Rimegepant (Standard)
Rimegepant (Standard) is the analytical standard of Rimegepant (HY-15498). This product is intended for research and analytical applications. Rimegepant (BMS-927711; BHV-3000) is an orally bioavailable and blood-brain barrier permeable antagonist of CGRP and AMY1 receptors, with a pIC50 of 8.01 and a Ki of 0.027 nM for human CGRP receptors. Rimegepant antagonizes cAMP production induced by αCGRP, βCGRP and amylin at CGRP and AMY1 receptors in humans, rats and mice, as well as at rat AMY3 receptors. Rimegepant can be used in research related to migraine .
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 1289023-67-1
- Formel: C28H28F2N6O3
- Molecular Weight:534.56
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Product Information
-
Chemical Information
- Reinheit & Dokumentation
-
Help & FAQs
Product Information
Information
Anwendung
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
-
CAS. Nr. 1289023-67-1
-
Molecular Weight 534.56
-
Formel C28H28F2N6O3
-
SMILES
N[C@H]1[C@H](C2=C(F)C(F)=CC=C2)CC[C@@H](OC(N3CCC(N4C(C=CC=N5)=C5NC4=O)CC3)=O)C6=NC=CC=C61
-
Synonyms
BMS-927711 (Standard); BHV-3000 (Standard)
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Nimick M, et al. Pharmacological characterization of ubrogepant and atogepant in cAMP assays at human, rat, and mouse calcitonin family receptors in transfected cells. Biochem Pharmacol. Published online August 30, 2025. [Content Brief]
[3]. Pistolesi A, et al. Biodistribution of atogepant and rimegepant in mouse peripheral and central structures of relevance to migraine pathogenesis. Cephalalgia. 2025;45(11):3331024251378713. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Rimegepant (Standard) Related Classifications
HY-15498R Related Classifications
Powered by Bioz