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Results for "

AcCoA

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-104032
    Ac-CoA Synthase-IN-1
    5+ Cited Publications

    		 RSV Infection Metabolic Disease
    Ac-CoA Synthase-IN-1 is a potent, reversible acetate-dependent acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC50 of 0.6 μM . Ac-CoA Synthase-IN-1 inhibits the respiratory syncytial virus (RSV) .
    Ac-CoA Synthase-IN-1
  • HY-145953
    VY-3-135
    4 Publications Verification

    		 Acetyl-CoA Carboxylase Cancer
    VY-3-135 is a potent, orally active, and stable ACSS2 inhibitor with an IC50 value of 44 nM. VY-3-135 is specific to ACSS2 among the AcCoA synthetase family of enzymes. VY-3-135 does not inhibit ACSS1 or ACSS3 enzymatic activity. VY-3-135 can be used for the research of breast cancer .
    VY-3-135
  • HY-156140
    Naa50-IN-1

    		Histone Acetyltransferase Others
    Naa50-IN-1 is an N-alpha-acetyltransferase 50 (Naa50) inhibitor with an IC50 of 7 nM against the human protein. Naa50-IN-1 exhibits selectivity toward the related enzymes Naa10 and Naa60. Naa50-IN-1 binds to the substrate-binding pocket of Naa50, and its binding affinity is enhanced by AcCoA .
    Naa50-IN-1
  • HY-P2827
    Acetyl-CoA synthetase

    ACS

    		 Acetyl-CoA synthetase Cancer
    Acetyl-CoA synthetase (ACS) is a key enzyme that catalyzes the conversion of acetate to acetyl-CoA (Ac-CoA). Acetyl-CoA synthetase catalyzes the formation of thioester bonds between coenzyme A and carboxylic acids, while simultaneously hydrolyzing ATP into AMP and pyrophosphate .
    Acetyl-CoA synthetase
  • HY-124609
    CAD031

    		AMPK Acetyl-CoA Carboxylase Neurological Disease
    CAD031 is an orally active AMPK/ACC1 signaling pathway activator and a derivative of the Alzheimer's disease (AD) targeted agent J147 (HY-13779) (more active than J147 in human neural stem cell assays). CAD031 can cross the blood-brain barrier, activate AMPK and inhibit ACC1, thereby increasing ac-CoA levels, improving mitochondrial function and reducing free fatty acid synthesis. CAD031 has neuroprotective, neurogenesis-promoting and memory-improving activities and can be used in the study of Alzheimer's disease and aging-related neurodegenerative diseases. CAD031 effectively enhances the memory of mice, improves dendritic structure, and stimulates cell division in the germinal zone of the brain of elderly mice .
    CAD031
  • HY-183249
    Ac-CoA Synthase-IN-2

    		Acetyl-CoA synthetase Fungal Infection
    Ac-CoA Synthase-IN-2 is an Ac-CoA Synthase (ACS) inhibitor and antifungal agent. Ac-CoA Synthase-IN-2 binds in the ATP/acetyl-AMP pocket of fungal and human ACS enzymes to exert competitive inhibition with ATP, and inhibits Cryptococcus neoformans CnKbc1-mediated acetoacetate-to-aceto-acetyl CoA conversion. Ac-CoA Synthase-IN-2 can be used for the research of fungal infections .
    Ac-CoA Synthase-IN-2
  • HY-104032R
    Ac-CoA Synthase-IN-1 (Standard)

    		Reference Standards RSV Infection Metabolic Disease
    Ac-CoA Synthase-IN-1 (Standard) is the analytical standard of Ac-CoA Synthase-IN-1 (HY-104032). This product is intended for research and analytical applications. Ac-CoA Synthase-IN-1 is a potent, reversible acetate-dependent acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC50 of 0.6 μM . Ac-CoA Synthase-IN-1 inhibits the respiratory syncytial virus (RSV) .
    Ac-CoA Synthase-IN-1 (Standard)

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