Cx43

By Targets:	Calcium Channel (1) Connexin (2) Gap Junction Protein (9) PKC (1) Reference Standards (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (2) Cardiovascular Disease (6) Inflammation/Immunology (3) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) Antisense Oligonucleotides (2) siRNAs (3)

Targets Recommended: CX3CR1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1136B

TAT-Gap19 1 Publications Verification	Gap Junction Protein	Cardiovascular Disease Inflammation/Immunology
TAT-Gap19, a Cx mimetic peptide, is a specific *connexin43 hemichannel (Cx43* HC)** inhibitor. TAT-Gap19 does not inhibits the corresponding Cx43 GJCs. TAT-Gap19 traverses the blood-brain barrier and alleviate liver fibrosis in mice .

HY-106225

Rotigaptide 1 Publications Verification ZP123	Gap Junction Protein	Cardiovascular Disease
Rotigaptide (ZP123) is a novel and specific modulator of connexin 43 (Cx43). Rotigaptide prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress. Rotigaptide is a potent antiarrhythmic peptide (AAP) with improved stability and has the potential for the investigation of cardiac arrhythmias-specifically atrial fibrillation .

HY-P1136

Gap19 5 Publications Verification	Gap Junction Protein	Cardiovascular Disease
Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective *connexin 43 (Cx43) hemichannel* blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial .

HY-P10849

IP3RPEP6	Calcium Channel	Others
IP3RPEP6 is an IP₃R competitive inhibitor. IP3RPEP6 has the IC₅₀ values of 9.0 μM, 3.9 μM and 4.3 μM for IP₃R1, IP₃R2 and IP₃R3, respectively. IP3RPEP6 does not affect the Ryanodine receptor and Cx43 hemichannels. IP3RPEP6 regulates calcium signaling within cells .

HY-P1136A

Gap19 TFA 5 Publications Verification	Gap Junction Protein	Cardiovascular Disease
Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective *connexin 43 (Cx43) hemichannel* blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 TFA is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 TFA has protective effects against myocardial .

HY-P0154

Epsilon-V1-2 5 Publications Verification ε-V1-2; EAVSLKPT	PKC	Inflammation/Immunology
Epsilon-V1-2 (ε-V1-2), a PKCε-derived peptide, is a selective PKCε inhibitor. Epsilon-V1-2 inhibits the translocationof PKCε, but not α-, β-, and δPKC .

HY-P1136C

TAT-Gap19 TFA 1 Publications Verification	Gap Junction Protein	Cardiovascular Disease Inflammation/Immunology
TAT-Gap19 TFA, a Cx mimetic peptide, is a specific *connexin43 hemichannel (Cx43* HC)** inhibitor. TAT-Gap19 TFA does not inhibits the corresponding Cx43 GJCs. TAT-Gap19 TFA traverses the blood-brain barrier and alleviate liver fibrosis in mice .

HY-167983

Cx43 HC-IN-1	Gap Junction Protein	Neurological Disease
Cx43 HC-IN-1 (Compound D4) is a selective and orally active inhibitor of connexin hemichannels (Cx43 HC). Cx43 HC-IN-1 effectively inhibits the hemichannel activity mediated by Cx43/Cx45 in denervated skeletal muscle fibers, significantly increasing the reinnervation rate of muscle fibers by neurons. Cx43 HC-IN-1 reduces neuroinflammation and neuronal overexcitation by inhibiting hemichannels in glial cells in the brain, and alleviates epilepsy in mice. Cx43 HC-IN-1 can be used for research on epilepsy and muscle diseases .

HY-P11197

ACT1	Gap Junction Protein	Cancer
ACT1 is a peptide that targets endogenous *Cx43* by stabilizing its activity at gap junctions. ACT1 stabilizes gap junction intercellular communication in breast cancer cells. ACT1 enhances the activity of Tamoxifen (HY-13757A) and Lapatinib (HY-50898) in breast cancer. ACT1 can be used for breast cancer research .

HY-106225R

Rotigaptide (Standard) ZP123 (Standard)	Reference Standards Gap Junction Protein	Cardiovascular Disease
Rotigaptide (Standard) is the analytical standard of Rotigaptide. This product is intended for research and analytical applications. Rotigaptide (ZP123) is a novel and specific modulator of connexin 43 (Cx43). Rotigaptide prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress. Rotigaptide is a potent antiarrhythmic peptide (AAP) with improved stability and has the potential for the investigation of cardiac arrhythmias-specifically?atrial fibrillation .

HY-177644A

Lufepirsen sodium	Connexin	Others
Lufepirsen sodium is an unmodified antisense oligonucleotide targeted to Connexin43 (Cx43). Connexin43 is a specific protein in the eye, which plays a role in wound healing.

HY-177644

Lufepirsen	Connexin	Others
Lufepirsen is an unmodified antisense oligonucleotide targeted to Connexin43 (Cx43). Connexin43 is a specific protein in the eye, which plays a role in wound healing.

HY-P992010

ALMB-0168	Gap Junction Protein	Cancer
ALMB-0168 is a *Cx43* hemichannel agonist monoclonal antibody. ALMB-0168 activates *Cx43* hemichannels to inhibit the growth and migration of osteosarcoma. ALMB-0168 is applicable to relevant research on osteosarcoma .

