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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1084 Results for "
Staphylococcus
" in MedChemExpress (MCE) Product Catalog:
Products (1084)
1084 Results for "Staphylococcus" in MCE Product Catalog:
Cat. No.: HY-126731
CAS No.: 69245-38-1
Category:
Target:
Cat. No.: HY-126929
CAS No.: 81534-36-3
Synonyms: TXN-B
Trioxacarcin B (TXN-B) is a potent cytotoxic agent and DNA-targeted inhibitor. Trioxacarcin B disrupts DNA function and induces apoptosis in cancer cells. Trioxacarcin B not only effectively inhibits the growth of various Gram-positive and Gram-negative bacteria as well as Plasmodium falciparum, but also blocks the colony formation of cancer stem cells, significantly reduces tumor volume and prolongs survival in preclinical in vivo models. The activity of Trioxacarcin B is highly dependent on its intact spiro-epoxide structure; it loses efficacy once this moiety undergoes hydrolysis, and Trioxacarcin B shows no activity against fungi, microalgae and small RNA viruses. Trioxacarcin B can be used for research on bacterial infections, malaria, and various cancers including colon cancer and melanoma .
Cat. No.: HY-144012H
CAS No.: 474922-84-4
Synonyms: 16:0 PEG5000 PE; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000] ammonium
DPPE-PEG5000 (16:0 PEG5000 PE) is a polymer-lipid conjugate and LipoParticle stabilizer with a PEG chain of 5,000 g/mol molecular weight attached to its polar head, and it can be internalized by biological membranes. DPPE-PEG5000 enables LipoParticle to maintain colloidal stability after 20-fold dilution in PBS or cell culture medium, and prevents aggregate formation during lyophilization and rehydration. DPPE-PEG5000 helps enhance the non-cytotoxic property of LipoParticle formulations against human osteoblasts. DPPE-PEG5000 serves as a PEG lipid functional end group for synthesizing liposomes (LPs), is used in the design of conjugated polymer nanoparticles, and applies to research related to bone and joint infections .
Cat. No.: HY-148775
Purity: ≥95.0%
Cat. No.: HY-165460
CAS No.: 414858-51-8
Research Areas:
AM-112 is a β-lactamase (β-lactamase) inhibitor and antibacterial agent, with IC50 values ranging from 0.0002 μg/mL to 0.67 μg/mL against class A, C, and D β-lactamase. By inhibiting PBP2, the penicillin-binding protein of E. coli, and protecting Ceftazidime (HY-B0593) from enzymatic hydrolysis, AM-112 significantly enhances the antibacterial efficacy of Ceftazidime against Gram-negative bacteria, enterococci, and staphylococci. AM-112 exhibits favorable pharmacokinetic properties and acid-base stability. AM-112 can be used for the research of bacterial infections .
Cat. No.: HY-165465
CAS No.: 887774-94-9
Apo6619 is an iron chelator with antibacterial activity that inhibits a variety of common bacteria associated with hospital-acquired infections. Apo6619 inhibits the growth of relevant bacterial strains in cation-adjusted Mueller-Hinton broth and RPMI 1640 tissue culture medium. Apo6619 can be used in antibacterial research on hospital-acquired infection-related bacteria based on the iron chelation mechanism .
Cat. No.: HY-181674
Target:
Research Areas:
ZHO-197 is a dual bacterial peptide deformylase and methionine aminopeptidase inhibitor with antibacterial activity. ZHO-197 exhibits an Escherichia coli peptide deformylase IC50 of 0.021 μM and a human peptide deformylase IC50 of 3.289 μM. ZHO-197 displays broad-spectrum antibacterial activity against gram-positive and gram-negative bacterial strains. ZHO-197 can be used for the research of bacterial infection .
