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18S

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By Targets:	Apoptosis (1) Biochemical Assay Reagents (1) Calcium Channel (1) Drug Isomer (1) Endogenous Metabolite (2) Epigenetic Reader Domain (2) GnRH Receptor (1) Reference Standards (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Metabolic Disease (4)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113138

3-Methyluridine 1 Publications Verification N3-Methyluridine	Endogenous Metabolite	Metabolic Disease
3-Methyluridine (m ³U; N3-Methyluridine) is a methylated nucleotide present in ribosomal RNA (rRNA), mainly targeting specific base sites of RNA molecules such as 23S rRNA. 3-Methyluridine can introduce a methyl group at the N3 position of uracil, affecting the secondary structure stability and base pairing ability of RNA, and regulating ribosome function. For example, it affects ribosomal subunit binding and tRNA interaction. 3-Methyluridine is often used as a key raw material for the synthesis of modified nucleotides, and is used to construct RNA oligonucleotides containing methylation modifications to study the effects of RNA methylation on gene expression and drug resistance .

HY-113040A

*(17R,18S)-Epoxyeicosatetraenoic acid* 17(R),18(S)-EETeTr	Calcium Channel	Cardiovascular Disease
(17R,18S)-Epoxyeicosatetraenoic acid (17 (R),18 (S)-EETeTr) is a physiologically active fatty acid metabolite and also a vasodilator targeting BKα. (17R,18S)-Epoxyeicosatetraenoic acid activates the outward potassium current mediated by BK channels, and this effect is independent of the BKβ1 subunit, intracellular/extracellular calcium levels, and sarcoplasmic reticulum calcium release regulated by RyR3. (17R,18S)-Epoxyeicosatetraenoic acid is produced by the epoxidation of eicosapentaenoic acid mediated by CYP1A1 variants. (17R,18S)-Epoxyeicosatetraenoic acid is applicable to research related to arrhythmia .

HY-P10378

GPR10 agonist 1	GnRH Receptor	Metabolic Disease
GPR10 agonist 1 (compound 18-S4) is a potent GPR10 agonist with EC₅₀ values of 80, 7.8 nM in the presence (10%) or absence (0%) of FBS, respectively. GPR10 agonist 1 has the potential for the research of chronic obesity .

HY-117948A

(S)-ML399	Drug Isomer Epigenetic Reader Domain	Cancer
(S)-ML399 (Compound 18S) is the enantiomer of ML399 (HY-117948). (S)-ML399 acts as a Menin-MLL interaction inhibitor with an IC₅₀ of 1400 nM. (S)-ML399 can be used to investigate acute leukemias with MLL translocations, including acute myeloid leukemia and acute lymphoblastic leukemia .

HY-169210

ECDD-S18	Apoptosis	Cancer
ECDD-S18 (compund ECDD-S18) induces apoptosis in a dose-dependent manner, effectively targets vacuolar ATPase (V-ATPase), and impairs lysosomal acidification .

HY-166024

18(S)-Methyleicosanoic acid	Biochemical Assay Reagents	Metabolic Disease
18(S)-Methyleicosanoic acid is an ester product.

HY-113138R

3-Methyluridine (Standard) N3-Methyluridine (Standard)	Endogenous Metabolite Reference Standards	Metabolic Disease
3-Methyluridine (Standard) is the analytical standard of 3-Methyluridine. This product is intended for research and analytical applications. 3-Methyluridine (m3U; N3-Methyluridine) is a methylated nucleotide present in ribosomal RNA (rRNA), mainly targeting specific base sites of RNA molecules such as 23S rRNA. 3-Methyluridine can introduce a methyl group at the N3 position of uracil, affecting the secondary structure stability and base pairing ability of RNA, and regulating ribosome function. For example, it affects ribosomal subunit binding and tRNA interaction. 3-Methyluridine is often used as a key raw material for the synthesis of modified nucleotides, and is used to construct RNA oligonucleotides containing methylation modifications to study the effects of RNA methylation on gene expression and drug resistance .

HY-N0967

(S,E)-Deca-2,9-diene-4,6-diyne-1,8-diol	Others	Others
(S,E)-Deca-2,9-diene-4,6-diyne-1,8-diol is a natural product .

