Omoprubart  (Synonyms: CAN-106)

Omoprubart is an anti-C5 complement recombinant humanized monoclonal antibody. Omolubat can prevent C5 from cleaving into C5a and C5b, thereby inhibiting the formation and activation of the C5b-dependent membrane attack complex (MAC) on the surface of susceptible cells, leading to cell lysis (destruction). Omoprubart can be used for the study of paroxysmal nocturnal hemoglobinuria (PNH).

IgG2-G4-kappa

Human IgG2 kappa, Isotype Control

Human

Complement C5/C5a

3569  [NCBI]

P05231

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

145.657 kDa

2763342-87-4

Liquid

Colorless to light yellow

Shipping with dry ice.

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

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  IgG2-G4-kappa

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  Immobilized Complement C5 Protein, Human (HEK293, His, HY-P73396) can bind Omoprubart. The EC₅₀ for this effect is 3.473 ng/mL.
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  Flow Cytometry analysis of HepG2 cells with Omoprubart (HY-P990753, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 kappa(HY-P99002, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

• [1]. Omoprubart