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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
51 Results for "
Calcitonin Gene Related Peptide
" in MedChemExpress (MCE) Product Catalog:
Products (51)
51 Results for "Calcitonin Gene Related Peptide" in MCE Product Catalog:
47
47 Publications Verification
Synonyms: BIBN-4096; BIBN 4096BS
Target:
Research Areas:
Olcegepant (BIBN-4096) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor with IC50 of 0.03 nM and Ki of 14.4 pM for human CGRP .
47
47 Publications Verification
Synonyms: BIBN-4096 hydrochloride; BIBN4096BS hydrochloride
Target:
Research Areas:
Olcegepant hydrochloride (BIBN-4096 hydrochloride) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor with IC50 of 0.03 nM and with a Ki of 14.4 pM for human CGRP .
12
12 Cited Publications
Cat. No.: HY-15498A
CAS No.: 1374024-48-2
Synonyms: BMS-927711 sulfate hydrate; BHV-3000 sulfate hydrate
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Rimegepant (BMS-927711) sulfate hydrate is a potent, orally active, selective and competitive calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki of 0.027 nM and an IC50 of 0.14 nM for hCGRP receptor. Rimegepant sulfate hydrate can be used for migraine research .
9
Target:
Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
9
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Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
6
6 Cited Publications
Cat. No.: HY-P1071
CAS No.: 90954-53-3
Synonyms: Calcitonin Gene-Related Peptide
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6
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3
3 Cited Publications
Cat. No.: HY-P77587
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CALCA; Calcitonin 1; Prev. CALC1; CGRP1; CGRP-Alpha; Calcitonin/Calcitonin-Related PolyPeptide, Alpha; Calcitonin; Katacalcin; CGRP; PCT; Calcitonin Gene-Related Peptide 1; CT; Calcitonin Gene-Related Peptide I; KC; Alpha-Type CGRP; Calcitonin Related Pol
Species:
Mouse
Source:
HEK293
2
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Telcagepant (MK-0974) is an orally active calcitonin gene-related peptide (CGRP) receptor antagonist with Kis of 0.77 nM and 1.2 nM for human and rhesus CGRP receptors, respectively.
2
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2
2 Cited Publications
Cat. No.: HY-P99019
CAS No.: 1655501-53-3
Synonyms: TEV-48125; LBR-101; PF-04427429; RN-307
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1
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1
1 Cited Publications
Synonyms: Zavegepant; BHV-3500
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Research Areas:
Vazegepant (Zavegepant; BHV-3500) is an orally active calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki of 23 pM for human CGRP receptor and an EC50 of 880 pM for reversing CGRP-induced vasodilation in human intracranial arteries. Vazegepant can block CGRP-mediated vasodilation in the trigeminal vascular system and inhibit neuronal circuit sensitization. Vazegepant can be used in migraine-related research .
1
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1
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1
1 Cited Publications
Synonyms: Zavegepant hydrochloride; BHV-3500 hydrochloride
Target:
Research Areas:
Vazegepant (Zavegepant hydrochloride; BHV-3500 hydrochloride) hydrochloride is an orally active calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki of 23 pM for human CGRP receptor and an EC50 of 880 pM for reversing CGRP-induced vasodilation in human intracranial arteries. Vazegepant hydrochloride can block CGRP-mediated vasodilation in the trigeminal vascular system and inhibit neuronal circuit sensitization. Vazegepant hydrochloride can be used in migraine-related research .
Synonyms: MK-8031; AGN-241689
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Atogepant (MK-8031) is an orally active and selective calcitonin gene-related peptide receptor (CGRP) antagonist. Atogepant can be used for researching migraine .
Synonyms: MK-1602
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Ubrogepant (MK-1602) is an orally active and selective antagonist of calcitonin gene-related peptide receptor (CGRP). Ubrogepant has high affinity for CGRP receptors in human and rhesus monkeys, and can effectively block the cAMP response stimulated by α-CGRP. Ubrogepant can be used in the study of acute migraine .
Cat. No.: HY-P99017
CAS No.: 1644539-04-7
Synonyms: ALD-403
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Research Areas:
Synonyms: OLDA
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease
N-Oleoyldopamine (OLDA) is an orally active TRPV1 activator and 5-LOX inhibitor with blood-brain barrier permeability. N-Oleoyldopamine excites histaminergic neurons in the tuberomammillary nucleus via a dopamine receptor mechanism, a process independent of TRPV1 and cannabinoid receptors. On one hand, N-Oleoyldopamine promotes the release of insulin and glucose-dependent insulinotropic polypeptide through a GPR119-dependent pathway to improve glucose tolerance; on the other hand, N-Oleoyldopamine improves left ventricular function and reduces myocardial infarction size by triggering the release of substance P and calcitonin gene-related peptide. N-Oleoyldopamine is used in studies related to glycemic abnormalities and myocardial ischemia-reperfusion injury .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
