Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
143 Results for "
DMSO
" in MedChemExpress (MCE) Product Catalog:
Products (143)
143 Results for "DMSO" in MCE Product Catalog:
Cat. No.: HY-DY1061
CAS No.: 158757-84-7
Solvent and concentration: DMSO: 2 mM
Cat. No.: HY-DY1073
CAS No.: 1392820-50-6
Solvent and concentration: DMSO: 2 mM
Cat. No.: HY-DY1089
CAS No.: 797785-10-5
Solvent and concentration: DMSO: 5 mM
Cat. No.: HY-DY1090
CAS No.: 216434-81-0
Solvent and concentration: DMSO: 5 mM
Cat. No.: HY-174322
Target:
Research Areas:
SHP2-IN-38 is a novel green-fluorescent SHP2 inhibitor with IC50 values of 2.89 μM (SHP2), 8.73 μM (SHP1), 11.08 μM (PTP1B), 33.07 μM (TCPTP). SHP2-IN-38 blocks the SHP2-mediated ERK signaling pathway and inhibits MV4-11 cells proliferation in vitro with IC50 of 7.90 μM. SHP2-IN-38 has an excitation wavelength of 360 nm, with a maximum emission wavelength of 550 nm in DMSO and 540 nm in DMF. SHP2-IN-38 shows green fluorescence imaging in HeLa cells and zebrafish.
Cat. No.: HY-D3104
CAS No.: 2767443-23-0
Target:
Research Areas:
ERNT is a fluorescent probe for monitoring endoplasmic reticulum (ER) polarity and detecting endoplasmic reticulum stress (ERS) during the progression of dynamic liver injury. ERNT functions based on a donor-π-acceptor (D-π-A) structure with an intramolecular charge transfer (ICT) effect. ERNT has multiple excitation/emission pairs: for in vitro cell imaging, the green channel has Ex/Em = 488/500-550 nm, and the red channel has Ex/Em = 488/570-620 nm; for in vivo liver imaging, Ex/Em = 520/620 nm; for solvent optical tests, Ex = 470 nm, with the maximum emission peak at 548 nm in low-polarity toluene and 668 nm in high-polarity DMSO. ERNT can evaluate the efficacy of hepatoprotective interventions by detecting changes in ER polarity, and also exhibits excellent photostability and low cytotoxicity .
Cat. No.: HY-DY1088
CAS No.: 75350-46-8
Synonyms: N-(5-Fluoresceinyl)maleimide (solution)
Solvent and concentration: DMSO: 10 mM
Cat. No.: HY-DY1097
CAS No.: 107091-89-4
Solvent and concentration: DMSO: 10 mM
The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.
Synonyms: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2
Target:
Research Areas:
Target:
Research Areas:
FITC (Fluorescein Isothiocyanate) (solution) , is one of the green fluorescein derivatives widely used in biology. FITC has the characteristics of high absorptivity and excellent fluorescence quantum yield. The isothiocyanate group of FITC can be combined with amino, sulfhydryl, imidazole, tyrosyl, carbonyl and other groups on the protein, so as to achieve protein labeling including antibodies and lectins. In addition to its use as a protein marker, FITC can also be used as a fluorescent protein tracer to rapidly identify pathogens by labeling antibodies, or for microsequencing of proteins and peptides (HPLC). The maximum excitation wavelength of FITC is 494 nm. Once excited, it fluoresces yellow-green at a maximum emission wavelength of 520 nm. In addition, FITC is also a hapten that can induce contact hypersensitivity (CHS) and induce an atopic dermatitis model .
Solvent and concentration: DMSO: 20 mM
The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.
Solvent and concentration: DMSO: 20 mM
The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.
Cat. No.: HY-DY1114
CAS No.: 53213-81-3
Research Areas:
DiOC5(3) (solution) is a mitochondrial Fluorescent dye that alters membrane potential, and it also acts as an inhibitor of NADH-ubiquinone reductase (respiratory complex I). DiOC5(3) (solution) increases the NADH/NAD ratio and induces excessive production of ROS. DiOC5(3) (solution) induces Apoptosis. DiOC5(3) accumulates in the mitochondria of leukemia stem-like cells via organic anion-transporting polypeptides, specifically labels these cells, and inhibits their proliferation. DiOC5(3) (solution) enhances the cellular uptake of Hoechst 33342 (HY-15559), reduces Hoechst 33342-associated cytotoxicity, and improves the resolution of DNA content analysis by flow cytometry. DiOC5(3) (solution) shows no detectable fluorescence signal when excited in the 400-500 nm ultraviolet light range. DiOC5(3) (solution) is applicable to leukemia-related research .
