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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
111 Results for "
PDK
" in MedChemExpress (MCE) Product Catalog:
Products (111)
111 Results for "PDK" in MCE Product Catalog:
製品番号: HY-P706083
純度: ≥ 80%, as determined by reducing SDS-PAGE.
別名: PDK1; Mitochondrial Pyruvate Dehydrogenase, Lipoamide, Kinase Isoenzyme 1; Pyruvate Dehydrogenase Kinase 1; Pyruvate Dehydrogenase Kinase, Isozyme 1; [Pyruvate Dehydrogenase (Acetyl-Transferring)] Kinase Isozyme 1, Mitochondrial; Pyruvate Dehydrogenase Kinase Isoform 1; Pyruvate Dehydrogenase Kinase, Isoenzyme 1; Protein-Serine/Threonine Kinase; PDH Kinase 1; PDHK1; Pyruvate Dehydrogenase (Acetyl-Transferring) Kinase Isozyme 1, Mitochondrial
Species:
Human
Source:
Sf9 insect cells
製品番号: HY-10514R
CAS 番号: 702675-74-9
Target:
研究分野:
BX795 (Standard) is the analytical standard of BX795 (HY-10514). This product is intended for research and analytical applications. BX795 is a potent and selective inhibitor of PDK1, with an IC50 of 6 nM. BX795 is also a potent and relatively specific inhibitor of TBK1 and IKKε, with an IC50 of 6 and 41 nM, respectively. BX795 blocks phosphorylation of S6K1, Akt, PKCδ, and GSK3β, and has lower selectivity over PKA, PKC, c-Kit, GSK3β etc. BX795 modulates autophagy .
製品番号: HY-16461
CAS 番号: 137038-57-4
別名: (-)-Solenopsin A
Category:
製品番号: HY-183318
CAS 番号: 3108258-69-8
Target:
研究分野:
PPARα/δ agonist 4 is a potent orally active and selective dual peroxisome proliferator-activated receptor (PPAR) α/δ agonist with EC50s of 0.36 and 1.31 nM, respectively. PPARα/δ agonist 4 exhibits >123-fold selectivity over PPARγ (EC50 = 160.84 nM). PPARα/δ agonist 4 upregulates expression of downstream fatty acid oxidation genes PDK4, CPT1A, and ACADVL. PPARα/δ agonist 4 can be used for the research of metabolic dysfunction-associated steatohepatitis .
製品番号: HY-N20662
CAS 番号: 2779545-15-0
製品番号: HY-175770
研究分野:
mIDH1-IN-2 is a brain-penetrant isocitrate dehydrogenase 1 (IDH1) inhibitor. mIDH1-IN-2 shows subnanomolar potency against IDH1 R132H and R132C (IC50 = 80.0 and 58.0 nM) and minimal activity against wt-IDH1/2. mIDH1-IN-2 also inhibits PDK1 (IC50 = 0.61 μM) and reduces PDH phosphorylation dose-dependently. mIDH1-IN-2 can inhibit cells proliferation, induces S phase arrest and promotes apoptosis. mIDH1-IN-2 can be used for the research of cancer, such as glioma .
製品番号: HY-181670
研究分野:
WH23 is a dehydrogenase/reductase SDR family member 11 (DHRS11) inhibitor with IC50 values of 0.037 μM. WH23 binds to DHRS11, forming a hydrogen bond with the enzyme’s His210 residue. WH23 suppresses androgen receptor mRNA and protein expression, reduces c-Myc expression, and inhibits cancer cell proliferation. WH23 inhibits PI3K/AKT signaling by reducing phosphorylation of PDK1, AKT, mTOR, and ERK. WH23 enhances Capivasertib (HY-15431)-induced cytotoxicity and apoptosis. WH23 can be used for the research of luminal androgen receptor-positive triple-negative breast cancer .
製品番号: HY-N6017
CAS 番号: 19906-72-0
製品番号: HY-P701738
純度: ≥ 90%, as determined by reducing SDS-PAGE.
別名: PDPK1; PkB Kinase Like Gene 1; 3-Phosphoinositide Dependent Protein Kinase 1; PkB Kinase; PDK1; PRO0461; 3-Phosphoinositide-Dependent Protein Kinase 1; HPDK1; Non-Specific Serine/Threonine Protein Kinase
Species:
Human
Source:
Sf9 insect cells
製品番号: HY-P701739
純度: ≥ 90%, as determined by reducing SDS-PAGE.
別名: PDPK1; PkB Kinase Like Gene 1; 3-Phosphoinositide Dependent Protein Kinase 1; PkB Kinase; PDK1; PRO0461; 3-Phosphoinositide-Dependent Protein Kinase 1; HPDK1; Non-Specific Serine/Threonine Protein Kinase
Species:
Human
Source:
Sf9 insect cells
製品番号: HY-183583
CAS 番号: 2709068-47-1
Target:
研究分野:
HIF-2α-IN-18 is a selective HIF-2α inhibitor with a human IC50 of 8.1 nM. HIF-2α-IN-18 binds to the HIF-2α PAS-B domain, induces conformational perturbations at the HIF-2α/ARNT dimerization interface, destabilizes the HIF-2α/ARNT heterodimer, and blocks HIF-2α-mediated transcriptional activity. HIF-2α-IN-18 inhibits hypoxia-induced expression of HIF-2α target genes EPO and SERPINE1, without inhibiting HIF-1α target genes PGK1 and PDK1. HIF-2α-IN-18 can be used for the research of clear cell renal cell carcinoma, hepatocellular carcinoma[1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
