74 Results for "

NPCs

" in MedChemExpress (MCE) Product Catalog:
Products (74)

74 Results for "NPCs" in MCE Product Catalog:

Cat. No.: HY-RS23218
Research Areas:  

Others

Npc1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Npc1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS23972
Research Areas:  

Others

Npc1l1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Npc1l1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-174365A
mPEG2000-NPC is an important PEG derivative whose reactive groups can be used to modify proteins, peptides or any other compounds with available amino groups at lysine residues or N-terminus .
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Cat. No.: HY-174365B
mPEG3400-NPC is an important PEG derivative whose reactive groups can be used to modify proteins, peptides or any other compounds with available amino groups at lysine residues or N-terminus .
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Cat. No.: HY-174365C
mPEG5000-NPC is an important PEG derivative whose reactive groups can be used to modify proteins, peptides or any other compounds with available amino groups at lysine residues or N-terminus .
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Cat. No.: HY-W1052829
Synonyms: 4-Arm-PEG2000-NPC
4-Arm-PEG2000-Nitrophenyl carbonate (4-Arm-PEG2000-NPC) is a four-arm PEG derivative. The core structure of 4-Arm-PEG2000-Nitrophenyl carbonate consists of four PEG chains, each modified at the end with a nitrophenyl carbonate group. 4-Arm-PEG2000-Nitrophenyl carbonate can be used for bioconjugation and drug delivery.
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Cat. No.: HY-W1052829A
Synonyms: 4-Arm-PEG10000-NPC
4-Arm-PEG10000-Nitrophenyl carbonate (4-Arm-PEG10000-NPC) is a four-arm PEG derivative. The core structure of 4-Arm-PEG10000-Nitrophenyl carbonate consists of four PEG chains, each modified at the end with a nitrophenyl carbonate group. 4-Arm-PEG10000-Nitrophenyl carbonate can be used for bioconjugation and drug delivery.
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Cat. No.: HY-W1052829B
Synonyms: 4-Arm-PEG20000-NPC
4-Arm-PEG20000-Nitrophenyl carbonate (4-Arm-PEG20000-NPC) is a four-arm PEG derivative. The core structure of 4-Arm-PEG20000-Nitrophenyl carbonate consists of four PEG chains, each modified at the end with a nitrophenyl carbonate group. 4-Arm-PEG20000-Nitrophenyl carbonate can be used for bioconjugation and drug delivery.
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Cat. No.: HY-W1052829C
Synonyms: 4-Arm-PEG5000-NPC
4-Arm-PEG5000-Nitrophenyl carbonate (4-Arm-PEG5000-NPC) is a four-arm PEG derivative. The core structure of 4-Arm-PEG5000-Nitrophenyl carbonate consists of four PEG chains, each modified at the end with a nitrophenyl carbonate group. 4-Arm-PEG5000-Nitrophenyl carbonate can be used for bioconjugation and drug delivery.
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Cat. No.: HY-W010514R
CAS No.: 1460-57-7
trans-Cyclohexane-1,2-diol (Standard) is the analytical standard of trans-Cyclohexane-1,2-diol (HY-W010514). This product is intended for research and analytical applications. trans-Cyclohexane-1,2-diol (TCHD) is a transient dilator of the nuclear pore complex (NPC). By interacting with the hydrophobic core (FG nucleoporin) of the NPC, trans-Cyclohexane-1,2-diol can disrupt the NPC structure and reversibly increase the permeability of the nuclear pore, allowing macromolecules larger than 40 kDa (such as plasmid DNA) to enter the cell nucleus by passive diffusion, thereby enhancing the nuclear import efficiency of non-viral vectors. trans-Cyclohexane-1,2-diol can improve the efficiency of in vitro electrotransfection or lipid-mediated gene transfection, especially significantly increasing gene expression in differentiated airway epithelial cells .
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Cat. No.: HY-N18304
CAS No.: 1162664-57-4
Brutieridin (Compound 1) is a flavanone glycoside that can be isolated from the juice of bergamot (Citrus bergamia). Brutieridin reduces the level of NPC1L1 in intestinal epithelial cells. Brutieridin decreases cholesterol uptake by intestinal epithelial cells. Brutieridin reduces HMGR activity. Brutieridin can be used in the research of hypercholesterolemia .
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Cat. No.: HY-136433S
CAS No.: 69340-07-4
Synonyms: 1,4-Dinitrosopiperazine-d8; DNP-d8
N,N'-Dinitrosopiperazine-d8 is the deuterium labeled N,N'-Dinitrosopiperazine . N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine;DNP) is a carcinogen with specificity for nasopharyngeal epithelium and facilitates NPC metastasis. N,N'-Dinitrosopiperazine regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568 .
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Cat. No.: HY-N15891
CAS No.: 1917340-40-9
Glyco-3ß,5α,6ß -trihydroxycholanoic acid (NPCBA2) is a bile acid which accumulates preferentially in Niemann-Pick C (NPC) patients. Glyco-3ß,5α,6ß -trihydroxycholanoic acid is a biomarker for the early diagnosis of Niemann-Pick C disease .
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Cat. No.: HY-182938
CAS No.: 1111050-17-9
Target:  

Autophagy

Research Areas:  

Metabolic Disease

Autophagy activator-2 is a potent autophagy activator with EC50 values of 14.33 μM. Autophagy activator-2 acts as a proteostasis modulator and small-molecule chaperone that upregulates I1061T mutant NPC1 expression and facilitates cholesterol efflux. Autophagy activator-2 reduces lysosomal hydrolase levels. Autophagy activator-2 can be used for the study of Niemann-Pick Type C disease .
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