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Cytotoxic natural product

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (2) Akt (1) Apoptosis (5) ATM/ATR (1) Bacterial (2) Caspase (1) CDK (1) Drug Derivative (2) Drug Intermediate (1) Endogenous Metabolite (2) Fungal (3) Hedgehog (2) HMG-CoA Reductase (HMGCR) (1) Insecticide (1) Interleukin Related (1) MAPKAPK2 (MK2) (1) NF-κB (1) NO Synthase (1) p38 MAPK (1) Parasite (2) Reactive Oxygen Species (ROS) (1) Reference Standards (7) STAT (1) TNF Receptor (1) Virus Protease (1)
By Research Areas:	Cancer (31) Infection (6) Inflammation/Immunology (7) Metabolic Disease (1)

By Targets:

ADC Payload (2)

Akt (1)

Apoptosis (5)

ATM/ATR (1)

Bacterial (2)

Caspase (1)

CDK (1)

Drug Derivative (2)

Drug Intermediate (1)

Endogenous Metabolite (2)

Fungal (3)

Hedgehog (2)

HMG-CoA Reductase (HMGCR) (1)

Insecticide (1)

Interleukin Related (1)

MAPKAPK2 (MK2) (1)

NF-κB (1)

NO Synthase (1)

p38 MAPK (1)

Parasite (2)

Reactive Oxygen Species (ROS) (1)

Reference Standards (7)

STAT (1)

TNF Receptor (1)

Virus Protease (1)

By Research Areas:

Cancer (31)

Infection (6)

Inflammation/Immunology (7)

Metabolic Disease (1)

Inhibitors & Agonists

Natural
Products

Targets Recommended: CTLA-4

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-117371

Hemiasterlin (-)-Hemiasterlin; Milnamide B	ADC Payload	Cancer
Hemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effects. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs) .

HY-N2228

(-)-Epigallocatechin-3-(3''-O-methyl) gallate (-)-EGCG-3''-O-ME	Others	Inflammation/Immunology Cancer
(-)-Epigallocatechin-3-(3''-O-methyl) gallate ((-)-EGCG-3''-O-ME) is a natural product that can be isolated from the tea leaf, with strong antioxidative activity. (-)-Epigallocatechin-3-(3''-O-methyl) gallate has a strong cytotoxic activity for rat cancer cells .

HY-N7933

Tetracosane ALKANE C24	Apoptosis	Inflammation/Immunology
Tetracosane (ALKANE C24) is a natural product that can be found in Acrostichum aureum. Tetracosane hows cytotoxicity and induces Apoptosis. Tetracosane has the potential for the research of peptic ulcer .

HY-N11519

Polyporusterone C	Others	Cancer
Polyporusterone C (Compound 3) is a natural product that can be isolated from Polyporus umbellatus. Polyporusterone C shows cytotoxic activities with IC₅₀s of 37, 26 and 42 μg/mL against L-1210 cells at 3, 5 and 7 days, respectively .

HY-N4012

Indole-3-glyoxylamide 3-Indoleglyoxamide	Others	Others
Indole-3-glyoxylamide (Compound 4) is a type of indole alkaloid. Indole-3-glyoxylamide shows no significant cytotoxic activity against Hela, Ishikawa, and MGC-803 cells .

HY-N3430

Kaempferol tetraacetate AF33	Others	Cancer
Kaempferol tetraacetate (AF33) is a natural product. Kaempferol tetraacetate shows cytotoxicity .

HY-129144

Dihydrodehydrodiconiferyl alcohol	TNF Receptor	Cancer
Dihydrodehydrodiconiferyl alcohol (compound 2) is a kind of neolignan. Dihydrodehydrodiconiferyl alcohol can be isolated from Anogeissus acuminata. Dihydrodehydrodiconiferyl alcohol has specific cytotoxic activity on melanoma cancer cell line .

HY-W010533

(E)-2-Methyl-2-pentenoic acid	Drug Intermediate	Others
(E)-2-Methyl-2-pentenoic acid is the component can be used to synthesize the cytotoxic natural product Lactimidomycin .

HY-N8679

Physalin C	Endogenous Metabolite	Cancer
Physalin C is a natural product that can be found in physalis angulata. Physalin C shows cytotoxic activities against MCF-7 and HepG2 cells .

