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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
162 Results for "
PDE5
" in MedChemExpress (MCE) Product Catalog:
Products (162)
162 Results for "PDE5" in MCE Product Catalog:
Cat. No.: HY-A0027AS
CAS No.: 1246911-67-0
Research Areas:
Fenspiride (hydrochloride) (Standard) is the analytical standard of Fenspiride (hydrochloride). This product is intended for research and analytical applications. Fenspiride, an orally active non-steroidal antiinflammatory agent, is an antagonist of H1-histamine receptor. Fenspiride inhibites phosphodiesterase 3 (PDE3), phosphodiesterase 4 (PDE4) and phosphodiesterase 5 (PDE5) activities with -log IC50 values of 3.44, 4.16 and approximately 3.8, respectively. Fenspiride can be used for the research of respiratory diseases .
Cat. No.: HY-B0442C
CAS No.: 224789-15-5
Cat. No.: HY-B0442S
CAS No.: 1189685-70-8
Cat. No.: HY-173640
CAS No.: 2785317-21-5
Research Areas:
ID11916 is an orally active androgen receptor (AR) antagonist and a phosphodiesterase 5 (PDE5) inhibitor. ID11916 blocks androgen binding to AR, nuclear translocation, and androgen-dependent transcriptional activity of AR, while increasing intracellular cGMP levels and activating PKG via inhibition. ID11916 shows potent anti-cancer effect in prostate cancer cell lines VCaP and 22Rv1 and in AR-positive breast cancer cell lines SK-BR-3 .
Cat. No.: HY-B0442AR
CAS No.: 224785-91-5
Category:
Cat. No.: HY-B0442AS
Cat. No.: HY-B0442CR
CAS No.: 224789-15-5
Category:
Cat. No.: HY-B0442R
CAS No.: 224785-90-4
Category:
Cat. No.: HY-N10156
CAS No.: 53377-61-0
Cat. No.: HY-W049735R
CAS No.: 149289-29-2
Category:
Cat. No.: HY-10790R
CAS No.: 153259-65-5
Synonyms: SB-207499 (Standard)
Research Areas:
Cilomilast (Standard) is the analytical standard of Cilomilast. This product is intended for research and analytical applications. Cilomilast (SB-207499) is a potent, selective and orally active inhibitor of Phosphodiesterase 4 (PDE4), with IC50s of ~100 and 120 nM for LPDE4 and HPDE4, respectively. Cilomilast shows selectivity for PDE4 over PDE1, PDE2, PDE3 and PDE5 (IC50=74, 65, >100, and 83 μM, respectively). Cilomilast has anti-inflammatory and immunomodulatory effects and can be used for thr research of asthma and chronic obstructive pulmonary disease (COPD) .
Cat. No.: HY-112631
CAS No.: 189362-27-4
Target:
Research Areas:
OPC-33540 is a highly selective and competitive PDE3 inhibitor with IC50 values of 0.32 nM (PDE3A) and 1.5 nM (PDE3B). OPC-33540 exhibits IC50s against PDE1, PDE2, PDE4, PDE5, and PDE7 of 42.9, 52.3, 100.8, 2.5, and 51.3 μM, respectively. OPC-33540 significantly enhances cAMP accumulation in platelets and effectively inhibits thrombin-induced platelet aggregation. OPC-33540 can be used in antithrombotic studies .
Cat. No.: HY-183463
CAS No.: 182282-60-6
Target:
Research Areas:
D 22888 is an orally active PDE4 inhibitor, with human PDE4 IC50 of 0.153 μM, and selectivity over PDE3 and PDE5. D 22888 elevates intracellular cAMP levels to modulate target cell functions. D 22888 acts as a relaxant of human bronchial ring inherent tone. D 22888 inhibits opsonized zymosan-induced superoxide anion generation by human eosinophils. D 22888 reduces bronchoalveolar lavage eosinophil numbers in allergen-challenged sensitized guinea pigs via single or chronic oral dosing. D 22888 can be used for the research of bronchial asthma .
Cat. No.: HY-B0442BR
CAS No.: 330808-88-3
Category:
Cat. No.: HY-187129
CAS No.: 82230-53-3
Target:
Research Areas:
Girisopam is a PDE inhibitor with IC50 values of 3.2, 4.0, and 12.5 μM against PDE4, PDE2, and PDE5, respectively. Girisopam exhibits anxiolytic, antidepressant, anti-aggressive, and antipsychotic activities. The binding sites of Girisopam are enriched exclusively in the basal ganglia of rat brains, and depletion of these sites is associated with damage to the striatonigral pathway. Girisopam enhances the potency of μ-opioid receptor agonists, attenuates the antagonistic effect of low-dose Naloxone (HY-17417A), and synergistically potentiates the anti-fighting effect of Chlorpromazine (HY-12708). Girisopam can be used in studies related to psychiatric disorders such as anxiety and depression [5].
Cat. No.: HY-P71591
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PDE5A; CGMP-Binding CGMP-Specific 3',5'-Cyclic Nucleotide Phosphodiesterase; Phosphodiesterase 5A; CGMP-Binding CGMP-Specific Phosphodiesterase; CGMP-Specific 3',5'-Cyclic Phosphodiesterase; CGMP-Specific Phosphodiesterase PDE5A1; CGMP-Specific Phosphodie
Species:
Mouse
Source:
E. coli
Cat. No.: HY-181774
CAS No.: 1807631-43-1
Target:
Research Areas:
PDE4/5-IN-1 is a selective phosphodiesterase 4/5 (PDE4/5) dual inhibitor. PDE4/5-IN-1 functionally inhibits PDE5, PDE4B2, and PDE4D2 activity. PDE4/5-IN-1 relaxes isolated rat prostate tissue, enhances nitric oxide-induced relaxation in isolated rat prostate tissue, and reduces alpha-1 adrenoceptor-mediated contractile responses in isolated rat prostate tissue. PDE4/5-IN-1 inhibits proliferation of human hyperplastic prostate cells. PDE4/5-IN-1 can be used for the research of benign prostatic hyperplasia .
Synonyms: SCH-446132
Target:
Research Areas:
Dasantafil (SCH-446132) is a small molecule phosphodiesterase-5A (PDE5A) inhibitor used to in genitourinary disorders and study erectile dysfunction .
Cat. No.: HY-161851
Target:
Research Areas:
MDL3 is a novel inhibitor of PDE4B and PDE5A. MDL3 against liver injury and inflammation and inhibits the pathological remodeling of adipose tissue .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
