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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
123 Results for "
P-loop flexibility
" in MedChemExpress (MCE) Product Catalog:
Products (123)
123 Results for "P-loop flexibility" in MCE Product Catalog:
Cat. No.: HY-P992232
Target:
Research Areas:
Cat. No.: HY-K0255
MCE IMAC Agarose (NTA) 6FF is prepared by covalently coupling tetradentate nitrilotriacetic acid (NTA) to an agarose matrix. It features high binding capacity, excellent specificity, and superior ligand stability. The resin allows flexible chelation with metal ions such as Zn2+, Ni2+, or Cu2+, and is suitable for the purification of His-tagged recombinant proteins expressed in bacterial, mammalian, insect, and baculovirus systems.
Cat. No.: HY-K0256
MCE Chelating Agarose (IDA) 6FF is prepared by covalently coupling tridentate iminodiacetic acid (IDA) to an agarose matrix. It features high binding capacity, excellent specificity, and superior ligand stability. The resin allows flexible chelation with metal ions such as Zn2+, Ni2+, or Cu2+, and is suitable for the purification of His-tagged recombinant proteins expressed in bacterial, mammalian, insect, and baculovirus systems.
Cat. No.: HY-KD1010
MCE offers a variety of multiplex fluorescence detection kits, featuring high quenching resistance, low cross-contamination, and strong stability. The seven-color kit can stain six indicators (MCE offers six VF series dyes: VF 480, VF 520, VF 570, VF 620, VF 690, and VF 780; you can flexibly select according to your actual needs).
Cat. No.: HY-W1048549B
Synonyms: HOOC-PEG3400-Thiol
Cat. No.: HY-W1048549D
Synonyms: HOOC-PEG10000-Thiol
Cat. No.: HY-189418
CAS No.: 2778223-60-0
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HL-3-68 is a SARS-CoV-2 main protease (MPro) inhibitor (IC50 = 0.29 μM; Ki = 0.89 μM; Kd = 0.75 μM). HL-3-68 stabilizes the primary binding site of MPro, locks the S1 and S2 subsites, and reduces loop flexibility. HL-3-68 is used for COVID-19 research .
Cat. No.: HY-KD1007
MCE offers a variety of multiplex fluorescence detection kits, featuring high quenching resistance, low cross-contamination, and strong stability. The six-color multiplex fluorescence staining kit can stain five indicators (MCE offers six VF series dyes: VF 480, VF 520, VF 570, VF 620, VF 690, and VF 780; you can flexibly select according to your actual needs).
Cat. No.: HY-KD1008
MCE offers a variety of multiplex fluorescence detection kits, featuring high quenching resistance, low cross-contamination, and strong stability. The six-color multiplex fluorescence staining kit can stain five indicators. (MCE offers six VF series dyes: VF 480, VF 520, VF 570, VF 620, VF 690, and VF 780; you can flexibly select according to your actual needs).
Cat. No.: HY-KD1009
MCE offers a variety of multiplex fluorescence detection kits, featuring high quenching resistance, low cross-contamination, and strong stability. The seven-color multiplex fluorescence staining kit can stain six indicators (MCE offers six VF series dyes: VF 480, VF 520, VF 570, VF 620, VF 690, and VF 780; you can flexibly select according to your actual needs).
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Guanosine 5′-(tetrahydrogen triphosphate), 1-methyl-
Cat. No.: HY-177582
CAS No.: 52940-67-7
Cat. No.: HY-183265
Research Areas:
GO847 is an orally active casein kinase 2 (CK2) inhibitor with an IC50 of 40.2 nM. GO847 increases intracellular ATP levels, impairs Mitochondrial metabolic flexibility, and promotes excessive mitochondrial ROS production. GO847 alters the period length of cellular circadian rhythms. GO847 inhibits the growth of acute myeloid leukemia cells. GO847 can be used for the research of acute myeloid leukemia .
Cat. No.: HY-185901
Cat. No.: HY-183639
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SUCNR1 antagonist-1 is an orally active SUCNR1 antagonist. SUCNR1 antagonist-1 forms stable, water-bridged hydrogen bonds with key residue Glu22 1.31 to stabilize binding conformation and modulates protein conformational flexibility. SUCNR1 antagonist-1 blocks succinate-mediated SUCNR1 signaling and induces cell apoptosis. SUCNR1 antagonist-1 can be used for the research of colorectal carcinoma .
Cat. No.: HY-184780
CAS No.: 84731-70-4
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Eco-DEHCH is a phthalate-free alternative plasticizer that safely and effectively softens plastics such as flexible PVC. Eco-DEHCH shows low binding affinity for various endocrine receptors, including estrogen, androgen, glucocorticoid, thyroid receptor α and thyroid receptor β. Eco-DEHCH causes dose-dependent accumulation of α2u-globulin in the kidneys of male Han Wistar rats, but has overall general safety .
Cat. No.: HY-187369
CAS No.: 3084436-73-4
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AR antagonist 18 is a selective androgen receptor antagonist with an IC50 of 20.6 nM. AR antagonist 18 exerts AR transcriptional inhibitory effects by interacting with AR residues Phe765 and Trp742 via conformational flexibility. AR antagonist 18 acts as a hair growth inducer, and exhibits low systemic exposure and reduced distribution to male reproductive organs in a mouse model of hair growth. AR antagonist 18 can be used for research on androgenetic alopecia .
Cat. No.: HY-181954
CAS No.: 2055109-19-6
ZW-49 is an orally active pan-EGFR inhibitor with IC50 values at 0.03-1.5 nM. ZW-49 inhibits all subgroups of EGFR mutations with selectivity over wild-type EGFR and other target families. ZW-49 blocks the ATP-binding pocket, occupies a conserved hydrophobic subpocket, avoids steric conflicts with PACC mutation P loops. ZW-49 inhibits cancer cells proliferation, induces G0/G1 phase cell-cycle arrest and apoptosis, and demonstrates anti-proliferative activity in xenograft mice models. ZW-49 can be used for the research of cancer, such as non-small cell lung cancer .
Cat. No.: HY-Y0284S2
CAS No.: 99873-99-1
Cat. No.: HY-181175
CAS No.: 1531606-19-5
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OMJ-4 is a mutant alpha-mannosidase modulator. OMJ-4 can restore mutant alpha-mannosidase's catalytic function, and induces changes in compactness and active-site flexibility to improve substrate accommodation. OMJ-4 acts as an inducer of substrate reactivity, increasing the reactivity of mannose disaccharide bound to mutant alpha-mannosidase. OMJ-4 reduces the activation energy required for the enzymatic reaction of mutant alpha-mannosidase. OMJ-4 can be used for the research of alpha-mannosidosis .
Cat. No.: HY-187330
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Anticancer agent 356 is a phthaloyl derivative with anticancer activity. Molecular docking results of Anticancer agent 356 show that it binds to the EGFR tyrosine kinase domain, KRIT1-Rap1-HEG1 ternary complex and EF-Pyl-GMPPNP complex, thereby stabilizing the complexes and reducing the flexibility of residues at the binding sites. Anticancer agent 356 exhibits cytotoxicity against prostate cancer cells and breast cancer cells. Anticancer agent 356 can be used in the research of prostate cancer and breast cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
