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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
162 Results for "
PDE5
" in MedChemExpress (MCE) Product Catalog:
Products (162)
162 Results for "PDE5" in MCE Product Catalog:
Cat. No.: HY-18253S
CAS No.: 1175992-76-3
Cat. No.: HY-108045R
CAS No.: 398507-55-6
Research Areas:
Lodenafil carbonate (Standard) is the analytical standard of Lodenafil carbonate. This product is intended for research and analytical applications. Lodenafil carbonate, a dimer that acts as a proagent delivering Lodenafil in vivo, is an orally active phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED) .
Cat. No.: HY-RS10229
Target:
Research Areas:
Pde5a Rat Pre-designed siRNA Set A contains three designed siRNAs for Pde5a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-119855S1
Synonyms: Methisosildenafil-d5
Cat. No.: HY-105341
CAS No.: 215297-27-1
Target:
Research Areas:
UK 343664 is a potent, orally active and selective PDE5 inhibitor. UK 343664 partially reverses Thromboxane-induced pulmonary hypertension .
Cat. No.: HY-119316
CAS No.: 2007971-51-7
Research Areas:
CM-414 is a brain-penetrant phosphodiesterase 5 (PDE5) and HDAC inhibitor with IC50s of 60 nM, 91 nM, 310 nM, 322 nM and 490 nM for PDE5, HDAC6, HDAC1, HDAC3 and HDAC2, respectively. CM-414 diminishes brain Aβ and tau phosphorylation (pTau) level in Tg2576 mice. CM-414 can be used for the study of Alzheimer's disease (AD) .
Cat. No.: HY-113972R
CAS No.: 31858-66-9
Target:
Cat. No.: HY-179550
Research Areas:
Avanafil metabolite M4 (Compound M-4ii) is a metabolite of Avanafil (HY-18252). Avanafil is a selective Phosphodiesterase-5 (PDE-5) inhibitor with IC50s of 5.2, 630, 5700, 6200, 12000, 27000, 51000 and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cGMP hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis .
Cat. No.: HY-W751650
Synonyms: UK-92480-d3 citrate
Cat. No.: HY-128114
CAS No.: 372154-05-7
Synonyms: UK-92480-d3N-1
Synonyms: Tunodafil hydrochloride
Target:
Research Areas:
Yonkenafil (Tunodafil) hydrochloride, a novel phosphodiesterase 5 (PDE5) inhibitor, is effective in reducing cerebral infarction, neurological deficits, edema, and neuronal damage in the infarcted area. Yonkenafil (Tunodafil) hydrochloride may improve cognitive function by modulating neurogenesis and has a potential therapeutic effect on Alzheimer's disease .
Cat. No.: HY-167906S
Cat. No.: HY-U00186
CAS No.: 189362-06-9
Synonyms: OPC33509
Target:
Research Areas:
K134 is a phosphodiesterase 3 (PDE3) inhibitor. The IC50s of K134 toward PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 µM, respectively.
Target:
Research Areas:
Amino Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor analog and tadalafil structural analog. Amino Tadalafil can be specifically detected by anti-tadalafil polyclonal antibodies, with a cross-reactivity of 105.2% with tadalafil. Amino Tadalafil can be incorporated into dietary supplements .
Cat. No.: HY-18253R
CAS No.: 268203-93-6
Synonyms: DA8159 (Standard)
Research Areas:
Udenafil (Standard) is the analytical standard of Udenafil. This product is intended for research and analytical applications. Udenafil (DA8159) is a potent, selective and orally active phosphodiesterase type 5 (PDE5) inhibitor. Udenafil also inhibits cGMP hydrolysis and can be used for erectile dysfunction research .
Cat. No.: HY-119316A
CAS No.: 1624792-70-6
Target:
Research Areas:
CM-545, the cis-isomer of CM-414 (HY-119316), is a dual inhibitor of PDE5, HDAC1, HDAC2, HDAC3, and HDAC6 with pIC50 values of 7.47, 6.65, 6.14, 6.55, and 6.84, repectively .
Cat. No.: HY-W705784
CAS No.: 212500-02-2
Target:
Research Areas:
T-1032 free base is a selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 1.0 nM. T-1032 free base shows relaxant effect on isolated rabbit corpus cavernosum. T-1032 free base can be used for the research of erectile dysfunction .
Cat. No.: HY-117109R
CAS No.: 385769-84-6
Target:
Research Areas:
Amino Tadalafil (Standard) is the analytical standard of Amino Tadalafil. This product is intended for research and analytical applications. Amino Tadalafil is a structural analogue of Tadalafil (HY-90009A). Tadalafil is a potent inhibitor of PDE5 with applications in several conditions, including erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
