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Results for "

DBA/1J

" in MedChemExpress (MCE) Product Catalog:

15

Inhibitors & Agonists

4

Biochemical Assay Reagents

1

Inhibitory Antibodies

1

Isotope-Labeled Compounds

1

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-10966
    SB-590885
    5+ Cited Publications

    		 Raf Apoptosis Neurological Disease Metabolic Disease Cancer
    SB-590885 is a BRAF/c-Raf kinase inhibitor that selectively targets B-Raf, and it amplifies the ERK/MAPK signaling pathway in RAS-activated cells. SB-590885 effectively inhibits the malignant proliferation, transformation and tumorigenicity of oncogenic B-Raf cells; it also induces the proliferation of erythroid progenitor cells, delays their differentiation and promotes hemoglobin synthesis, thereby improving ineffective erythropoiesis and reducing apoptosis. SB-590885 exerts a synergistic effect with TGF-β inhibitors and glucocorticoids, significantly promoting the formation of erythroid colonies in cells from patients with Diamond-Blackfan anemia (DBA). SB-590885 is mainly used in relevant studies on DBA, cisplatin-induced myelosuppression-related anemia, and pan-cancers such as melanoma and colorectal cancer .
    SB-590885
  • HY-W013053
    Dibenz[a,h]anthracene

    DBA; 1,2,5,6-Dibenzanthracene; Benzo[k]tetraphene

    		 Environmental Pollutants DNA/RNA Synthesis MDM-2/p53 Apoptosis Cancer
    Dibenz[a,h]anthracene (DBA) is an orally active polycyclic aromatic hydrocarbon, a by-product of incomplete combustion of organic matter, a potent carcinogen, and an agonist of AhR. Dibenz[a,h]anthracene induces dose-dependent increases in DNA adduct formation and lacZ mutation frequency. Dibenz[a,h]anthracene upregulates St3gal5. Dibenz[a,h]anthracene can be used in cancer-related research .
    Dibenz[a,h]anthracene
  • HY-W002251
    Benzo[b]thiophene-3-carbaldehyde

    		Biochemical Assay Reagents Others
    Benzo[b]thiophene-3-carbaldehyde is a 3-formyl-substituted benzo[b]thiophene derivative that acts as an oxidizable substrate to convert to benzo[b]thiophene-3-carboxylic acid under liquid-phase conditions. Compared with analogs such as benzaldehyde and thiophene-2-carbaldehyde, Benzo[b]thiophene-3-carbaldehyde has lower oxidation difficulty, and can significantly increase the reaction rate in the presence of initiators (such as Na +Br - or DBA). Benzo[b]thiophene-3-carbaldehyde also serves as a key starting material for the synthesis of compounds including heteroaryl chalcones .
    Benzo[b]thiophene-3-carbaldehyde
  • HY-P991059
    VIS-410

    		Influenza Virus Infection
    VIS-410 is an antibody inhibitor targeting the stem region of hemagglutinin (HA). VIS-410 inhibits influenza virus replication by blocking HA-mediated membrane fusion. VIS-410 exhibits broad-spectrum neutralization against influenza A viruses with group 1 and group 2 hemagglutinins, including subtypes such as H1N1, H3N2, H5N1, and H7N9 (H5N1 IC50 = 1.5 μg/mL). VIS-410 is applicable to research related to influenza A virus infection .
    VIS-410
  • HY-105365
    PD 175069

    		Calcium Channel Neurological Disease
    PD 175069 is a potent and selective N-type calcium channel antagonist with an IC50 of 0.32 μM. PD 175069 is efficacious in an audiogenic seizure model using DBA/2 mice. PD 175069 can be used for research on neurological conditions such as neuropathic pain and stroke .
    PD 175069
  • HY-NP098
    Dolichos Biflorus Agglutinin (Fluorescein)

    DBA (Fluorescein)

    		 Fluorescent Dye Others
    Dolichos Biflorus Agglutinin (DBA) Fluorescein is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Dolichos Biflorus Agglutinin (DBA) Fluorescein is a biological material or organic compound that can be used in life science research .
    Dolichos Biflorus Agglutinin (Fluorescein)
  • HY-NP0176
    Dolichos Biflorus Agglutinin (Biotinylated)

    DBA，Biotinylated

    		 Fluorescent Dye Others
    Dolichos Biflorus Agglutinin (DBA，Biotinylated) is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Dolichos Biflorus Agglutinin (DBA，Biotinylated) is a biological material or organic compound that can be used in life science research .
    Dolichos Biflorus Agglutinin (Biotinylated)
  • HY-NP0154
    Dolichos Biflorus Agglutinin (Rhodamine)

