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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
CAPRIN1
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "CAPRIN1" in MCE Product Catalog:
9
9 Cited Publications
Cat. No.: HY-162288
CAS No.: 3036029-72-5
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FAZ-3532 is a G3BP inhibitor (Kd = 0.54 μM) which binds to the NTF2L nsP3 binding pocket in G3BP1. FAZ-3532 disrupts the co-condensation of RNA, G3BP1, and caprin 1. FAZ-3532 inhibits G3BP-driven stress granule formation. FAZ-3532 can be studied as a powerful tool to probe the biology of stress granules and a promising interventions designed to modulate stress granule formation [1].
3
3 Cited Publications
Cat. No.: HY-162289
CAS No.: 3036029-78-1
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FAZ-3780 is an inhibitor that binds to the NTF2L domain of G3BP1/2. FAZ-3780 binds to the NTF2L nsP3 of G3BP1 with high affinity, with a Kd of 0.15 μM and a Pep-FRET IC50 of 0.7 μM. FAZ-3780 targets the protein-protein interaction domain of G3BP1/2, and specifically inhibits the co-condensation of G3BP1, caprin 1 and RNA in vitro. FAZ-3780 inhibits stress granule formation and disassembles pre-formed stress granules. FAZ-3780 can be used in studies related to cancer and neurodegenerative diseases [1].
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HB007 is a SUMO1 molecular glue degrader targeting CAPRIN1 and FBXO42. HB007 selectively binds CAPRIN1 to induce CAPRIN1-FBXO42 interaction, recruits SUMO1 to the CAPRIN1-CUL1-FBXO42 E3 ligase complex, and drives SUMO1 ubiquitination and degradation without affecting SUMO2/3. HB007 induces TCF4 deSUMOylation and proteasomal degradation to inhibit StarD7 transcriptional activity, reduces StarD7 mRNA and protein levels, and triggers ER stress and ROS production. HB007 can be used for the research of brain cancer, breast cancer, colon cancer, lung cancer [1] .
Cat. No.: HY-161110
CAS No.: 3090769-17-5
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APP degrader-1 (Compound 0152) is an orally active amyloid precursor protein (APP) degrader that induces APP degradation and reduces the extracellular release of Aβ42. APP degrader-1 can bind to both CAPRIN1 and APP, and enhances their interaction as well as CAPRIN1-mediated APP degradation through the endosome-lysosome pathway [1].
Cat. No.: HY-RS01897
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CAPRIN1 Human Pre-designed siRNA Set A contains three designed siRNAs for CAPRIN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P990346
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Cat. No.: HY-P705937
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CAPRIN1; GPI-P137; Prev. GPIAP1; P137GPI; Prev. M11S1; Membrane Component, Chromosome 11, Surface Marker 1; CAPRIN-1; GPI-Anchored Membrane Protein 1, Isoform CRA_d; RNG105; Activation/Proliferation-Associated Protein 1; GPI-Anchored Membrane Protein 1; C
Species:
Human
Source:
HEK293
Cat. No.: HY-P89957
Synonyms: GPIAP1, GPIP137, M11S1, RNG105, CAPRIN1, CAPRIN-1, Cell cycle-associated protein 1, Cytoplasmic activation- and proliferation-associated protein 1, GPI-anchored membrane protein 1, GPI-anchored protein p137, Membrane component chromosome 11 surface marker 1, RNA granule protein 105, GPI-p137, p137GPI
Cat. No.: HY-165042
CAS No.: 93378-78-0
Synonyms: 1,2-Palmitin-3-CAPRIN; 1,2-Palmitin-3-decanoin; TG(16:0/16:0/10:0)
1,2-Dipalmitoyl-3-decanoyl-rac-glycerol (1,2-Palmitin-3-caprin), a compound mentioned in the chemical analysis of triglycerides and diacylglycerols in bovine milk fat, was identified by a specific chromatography-mass spectrometry technique, which is environmentally friendly and efficient.
Cat. No.: HY-165105
CAS No.: 81246-69-7
Synonyms: TG(18:1/10:0/18:1); 1,3-Dioleoyl-2-caproyl glycerol; 1,3-Olein-2-CAPRIN
1,3-Dioleoyl-2-decanoyl glycerol (TG(18:1/10:0/18:1)) is a compound that was investigated in the study of triglyceride composition in human milk and infant formula. The analysis and comparison of the compound using a specific chromatography-mass spectrometry technique revealed differences in triglyceride content between human milk and infant formula.
Cat. No.: HY-162288R
CAS No.: 3036029-72-5
Target:
Research Areas:
FAZ-3532 (Standard) is the analytical standard of FAZ-3532 (HY-162288). This product is intended for research and analytical applications. FAZ-3532 is a G3BP inhibitor (Kd = 0.54 μM) which binds to the NTF2L nsP3 binding pocket in G3BP1. FAZ-3532 disrupts the co-condensation of RNA, G3BP1, and caprin 1. FAZ-3532 inhibits G3BP-driven stress granule formation. FAZ-3532 can be studied as a powerful tool to probe the biology of stress granules and a promising interventions designed to modulate stress granule formation [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
