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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
CPVT
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "CPVT" in MCE Product Catalog:
3
3 Cited Publications
Cat. No.: HY-W010950
CAS No.: 54143-55-4
Target:
Research Areas:
Flecainide is an orally active antiarrhythmic agent. Flecainide can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT) .
3
3 Cited Publications
Cat. No.: HY-W010950A
CAS No.: 57415-44-8
Target:
Research Areas:
Flecainide hydrochloride is an orally active antiarrhythmic agent. Flecainide hydrochloride can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide hydrochloride can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT) .
1
1 Cited Publications
Target:
Research Areas:
TMDJ-035 is a high-affinity, selective RyR2 inhibitor with an EC50 of 0.0130 μM. TMDJ-035 reduces RyR2 protein expression without affecting action potential-induced Ca 2+ transients. TMDJ-035 decreases ATP content and intracellular Ca 2+ levels. TMDJ-035 inhibits arrhythmias in a CPVT mouse model carrying mutant RyR2s. TMDJ-035 has no effect on electrocardiogram parameters or cardiac systolic function. TMDJ-035 exacerbates heart failure in mouse myocardial infarction models and hypoxic cardiomyocytes by altering cardiac function, causing tissue damage, promoting inflammatory infiltration, collagen deposition, and changes in Myosin heavy chain/actin expression. TMDJ-035 can be used in studies related to heart failure, catecholaminergic polymorphic ventricular tachycardia, and arrhythmias .
1
1 Cited Publications
Cat. No.: HY-P7710
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CALM1; Epididymis Secretory Protein Li 72; Prev. CALML2; Calmodulin-3; DD132; CAMIII; PHKD1; CPVT4; CAMI; LQT14; PHKD; CALM3; Calmodulin 1 (Phosphorylase Kinase, Delta); CALM2; Phosphorylase Kinase Subunit Delta 1; CAM2; Phosphorylase Kinase Subunit Delta; CAM3; Prepro-Calmodulin 1; CAMB; Calmodulin-1; CAMC; Calmodulin 3 (Phosphorylase Kinase, Delta), Isoform CRA_b; CAM1; Calmodulin 1 (Phosphorylase Kinase, Delta), Isoform CRA_a; CALM; EF-Hand Calcium-Binding Domain-Containing Protein 11; CaM; CDNA FLJ61744, Highly Similar To Calmodulin; CAM; Phosphorylase Kinase, Delta Subunit; Calmodulin 1; Calmodulin-2
Species:
Human
Source:
E. coli
Cat. No.: HY-W010950S
CAS No.: 127413-31-4
Cat. No.: HY-W010950AR
CAS No.: 57415-44-8
Research Areas:
Flecainide hydrochloride is an orally active antiarrhythmic agent. Flecainide hydrochloride can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide hydrochloride can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT) .
Cat. No.: HY-W010950R
CAS No.: 54143-55-4
Research Areas:
Flecainide (Standard) is the analytical standard of Flecainide. This product is intended for research and analytical applications. Flecainide is an orally active antiarrhythmic agent. Flecainide can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
