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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
115 Results for "
FAD
" in MedChemExpress (MCE) Product Catalog:
Products (115)
115 Results for "FAD" in MCE Product Catalog:
Cat. No.: HY-138830B
CAS No.: 1818252-52-6
Target:
Research Areas:
TAK-418 free base is an orally active, blood-brain barrier-penetrant LSD1 inhibitor with a human IC50 of 2.9 nM. TAK-418 free base irreversibly inhibits LSD1 by forming a compact flavin-FAD adduct with the catalytic domain FAD, blocking the demethylation of H3K4me1/2 and H3K9me1/2 without disrupting the LSD1-GFI1B interaction. TAK-418 free base restores normally dysregulated brain gene expression and DNA methylation, increases H3K4me1/2/3 and H3K9me2 at the Ucp2 locus, and induces Ucp2 mRNA expression. TAK-418 free base rescues defective H3K4 histone modifications, normalizes adult neurogenesis, and improves recognition memory, social behavior, and cognition in rodent models. TAK-418 free base can be used in research related to neurodevelopmental disorders, Alzheimer's disease, and autism spectrum disorders .
Cat. No.: HY-P70953A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GFER; Growth Factor, Erv1 (S. Cerevisiae)-Like (Augmenter Of Liver Regeneration); Growth Factor, Augmenter Of Liver Regeneration; Augmenter Of Liver Regeneration; HERV1; ERV1 Homolog (S. Cerevisiae); ALR; Erv1-Like Growth Factor; FAD-Linked Sulfhydryl Oxi
Species:
Human
Source:
E. coli
Cat. No.: HY-P74126A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GFER; Growth Factor, Erv1 (S. Cerevisiae)-Like (Augmenter Of Liver Regeneration); Growth Factor, Augmenter Of Liver Regeneration; Augmenter Of Liver Regeneration; HERV1; ERV1 Homolog (S. Cerevisiae); ALR; Erv1-Like Growth Factor; FAD-Linked Sulfhydryl Oxi
Species:
Human
Source:
HEK293
Cat. No.: HY-P71571
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GFER; Growth Factor, Erv1 (S. Cerevisiae)-Like (Augmenter Of Liver Regeneration); Growth Factor, Augmenter Of Liver Regeneration; Augmenter Of Liver Regeneration; HERV1; ERV1 Homolog (S. Cerevisiae); ALR; Erv1-Like Growth Factor; FAD-Linked Sulfhydryl Oxi
Species:
Rat
Source:
E. coli
Cat. No.: HY-182891
Target:
Research Areas:
MC4455 is a LSD1/PRMT5 dual inhibitor. MC4455 inhibits the LSD1/CoREST and PRMT5/MEP50 complex with IC50 values of 0.104 μM and 0.014 μM. MC4455 covalently binds to LSD1’s FAD cofactor, stabilizes the LSD1/CoREST complex. MC4455 induces myeloid differentiation, alters transcriptomic profiles, drives alternative splicing changes, and impairs leukemic cell viability in AML cells. MC4455 can be used for the research of acute myeloid leukemia .
Cat. No.: HY-P74126
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GFER; Growth Factor, Erv1 (S. Cerevisiae)-Like (Augmenter Of Liver Regeneration); Growth Factor, Augmenter Of Liver Regeneration; Augmenter Of Liver Regeneration; HERV1; ERV1 Homolog (S. Cerevisiae); ALR; Erv1-Like Growth Factor; FAD-Linked Sulfhydryl Oxi
Species:
Human
Source:
HEK293
Cat. No.: HY-183105
CAS No.: 2133291-32-2
Target:
Research Areas:
DC551040 is an orally active and selective lysine demethylase 1 (LSD1) inhibitor with a human IC50 of 2.14 nM. DC551040 binds to LSD1 via π-π stacking with Trp552, polar interactions with Phe538, and covalent adduct formation with FAD, and disrupts the LSD1-GFI1B-CoREST complex. DC551040 induces H3K4me2 accumulation, apoptosis, and cell differentiation, activates STAT5, NF-κB, AKT, and IL6-STAT3 pathways, and upregulates IL6 expression. DC551040 can be used for the research of acute myeloid leukemia .
Cat. No.: HY-P86790
Synonyms: BRCA 2 antibody; BRCA1/BRCA2 containing complex subunit 2 antibody; Brca2 antibody; BRCA2, DNA repair associated antibody; BRCA2_HUMAN antibody; BRCC 2 antibody; BRCC2 antibody; Breast and ovarian cancer susceptibility gene early onset antibody; breast and ovarian cancer susceptibility protein 2 antibody; Breast cancer 2 early onset antibody; BRCA 2 antibody; BRCA1/BRCA2 containing complex subunit 2 antibody; Brca2 antibody; BRCA2, DNA repair associated antibody; BRCA2_HUMAN antibody; BRCC 2 antibody; BRCC2 antibody; Breast and ovarian cancer susceptibility gene early onset antibody; breast and ovarian cancer susceptibility protein 2 antibody; Breast cancer 2 early onset antibody; Breast Cancer 2 tumor suppressor antibody; Breast cancer susceptibility protein BRCA2 antibody; Breast cancer type 2 susceptibility protein antibody; BROVCA2 antibody; FACD antibody; FAD 1 antibody; FAD antibody; FAD1 antibody; FANCB antibody; FANCD 1 antibody; FANCD antibody; FANCD1 antibody; FANCD1 gene antibody; Fanconi anemia complementation group D1 antibody; Fanconi anemia group D1 protein antibody; GLM3 antibody; mutant BRCA2 antibody; OTTHUMP00000018803 antibody; OTTHUMP00000042401 antibody; PNCA2 antibody; XRCC11 antibody;
Cat. No.: HY-P703046
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: KDM1B; BA204B7.3; Prev. AOF1; FLJ33898; Prev. C6orf193; FLJ43328; LSD2; [Histone-H3]-N(6),N(6)-Dimethyl-L-Lysine(4) FAD-Dependent Demethylase; Flavin-Containing Amine Oxidase Domain-Containing Protein 1; Amine Oxidase (Flavin Containing) Domain 1; Lysine-
Species:
Mouse
Source:
Sf9 insect cells
Cat. No.: HY-113308AS1
CAS No.: 1265476-97-8
Cat. No.: HY-113308AS2
Cat. No.: HY-113308S
CAS No.: 1265681-64-8
Cat. No.: HY-113308AR
CAS No.: 6042-32-6
Cat. No.: HY-P85484
Synonyms: Amine oxidase; flavin containing; domain 2; AOF2; BHC110; BRAF35 HDAC complex protein BHC110; BRAF35-HDAC complex protein BHC110; FAD binding protein BRAF35 HDAC complex, 110 kDa subunit; Flavin-containing amine oxidase domain-containing protein 2; KDM 1; KDM1; Kdm1a; KDM1A_HUMAN; LSD 1; LSD1; Lysine; K; specific demethylase 1; Lysine; K; specific demethylase 1A; Lysine specific histone demethylase 1; Lysine specific histone demethylase 1A; Lysine-specific histone demethylase 1A.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
