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Omoprubart

(Synonyms: CAN-106)
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Based on 1 Customer Validation

Omoprubart is an anti-C5 complement recombinant humanized monoclonal antibody. Omolubat can prevent C5 from cleaving into C5a and C5b, thereby inhibiting the formation and activation of the C5b-dependent membrane attack complex (MAC) on the surface of susceptible cells, leading to cell lysis (destruction). Omoprubart can be used for the study of paroxysmal nocturnal hemoglobinuria (PNH).

For research use only. We do not sell to patients.

  • Purity: 97.769%
  • CAS No.: 2763342-87-4
  • Molecular Weight:145.657 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Omoprubart
  • Experimental Validation Results for Omoprubart
  • Experimental Validation Results for Omoprubart
  • Omoprubart Chemical Structure
    Omoprubart Chemical Structure
CAS No.: 2763342-87-4
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Omoprubart Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    IgG2-G4-kappa

  • 1/16

    Immobilized Complement C5 Protein, Human (HEK293, His, HY-P73396) can bind Omoprubart. The EC50 for this effect is 3.473 ng/mL.

  • 1/16

    Flow Cytometry analysis of HepG2 cells with Omoprubart (HY-P990753, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 kappa(HY-P99002, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Omoprubart Chemical Structure
    1/16
  • Omoprubart
  • Immobilized Complement C5 Protein, Human (HEK293, His, HY-P73396) can bind Omoprubart. The EC50 for this effect is 3.473 ng/mL.
  • Flow Cytometry analysis of HepG2 cells with Omoprubart (HY-P990753, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 kappa(HY-P99002, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • IgG2-G4-kappa