Verdamicin
Verdamicin is an aminoglycoside antibiotic isolated from Micromonospora grisea, exhibiting broad-spectrum antibacterial activity against Gram-negative and Gram-positive bacteria. Verdamicin inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Verdamicin exerts bactericidal effects against Gram-negative and Gram-positive isolates. Verdamicin can be used for research on bacterial infections.
For research use only. We do not sell to patients.
- CAS No.: 49863-48-1
- Formula: C20H39N5O7
- Molecular Weight:461.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Biological Activity
Description
In Vitro
Verdamicin (0.25-16 μg/mL; 18 h) is highly active against non-Gentamicin (HY-A0276A)-resistant E. coli, with an MIC90 of 0.5 μg/mL and 98.1% susceptibility[1].
Verdamicin (0.125-128 μg/mL; 18 h) is highly active against non-Gentamicin-resistant K. pneumoniae, with an MIC90 of 0.5 μg/mL and 98.8% susceptibility[1].
Verdamicin (0.25-32 μg/mL; 18 h) is highly active against non-Gentamicin-resistant E. cloacae, with an MIC90 of 0.5 μg/mL and 98.2% susceptibility[1].
Verdamicin (0.25-32 μg/mL; 18 h) is highly active against non-Gentamicin-resistant E. aerogenes, with an MIC90 of 1 μg/mL and 98.1% susceptibility[1].
Verdamicin (0.25-0.5 μg/mL; 18 h) is highly active against non-Gentamicin-resistant C. diversus, with an MIC90 of 0.5 μg/mL and 100.0% susceptibility[1].
Verdamicin (0.5-8 μg/mL; 18 h) is highly active against non-Gentamicin-resistant P. mirabilis, with an MIC90 of 2 μg/mL and 100.0% susceptibility[1].
Verdamicin (0.25->128 μg/mL; 18 h) is highly active against non-Gentamicin-resistant S. marcescens, with an MIC90 of 0.5 μg/mL and 96.3% susceptibility[1].
Verdamicin (0.25->128 μg/mL; 18 h) exhibits poor activity against Gentamicin-resistant S. marcescens, with an MIC90 of >128 μg/mL and 10.0% susceptibility[1].
Verdamicin (0.5-4 μg/mL; 18 h) is highly active against non-Gentamicin-resistant M. morganii, with an MIC90 of 2 μg/mL and 100.0% susceptibility[1].
Verdamicin (0.25-128 μg/mL; 18 h) shows moderate activity against non-Gentamicin-resistant C. freundii, with an MIC90 of 64 μg/mL and 72.2% susceptibility[1].
Verdamicin (0.5-8 μg/mL; 18 h) is active against non-Gentamicin-resistant P. rettgeri, with an MIC90 of 8 μg/mL and 100.0% susceptibility[1].
Verdamicin (0.25-32 μg/mL; 18 h) is highly active against non-Gentamicin-resistant A. calcoaceticus, with an MIC90 of 2 μg/mL and 98.0% susceptibility[1].
Verdamicin (0.25->128 μg/mL; 18 h) shows moderate activity against non-Gentamicin-resistant P. aeruginosa, with an MIC90 of 16 μg/mL and 86.9% susceptibility[1].
Verdamicin (0.5-8 μg/mL; 18 h) is active against non-Gentamicin-resistant other Pseudomonas spp., with an MIC90 of 8 μg/mL and 100.0% susceptibility[1].
Verdamicin (0.5-2 μg/mL; 18 h) is active against non-Gentamicin-resistant H. influenzae, with an MIC90 of 1 μg/mL[1].
Verdamicin (0.25-4 μg/mL; 18 h) is active against non-Gentamicin-resistant H. parainfluenzae, with an MIC90 of 2 μg/mL[1].
Verdamicin (0.06-32 μg/mL; 18 h) is active against non-Gentamicin-resistant S. aureus, with an MIC90 of 8 μg/mL and 94.8% susceptibility[1].
Verdamicin (≤0.03-32 μg/mL; 18 h) shows moderate activity against non-Gentamicin-resistant S. epidermidis, with an MIC90 of 32 μg/mL and 75.0% susceptibility[1].
Verdamicin (4->128 μg/mL; 18 h) exhibits poor activity against Gentamicin-resistant E. coli, with an MIC90 of 128 μg/mL and 3.5% susceptibility[1].
