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Results for "

AMY1

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

4

Peptides

1

Isotope-Labeled Compounds

3

Antibodies

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15498
    Rimegepant
    5+ Cited Publications

    BMS-927711; BHV-3000

    		 CGRP Receptor Neurological Disease
    Rimegepant (BMS-927711; BHV-3000) is an orally bioavailable and blood-brain barrier permeable antagonist of CGRP and AMY1 receptors, with a pIC50 of 8.01 and a Ki of 0.027 nM for human CGRP receptors. Rimegepant antagonizes cAMP production induced by αCGRP, βCGRP and amylin at CGRP and AMY1 receptors in humans, rats and mice, as well as at rat AMY3 receptors. Rimegepant can be used in research related to migraine [1].
    Rimegepant
  • HY-P1464
    Amylin, amide, rat

    AMYlin (rat)

    		 Amylin Receptor Metabolic Disease
    Amylin, amide, rat is a potent and high affinity ligand of Amylin receptor AMY1 and AMY3 receptors and variably of AMY2 receptors; binding studies are generally used for the latter receptor.
    Amylin, amide, rat
  • HY-P10798A
    Eloralintide sodium

    LY-3841136 sodium

    		 Amylin Receptor Calcium Channel Metabolic Disease
    Eloralintide sodium is an Amylin Receptor agonist. Eloralintide sodium selectively activates AMY1R and AMY3R in cells expressing human or rat AMY1R, AMY3R or CTR. Eloralintide sodium activates AMYRs and CTR in rats, inducing a sustained decrease in plasma Ca 2+ levels. Eloralintide sodium reduces appetite and body weight in both lean and obese rats. Eloralintide sodium can be used for research related to obesity [1] .
    Eloralintide sodium
  • HY-P11245
    NN1213

    		Amylin Receptor Metabolic Disease
    NN1213, a long-acting human amylin peptide analog, is a selective Amylin receptor agonist with EC50 values of 0.177 and 0.262 nM for hAMY3R and rAMY3R, respectively. NN1213 significantly reduces food intake and fat mass. NN1213 can reduce body weightin diet-induced obese rats. NN1213 can be used for the research of obesity [1] .
    NN1213
  • HY-P4863
    Biotinyl-Amylin (human)

    		CGRP Receptor Neurological Disease Metabolic Disease
    Biotinyl-Amylin (human) is a biotin-labeled derivative of Amylin, amide, human (HY-P1070). Biotinyl-Amylin (human) acts as a competitive agonist for the Calcitonin Receptor (CTR) and for the Amylin receptors (AMY1, AMY2, and AMY3) formed by the association of CTR with RAMP1/2/3. By mimicking endogenous human amylin, Biotinyl-Amylin (human) binds to and activates CTR and AMY receptors, thereby initiating downstream signaling pathways involving cAMP, CREB, and ERK1/2, while retaining high-affinity receptor binding and activation capabilities. Biotinyl-Amylin (human) is primarily utilized in studies investigating the metabolic regulatory mechanisms underlying obesity and diabetes; it is also applicable to pharmacological research, receptor localization studies, and ligand-binding assays related to Amylin receptors in the context of Alzheimer's disease [1].
    Biotinyl-Amylin (human)
  • HY-RS00672
    AMY1A Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    AMY1A Human Pre-designed siRNA Set A contains three designed siRNAs for AMY1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    AMY1A Human Pre-designed siRNA Set A
    AMY1A Human Pre-designed siRNA Set A
  • HY-15498S
    Rimegepant-d4

    BMS-927711-d4; BHV-3000-d4

    		 Isotope-Labeled Compounds CGRP Receptor Neurological Disease
    Rimegepant-d4 (BMS-927711-d4) is the deuterium labeled Rimegepant (HY-15498). Rimegepant (BMS-927711) is an orally bioavailable and blood-brain barrier permeable antagonist of CGRP and AMY1 receptors, with a pIC50 of 8.01 and a Ki of 0.027 nM for human CGRP receptors. Rimegepant antagonizes cAMP production induced by αCGRP, βCGRP and amylin at CGRP and AMY1 receptors in humans, rats and mice, as well as at rat AMY3 receptors. Rimegepant can be used in research related to migraine [1].
    Rimegepant-d4
  • HY-RS08880
    MYCBP Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    MYCBP Human Pre-designed siRNA Set A contains three designed siRNAs for MYCBP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MYCBP Human Pre-designed siRNA Set A
    MYCBP Human Pre-designed siRNA Set A

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