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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
CYP11B2
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "CYP11B2" in MCE Product Catalog:
4
Target:
Research Areas:
Osilodrostat (LCI699) is a potent, orally active11β-hydroxylase (CYP11B1) inhibitor with an IC50 value of 35 nM. Osilodrostat is a potent, orally aldosterone synthase (CYP11B2) inhibitor with IC50 values of 0.7 nM and 160 nM for human aldosterone synthase and rat aldosterone synthase, respectively. Osilodrostat inhibits aldosterone and corticosterone synthesis. Osilodrostat has blood pressure lowering ability. Osilodrostat can be used for research of Cushing syndrome (CS) .
4
Target:
Research Areas:
Osilodrostat (LCI699) phosphate is a potent, orally active11β-hydroxylase (CYP11B1) inhibitor with an IC50 value of 35 nM. Osilodrostat phosphate is a potent, orally aldosterone synthase (CYP11B2) inhibitor with IC50 values of 0.7 nM and 160 nM for human aldosterone synthase and rat aldosterone synthase, respectively. Osilodrostat phosphate inhibits aldosterone and corticosterone synthesis. Osilodrostat phosphate has blood pressure lowering ability. Osilodrostat phosphate can be used for research of Cushing syndrome (CS) .
Target:
Research Areas:
BI 689648 is a novel, highly selective aldosterone synthase inhibitor which can inhibit CYP11B1 and CYP11B2 with IC50s of 310 and 2.1 nM, respectively.
Cat. No.: HY-RS17177
Target:
Research Areas:
Cyp11b2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cyp11b2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-19833
CAS No.: 1260006-20-9
Synonyms: CFG920
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Research Areas:
Lapiteronel (CFG920) is an orally active, nonsteroidal, reversible dual CYP17 and CYP11B2 inhibitor. Lapiteronel has the potential for metastatic castration-resistant prostate cancer research .
Cat. No.: HY-RS03436
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Research Areas:
CYP11B2 Human Pre-designed siRNA Set A contains three designed siRNAs for CYP11B2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Research Areas:
CYP11B2-IN-1 is a CYP11B2 inhibitor with an IC50 of 2.3 nM. CYP11B2-IN-1 inhibits CYP11B1 with an IC50 of 142 nM .
Cat. No.: HY-RS23627
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Research Areas:
Cyp11b2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cyp11b2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-176480
CAS No.: 3072732-90-9
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Research Areas:
CYP11B2-IN-3 (compound 32) is an orally active and selective CYP11B2 inhibitor with IC50 values of 12.92 nM and 2341 nM for CYP11B2 and CYP11B1, respectively. CYP11B2-IN-3 can be used for study of hypertension .
Cat. No.: HY-162574
CAS No.: 2241573-22-6
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Research Areas:
CYP11B2-IN-2 (Compound 10k) is an inhibitor for enzyme aldosterone synthase CYP11B2 with an IC50 of 0.3 nM. CYP11B2-IN-2 CYP11B-IN-2 is labeled with 18F and can be used as a positron emission tomography (PET) tracer for the diagnosis of primary aldosteronism .
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Research Areas:
CYP19A1/CYP11B2-IN-1 (Compound X21) is a potent and selective aromatase and
aldosterone synthase dual inhibitor with IC50s of 2.3 nM and 29 nM for aromatase (CYP19A1) and aldosterone synthase (CYP11B2), respectively. CYP19A1/CYP11B2-IN-1 has excellent antiproliferative and pro-apoptotic activity against the cancer cell. CYP19A1/CYP11B2-IN-1 can be used for research of breast cancer .
Cat. No.: HY-W002108
CAS No.: 553-03-7
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Research Areas:
3,4-Dihydroquinolin-2(1H)-one is a building block, that can be used for synthesis of antipsychotic agent, such as Aripiprazole (HY-14546) or CYP11B2 inhibitors .
Cat. No.: HY-163751
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Research Areas:
STING-IN-9 (compound 2) is a potent inhibitor of human CYP11B2. STING-IN-9 showed more than 80 times higher selectivity over human CYP11B1 in vitro .
Cat. No.: HY-16276R
CAS No.: 928134-65-0
Synonyms: LCI699 (Standard)
Research Areas:
Osilodrostat (Standard) is the analytical standard of Osilodrostat. This product is intended for research and analytical applications. Osilodrostat (LCI699) is a potent, orally active11β-hydroxylase (CYP11B1) inhibitor with an IC50 value of 35 nM. Osilodrostat is a potent, orally aldosterone synthase (CYP11B2) inhibitor with IC50 values of 0.7 nM and 160 nM for human aldosterone synthase and rat aldosterone synthase, respectively. Osilodrostat inhibits aldosterone and corticosterone synthesis. Osilodrostat has blood pressure lowering ability. Osilodrostat can be used for research of Cushing syndrome (CS) .
Cat. No.: HY-P72163
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CYP11B2; Cytochrome P450 11B2, Mitochondrial; Prev. CYP11B; Steroid 11-Beta-Monooxygenase; ALDOS; Steroid 18-Hydroxylase; P-450C18; Aldosterone Synthase; P450aldo; Cytochrome P-450Aldo; CYP11BL; Cytochrome P-450C18; CPN2; CYPXIB2; Cytochrome P450, Subfami
Species:
Human
Source:
E. coli
Cat. No.: HY-101217R
CAS No.: 1633009-87-6
Target:
Research Areas:
BI 689648 (Standard) is the analytical standard of BI 689648 (HY-101217). This product is intended for research and analytical applications. BI 689648 is a novel, highly selective aldosterone synthase inhibitor which can inhibit CYP11B1 and CYP11B2 with IC50s of 310 and 2.1 nM, respectively.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