HY-W391625

(Rac)-Dehydrocostus Lactone (Rac)-Epiligulyl oxide	Fungal	Cancer
(Rac)-Dehydrocostus Lactone ((Rac)-Epiligulyl oxide) is a natural product with antiparasitic activity. (Rac)-Dehydrocostus Lactone can significantly inhibit the growth of Trypanosoma brucei rhodesiense. (Rac)-Dehydrocostus Lactone exhibits a broad spectrum of biological effects, including anti-inflammatory, anticancer, antiviral and antimicrobial activities. (Rac)-Dehydrocostus Lactone also has antifungal, antioxidant, antidiabetic, antiulcer and antihelminthic effects. (Rac)-Dehydrocostus Lactone exhibits different IC(50) values in cytotoxicity tests and has a high selectivity index .

HY-N7173

7-Methoxy-β-carboline-1-propionic acid	Parasite	Infection
7-Methoxy-β-carboline-1-propionic acid (compound 46) is a cytotoxic and antimalarial compound. 7-Methoxy-β-carboline-1-propionic acid can be extracted from the roots of Eurycoma longifolia .

HY-133220A

Guajadial F	Others	Cancer
Guajadial F is a natural product that can be found in Psidium guajava. Guajadial F shows cytotoxicity .

HY-N1912

Andropanolide	Others	Cancer
Andropanolide is a natural product that exerts cytotoxicity toward carcinoma cells and significantly inhibits the overproduction of nitric oxide (NO) in Lipopolysaccharides (HY-D1056) (LPS)-stimulated RAW264.7 macrophages .

HY-N8088

Neolancerin	Others	Cancer
Neolancerin is a natural product with weak cytotoxic activity against HL-60 cells .

HY-N16580

(+)-Lariciresinol 9′-p-coumarate	Others	Cancer
(+)-Lariciresinol 9′-p-Coumarate is a type of lignan. (+)-Lariciresinol 9′-p-Coumarate exhibits inhibitory activity against leukemia and other tumor cell lines .

HY-N0763R

Angelicin (Standard) Isopsoralen (Standard)	Reference Standards Apoptosis Virus Protease	Cancer
Angelicin (Standard) is the analytical standard of Angelicin. This product is intended for research and analytical applications. Angelicin is a natural tricyclic aromatic hydrocarbon compound that is structurally related to psoralen and has anti-cancer, anti-inflammatory, anti-viral and other activities. Cytotoxic, IC₅₀: 49.56 μM; inhibits MHV-68, IC₅₀: 5.39 μg/ml (28.95 μM).

HY-129149

Ganoderic acid SZ	HMG-CoA Reductase (HMGCR)	Metabolic Disease
Ganoderic acid SZ is a natural product with 3-hydroxy-3-methylglutaryl-CoA reductase inhibitory activity. Ganoderic acid SZ shows stronger activity than the positive control atorvastatin in inhibiting HMG-CoA reductase. Ganoderic acid SZ exhibits significant inhibition of yeast-derived α-glucosidase with IC50 values achieved at very low concentrations. Ganoderic acid SZ also exhibits cytotoxicity against K562 cells with IC?? values in the range of 10-20 μM .

HY-122948

Isogambogenic acid	Others	Cancer
Isogambogenic acid is a natural product that can be isolated from Resina Garciniae. Isogambogenic acid has cytotoxicity to cancer cell lines with IC₅₀ values of 0.4327-5.942 μmol/L .

HY-N8317

Rubicordifolin	Others	Cancer
Rubicordifolin is a natural product that can be isolated from Rubia cordifolia. Rubicordifolin inhibits the growth of sarcoma ascites in mice. Rubicordifolin has significant cytotoxic activity both in vitro and in vivo .

HY-N2852

α-Terthienylmethanol	Reactive Oxygen Species (ROS)	Others
α-Terthienylmethanol is a terthiophene isolated from the n-hexane fraction of E. prostrata. α-Terthienylmethanol has potent cytotoxic activity against human endometrial cancer cells (Hec1A and Ishikawa) (IC₅₀ < 1 μM). α-Terthienylmethanol increases the intracellular level of ROS and decreases that of GSH .

HY-118306

Amphidinolide F	Others	Cancer
Amphidinolide F is a cytotoxic marine natural product contains a macrolactone .

