Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
115 Results for "
TRPC
" in MedChemExpress (MCE) Product Catalog:
Products (115)
115 Results for "TRPC" in MCE Product Catalog:
Cat. No.: HY-RS16614
Target:
Research Areas:
Trpc5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Trpc5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17997
Target:
Research Areas:
Trpc1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Trpc1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18846
Target:
Research Areas:
Trpc7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Trpc7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23049
Target:
Research Areas:
Trpc5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Trpc5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23198
Target:
Research Areas:
Trpc3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Trpc3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23421
Target:
Research Areas:
Trpc4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Trpc4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24469
Target:
Research Areas:
Trpc1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Trpc1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS25338
Target:
Research Areas:
Trpc7 Rat Pre-designed siRNA Set A contains three designed siRNAs for Trpc7 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-111527R
CAS No.: 896203-18-2
Target:
Research Areas:
PPZ2 (Standard) is the analytical standard of PPZ2 (HY-111527). This product is intended for research and analytical applications. PPZ2 is a diacylglycerol (DAG)-activated TRPC3/TRPC6/TRPC7 channel activator with activity in promoting neuronal development and survival. PPZ2 activates recombinant TRPC3/TRPC6/TRPC7 channels in a dose-dependent manner without affecting other TRPC channels. PPZ2 elicits cation currents and calcium ion (Ca(2+)) influx in cultured central neurons. PPZ2 is able to induce BDNF-like neurite outgrowth and neuroprotection, an effect that disappears after TRPC3/TRPC6/TRPC7 knocKdown or inhibition. PPZ2 also increases the activation of the calcium-dependent transcription factor cAMP response element binding protein. The effects of PPZ2 suggest that calcium signaling mediated by activation of DAG-activated TRPC channels plays an important role in its neurotrophic effects .
Cat. No.: HY-101507R
CAS No.: 1628287-16-0
Synonyms: Pico145 (Standard); HC-608 (Standard)
Target:
Research Areas:
Zerencotrep (Standard) is the analytical standard of Zerencotrep (HY-101507). This product is intended for research and analytical applications. Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (-)-englerin A-activated TRPC4/TRPC5 channels, with IC50s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8 .
Cat. No.: HY-184164
Target:
Research Areas:
JD03-02 is an orally active, blood-brain barrier-permeable TRPC1/5 heterodimer inhibitor with an IC50 of 0.2 nM. JD03-02 preferentially binds to a unique ligand-binding pocket at the interface of TRPC1-TRPC5, exerts almost no inhibitory effect on TRPC5 homotetramers, and thus avoids side effects such as obesity and hyperkinesia. JD03-02 induces anxiolytic and antidepressant effects in mouse models. JD03-02 can be used in studies related to depression and anxiety disorders .
Cat. No.: HY-111925R
CAS No.: 2361241-23-6
Target:
Research Areas:
BI-749327 (Standard) is the analytical standard of BI-749327 (HY-111925). This product is intended for research and analytical applications. BI-749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC50s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. BI-749327 is 85-fold more selective for mouse TRPC6 than TRPC3 and 42-fold versus TRPC7 .
Cat. No.: HY-30234B
CAS No.: 17162-20-8
Target:
Research Areas:
Infection Neurological Disease Inflammation/Immunology Endocrinology
Clemizole sulfate is an orally active, blood-brain barrier permeable TRPC5 inhibitor, with an IC50 value of 1.05-1.34 μM against mouse TRPC5. Clemizole sulfate blocks TRPC1:TRPC5, TRPC3, TRPC4, TRPC6, TRPC7, hERG, hKCNQ1/hKCNE1 and hKv1.5 channels, and activates TRPA1; it modulates 5HT-2B and HTR2A receptors; it inhibits HCV RNA replication, CrtN enzymatic activity, oxidative stress, neuroinflammation, cell apoptosis and bacterial virulence; it maintains blood-brain barrier (BBB) integrity; it enhances DNA repair capacity; it improves cell viability; and it alters cardiac electrophysiological properties. Clemizole sulfate can be used in the research of Dravet syndrome, hepatitis C virus infection, Staphylococcus aureus skin infection, Cisplatin (HY-17394)-induced nephrotoxicity, STXBP1-related diseases, traumatic brain injury and xeroderma pigmentosum type C .
Cat. No.: HY-108465R
CAS No.: 1160514-60-2
Target:
Research Areas:
Pyr3 (Standard) is the analytical standard of Pyr3 (HY-108465). This product is intended for research and analytical applications. Pyr3 is a selective inhibitor of transient receptor potential canonical channel 3 (TRPC3), with an IC50 of 700 nM for TRPC3-mediated Ca2+ influx.
Cat. No.: HY-P703229
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: TRPC6; TRP6; Short transient receptor potential channel 6; TRPC6; Transient receptor protein 6; TRP-6; TRPC6; Transient Receptor Potential Cation Channel, Subfamily C, Member 6; FSGS2; Transient Receptor Potential Cation Channel Subfamily C Member 6; Foca
Species:
Human
Source:
HEK293
Cat. No.: HY-P703228
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: TRPC3; TRP3; Short transient receptor potential channel 3; TRPC3; Transient receptor protein 3; TRP-3; hTrp-3; hTrp3; Transient Receptor Potential Cation Channel Subfamily C Member 3 Short Isoform; TRPC3; HTrp3; SCA41; HTrp-3; SCA41; Uncharacterized Prote
Species:
Human
Source:
HEK293
Cat. No.: HY-P705532
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TRPC3; TRP3; Short transient receptor potential channel 3; TRPC3; Transient receptor protein 3; TRP-3; hTrp-3; hTrp3; Transient Receptor Potential Cation Channel Subfamily C Member 3 Short Isoform; TRPC3; HTrp3; SCA41; HTrp-3; SCA41; Uncharacterized Prote
Species:
Human
Source:
HEK293
Cat. No.: HY-P810475
Synonyms: TRPC1, Transient Receptor Potential Cation Channel Subfamily C Member 1, HTRP-1, Short Transient Receptor Potential Channel 1, Transient Receptor Protein 1, TRP1, Transient Receptor Potential Cation Channel, Subfamily C, Member 1, Capacitative Calcium Channel Protein Trp1, Transient Receptor Potential Canonical 1, TRPC1, TRP-1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
