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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
C5b
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "C5b" in MCE Product Catalog:
7
4
4 Cited Publications
Cat. No.: HY-P9914
CAS No.: 219685-50-4
Synonyms: Anti-Human C5, Humanized Antibody; h5G1.1
Target:
Research Areas:
Cardiovascular Disease Infection Neurological Disease Inflammation/Immunology
1
1 Cited Publications
Target:
Research Areas:
Compound C5-IN-1 (Compound 7) is a selective allosteric inhibitor of complement component protein C5. Compound C5-IN-1 prevents C5 from being cleaved by C5 convertase, inhibits the cleavage of C5 into C5a and C5b, and thus blocks the formation of membrane attack complex (MAC). Compound C5-IN-1 has an IC50 of 0.77 μM and 5 nM in 50% human whole blood and 2% human serum to block MAC deposition induced by zymosan, respectively. Compound C5-IN-1 can be used to study diseases related to complement overactivation, such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) .
1
1 Cited Publications
Cat. No.: HY-P700862
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: Complement C5; C5; CPAMD4; ECLZB; C5a; C5b; C5D
1
1 Cited Publications
Cat. No.: HY-P81185
Synonyms: C5; C6; C7; C8; C9; Complement component 5; Complement component 6; Complement component 7; Complement component 8; Complement component 9; MAC; Membrane attack complex; TCC; Terminal complement complex.
Synonyms: ARC1905
Target:
Research Areas:
Avacincaptad pegol (ARC1905) sodium is a 40KDa PEG-conjugated aptamer. Avacincaptad pegol sodium targets complement factor 5 (C5), inhibits the cleavage of C5 into C5a and C5b, limits inflammatory stimulation and complement membrane attack complex (MAC), and is used to study age-related macular degeneration (AMD). Avacincaptad pegol sodium limits irregular cell apoptosis by targeting downstream factors in the complement cascade while preserving the early steps of the complement system .
Cat. No.: HY-P99965
CAS No.: 1917321-26-6
Synonyms: SKY59; RO7112689; RG-6107
Target:
Research Areas:
Cat. No.: HY-148457
CAS No.: 1613641-69-2
Synonyms: Izervay
Target:
Research Areas:
Avacincaptad pegol (Izervay) is a selective inhibitor targeting complement component C5, and is a pegylated ribonucleic acid aptamer. Avacincaptad pegol inhibits the cleavage of C5 into pro-inflammatory C5a and C5b, which forms the membrane attack complex (C5b-9), thereby reducing inflammatory cell recruitment and retinal cell damage. Avacincaptad pegol can slow the growth of geographic atrophy (GA) lesions and reduce the risk of persistent vision loss. Avacincaptad pegol can be used in research of geographic atrophy associated with age-related macular degeneration (AMD) and has been approved by the FDA .
Cat. No.: HY-P99638
CAS No.: 2456407-94-4
Synonyms: ALXN-1720
Target:
Research Areas:
Cat. No.: HY-P990753
CAS No.: 2763342-87-4
Synonyms: CAN-106
Target:
Research Areas:
Cat. No.: HY-P990955
CAS No.: 2839652-75-2
Synonyms: ADX-097
Target:
Research Areas:
Cat. No.: HY-P704336
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Complement C5; C5; CPAMD4; ECLZB; C5a; C5b; C5D
Cat. No.: HY-P704546
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: Complement C5; C5; CPAMD4; ECLZB; C5a; C5b; C5D
Cat. No.: HY-P704547
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Complement C5; C5; CPAMD4; ECLZB; C5a; C5b; C5D
Cat. No.: HY-RS01749
Target:
Research Areas:
C5 Human Pre-designed siRNA Set A contains three designed siRNAs for C5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P705283
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Complement C5; Hemolytic Complement; C5a
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