HY-N3966

Goniodiol 8-acetate	Others	Others
Goniodiol 8-acetate is a styrylpyrones that can be isolated from the leaves of Goniothalamus amuyon. Goniodiol 8-acetate has cytotoxic activity .

HY-133220

Guajadial E	Others	Cancer
Guajadial E is a natural product that can be found in Psidium guajava. Guajadial E shows cytotoxicity .

HY-N1081A

Viteralone (S)-Viteralone	Others	Cancer
Viteralone (compound 5) is a natural product that can be isolated from Vitex negundo. Viteralone is cytotoxic to HL-60 cancer cells .

HY-133223

Hispidanin B	Others	Cancer
Hispidanin B is a natural product that can be extracted from the rhizomes of Isodon hispida. Hispidanin B has cytotoxic activities against cancer cells .

HY-N12142

Anticancer agent 156	Others	Cancer
Anticancer agent 156 (compound 11) is a powerful anticancer agent based on Miliusanes (anticancer lead molecule). Anticancer agent 156 effectively inhibits the growth of human cancer cells and shows significant cytotoxicity to gastric cancer cells .

HY-143242

Phidianidine B	Others	Others
Phidianidine B is a highly cytotoxic 1,2,4-oxadiazole marine metabolite. Phidianidine B is a natural product that can be isolated from a marine mollusk .

HY-N14309

Astechrome	Parasite	Infection
Astechrome is a natural product with a strong antimalarial activity with an IC₅₀ value of 0.94 μM. Astechrome exhibits cytotoxicity against Vero cells with IC₅₀ value of 7.9 μM .

HY-N3916

Galanolactone (+)-Galanolactone	Fungal	Infection
Galanolactone is a natural product that can be isolated from the seeds of Alpinia galanga. Galanolactone shows antifungal activitie. Galanolactone shows cytotoxicity against KB cells with an EC₅₀ of 38.5 µg/ml .

HY-129148

Ganoderic acid AM1 GAAM1	Others	Cancer
Ganoderic acid AM1 (GAAM1) is a natural product that can be found in ganoderma lucidum. Ganoderic acid AM1 shows cytotoxicity with an IC₅₀ value of 19.8 µM for HeLa cells .

HY-N8846

dl-Aloesol	Fungal	Infection
dl-Aloesol is a natural product that can be isolated from fungus Aspergillus sp. Aspergillus sp metabolites has cytotoxic, antibacterial, free radical scavenging, anti-parasitic, antiviral and antiproliferative activities, etc .

HY-156186

Anticancer agent 160	Others	Cancer
Anticancer agent 160 (Compound 6) is a natural product derived from Parthenium hysterophorus. Anticancer agent 160 is cytotoxic to HCT-116 cells, IC₅₀=5.0 μM .

HY-156089

Triptoquinone H	Others	Inflammation/Immunology Cancer
Triptoquinone H is a class of natural product isolated from traditional Chinese medicine Tripterygium hypoglaucu. Triptoquinone H has strong cytotoxic, immunomodulatory and anti-inflammatory activities. Triptoquinone H can be used for cancer or inflammatory diseases research .

HY-N2445R

Flavokawain C (Standard)	Reference Standards Apoptosis	Cancer
Flavokawain C (Standard) is the analytical standard of Flavokawain C. This product is intended for research and analytical applications. Flavokawain C is a natural chalcone found in Kava root. Flavokawain C exerts cytotoxicity against human cancer cell lines, with an IC₅₀ of 12.75 μM for HCT 116 cells .

HY-N11651

Peganumine A	Others	Others
Peganumine A is a natural product that can be found in Peganum harmala. Peganumine A shows cytotoxicity with IC₅₀s of5.8, 38.5, 40.2, 55.4 µM for HL-60, MCF-7, PC-3, and HepG2 cells ,respectively .

HY-N3057R

Pinostrobin chalcone (Standard)	Reference Standards Others	Cancer
Pinostrobin chalcone (Standard) is the analytical standard of Pinostrobin chalcone. This product is intended for research and analytical applications. Pinostrobin chalcone is found to be potent natural cytotoxic compounds against MDA-MB-231 and HT-29 colon cancer cell lines(IC₅₀ = 20.42±2.23 and 22.51±0.42 μg/mL) .

