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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
3 T3-L1 adipocytes
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "3 T3-L1 adipocytes" in MCE Product Catalog:
4
4 Cited Publications
Research Areas:
GPR81 agonist 1 is a potent and highly selective GPR81 agonist, with EC50s of 58 nM and 50 nM for human and mouse GPR81, respectively. GPR81 agonist 1 inhibits lipolysis in differentiated 3T3-L1 adipocytes. GPR81 agonist 1 suppresses lipolysis in mice without cutaneous flushing. GPR81 agonist 1 displays remarkable selectivity for GPR81 over GPR109a .
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1
1 Cited Publications
Cat. No.: HY-N0704
CAS No.: 55576-66-4
1
1 Cited Publications
Synonyms: trans-10,cis-12 CLA2
Research Areas:
(10E,12Z)-Octadeca-10,12-dienoic acid (trans-10,cis-12 CLA2) is an orally active PPARα activator and inhibits adipocyte differentiation. (10E,12Z)-Octadeca-10,12-dienoic acid and its downstream metabolites have various antioxidant and antitumor activities. (10E,12Z)-Octadeca-10,12-dienoic acid can induce proinflammatory cytokines and chemokines, which would lead to decreased adipogenesis and insulin resistance in adipose tissue. (10E,12Z)-Octadeca-10,12-dienoic acid can affect many aspects of milk fat synthesis. (10E,12Z)-Octadeca-10,12-dienoic acid reduces expression of lipogenic enzymes and inhibits the desaturation of fatty acids. (10E,12Z)-Octadeca-10,12-dienoic acid can reduce lipoprotein lipase (LPL) activity in cultured 3T3-L1 adipocytes and enhance triacylglycerol release from these cells. (10E,12Z)-Octadeca-10,12-dienoic acid decreases the expression of hepatic stearoyl-CoA desatyrase mRNA in mice. (10E,12Z)-Octadeca-10,12-dienoic acid is associated with changes in mucosal NF-κB and Cyclin D1 protein levels in mice .
Cat. No.: HY-N6858
CAS No.: 781658-23-9
Synonyms: 4-Hydroxy-L-isoleucine
Category:
other families Leguminosae Ketones, Aldehydes, Acids Metabolic Disease Plants Disease Research Fields Trigonella foenum-graecum Linn.
Target:
Cat. No.: HY-N0930B
CAS No.: 2368870-39-5
Cat. No.: HY-N0930A
CAS No.: 14279-86-8
Research Areas:
Galegine hemisulfate, a guanidine derivative, contributes to weight loss in mice. Galegine hemisulfate activates AMPK in 3T3-L1 adipocytes and L6 myotubes, as well as in the H4IIE rat hepatoma and HEK293 human kidney cell lines. Galegine hemisulfate has antibacterial activity, with minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains .
Cat. No.: HY-W012865
CAS No.: 80-69-3
Research Areas:
Tartronic acid, a dicarboxylic acid derive, is an inhibitor of the transformation of carbohydrates into fat under fat-deficient diet conditions. Tartronic acid promotes 3T3-L1 adipocyte differentiation by increasing the protein expression of FABP-4, PPARγ and SREBP-1. Tartronic acid promotes de novo lipogenesis and inhibits CPT-1β by upregulating acetyl-CoA and malonyl-CoA. Tartronic acid promotes weight gain and induces adipocyte hypertrophy in epididymal white adipose tissue and lipid accumulation in the livers of high-fat diet induced obese mice. Tartronic acid can be used for lipid metabolic disease research .
Cat. No.: HY-N1185
CAS No.: 59979-61-2
Target:
Cat. No.: HY-N13160
CAS No.: 85889-03-8
Category:
Target:
Cat. No.: HY-175725
CAS No.: 1825366-87-7
Target:
Research Areas:
NR4A1 agonist 1 is a NR4A1 agonist with a Ki value of 2.96 μM. NR4A1 agonist 1 exhibits lipid-lowering activity in 3T3-L1 adipocytes, with an EC50 of 0.13 μM, significantly decreasing triglyceride (TG) accumulation and lipid droplet accumulation. NR4A1 agonist 1 can be used for the study of obesity .
Cat. No.: HY-124535
CAS No.: 351071-62-0
Target:
Research Areas:
TGX-115 is a p110β/p110δ-selective, PI3-K inhibitor. TGX-115 blocks p110β-mediated Akt phosphorylation induced by lysophosphatidic acid (LPA) in L6 myotubes, reduces insulin-stimulated PI(3,4)P2 and PIP3 levels in 3T3-L1 adipocytes. TGX-115 can be used for the study of diabetes mellitus .
Cat. No.: HY-125357
CAS No.: 148619-41-4
Target:
Research Areas:
Cat. No.: HY-122959
CAS No.: 73793-68-7
Cat. No.: HY-156093
CAS No.: 3040015-86-6
Target:
Research Areas:
TPH1-IN-1 (compound 40) is a xanthine derivative and an inhibitor of tryptophan hydroxylase TPH1 (IC50: 110.1 nM). TPH1-IN-1 has good in vitro activity and liver microsome stability, and effectively inhibits adipocyte differentiation of T3-L1 cells .
Cat. No.: HY-133556
CAS No.: 2415643-79-5
Target:
Research Areas:
IQZ23 inhibits adipocyte differentiation via AMPK pathway activation. IQZ23 exerts a high efficacy in decreasing the triglyceride level (EC50=0.033 μM) in 3T3-L1 adipocytes. IQZ23 could be used for the research of obesity and related metabolic disorders .
Cat. No.: HY-N7661
CAS No.: 54334-04-2
Category:
Target:
Cat. No.: HY-N2961
CAS No.: 73731-86-9
Target:
Synonyms: 2-Hydroxybenzyl alcohol (Standard); Saligenin (Standard)
Category:
Target:
Cat. No.: HY-N7907
CAS No.: 142449-93-2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
