12 Results for "

CD49d

" in MedChemExpress (MCE) Product Catalog:
Products (12)

12 Results for "CD49d" in MCE Product Catalog:

6
6 Publications Verification
Cat. No.: HY-14951
CAS No.: 402567-16-2
Purity:  99.75%
Synonyms: SB 683699
Target:  

Integrin

Research Areas:  

Neurological Disease

Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist. Firategrast reduces trafficking of lymphocytes into the central nervous system (CNS) and decreases multiple sclerosis (MS) activity .
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3
3 Cited Publications
Cat. No.: HY-108831A
CAS No.: 189261-10-7
Purity:  98.72%
Synonyms: AN100226; BG00002
Natalizumab (Anti-CD49d) (AN100226; BG00002) Solution is a humanized monoclonal IgG4 antibody inhibitor that selectively targets α4 integrin (CD49d), blocking the interaction of integrins such as α4β1 (VLA-4) with vascular cell adhesion molecule VCAM-1, intercellular adhesion molecule ICAM-1, and fibronectin by competitively binding to the α4 subunit. Natalizumab solution inhibits the adhesion, retention, and transendothelial migration of immune cells (such as CD4 + T cells), reducing the infiltration of inflammatory cells into the central nervous system or lesion sites, thereby exerting anti-inflammatory and immunomodulatory activity. Natalizumab (Anti-CD49d) solution is used in the study of relapsing-remitting multiple sclerosis (RRMS) and is also applied in the research of autoimmune or inflammation-related diseases such as Crohn's disease, B-cell lymphoma, and non-infectious uveitis. Natalizumab (Anti-CD49d) can also prevent lymphocytes from entering the central nervous system, thus preventing acute demyelinating relapses .
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3
3 Cited Publications
Cat. No.: HY-108831
CAS No.: 189261-10-7
Purity:  99.10%
Natalizumab (AN100226; BG00002) is a humanized monoclonal IgG4 antibody inhibitor that selectively targets α4 integrin (CD49d). It blocks the interaction of integrins such as α4β1 (VLA-4) with vascular cell adhesion molecule VCAM-1, intercellular adhesion molecule ICAM-1, and fibronectin by competitively binding to the α4 subunit. Natalizumab inhibits the adhesion, retention, and transendothelial migration of immune cells (such as CD4 + T cells), reducing the infiltration of inflammatory cells into the central nervous system or lesion sites, thus exerting anti-inflammatory and immunomodulatory activity. Natalizumab is used in the study of relapsing-remitting multiple sclerosis (RRMS) and also has applications in the study of autoimmune or inflammation-related diseases such as Crohn's disease, B-cell lymphoma, and non-infectious uveitis. Natalizumab can also prevent lymphocytes from entering the central nervous system, thereby preventing acute demyelinating relapses .
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Cat. No.: HY-P990144

Target:  

Integrin

Research Areas:  

Inflammation/Immunology Cancer

Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) is an anti-mouse/human VLA-4/CD49d IgG2b monoclonal antibody. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) can reduce VLA-4 positive cells. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) can inhibit the migration of Tc1 cells to tumors. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) inhibits the retention of leukemia cells in the spleen and bone marrow by blocking VLA-4. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) can be used for research on inflammation conditions and cancer such as experimental autoimmune encephalomyelitis (EAE), melanoma and leukemia .
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Cat. No.: HY-12308
CAS No.: 317353-73-4
Purity:  ≥98.0%
Target:  

Integrin

Research Areas:  

Inflammation/Immunology

TCS 2314 (compound 3) is orally active and selective very late antigen-4 (VLA-4, α4β1, CD49d/CD29) antagonist with an IC50 of 4.4 nM .
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Cat. No.: HY-153481
CAS No.: 350263-41-1
Synonyms: ISIS-107248; Avicursen
Target:  

Integrin

Research Areas:  

Others

ATL 1102 (Avicursen) is a novel second-generation antisense oligonucleotide to CD49d mRNA
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Cat. No.: HY-RS06951
Research Areas:  

Others

ITGA4 Human Pre-designed siRNA Set A contains three designed siRNAs for ITGA4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-153481A
Synonyms: ISIS-107248 sodium; Avicursen sodium
Target:  

Integrin

Research Areas:  

Others

ATL 1102 (Avicursen) sodium is a novel second-generation antisense oligonucleotide to CD49d mRNA
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Cat. No.: HY-P83456
Synonyms: ITGA4; CD49d; Integrin alpha-4; CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD49d

Host:  

Rabbit

Application:  

WB

Reactivity:  

Human

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Cat. No.: HY-RS17832
Research Areas:  

Others

Itga4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Itga4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P84085
Synonyms: ITGA4; IA4

Host:  

Mouse

Application:  

WB, FC, ELISA

Reactivity:  

Human

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Cat. No.: HY-P84085A
Synonyms: ITGA4; IA4

Host:  

Mouse

Application:  

WB, FC, ELISA

Reactivity:  

Human

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