10 Results for "

Chromobacterium

" in MedChemExpress (MCE) Product Catalog:
Products (10)

10 Results for "Chromobacterium" in MCE Product Catalog:

75
Romidepsin
Romidepsin
0 Images
75 Cited Publications
Cat. No.: HY-15149
CAS No.: 128517-07-7
Purity:  99.87%
Synonyms: FK 228; FR 901228; NSC 630176
Target:  

HDAC Apoptosis

Research Areas:  

Cancer

Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC50s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively . Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis .
loading...
    loading...
View All Sizes
18
YM-254890
YM-254890
0 Images
18 Cited Publications
Cat. No.: HY-111557
CAS No.: 568580-02-9
Purity:  ≥95.0%
Category:  

Cardiovascular Disease Natural Products Microorganisms Disease Research Fields

Target:  

P2Y Receptor

YM-254890 is a selective Gαq/11 protein inhibitor isolated from Chromobacterium sp. YM-254890 shows no inhibition of other G protein subtypes. YM-254890 inhibits platelet aggregation induced by ADP by blocking the P2Y1 signal transduction pathway, with an IC50 value below 0.6 μM .
loading...
    loading...
View All Sizes
2(5H)-Furanone
2(5H)-Furanone
0 Images
Cat. No.: HY-W008270
CAS No.: 497-23-4
Synonyms: γ-Crotonolactone
Category:  

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Bacterial

2(5H)-Furanone (γ-Crotonolactone) is an endogenous metabolite. 2(5H)-Furanone mimics N-acyl homoserine lactone signals, occupies the binding site of LuxR homologs, and interferes with quorum sensing-mediated gene regulation. 2(5H)-Furanone inhibits quorum sensing mediated by AHLs with different acyl chain lengths. 2(5H)-Furanone inhibits biofilm formation of environmental Aeromonas hydrophila strains on polystyrene plates. 2(5H)-Furanone suppresses spike-and-wave discharges in a rat model of generalized absence seizures and exhibits selective activity against absence seizures. 2(5H)-Furanone can be used in studies related to bacteria infections and generalized absence seizures.
loading...
    loading...
View All Sizes
2-tert-Butyl-1,4-benzoquinone
2-tert-Butyl-1,4-benzoquinone
0 Images
Cat. No.: HY-W017187
CAS No.: 3602-55-9
Target:  

Bacterial Drug Metabolite Keap1-Nrf2 Heme Oxygenase (HO)

Research Areas:  

Infection

2-tert-Butyl-1,4-benzoquinone is a food additive oxidant, an electrophilic metabolite of Butylated hydroxyanisole (HY-B1066), and an antibacterial agent. 2-tert-Butyl-1,4-benzoquinone reduces virulence factors, activates Nrf2, and induces S-arylation of its negative regulator Keap1. 2-tert-Butyl-1,4-benzoquinone induces HO-1. 2-tert-Butyl-1,4-benzoquinone exhibits quorum sensing inhibitory activity against Chromobacterium violaceum .
loading...
    loading...
View All Sizes
N-(3-Oxodecanoyl)-L-homoserine lactone
N-(3-Oxodecanoyl)-L-homoserine lactone
0 Images
Cat. No.: HY-134560
CAS No.: 147795-40-2
Purity:  99.62%
Synonyms: 3-Oxo-C10-HSL
Category:  

Microorganisms Ketones, Aldehydes, Acids

Target:  

Bacterial

N-(3-Oxodecanoyl)-L-homoserine lactone (3-Oxo-C10-HSL) is a bacterial signaling molecule with quorum-sensing agonistic activity and competitive antagonistic activity against short-chain AHLs. N-(3-Oxodecanoyl)-L-homoserine lactone binds to VanR to form a complex, activates the transcription of the vanI gene, and establishes an autoregulatory loop for its own synthesis. N-(3-Oxodecanoyl)-L-homoserine lactone inhibits the synthesis of violacein induced by short-chain AHLs. N-(3-Oxodecanoyl)-L-homoserine lactone serves as the sole carbon and nitrogen source for Rhodococcus erythropolis W2 and can be completely degraded. N-(3-Oxodecanoyl)-L-homoserine lactone can be used in studies related to bacterial infections .
loading...
    loading...
View All Sizes
Romidepsin-d7
Romidepsin-d7
0 Images
Cat. No.: HY-15149S2
Synonyms: FK 228-d7; FR 901228-d7; NSC 630176-d7
Romidepsin-d7 (FK 228-d7) is deuterium labeled Romidepsin. Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC50s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively . Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis .
loading...
    loading...
View All Sizes
Romidepsin (GMP)
Romidepsin (GMP)
0 Images
Cat. No.: HY-15149G
Synonyms: FK 228 (GMP); FR 901228 (GMP); NSC 630176 (GMP)
Romidepsin (GMP) (FK 228 (GMP)) is Romidepsin (HY-15149) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC50s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively . Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis .
loading...
    loading...
View All Sizes
Aculene D
Aculene D
0 Images
Cat. No.: HY-N10192
CAS No.: 2043948-38-3
Category:  

Infection Microorganisms Terpenoids Sesquiterpenes Disease Research Fields

Target:  

Endogenous Metabolite Bacterial

Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations .
loading...
    loading...
View All Sizes
YM-254891
YM-254891
0 Images
Cat. No.: HY-N17826
CAS No.: 726188-99-4
Category:  

Natural Products Microorganisms

Target:  

Drug Derivative Bacterial P2Y Receptor Endogenous Metabolite

YM-254891 is a YM-254890 (HY-111557) analogue and Gαq/11 inhibitor. YM-254891 can be isolated from the fermentation broth of Chromobacterium sp. QS3666. YM-254891 inhibits ADP-induced platelet aggregation .
loading...
    loading...
View All Sizes
(E/Z)-Platyphyllenone
(E/Z)-Platyphyllenone
0 Images
Cat. No.: HY-N3043A
CAS No.: 56973-65-0
Category:  

Microorganisms Phenols Polyphenols

Target:  

Bacterial

(E/Z)-Platyphyllenone is a diarylheptanoid compound that can be found in Alnus viridis ssp. viridis. (E/Z)-Platyphyllenone inhibits the biosynthesis of violacein, but stimulates the production of AHL and AHQ quorum-sensing signal molecules as well as the synthesis of pyocyanin in Pseudomonas aeruginosa PAO1, and exhibits strong cytotoxicity against human lung fibroblasts. (E/Z)-Platyphyllenone can be used in studies on Pseudomonas aeruginosa .
loading...
    loading...
View All Sizes
Assay Types