87 Results for "

polyketide

" in MedChemExpress (MCE) Product Catalog:
Products (87)

87 Results for "polyketide" in MCE Product Catalog:

Neosartoricin D
Neosartoricin D
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Cat. No.: HY-N16429
CAS No.: 1442657-25-1
Category:  

Natural Products Microorganisms

Target:  

Endogenous Metabolite

Neosartoricin D, a polyketide, is a microbial secondary metabolite. Neosartoricin D can be isolated from the cultural of Aspergillus nidulans. Neosartoricin D is an analog of Neosartoricin B (HY-N10311). Neosartoricin B is the secondary metabolite, which can be produced by Aspergillus nidulans. Neosartoricin B may regulate immunomodulatory effects with the host during infection and colonization by pathogenic fungi .
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Ethylmalonyl-CoA pentalithium
Ethylmalonyl-CoA pentalithium
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Cat. No.: HY-126955A
Synonyms: Ethylmalonyl coenzyme A pentalithium
Target:  

Endogenous Metabolite

Research Areas:  

Metabolic Disease

Ethylmalonyl-CoA pentalithium (Ethylmalonyl coenzyme A pentalithium) is a metabolic intermediate and biosynthetic precursor associated with crotonyl-CoA carboxylase/reductase. Ethylmalonyl‑CoA pentalithium is generated via the reductive carboxylation of crotonyl-CoA catalyzed by crotonyl-CoA carboxylase/reductase (CCR); it can be recognized by the PKS acyltransferase AT and participate in the biosynthesis of antibiotic polyketide natural products. Ethylmalonyl-CoA pentalithium is used in biosynthesis-related research .
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Dihydrocitrinone
Dihydrocitrinone
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Cat. No.: HY-N19229
CAS No.: 65718-85-6
Category:  

Natural Products Phoenix dactylifera L. Arecaceae Extract Plants

Target:  

Endogenous Metabolite

Dihydrocitrinone is a polyketide secondary metabolite and the major urinary metabolite of citrinin, which can be isolated from Aspergillus strains derived from the rhizosphere soil of date palms. Dihydrocitrinone exerts independent toxic effects in renal cell cultures and zebrafish embryo models, enhances the toxic effects of Ochratoxin A through additive or synergistic actions, and increases the level of miR-731 in zebrafish embryos when acting in combination with Ochratoxin A .
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3-(2,6-Dihydroxyphenyl)-4-hydroxy-6-methylisobenzofuran-1(3H)-one
3-(2,6-Dihydroxyphenyl)-4-hydroxy-6-methylisobenzofuran-1(3H)-one
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Cat. No.: HY-N19681
CAS No.: 1083198-53-1
Category:  

Microorganisms Phenols Polyphenols

Target:  

Endogenous Metabolite

3-(2,6-Dihydroxyphenyl)-4-hydroxy-6-methylisobenzofuran-1(3H)-one is a polyketide compound found in the mangrove endophytic fungus Phomopsis sp. xy21. 3-(2,6-Dihydroxyphenyl)-4-hydroxy-6-methylisobenzofuran-1(3H)-one shows neuroprotective activity against Corticosterone (HY-B1618)-induced injury in neuronal cells .
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Ariestatin A
Ariestatin A
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Cat. No.: HY-N20697
Category:  

Microorganisms Phenols Polyphenols

Target:  

Bacterial

Ariestatin A is an antibacterial agent that exhibits significant inhibitory effects against a variety of Gram-positive bacteria, including Bacillus subtilis, Staphylococcus aureus, and methicillin-resistant Staphylococcus aureus. Ariestatin A is extracted from the fungus Austroacremonium gemini MST-FP2131, and it is a glycosylated hybrid polyketide with a saturated C15 alkyl side chain. Ariestatin A shows no cytotoxic activity against mammalian cells and does not affect the growth of Saccharomyces cerevisiae. Ariestatin A can be used for bacterial infections caused by the aforementioned Gram-positive bacteria .
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(Z)-Corallopyronin A
(Z)-Corallopyronin A
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Cat. No.: HY-N21895
CAS No.: 96789-48-9
Category:  

Microorganisms Terpenoids Sesquiterpenes

Target:  

Drug Isomer Endogenous Metabolite Bacterial DNA/RNA Synthesis

(Z)-Corallopyronin A is an isomer of Corallopyronin A (HY-N11622). Corallopyronin A is a polyketide natural product derived from myxobacteria and acts as a bacterial RNA polymerase (RNAP) inhibitor with antibacterial activity. Corallopyronin A binds to the switch region of RNA polymerase and allosterically blocks the transcription initiation process. Corallopyronin A exhibits in vitro antibacterial activity against Staphylococcus aureus, coagulase-negative staphylococci, Neisseria gonorrhoeae, and the filarial endosymbiont Wolbachia. (Z)-Corallopyronin A can be used for research related to bacterial infections .
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Nafuredin A
Nafuredin A
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Cat. No.: HY-184460
CAS No.: 224427-79-6
Category:  

Microorganisms Ketones, Aldehydes, Acids

Target:  

Fungal Ferroptosis

Nafuredin A is a trinorsesquiterpene and polyketide derivative found in the mangrove sediment-derived fungi Talaromyces sp. SCSIO 41412 and Trichoderma harzianum D13. Nafuredin A regulates the ferroptosis pathway and upregulates ferroptosis-related genes. Nafuredin A alleviates hypoxia-reoxygenation-induced injury in oxygen-glucose deprivation/reperfusion cell models. Nafuredin A reduces pro-inflammatory cytokines and exerts hepatoprotective effects in animal models of hepatic ischemia-reperfusion injury. Nafuredin A inhibits the growth of phytopathogenic fungi Magnaporthe oryzae and Valsa mali. Nafuredin A can be used in studies related to hepatic ischemia-reperfusion injury and phytopathogenic fungal infections .
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