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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
157 Results for "
Axl
" in MedChemExpress (MCE) Product Catalog:
Products (157)
157 Results for "Axl" in MCE Product Catalog:
Target:
Research Areas:
BPI-9016M is a potent, orally active, and selective dual c-Met and AXL tyrosine kinases inhibitor. BPI-9016M suppresses tumor cell growth, migration and invasion of lung adenocarcinoma .
Cat. No.: HY-100946R
CAS No.: 1437321-24-8
Synonyms: RXDX-106 (Standard)
Research Areas:
CEP-40783 (Standard) is the analytical standard of CEP-40783 (HY-100946). This product is intended for research and analytical applications. CEP-40783 is a potent, selective and orally available inhibitor of AXL and c-Met with IC50 values of 7 nM and 12 nM, respectively.
Cat. No.: HY-W400801
CAS No.: 1457983-33-3
Synonyms: G-749 hydrochloride
Target:
Research Areas:
Denfivontinib (G-749) hydrochloride is an AXL inhibitor that has synergistic antitumor effects with the PD-1 inhibitor Pembrolizumab (HY-P9902). Denfivontinib can enhance the NOD-like receptor pathway, thereby promoting the formation of the NLRP3 inflammasome .
Cat. No.: HY-P704624
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GAS6; AXSF; Prev. AxlLG; DKFZp666G247; Axl Receptor Tyrosine Kinase Ligand; FLJ34709; Growth Arrest-Specific Protein 6; GAS-6; Growth Arrest Specific 6; Axl Stimulatory Factor
Species:
Human
Source:
HEK293
Cat. No.: HY-P704625
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GAS6; AXSF; Prev. AxlLG; DKFZp666G247; Axl Receptor Tyrosine Kinase Ligand; FLJ34709; Growth Arrest-Specific Protein 6; GAS-6; Growth Arrest Specific 6; Axl Stimulatory Factor
Species:
Human
Source:
HEK293
Cat. No.: HY-115778
CAS No.: 2011034-35-6
Target:
Research Areas:
UNC3133 is an orally active, limitedly selective MerTK inhibitor with an IC50 of 3.0 nM. UNC3133 inhibits Axl, Tyro3 and Flt3 kinases, with IC50 values of 17 nM, 31 nM and 6.8 nM, respectively. UNC3133 is applicable to the research of inflammatory diseases and cancers .
Cat. No.: HY-15150C
CAS No.: 1037624-76-2
Synonyms: (R)-R428; (R)-BGB324
Target:
Research Areas:
(R)-Bemcentinib ((R)-R428) is the R-isomer of Bemcentinib (HY-15150). Bemcentinib (R428) is a selective, orally active Axl inhibitor with an IC50 of 14 nM. Bemcentinib blocks tumor metastasis and prolongs survival in metastatic breast cancer models .
Cat. No.: HY-13016S1
CAS No.: 1802168-53-1
Synonyms: XL184-d4; BMS-907351-d4
Cat. No.: HY-107145AR
CAS No.: 1394820-69-9
Research Areas:
Ningetinib (Standard) is the analytical standard of Ningetinib (HY-107145A). This product is intended for research and analytical applications. Ningetinib is a potent, orally bioavailable small molecule tyrosine Kinase inhibitor (TKi) with IC50s of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively.
Cat. No.: HY-107145R
CAS No.: 1394820-77-9
Research Areas:
Ningetinib Tosylate (Standard) is the analytical standard of Ningetinib Tosylate (HY-107145). This product is intended for research and analytical applications. Ningetinib Tosylate is a potent, orally bioavailable small molecule tyrosine Kinase inhibitor (TKi) with IC50s of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively.
Synonyms: XL184-d6; BMS-907351-d6
Research Areas:
UNC5293 is a MERTK-selective and potent inhibitor (Ki=190 pM). UNC5293 inhibits MERTK (IC50=0.9 nM) and is more selective over Axl, Tyro3 and Flt3. UNC5293 exhibits excellent mouse PK properties and is used for bone marrow leukemia research .
Target:
Research Areas:
RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50in cell assays, and suppresses lung cancer tumor growth .
Cat. No.: HY-14721A
CAS No.: 1103508-80-0
Synonyms: EMD-1214063 hydrochloride
Target:
Research Areas:
Tepotinib (EMD-1214063) hydrochloride is an orally active and highly selective, reversible, ATP-competitive c-Met inhibitor with an IC50 of 3 nM, >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer. Tepotinib hydrochloride inhibits c-Met phosphorylation and induces autophagy. Tepotinib hydrochloride has antitumor effects .
Target:
Research Areas:
UNC2881 is an orally active and specific Mer kinase inhibitor, inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM. UNC2881 shows additional inhibition against Axl and Tyro with IC50s of 360 nM and 250 nM, respectively. UNC2881 potently inhibits collagen-induced platelet aggregation, can be used for pathologic thrombosis research .
Cat. No.: HY-100833R
CAS No.: 251349-54-9
Target:
Research Areas:
Cabozantinib (S-malate) (Standard) is the analytical standard of Cabozantinib (S-malate). This product is intended for research and analytical applications. Cabozantinib S-malate (XL184 S-malate) is a potent multiple receptor tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.
Cat. No.: HY-12044R
CAS No.: 1140909-48-3
Synonyms: XL184 S-malate (Standard); BMS-907351 S-malate (Standard)
Target:
Research Areas:
Cabozantinib (S-malate) (Standard) is the analytical standard of Cabozantinib (S-malate). This product is intended for research and analytical applications. Cabozantinib S-malate (XL184 S-malate) is a potent multiple receptor tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
