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Results for "

CD49d

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Integrin (7) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (3) Inflammation/Immunology (4) Neurological Disease (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) Antisense Oligonucleotides (2) siRNAs (2)

Inhibitors & Agonists

Inhibitory Antibodies

Antibodies

Oligonucleotides

Targets Recommended: CD1 CD38 CD28 CD19 CD20 CD22 Transferrin Receptor CD3 P-selectin CD6 CD2 CD276/B7-H3 CD73 c-Kit LAG-3 L-Selectin CTLA-4 CD47 ALCAM/CD166 Neprilysin E-Selectin Scavenger Receptor Class B type I (SR-BI） FLT3 Tim3 CD44 Anaplastic lymphoma kinase (ALK) CD74 Human leukocyte immunoglobulin (Ig)-like receptors (LILR) P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108831A

*Natalizumab (Anti-CD49d)* 3 Publications Verification AN100226; BG00002	Integrin	Inflammation/Immunology Cancer
Natalizumab (Anti-CD49d) (AN100226; BG00002) Solution is a humanized monoclonal IgG4 antibody inhibitor that selectively targets α4 integrin (CD49d), blocking the interaction of integrins such as α4β1 (VLA-4) with vascular cell adhesion molecule VCAM-1, intercellular adhesion molecule ICAM-1, and fibronectin by competitively binding to the α4 subunit. Natalizumab solution inhibits the adhesion, retention, and transendothelial migration of immune cells (such as CD4 ⁺ T cells), reducing the infiltration of inflammatory cells into the central nervous system or lesion sites, thereby exerting anti-inflammatory and immunomodulatory activity. Natalizumab (Anti-CD49d) solution is used in the study of relapsing-remitting multiple sclerosis (RRMS) and is also applied in the research of autoimmune or inflammation-related diseases such as Crohn's disease, B-cell lymphoma, and non-infectious uveitis. Natalizumab (Anti-CD49d) can also prevent lymphocytes from entering the central nervous system, thus preventing acute demyelinating relapses .

HY-14951

Firategrast Maximum Cited Publications 6 Publications Verification SB 683699	Integrin	Neurological Disease
Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist. Firategrast reduces trafficking of lymphocytes into the central nervous system (CNS) and decreases multiple sclerosis (MS) activity .

HY-108831

Natalizumab 3 Publications Verification	Integrin	Inflammation/Immunology Cancer
Natalizumab (AN100226; BG00002) is a humanized monoclonal IgG4 antibody inhibitor that selectively targets α4 integrin (CD49d). It blocks the interaction of integrins such as α4β1 (VLA-4) with vascular cell adhesion molecule VCAM-1, intercellular adhesion molecule ICAM-1, and fibronectin by competitively binding to the α4 subunit. Natalizumab inhibits the adhesion, retention, and transendothelial migration of immune cells (such as CD4 ⁺ T cells), reducing the infiltration of inflammatory cells into the central nervous system or lesion sites, thus exerting anti-inflammatory and immunomodulatory activity. Natalizumab is used in the study of relapsing-remitting multiple sclerosis (RRMS) and also has applications in the study of autoimmune or inflammation-related diseases such as Crohn's disease, B-cell lymphoma, and non-infectious uveitis. Natalizumab can also prevent lymphocytes from entering the central nervous system, thereby preventing acute demyelinating relapses .

HY-P990144

*Anti-Mouse/Human VLA-4/CD49d* Antibody (PS/2)**	Integrin	Inflammation/Immunology Cancer
Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) is an anti-mouse/human *VLA-4/CD49d* IgG2b monoclonal antibody. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) can reduce VLA-4 positive cells. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) can inhibit the migration of Tc1 cells to tumors. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) inhibits the retention of leukemia cells in the spleen and bone marrow by blocking VLA-4. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) can be used for research on inflammation conditions and cancer such as experimental autoimmune encephalomyelitis (EAE), melanoma and leukemia .

HY-12308

TCS 2314	Integrin	Inflammation/Immunology
TCS 2314 (compound 3) is orally active and selective very late antigen-4 (VLA-4, α4β1, CD49d/CD29) antagonist with an IC₅₀ of 4.4 nM .

