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Results for "

CEACAM5

" in MedChemExpress (MCE) Product Catalog:

14

Inhibitors & Agonists

1

Fluorescent Dye

12

Inhibitory Antibodies

17

Recombinant Proteins

5

Antibodies

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P99054

    SAR-408377; PF-08046050 Antibody; SAR445953 Antibody

    Transmembrane Glycoprotein ADC Antibody Cancer
    Tusamitamab is an IgG1 monoclonal antibody that targets CEACAM5. Tusamitamab can be used to synthesize ADC Tusamitamab ravtansine (SAR408701) (HY-P99542) .
    Tusamitamab
  • HY-P99542

    SAR-408701; HuMAb2-3-SPDB-DM4

    Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin Cancer
    Tusamitamab ravtansine (SAR-408701) is a targeted ADC against tumor cells expressing CEACAM5, composed of a humanized anti-CEACAM5 monoclonal antibody covalently linked to the potent cytotoxic agent, maytansinoid DM4 (HY-12454), via a cleavable linker. Tusamitamab ravtansine has an average drug-to-antibody ratio (DAR) of 3.8 .
    Tusamitamab ravtansine
  • HY-177434

    Precem-TcT; M 9140

    Antibody-Drug Conjugates (ADCs) Transmembrane Glycoprotein Topoisomerase Cancer
    Precemtabart tocentecan (Precem-TcT; M 9140) is an anti-CEACAM5 (carcinoembryonic antigen-related cell adhesion molecule 5) antibody-drug conjugate (ADC). Precemtabart tocentecan consists of a tumor-specific anti-CEACAM5 monoclonal antibody Precemtabart (HY-P990940), a highly hydrophilic and stable cleavable β-glucuronide linker, and a topoisomerase 1 inhibitor payload Exatecan (HY-13631), and the drug-linker conjugate for ADC is Mal-Gly-PAB-Exatecan-D-glucuronic acid (HY-153179). Precemtabart tocentecan inhibits the growth of CEACAM5-positive cancer cells. Precemtabart tocentecan exhibits significant antitumor activity in CEACAM5-expressing xenograft models. Precemtabart tocentecan can be used for the study of CEACAM5-expressing advanced solid tumors, especially mCRC .
    Precemtabart tocentecan
  • HY-164899

    2-aminopyridine-3-carboxylic acid imidazolide

    Transmembrane Glycoprotein Cancer
    2A3 (2-aminopyridine-3-carboxylic acid imidazolide) is a T cell activator that specifically binds to CEACAM6 and CEACAM5. 2A3 exhibits enzymatic activity that catalyzes the glucuronidation of specific substrates (e.g., 1-naphthol), and possesses significant cytotoxic activity. When integrated into CAR T cells or used alone, 2A3 acts by inducing cytokine release, degranulation, and direct cytotoxicity. 2A3 kills pancreatic and breast cancer cells with high target antigen expression in vitro, and significantly inhibits the growth of pancreatic cancer xenografts in vivo. 2A3 broadly targets malignant tumors with overexpressed CEACAM5, CEACAM6, or co-expressed both, and shows high expression mainly in tissues such as the liver and colon. 2A3 serves as an important research tool for the immunotherapy of pancreatic and breast cancer . 2A3 is a novel SHAPE reagent, which can be used for the analysis of RNA structure both in vitro and in vivo . 2A3 is an electrophilic chemical probe that acylates the 2'-OH in the RNA backbone. 2A3 can be used for RNA SHAPE-MaP experiments and is capable of analyzing the RNA secondary structures at single nucleotide resolution.
    2A3
  • HY-P99681

    IMMU 130; hMN-14-SN-38

    Antibody-Drug Conjugates (ADCs) Cancer
    Labetuzumab govitecan (IMMU 130) is an Anti-CEACAM5/SN-38 antibody-drug conjugate (ADC). Labetuzumab govitecan consists of the antibody Labetuzumab, SN-38, and a pH-sensitive Linker. Labetuzumab govitecan can be used for research of cancers, such as colorectal cancer .
    Labetuzumab govitecan
  • HY-P991060

    Transmembrane Glycoprotein Cancer
    Cergutuzumab is a fully human IgG1 antibody that targets carcinoembryonic antigen (CEA, CEACAM5, CD66e). Cergutuzumab can be used to form the recombinant protein Cergutuzumab amunaleukin (HY-P99498) .
    Cergutuzumab
  • HY-RS02441

    Small Interfering RNA (siRNA) Others

    CEACAM5 Human Pre-designed siRNA Set A contains three designed siRNAs for CEACAM5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CEACAM5 Human Pre-designed siRNA Set A
    CEACAM5 Human Pre-designed siRNA Set A
  • HY-P991469

    MEDI-565

    Transmembrane Glycoprotein Cancer
    AMG-211 (MEDI-565)i s a bispecific antibody targeting CD3E and CEACAM5/CEA/CD66e. AMG-211 can be used in Gastrointestinal cancer and Solid tumours research .
    AMG-211
  • HY-P990853

    Transmembrane Glycoprotein Cancer
    Anti-CEACAM5 Antibody (4H11-8) is a kind of mouse IgG1 κ chimeric antibody, targeting to human CEACAM5. Anti-CEACAM5 Antibody (4H11-8) reacts with human CEACAM5 (carcinoembryonic antigen-related cell adhesion molecule 5). Anti-CEACAM5 Antibody (4H11-8) can be used for detecting CEACAM5 in cancer.
    Anti-CEACAM5 Antibody (4H11-8)
  • HY-RS17043

    Small Interfering RNA (siRNA) Others

    Ceacam5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ceacam5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ceacam5 Mouse Pre-designed siRNA Set A
    Ceacam5 Mouse Pre-designed siRNA Set A
  • HY-P991936

    Transmembrane Glycoprotein Cancer
    Anti-CEACAM5/CEA/CD66e Antibody (16C3) is an antibody against human CEACAM5/CEA/CD66e. Recommend Isotype Controls:?Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-CEACAM5/CEA/CD66e Antibody (16C3)
  • HY-P992350

    ADC Antibody Transmembrane Glycoprotein Cancer
    EBC-129 Antibody is a specific antibody for the synthetic antibody-drug conjugate (ADC) EBC-129, which specifically targets CEACAM5 and CEACAM6 glycosylated at N256. EBC-129 Antibody can be used for the research of pancreatic ductal adenocarcinoma .
    EBC-129 Antibody
  • HY-P992090

    Radionuclide-Drug Conjugates (RDCs) Transmembrane Glycoprotein Inflammation/Immunology
    Altumomab is a anti-huamn monoclonal antibody targeting CEACAM5/CEA/CD66e .
    Altumomab
  • HY-P990854

    Transmembrane Glycoprotein Cancer
    Anti-CEACAM1/3/5/6/8 Antibody (6G5j) is a kind of mouse IgG1 κ chimeric antibody, targeting to human CEACAM1/3/5/6/8. Anti-CEACAM1/3/5/6/8 Antibody (6G5j) reacts with an antigen epitope shared by human carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 1, 3, 5, 6, and 8. Anti-CEACAM1/3/5/6/8 Antibody (6G5j) can be used for the detections of western blot, ELISA, immunofluorescence immunohistochemistry and flow cytometry in cancer .
    Anti-CEACAM1/3/5/6/8 Antibody (6G5j)

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