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Cat. No.: HY-15498R

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Rimegepant (Standard)

Name: Rimegepant (Standard)
Brand: MedChemExpress
SKU: HY-15498R
Availability: PreOrder

(Synonyms: BMS-927711 (Standard); BHV-3000 (Standard))

Rimegepant (Standard) is the analytical standard of Rimegepant (HY-15498). This product is intended for research and analytical applications. Rimegepant (BMS-927711; BHV-3000) is an orally bioavailable and blood-brain barrier permeable antagonist of CGRP and AMY1 receptors, with a pIC₅₀ of 8.01 and a K_i of 0.027 nM for human CGRP receptors. Rimegepant antagonizes cAMP production induced by αCGRP, βCGRP and amylin at CGRP and AMY1 receptors in humans, rats and mice, as well as at rat AMY3 receptors. Rimegepant can be used in research related to migraine .

For research use only. We do not sell to patients.

CAS No.: 1289023-67-1
Formula: C₂₈H₂₈F₂N₆O₃
Molecular Weight:534.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Rimegepant (Standard) Chemical Structure

CAS No.: 1289023-67-1

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Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 1289023-67-1
Molecular Weight 534.56
Formula C₂₈H₂₈F₂N₆O₃
SMILES

N[C@H]1[C@H](C2=C(F)C(F)=CC=C2)CC[C@@H](OC(N3CCC(N4C(C=CC=N5)=C5NC4=O)CC3)=O)C6=NC=CC=C61
Synonyms

BMS-927711 (Standard); BHV-3000 (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nimick M, et al. Pharmacological characterization of ubrogepant and atogepant in cAMP assays at human, rat, and mouse calcitonin family receptors in transfected cells. Biochem Pharmacol. Published online August 30, 2025. [Content Brief]

[2]. Guanglin Luo, et al. Discovery of (5S,6S,9R)-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): An Oral Calcitonin Gene-Related Peptide (CGRP) Antagonist in Clinical Trials for Treating Migraine. J. Med. Chem., 02 Nov 2012.

[3]. Pistolesi A, et al. Biodistribution of atogepant and rimegepant in mouse peripheral and central structures of relevance to migraine pathogenesis. Cephalalgia. 2025;45(11):3331024251378713. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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