas:
AS1517499 (Standard) is the analytical standard of AS1517499 (HY-100614). This product is intended for research and analytical applications. AS1517499 is a potent and brain-permeable STAT6 phosphorylation inhibitor with an IC50 of 21 nM.
Cat. No.: HY-184991
CAS No.: 2982853-56-3
Research Areas:
AK305 is a small-molecule ligand for the SH2 domains of STAT5A, STAT5B and STAT6, with a Ki of 0.4 μM for STAT6 and a Ki of 1.0 μM for both STAT5A and STAT5B. AK305 exhibits only very low or no cell growth inhibitory activity in leukemia cells and does not alter STAT protein levels. AK305 serves as the STAT5 ligand for AK-2292 (HY-148813), a STAT5 PROTAC degrader. AK305 can be used in the research of acute myeloid leukemia .
Cat. No.: HY-179608
CAS No.: 3067883-29-5
Research Areas:
E3 Ligase Ligand-linker Conjugate 218 is an E3 ligase ligand-linker conjugate, and can be used for synthesis of PROTAC STAT6 degrader-2 (HY-179233) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