HY-RS25249

Gja1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gja1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gja1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gja1 Rat Pre-designed siRNA Set A Gja1 Rat Pre-designed siRNA Set A

HY-RS05440

GJA1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GJA1 Human Pre-designed siRNA Set A contains three designed siRNAs for GJA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GJA1 Human Pre-designed siRNA Set A GJA1 Human Pre-designed siRNA Set A

HY-RS18762

Gja1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gja1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gja1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gja1 Mouse Pre-designed siRNA Set A Gja1 Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area

HY-P1136B

TAT-Gap19 1 Publications Verification	Gap Junction Protein	Cardiovascular Disease Inflammation/Immunology
TAT-Gap19, a Cx mimetic peptide, is a specific *connexin43 hemichannel (Cx43* HC)** inhibitor. TAT-Gap19 does not inhibits the corresponding Cx43 GJCs. TAT-Gap19 traverses the blood-brain barrier and alleviate liver fibrosis in mice .

HY-P1136

Gap19 5 Publications Verification	Gap Junction Protein	Cardiovascular Disease
Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective *connexin 43 (Cx43) hemichannel* blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial .

HY-P10849

IP3RPEP6	Calcium Channel	Others
IP3RPEP6 is an IP₃R competitive inhibitor. IP3RPEP6 has the IC₅₀ values of 9.0 μM, 3.9 μM and 4.3 μM for IP₃R1, IP₃R2 and IP₃R3, respectively. IP3RPEP6 does not affect the Ryanodine receptor and Cx43 hemichannels. IP3RPEP6 regulates calcium signaling within cells .

HY-P1136A

Gap19 TFA 5 Publications Verification	Gap Junction Protein	Cardiovascular Disease
Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective *connexin 43 (Cx43) hemichannel* blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 TFA is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 TFA has protective effects against myocardial .

HY-P0154

Epsilon-V1-2 5 Publications Verification ε-V1-2; EAVSLKPT	PKC	Inflammation/Immunology
Epsilon-V1-2 (ε-V1-2), a PKCε-derived peptide, is a selective PKCε inhibitor. Epsilon-V1-2 inhibits the translocationof PKCε, but not α-, β-, and δPKC .

HY-P1136C

TAT-Gap19 TFA 1 Publications Verification	Gap Junction Protein	Cardiovascular Disease Inflammation/Immunology
TAT-Gap19 TFA, a Cx mimetic peptide, is a specific *connexin43 hemichannel (Cx43* HC)** inhibitor. TAT-Gap19 TFA does not inhibits the corresponding Cx43 GJCs. TAT-Gap19 TFA traverses the blood-brain barrier and alleviate liver fibrosis in mice .

HY-P11197

ACT1	Gap Junction Protein	Cancer
ACT1 is a peptide that targets endogenous *Cx43* by stabilizing its activity at gap junctions. ACT1 stabilizes gap junction intercellular communication in breast cancer cells. ACT1 enhances the activity of Tamoxifen (HY-13757A) and Lapatinib (HY-50898) in breast cancer. ACT1 can be used for breast cancer research .

Cat. No.	Product Name	Target	Research Area	Image

HY-P992010

ALMB-0168	Gap Junction Protein	Cancer
ALMB-0168 is a *Cx43* hemichannel agonist monoclonal antibody. ALMB-0168 activates *Cx43* hemichannels to inhibit the growth and migration of osteosarcoma. ALMB-0168 is applicable to relevant research on osteosarcoma .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P72205

	GJA1 Protein, Human (His) 1 Publications Verification Connexin 43; Connexin-43; Cx 43; Cx43; CxA1_HUMAN; DFNB38; Gap junction 43 kDa heart protein; Gap junction alpha-1 protein; Gap junction protein alpha 1 43kDa connexin 43; ; Gap junction protein alpha 1 43kDa; Gap junction protein alpha like; GJA 1; Gja1; GJAL; ODD; ODDD; ODOD; SDTY3	Human	E. coli
	The GJA1 protein regulates bladder capacity through gap junctions, clusters of transmembrane channels that allow the diffusion of low molecular weight materials between adjacent cells. GJA1 protein also regulates NOV expression and localization and is important for ventricular gap junction communication. GJA1 Protein, Human (His) is the recombinant human-derived GJA1 protein, expressed by E. coli , with N-6*His labeled tag.

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Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	IHC-P (2) ICC/IF (2) IP (1) IHC-F (1) WB (2) ELISA (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Polyclonal (1) Monoclonal (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86348

	Connexin 43 Antibody (YA6040) GJA1; GJAL; Gap junction alpha-1 protein; Connexin-43; Cx43; Gap junction 43 kDa heart protein	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Connexin 43 Antibody (YA6040) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Connexin 43.

HY-P80628

	Connexin 43 Antibody Connexin 43; Connexin-43; Cx 43; Cx43; CxA1_HUMAN; DFNB38; Gap junction 43 kDa heart protein; Gap junction alpha-1 protein; Gap junction protein alpha 1 43kDa (connexin 43); Gap junction protein alpha 1 43kDa; Gap junction protein alpha like; GJA 1; Gja1;	WB, IHC-F, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	Connexin 43 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Connexin 43.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-177644A

Lufepirsen sodium		Antisense Oligonucleotides
Lufepirsen sodium is an unmodified antisense oligonucleotide targeted to Connexin43 (Cx43). Connexin43 is a specific protein in the eye, which plays a role in wound healing.

HY-177644

Lufepirsen		Antisense Oligonucleotides
Lufepirsen is an unmodified antisense oligonucleotide targeted to Connexin43 (Cx43). Connexin43 is a specific protein in the eye, which plays a role in wound healing.

HY-RS25249

Gja1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Gja1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gja1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS05440

GJA1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
GJA1 Human Pre-designed siRNA Set A contains three designed siRNAs for GJA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS18762

Gja1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Gja1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gja1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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