1 Result for "

(R)-2-Hydroxyglutaric acid

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "(R)-2-Hydroxyglutaric acid" in MCE Product Catalog:

4
4 Cited Publications
Cat. No.: HY-113038
CAS No.: 13095-47-1
Synonyms: (R)-2-Hydroxyglutarate; (R)-2-Hydroxyglutaric acid; (R)-2-Hydroxypentanedioic acid
D-α-Hydroxyglutaric acid ((R)-2-Hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR signaling .
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