HY-153481

ATL 1102 ISIS-107248; Avicursen	Integrin	Others
ATL 1102 (Avicursen) is a novel second-generation antisense oligonucleotide to *CD49d* mRNA

HY-RS06951

ITGA4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ITGA4 Human Pre-designed siRNA Set A contains three designed siRNAs for ITGA4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ITGA4 Human Pre-designed siRNA Set A ITGA4 Human Pre-designed siRNA Set A

HY-153481A

ATL 1102 sodium ISIS-107248 sodium; Avicursen sodium	Integrin	Others
ATL 1102 (Avicursen) sodium is a novel second-generation antisense oligonucleotide to *CD49d* mRNA

HY-RS17832

Itga4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Itga4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Itga4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Itga4 Mouse Pre-designed siRNA Set A Itga4 Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area	Image

HY-108831A

*Natalizumab (Anti-CD49d)* 3 Publications Verification AN100226; BG00002	Integrin	Inflammation/Immunology Cancer
Natalizumab (Anti-CD49d) (AN100226; BG00002) Solution is a humanized monoclonal IgG4 antibody inhibitor that selectively targets α4 integrin (CD49d), blocking the interaction of integrins such as α4β1 (VLA-4) with vascular cell adhesion molecule VCAM-1, intercellular adhesion molecule ICAM-1, and fibronectin by competitively binding to the α4 subunit. Natalizumab solution inhibits the adhesion, retention, and transendothelial migration of immune cells (such as CD4 ⁺ T cells), reducing the infiltration of inflammatory cells into the central nervous system or lesion sites, thereby exerting anti-inflammatory and immunomodulatory activity. Natalizumab (Anti-CD49d) solution is used in the study of relapsing-remitting multiple sclerosis (RRMS) and is also applied in the research of autoimmune or inflammation-related diseases such as Crohn's disease, B-cell lymphoma, and non-infectious uveitis. Natalizumab (Anti-CD49d) can also prevent lymphocytes from entering the central nervous system, thus preventing acute demyelinating relapses .

HY-108831

Natalizumab 3 Publications Verification	Integrin	Inflammation/Immunology Cancer
Natalizumab (AN100226; BG00002) is a humanized monoclonal IgG4 antibody inhibitor that selectively targets α4 integrin (CD49d). It blocks the interaction of integrins such as α4β1 (VLA-4) with vascular cell adhesion molecule VCAM-1, intercellular adhesion molecule ICAM-1, and fibronectin by competitively binding to the α4 subunit. Natalizumab inhibits the adhesion, retention, and transendothelial migration of immune cells (such as CD4 ⁺ T cells), reducing the infiltration of inflammatory cells into the central nervous system or lesion sites, thus exerting anti-inflammatory and immunomodulatory activity. Natalizumab is used in the study of relapsing-remitting multiple sclerosis (RRMS) and also has applications in the study of autoimmune or inflammation-related diseases such as Crohn's disease, B-cell lymphoma, and non-infectious uveitis. Natalizumab can also prevent lymphocytes from entering the central nervous system, thereby preventing acute demyelinating relapses .

HY-P990144

*Anti-Mouse/Human VLA-4/CD49d* Antibody (PS/2)**	Integrin	Inflammation/Immunology Cancer
Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) is an anti-mouse/human *VLA-4/CD49d* IgG2b monoclonal antibody. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) can reduce VLA-4 positive cells. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) can inhibit the migration of Tc1 cells to tumors. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) inhibits the retention of leukemia cells in the spleen and bone marrow by blocking VLA-4. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) can be used for research on inflammation conditions and cancer such as experimental autoimmune encephalomyelitis (EAE), melanoma and leukemia .

Host:	Mouse (2) Rabbit (1)
Reactivity:	Human (3)
Application:	WB (3) FC (2) ELISA (2)
Isotype:	IgG (1) IgG2a (2)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83456

	*Integrin alpha 4/CD49D* Antibody (YA3201)** ITGA4; CD49d; Integrin alpha-4; CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD49d	WB	Human
	Integrin alpha 4/CD49D Antibody (YA3201) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Integrin alpha 4/CD49D.

HY-P84085

	*Integrin alpha 4/CD49D* Antibody (YA3782)** ITGA4; IA4	WB, FC, ELISA	Human
	Integrin alpha 4/CD49D Antibody (YA3782) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Integrin alpha 4/CD49D.

HY-P84085A

	*Integrin alpha 4/CD49D* Antibody (YA3782)(PBS only)** ITGA4; IA4	WB, FC, ELISA	Human
	Integrin alpha 4/CD49D Antibody (YA3782) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Integrin alpha 4/CD49D.

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ATL 1102 ISIS-107248; Avicursen		Antisense Oligonucleotides
ATL 1102 (Avicursen) is a novel second-generation antisense oligonucleotide to *CD49d* mRNA

ITGA4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ITGA4 Human Pre-designed siRNA Set A contains three designed siRNAs for ITGA4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ATL 1102 sodium ISIS-107248 sodium; Avicursen sodium		Antisense Oligonucleotides
ATL 1102 (Avicursen) sodium is a novel second-generation antisense oligonucleotide to *CD49d* mRNA

Itga4 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Itga4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Itga4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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