Cat. No.: HY-N21935
CAS No.: 49863-48-1
Category:
Target:
Cat. No.: HY-30234B
CAS No.: 17162-20-8
Target:
Research Areas:
Infection Neurological Disease Inflammation/Immunology Endocrinology
Clemizole sulfate is an orally active, blood-brain barrier permeable TRPC5 inhibitor, with an IC50 value of 1.05-1.34 μM against mouse TRPC5. Clemizole sulfate blocks TRPC1:TRPC5, TRPC3, TRPC4, TRPC6, TRPC7, hERG, hKCNQ1/hKCNE1 and hKv1.5 channels, and activates TRPA1; it modulates 5HT-2B and HTR2A receptors; it inhibits HCV RNA replication, CrtN enzymatic activity, oxidative stress, neuroinflammation, cell apoptosis and bacterial virulence; it maintains blood-brain barrier (BBB) integrity; it enhances DNA repair capacity; it improves cell viability; and it alters cardiac electrophysiological properties. Clemizole sulfate can be used in the research of Dravet syndrome, hepatitis C virus infection, Staphylococcus aureus skin infection, Cisplatin (HY-17394)-induced nephrotoxicity, STXBP1-related diseases, traumatic brain injury and xeroderma pigmentosum type C .
Cat. No.: HY-30234S
CAS No.: 1251554-64-9
Category:
other families Ketones, Aldehydes, Acids Plants Disease Research Fields Inflammation/Immunology
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Research Areas:
Moenomycin complex is a class of antibacterial agents and PBP inhibitors, with Kd values ranging from 94 nM to 1690 nM against various bacterial PBPs. Moenomycin complex inhibits bacterial growth by blocking the transglycosylase activity of class A penicillin-binding proteins (PBPs). Moenomycin complex is used in the research of bacterial infections .
Target:
Holomycin is an antibiotic with dithiolopyrrolone structure. Holomycin can inhibit bacterial RNA synthesis. Holomycin has antitumor activity. Holomycin can be used for the research of bacterial infection .
Cat. No.: HY-187837
CAS No.: 1426216-93-4
Synonyms: OPS-2071
Research Areas:
Abimufloxacin (OPS-2071) is a broad-spectrum quinolone antibacterial agent. Abimufloxacin inhibits the supercoiling activity of DNA gyrase, the decatenation activity of topoisomerase IV, the activation and proliferation of T cells, macrophage activity, as well as the production of TNF-α and IFN-γ. Abimufloxacin exhibits activity against enteropathogenic Gram-positive bacteria, Gram-negative bacteria, quinolone-resistant bacteria, and Crohn's disease-associated bacteria (including Clostridioides difficile and Campylobacter jejuni). Abimufloxacin alleviates colonic inflammation in a mouse model of T cell-mediated colitis. Abimufloxacin can be used in research related to diseases such as intestinal infections and Crohn's disease .
Cat. No.: HY-189124
Target:
Research Areas:
Antibacterial agent 372 is a potent antibacterial agent. Antibacterial agent 372 is a DNA gyrase inhibitor that binds to the ATP-binding pocket of the GyrB subunit, downregulates gyrB gene expression, and impedes DNA replication and supercoiling. Antibacterial agent 372 exhibits broad-spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Antibacterial agent 372 can be used for research on microbial infections .
Cat. No.: HY-206972
CAS No.: 26063-00-3
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Research Areas:
Poly (3-hydroxybutyrate) is a bacterially derived (R)-3-hydroxybutyrate homopolymer and a degradable biomaterial. Poly (3-hydroxybutyrate) degrades in vivo via lipases and esterases, breaking down into 3-Hydroxybutyric acid (HY-113378). Poly (3-hydroxybutyrate) can be compounded with 15% Hydroxyapatite (HA) (HY-D0835A) or 7.5-10% nanobioglass for use as a bone scaffold .
Cat. No.: HY-D3430
Cat. No.: HY-W015786
CAS No.: 622-62-8
Category:
Monophenols Marine natural products Metabolic Disease Phenols Endogenous metabolite Disease Research Fields
Target:
Cat. No.: HY-W015786R
CAS No.: 622-62-8
Category:
Cat. No.: HY-W019922
CAS No.: 7783-40-6
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