HY-181064

FWG-33B	Epigenetic Reader Domain	Cancer
FWG-33B is an activator of TRMT112:METTL5 complex with an IC₅₀ value of 0.47 μM. FWG-33B can be used for the research of breast carcinoma, hepatocellular carcinoma, nasopharyngeal carcinoma .

Cat. No.	Product Name	Target	Research Area

HY-P10378

GPR10 agonist 1	GnRH Receptor	Metabolic Disease
GPR10 agonist 1 (compound 18-S4) is a potent GPR10 agonist with EC₅₀ values of 80, 7.8 nM in the presence (10%) or absence (0%) of FBS, respectively. GPR10 agonist 1 has the potential for the research of chronic obesity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113138

3-Methyluridine 1 Publications Verification N3-Methyluridine	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
3-Methyluridine (m ³U; N3-Methyluridine) is a methylated nucleotide present in ribosomal RNA (rRNA), mainly targeting specific base sites of RNA molecules such as 23S rRNA. 3-Methyluridine can introduce a methyl group at the N3 position of uracil, affecting the secondary structure stability and base pairing ability of RNA, and regulating ribosome function. For example, it affects ribosomal subunit binding and tRNA interaction. 3-Methyluridine is often used as a key raw material for the synthesis of modified nucleotides, and is used to construct RNA oligonucleotides containing methylation modifications to study the effects of RNA methylation on gene expression and drug resistance .

HY-113138R

3-Methyluridine (Standard) N3-Methyluridine (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
3-Methyluridine (Standard) is the analytical standard of 3-Methyluridine. This product is intended for research and analytical applications. 3-Methyluridine (m3U; N3-Methyluridine) is a methylated nucleotide present in ribosomal RNA (rRNA), mainly targeting specific base sites of RNA molecules such as 23S rRNA. 3-Methyluridine can introduce a methyl group at the N3 position of uracil, affecting the secondary structure stability and base pairing ability of RNA, and regulating ribosome function. For example, it affects ribosomal subunit binding and tRNA interaction. 3-Methyluridine is often used as a key raw material for the synthesis of modified nucleotides, and is used to construct RNA oligonucleotides containing methylation modifications to study the effects of RNA methylation on gene expression and drug resistance .

HY-N0967

(S,E)-Deca-2,9-diene-4,6-diyne-1,8-diol	Natural Products other families Torricellia angulata var. intermedia (Harms) Hu Plants Source Classification	Others
(S,E)-Deca-2,9-diene-4,6-diyne-1,8-diol is a natural product .

Host:	Mouse (3) Rabbit (2)
Reactivity:	Human (5) Rat (4) Mouse (4)
Application:	IHC-P (2) ICC/IF (4) IP (1) WB (5) FC (3) ELISA (2)
Isotype:	IgG (2) IgG1 (1) IgG2a (2)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (4) Recombinant (1)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P88457

	DTNA (Dystrobrevin alpha) Antibody (YA8141) D18S892E; DRP3; DTN; DTN-A; LVNC1	WB, ICC/IF, FC	Human, Mouse, Rat
	DTNA (Dystrobrevin alpha) Antibody (YA8141) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to DTNA (Dystrobrevin alpha).

HY-P88457A

	DTNA (Dystrobrevin alpha) Antibody (YA8141)(PBS only) D18S892E; DRP3; DTN; DTN-A; LVNC1	WB, ICC/IF, FC	Human, Mouse, Rat
	DTNA (Dystrobrevin alpha) Antibody (YA8141) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to DTNA (Dystrobrevin alpha).

HY-P83322

	Rad18 Antibody (YA3067) E3 ubiquitin-protein ligase RAD18; hHR18; hRAD18; RAD18; RAD18; S. cerevisiae; homolog; RING finger protein 73; RNF73	WB, FC	Human, Mouse, Rat
	Rad18 Antibody (YA3067) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Rad18.

HY-P85790

	CD146 Antibody (YA5482) Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; CD antigen CD146;	IHC-P, WB, ICC/IF, ELISA	Human
	CD146 Antibody (YA5482) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD146.

HY-P86410

	CD146 Antibody (YA6102) Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; CD antigen CD146)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	CD146 Antibody (YA6102) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD146.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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18S

Inhibitors & Agonists

Peptides

NaturalProducts

Antibodies

Natural
Products