Solvent and concentration: DMSO: 10 mM
Solvent and concentration: DMSO: 10 mM
Cat. No.: HY-W327027
CAS No.: 314742-00-2
Target:
Research Areas:
7-(2,4-Dinitrophenoxy)-4-methyl-2H-chromen-2-one (Compound 1) is a fluorescent probe for the detection of hydrogen sulfide (H2S). 7-(2,4-Dinitrophenoxy)-4-methyl-2H-chromen-2-one has a low detection limit (4×10 -6 mol/L), good selectivity and high sensitivity. 7-(2,4-Dinitrophenoxy)-4-methyl-2H-chromen-2-one shows almost no cytotoxicity at concentrations of 150 µg/mL. 7-(2,4-Dinitrophenoxy)-4-methyl-2H-chromen-2-one has the excitation peak of 331 nm, and the emission peak about 385 nm in DMSO solvent. Upon the addition of increasing amounts of HS -, the fluorescence intensity increases obviously at about 392 nm .
Cat. No.: HY-D3094
CAS No.: 2687198-42-9
Target:
Research Areas:
TPE-SQ5 is a ratiometric Fluorescent probe for hypochlorite (ClO -) detection with a limit of detection of 5.6 nM. TPE-SQ5 exhibits high selectivity and high sensitivity towards ClO -. TPE-SQ5 can be oxidized by ClO - to form an epoxide, which quenches its deep red fluorescence; subsequently, the epoxide decomposes into a hemicyanine and a sulfonic acid-substituted oxindole, producing blue-green fluorescence to achieve a ratiometric response. TPE-SQ5 can form nanoparticles with Pluronic F-127 via the nanoprecipitation method, and these nanoparticles possess cell permeability. TPE-SQ5 has unique Ex/Em spectra in different solvents and nanoparticle forms, with emission peaks at 643 nm (380 nm excitation, 95% H2O/THF), 631 nm (564 nm excitation, DMSO), 652 nm (536 nm excitation, THF) and 630 nm (524 nm excitation, nanoparticles); the Ex/Em settings used for cell imaging are 488/550-650 nm (red channel) and 405/450-550 nm (green channel) .
Cat. No.: HY-P1363S1
Target:
Research Areas:
Cat. No.: HY-L901P
80,000 compounds
A Lead-like, diverse library is the foundation for achieving biological activity diversity. The MCE Lead-like Diverse Library Plus is a further supplement to the 50K Lead-like Compound Library (HY-L901), consisting of over 80,000 lead-like compounds, with an additional 30,000 structurally novel lead-like molecules. These compounds occupy a broader "chemical space", making it a powerful tool for new drug discovery.
Cat. No.: HY-L0103V
680,000 compounds
UORSY Screening Compounds Library contains about 680,000 compounds. The library has extensively developed a polymerization synthesis method that provides a highly diverse chemical structure. More than 85% of the compounds in the library have drug-like physicochemical properties, and more than 35% of the compounds have lead-like properties.
Cat. No.: HY-L906
646 compounds
On May 15, 2024, "Dimerization and antidepressant recognition at noradrenaline transporter" was published online by Nature. The research findings were an effort from Shanghai Institute of Materia Medica, Chinese Academy of Sciences. This study unraveled the important neural system target - the noradrenaline transporter (NET), obtaining the binding modes of human NET homodimers with the natural substrate norepinephrine (NE) and six selective antidepressants. It laid an important theoretical foundation for understanding the physiological regulation mechanisms of NET and other monoamine transporters.
The Norepinephrine Transporter (NET) Compound Library is obtained by computer-aided virtual screening based on the HY-L901 compound library . The specific screening process includes molecular docking screening, key pharmacophore screening, and CNS-MPO screening, which can be used for new drug discovery targeting the noradrenaline transporter.
Cat. No.: HY-L902
4,999 compounds
MCE 5K Scaffold Library consists of 5,000 lead-like compounds. Each compound represents one unique scaffold. All compounds are compatible with Lipinski’s rule (Rule of 5) with multiple characteristics such as calculated good solubility (-3.2 < logP < 5), oral bioavailability (RotB <= 10), drug transportability (PSA < 120). Compounds contained within the library have been screened to remove any inappropriate chemical structures, avoiding “false hits”. The sufficient diverse of compound structure makes this library a powerful tool for drug screening.
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
