18 Results for "

Aquaporin-4

" in MedChemExpress (MCE) Product Catalog:
Products (18)

18 Results for "Aquaporin-4" in MCE Product Catalog:

25
25 Publications Verification
Cat. No.: HY-W008574
CAS No.: 51987-99-6
Target:  

PROTAC Linkers

Research Areas:  

Inflammation/Immunology Cancer

TGN-020 is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM . TGN-020 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .TGN-020 alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats [4].
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25
25 Publications Verification
Cat. No.: HY-W008574A
CAS No.: 1313731-99-5
Target:  

PROTAC Linkers

Research Areas:  

Inflammation/Immunology Cancer

TGN-020 sodium is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM . TGN-020 sodium is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . TGN-020 sodium alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats [4].
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1
1 Cited Publications
Cat. No.: HY-115460
CAS No.: 634913-39-6
Purity:  98.00%
Target:  

Aquaporin

AER-271, a phosphonate proagent derivative of AER-270, is an aquaporin-4 (AQP4) inhibitor for the research of acute ischemic stroke .
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Cat. No.: HY-W176557
CAS No.: 877459-36-4
Target:  

Aquaporin Amyloid-β

Research Areas:  

Neurological Disease

TGN-073 is an orally active, blood-brain barrier-permeable aquaporin 4 (AQP4) modulator. TGN-073 increases the uptake and distribution of brain MRI tracers in the brain parenchyma and reduces the levels of insoluble amyloid β-40 and β-42. TGN-073 can be used in research related to Alzheimer's disease, dementia, traumatic brain injury and pain .
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Cat. No.: HY-N3097
CAS No.: 18836-52-7
Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin (HY-10448), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 (HMGB1) and the expression of RAGE/TLR4. Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin. Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4 and DHODH. Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H⁺-ATPase and aquaporin 4 (AaAQP4). Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer) and has inhibitory effects on certain bacteria [4] .
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Cat. No.: HY-P10887
CAS No.: 2988012-71-9
Synonyms: AV-001
Pegevongitide (AV-001) is a Tie2 agonist. Pegevongitide resists the increased endothelial cell permeability induced by SARS-CoV-2 infection. Pegevongitide activates the angiogenin (angiogenin)/Tie2 signaling pathway. Pegevongitide reduces perivascular space dilation and upregulates perivascular Aquaporin-4 expression. Pegevongitide decreases the expression of TNF-α, PAI-1, CXCL9 and P-selectin, improves white matter integrity, enhances cognitive function and exerts neuroprotective effects. Pegevongitide improves white matter integrity in middle-aged rats with vascular dementia induced by multiple microinfarctions . Pegevongitide can be used in related research on diseases such as COVID-19 and vascular dementia .
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Cat. No.: HY-P10937
CAS No.: 2891466-35-4
Target:  

Aquaporin

Research Areas:  

Inflammation/Immunology

AQP4 (205-215) is a fragment of Aquaporin-4 (AQP4). AQP4 is a neuromyelitis optica autoantigen that is upregulated and presented in B cells after engagement of CD40. AQP4 is associated with autoimmune inflammatory diseases of the central nervous system (CNS), neuromyelitis optica (NMO) .
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Cat. No.: HY-P10937A
Target:  

Aquaporin

Research Areas:  

Inflammation/Immunology

AQP4 (205-215) TFA is a fragment of Aquaporin-4 (AQP4). AQP4 is a neuromyelitis optica autoantigen that is upregulated and presented in B cells after engagement of CD40. AQP4 is associated with autoimmune inflammatory diseases of the central nervous system (CNS), neuromyelitis optica (NMO) .
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Cat. No.: HY-P83459A
Synonyms: Aquaporin 4; WCH4; Mercurial-insensitive water channel; MIWC; AQP 4; AQP4; Aquaporin4; HMIWC 2; HMIWC2; Mercurial insensitive water channel; MGC22454; MIWC; AQP4_HUMAN; Aquaporin-4; AQP-4.

Host:  

Rabbit

Application:  

WB, IHC-P, IHC-F, FC, ICC/IF

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-P85657
Synonyms: AQP4; Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; WCH4

Host:  

Mouse

Application:  

WB, IHC-P, ICC/IF

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-P83459
Synonyms: AQP4; Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; WCH4

Host:  

Rabbit

Application:  

IHC-P

Reactivity:  

Human, Rat

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Cat. No.: HY-P72087A
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: AQP4; HAQP4; Aquaporin 4; WCH4; MIWC; Aquaporin Type4 Transcript Variant C; Mercurial-Insensitive Water Channel; Alternative Protein AQP4; Aquaporin-4; Aquaporin Type4; AQP-4; MLC4
Species:  
Human
Source:  
E. coli
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Cat. No.: HY-P702216
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: AQP4; HAQP4; Aquaporin 4; WCH4; MIWC; Aquaporin Type4 Transcript Variant C; Mercurial-Insensitive Water Channel; Alternative Protein AQP4; Aquaporin-4; Aquaporin Type4; AQP-4; MLC4
Species:  
Mouse
Source:  
E. coli Cell-free
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Cat. No.: HY-P72087
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: AQP4; HAQP4; Aquaporin 4; WCH4; MIWC; Aquaporin Type4 Transcript Variant C; Mercurial-Insensitive Water Channel; Alternative Protein AQP4; Aquaporin-4; Aquaporin Type4; AQP-4; MLC4
Species:  
Human
Source:  
E. coli
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Cat. No.: HY-N3097R
CAS No.: 18836-52-7
Pellitorine (Standard) is the analytical standard of Pellitorine (HY-N3097). Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin (HY-10448), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 (HMGB1) and the expression of RAGE/TLR4. Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin. Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4 and DHODH. Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H⁺-ATPase and aquaporin 4 (AaAQP4). Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer) and has inhibitory effects on certain bacteria.
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Cat. No.: HY-P991869
Synonyms: AQmabAM; rAb-53

Target:  

Aquaporin

Research Areas:  

Neurological Disease

Aquaporumab (AQmabAM) is an engineered human monoclonal IgG antibody. Aquaporumab is a selective inhibitor of aquaporin 4 (AQP4), binding tightly to AQP4 and competitively displacing AQP4-IgG from serum [1][2]. Aquaporumab significantly reduces neuromyelitis optica lesions in spinal cord slice cultures and in mice receiving intracerebral injection of AQP4-IgG and complement [1][2]. Aquaporumab can be used for research on neuromyelitis optica spectrum disorders [1][2]."}
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Cat. No.: HY-18805
CAS No.: 1752-96-1
Synonyms: N-Phenylnicotinamide
Target:  

Aquaporin

Research Areas:  

Neurological Disease

Nicotinanilide (N-Phenylnicotinamide) (Compound 12) is an aquaporin 4 (AQP4) inhibitor. Nicotinanilide can be used for research on diseases associated with AQP4 dysfunction, such as epilepsy and migraine .
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Cat. No.: HY-W017091
CAS No.: 538-43-2
Target:  

Aquaporin

3-Phenoxy-1,2-propanediol (compound 15) is a weak aquaporin 4 (AQP4) inhibitor . 3-Phenoxy-1,2-propanediol is an important intermediate for pharmaceuticals .
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