    DBA (Rhodamine)

    		 Fluorescent Dye Others
    Dolichos Biflorus Agglutinin (DBA) Rhodamine is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Dolichos Biflorus Agglutinin (DBA) Rhodamine is a biological material or organic compound that can be used in life science research .
    Dolichos Biflorus Agglutinin (Rhodamine)
  • HY-128960
    DBA-DM4

    		Drug-Linker Conjugates for ADC Cancer
    DBA-DM4 is a agent-linker conjugate composed of a potent a tubulin inhibitor DM1 and a linker SPDP to make antibody agent conjugate (ADC) .
    DBA-DM4
  • HY-W013053R
    Dibenz[a,h]anthracene (Standard)

    DBA (Standard); 1,2,5,6-Dibenzanthracene (Standard); Benzo[k]tetraphene (Standard)

    		 DNA/RNA Synthesis Apoptosis Reference Standards MDM-2/p53 Cancer
    Dibenz[a,h]anthracene (Standard) is the analytical standard of Dibenz[a,h]anthracene. This product is intended for research and analytical applications. Dibenz[a,h]anthracene (DBA) is a polycyclic aromatic hydrocarbon (PAH) of considerable tumorigenicity. Dibenz[a,h]anthracene results in DNA adduct formation leading to the activation of a DNA damage response. Dibenz[a,h]anthracene induces cell cycle arrest and apoptosis via both Tp53-dependent and Tp53-independent mechanisms .
    Dibenz[a,h]anthracene (Standard)
  • HY-141597
    Acid-C3-SSPy

    		ADC Linker Cancer
    Acid-C3-SSPy is a cleavable DBA-DM4 linker used in the synthesis of DBA-DM4 (HY-128960), a agent-linker conjugate for ADC .
    Acid-C3-SSPy
  • HY-100840
    (S)-4C3HPG

    (S)-4-Carboxy-3-hydroxyphenylglycine

    		 mGluR Neurological Disease
    (S)-4C3HPG ((S)-4-Carboxy-3-hydroxyphenylglycine) is an antagonist of metabotropic glutamate receptor 1a (mGluR 1a) and an agonist of GluR2. (S)-4C3HPG has the anticonvulsant activity and protects against audiogenic seizures in DBA/2 mice .
    (S)-4C3HPG
  • HY-12153
    JNJ-1930942

    		Cholinesterase (ChE) Neurological Disease
    JNJ-1930942 is a selective and blood-brain barrier (BBB) penetrant α(7) nAChR positive allosteric modulator.JNJ-1930942 enhances the Choline (HY-B0282)-evoked rise in intracellular Ca 2+ levels and neurotransmission at hippocampal dentate gyrus synapses. JNJ-1930942 reverses the naturally occurring sensory gating deficit in DBA/2 mice .
    JNJ-1930942
  • HY-10966R
    SB-590885 (Standard)
    5+ Cited Publications

    		 Reference Standards Raf Apoptosis Cancer
    SB-590885 (Standard) is the analytical standard of SB-590885 (HY-10966). This product is intended for research and analytical applications. SB-590885 is a BRAF/c-Raf kinase inhibitor that selectively targets B-Raf, and it amplifies the ERK/MAPK signaling pathway in RAS-activated cells. SB-590885 effectively inhibits the malignant proliferation, transformation and tumorigenicity of oncogenic B-Raf cells; it also induces the proliferation of erythroid progenitor cells, delays their differentiation and promotes hemoglobin synthesis, thereby improving ineffective erythropoiesis and reducing apoptosis. SB-590885 exerts a synergistic effect with TGF-β inhibitors and glucocorticoids, significantly promoting the formation of erythroid colonies in cells from patients with Diamond-Blackfan anemia (DBA). SB-590885 is mainly used in relevant studies on DBA, cisplatin-induced myelosuppression-related anemia, and pan-cancers such as melanoma and colorectal cancer .
    SB-590885 (Standard)
  • HY-W013053S
    Dibenz[a,h]anthracene-d14

    DBA-d14; 1,2,5,6-Dibenzanthracene-d14; Benzo[k]tetraphene-d14

    		 Isotope-Labeled Compounds Others
    Dibenz[a,h]anthracene-d14 is the deuterium Dibenz[a,h]anthracene.
    Dibenz[a,h]anthracene-d14

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