Verdamicin (0.25->128 μg/mL; 18 h) exhibits poor activity against Gentamicin-resistant K. pneumoniae, with an MIC90 of >128 μg/mL and 10.7% susceptibility[1].
Verdamicin (0.25->128 μg/mL; 18 h) exhibits poor activity against Gentamicin-resistant E. cloacae, with an MIC90 of >128 μg/mL and 5.3% susceptibility[1].
Verdamicin (32->128 μg/mL; 18 h) exhibits no activity against Gentamicin-resistant E. aerogenes, with an MIC90 of >128 μg/mL and 0.0% susceptibility[1].
Verdamicin (16->128 μg/mL; 18 h) exhibits no activity against Gentamicin-resistant C. diversus, with an MIC90 of >128 μg/mL and 0.0% susceptibility[1].
Verdamicin (2->128 μg/mL; 18 h) exhibits poor activity against Gentamicin-resistant P. mirabilis, with an MIC90 of >128 μg/mL and 18.2% susceptibility[1].
Verdamicin (8->128 μg/mL; 18 h) exhibits poor activity against Gentamicin-resistant M. morganii, with an MIC90 of 128 μg/mL and 8.3% susceptibility[1].
Verdamicin (0.5->128 μg/mL; 18 h) exhibits poor activity against Gentamicin-resistant C. freundii, with an MIC90 of >128 μg/mL and 26.3% susceptibility[1].
Verdamicin (1 μg) produces a 17.0 mm zone of inhibition against Staphylococcus aureus ATCC 6538P[3].
Verdamicin (0.08-3.0 μg/mL; 18-24 h) exhibits broad in vitro activity against Staphylococcus aureus (coagulase-positive and coagulase-negative), Streptococcus pyogenes, and Diplococcus pneumoniae with MIC values ranging from 0.08 to 3.0 μg/mL[3].
Verdamicin (0.03-50 μg/mL; 18-24 h) demonstrates potent in vitro activity against susceptible gram-negative bacteria including E. coli, Proteus, Salmonella, Klebsiella, and Serratia (MIC 0.03-0.8 μg/mL), with cross-resistance observed against gentamicin-resistant Pseudomonas strains[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CF-1 (male, albino, ~20 g)[3]
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Dosage:0.2-2.5 mg/kg (S. aureus); 2.1-15.3 mg/kg (S. pyogenes); 6.2-20.3 mg/kg (D. pneumoniae); 0.3-21.0 mg/kg (E. coli); 0.1-3.7 mg/kg (K. pneumoniae); 0.4-7.6 mg/kg (Proteus sp.); 1.7-48.0 mg/kg (P. aeruginosa); 0.3-15.0 mg/kg (Salmonella sp.); 0.4-2.9 mg/kg (Serratia sp.)
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Administration:s.c.; single dose; 1 h after infection
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Result:Achieved mean protective doses ranging from 0.2-2.5 mg/kg against S. aureus (6 strains), 2.1-15.3 mg/kg against S. pyogenes (8 strains), 6.2-20.3 mg/kg against D. pneumoniae (3 strains), 0.3-21.0 mg/kg against E. coli (9 strains), 0.1-3.7 mg/kg against K. pneumoniae (7 strains), 0.4-7.6 mg/kg against Proteus sp. (6 strains), 1.7-48.0 mg/kg against P. aeruginosa (10 strains), 0.3-15.0 mg/kg against Salmonella sp. (55 strains), and 0.4-2.9 mg/kg against Serratia sp. (4 strains).
Chemical Information
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CAS No. 49863-48-1
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Molecular Weight 461.55
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Formula C20H39N5O7
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SMILES
O[C@H]1[C@@H](O[C@@H]2[C@H]([C@@H]([C@H](C[C@H]2N)N)O[C@H]3OC([C@H](C)N)=CC[C@H]3N)O)OC[C@@](C)([C@@H]1NC)O
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Structure Classification
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Initial Source
Pseudomonas spp.
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Verdamicin Related Classifications
HY-N21935 Related Classifications
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Keywords
- Verdamicin
- 49863-48-1
- Antibiotic
- Bacterial
- Enterobacteriaceae
- Pseudomonas aeruginosa
- Proteus rettgeri
- Micromonospora sagamiensis KY11525
- Micromonospora grisea
- Staphylococcus aureus ATCC 6538P
- Micromonospora inyoensis NRRL3292
- Micromonospora zionensis NRRL5466
- Diplococcus pneumoniae
- Streptococcus pyogenes
- Inhibitor
- inhibitor
- inhibit