HY-N0446R

10-Methoxycamptothecin (Standard)	ADC Payload Reference Standards	Cancer
10-Methoxycamptothecin (Standard) is the analytical standard of 10-Methoxycamptothecin. This product is intended for research and analytical applications. 10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, and has been confirmed to possess high anti-cancer properties. 10-Methoxycamptothecin has higher cytotoxicity than 10-hydroxycamptothecin by testing antitumor activity against 2774 cell lines .

HY-N8270

Physalin H	Hedgehog Endogenous Metabolite	Cancer
Physalin H is a natural product that can be isolated from Solanum nigrum. Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC₅₀ value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC₅₀ values of 5.7 and 6.8 μM, respectively .

HY-N0591R

Dehydrocostus Lactone (Standard) (-)-Dehydrocostus lactone (Standard); Epiligulyl oxide (Standard)	Reference Standards Bacterial Apoptosis p38 MAPK NF-κB MAPKAPK2 (MK2) Akt NO Synthase Interleukin Related Caspase	Infection Inflammation/Immunology Cancer
Dehydrocostus Lactone (Standard) ((-)-Dehydrocostus lactone (Standard)) is the analytical standard of Dehydrocostus Lactone (HY-N0591). This product is intended for research and analytical applications. Dehydrocostus Lactone is a natural sesquiterpene that can be isolated from Saussurea lappa. Dehydrocostus Lactone has multiple activities such as anti-inflammatory, antibacterial, anti-tumor, and immunomodulatory effects. Dehydrocostus Lactone has an MIC of 2 µg/mL against Mycobacterium tuberculosis. Dehydrocostus Lactone can also inhibit the killing activity of cytotoxic T lymphocytes and induce apoptosis in tumor cells.

HY-N6954R

Garcinone C (Standard)	Reference Standards ATM/ATR STAT CDK Hedgehog	Inflammation/Immunology Cancer
Garcinone C (Standard) is the analytical standard of Garcinone C. This product is intended for research and analytical applications. Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active .

HY-N7933R

Tetracosane (Standard) ALKANE C24 (Standard)	Reference Standards Apoptosis	Inflammation/Immunology
Tetracosane (Standard) is the analytical standard of Tetracosane. This product is intended for research and analytical applications. Tetracosane (ALKANE C24) is a natural product that can be found in Acrostichum aureum. Tetracosane hows cytotoxicity and induces Apoptosis. Tetracosane has the potential for the research of peptic ulcer .

HY-N9885

Xuedanencins D	Others	Cancer
Xuedanencins D is a cucurbitane-type triterpenoid natural product without significant cytotoxicity against human cervical cancer HeLa cells (IC₅₀ >100 μM). Xuedanencins D can be naturally extracted from the 95% ethanol extract of the tubers of Hemsleya penxianensis (a plant of the Hemsleya genus in the Cucurbitaceae family) .

HY-N9836

8,9-Dehydrothymol isobutyrate	Drug Derivative	Others
8,9-Dehydrothymol isobutyrate is a thymol (HY-N6810) derivative that can be naturally extracted from the essential oil of the trunk bark of Tetraclinis articulata (Vahl) Mast. This plant essential oil exhibits certain cytotoxicity and can be used as a research subject in the fields of natural product chemistry and the active components of plant essential oils .

HY-N9674

Epimedonin H	Others	Cancer
Epimedonin H is a selective prenylated 2-phenoxychromone compound with no significant cytotoxicity against five human cancer cell lines, including HL-60 and SMMC-7721 (IC₅₀ > 10 μM). Epimedonin H can be used in potential activity screening studies in the field of natural product chemistry. Epimedonin H can be extracted from the dried aerial parts of Epimedium brevicornum (a plant of the genus Epimedium in the Berberidaceae family) .

HY-W753557

Avocadene	Drug Derivative Insecticide Bacterial	Infection Inflammation/Immunology Cancer
Avocadene is a natural product isolated from Persea americana leaves, with anticancer, insecticidal, anti-Helicobacter pylori, and anti-inflammatory activity. Avocadene exerts antibacterial and anti‑inflammatory effects by suppressing Helicobacter pylori growth and inhibiting protein denaturation. Avocadene displays obvious cytotoxic activity against human prostate cancer PC‑3 cells with an IC₅₀ of 0.5 μg/mL. Avocadene can be used for research of Helicobacter pylori‑associated gastrointestinal inflammation, gastroduodenal injury and prostate tumors .

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Cytotoxic natural product

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