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Results for "

DOCK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DOCK (8) Acyltransferase (1) Adrenergic Receptor (2) Akt (3) Aldose Reductase (1) AMPK (3) Amylases (3) Amyloid-β (5) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (5) Apoptosis (27) Autophagy (2) Bacterial (14) Bcl-2 Family (5) Beta-lactamase (2) Beta-secretase (1) Biochemical Assay Reagents (5) Btk (1) c-Met/HGFR (1) Cannabinoid Receptor (1) Carbonic Anhydrase (3) Caspase (9) CCR (1) CDK (8) CFTR (1) CGRP Receptor (1) Cholinesterase (ChE) (9) Collagen (2) COX (5) Cytochrome P450 (2) Dihydrofolate reductase (DHFR) (4) Dihydroorotate Dehydrogenase (1) Dipeptidyl Peptidase (1) DNA/RNA Synthesis (2) Drug Derivative (3) Drug Intermediate (5) EGFR (12) Endogenous Metabolite (5) Environmental Pollutants (1) Epoxide Hydrolase (1) ERK (2) Estrogen Receptor/ERR (5) Exosomes (1) Fructose-1,6-bisphosphate aldolase (1) Fungal (7) FXR (1) G protein-coupled Bile Acid Receptor 1 (1) GABA Receptor (3) Glutathione S-transferase (1) Glycosidase (7) HBV (1) HDAC (4) Histone Demethylase (1) Histone Methyltransferase (1) HIV (2) HPPD (1) HSP (4) Indoleamine 2,3-Dioxygenase (IDO) (1) Insecticide (1) Interleukin Related (3) IRE1 (2) Isotope-Labeled Compounds (1) JAK (2) Keap1-Nrf2 (1) MARK (1) MEK (1) METTL3 (1) MicroRNA (1) Microtubule/Tubulin (4) MMP (3) Monoamine Oxidase (2) nAChR (1) NADPH Oxidase (1) Necroptosis (3) NO Synthase (1) NOD-like Receptor (NLR) (2) NTPDase (1) Orphan Nuclear Receptor (2) Orthopoxvirus (1) P2Y Receptor (1) p38 MAPK (2) PARP (2) PD-1/PD-L1 (2) PDGFR (1) PDK-1 (1) Penicillin-binding protein (PBP) (1) Phosphatase (1) Phosphodiesterase (PDE) (1) Phospholipase (3) PI3K (1) PKA (1) PKC (3) Polo-like Kinase (PLK) (2) PPAR (2) Prion Protein (1) Pyroptosis (2) Raf (2) Ras (3) Reactive Oxygen Species (ROS) (5) Reference Standards (9) Reverse Transcriptase (2) ROS Kinase (1) S-adenosylhomocysteine hydrolase (SAHH) (1) SARS-CoV (7) SHP1 (1) Sirtuin (4) Small Interfering RNA (siRNA) (19) STAT (3) Survivin (2) Tau Protein (1) TNF Receptor (2) Topoisomerase (2) Trk Receptor (1) TRP Channel (1) Tyrosinase (2) VEGFR (4) Virus Protease (5) Wnt (2)
By Research Areas:	Cancer (82) Cardiovascular Disease (5) Endocrinology (2) Infection (37) Inflammation/Immunology (30) Metabolic Disease (22) Neurological Disease (34)
Click Chemistry:	Tetrazine (1) Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (4) Mouse Pre-designed siRNA Sets (4) Human Pre-designed siRNA Sets (11) siRNAs (19)

202

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: DOCK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0451

Acacetin Maximum Cited Publications 13 Publications Verification 5,7-Dihydroxy-4'-methoxyflavone	Apoptosis Autophagy	Neurological Disease Inflammation/Immunology Cancer
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an orally active flavonoid derived from Dendranthema morifolium. Acacetin docks in the ATP binding pocket of PI3Kγ. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory activity and has the potential for pain-related diseases research .

HY-110100

CPYPP 3 Publications Verification	DOCK	Inflammation/Immunology
CPYPP is a DOCK2-Rac1 interaction inhibitor. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2 ^DHR-2 for Rac1 in a dose-dependent manner with an IC₅₀ of 22.8 µM. CPYPP also inhibits *DOCK180* and *DOCK5* and less inhibits DOCK9 .

HY-136177

Tris(2,4-di-tert-butylphenyl)phosphate	Phospholipase	Inflammation/Immunology
Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A₂ (sPLA₂) through molecular docking .

HY-Y0775

1-Bromo-2,5-pyrrolidinedione	Biochemical Assay Reagents Collagen	Others
1-Bromo-2,5-pyrrolidinedione is a collagen protein ligand in docking experiments. 1-Bromo-2,5-pyrrolidinedione can be used to study wound healing-related diseases .

HY-139604

PCC0208017 3 Publications Verification	MARK Apoptosis	Cancer
PCC0208017 is a microtubule affinity regulating kinases (MARK3/MARK4) inhibitor with IC₅₀s of 1.8 and 2.01 nM, respectively. PCC0208017 has much lower inhibitory activity against MARK1 and MARK2, with IC₅₀s of 31.4 and 33.7 nM, respectively. PCC0208017 suppresses glioma progression in vitro and in vivo. PCC0208017 disrupts microtubule dynamics and induces G2/M phase cell cycle arrest and cell apoptosis. PCC0208017 demonstrates robust antitumor activity in vivo and displays good BBB permeability .

HY-N2414

Periplogenin 1 Publications Verification	Reactive Oxygen Species (ROS) Necroptosis Pyroptosis Interleukin Related Caspase NOD-like Receptor (NLR)	Neurological Disease Inflammation/Immunology Cancer
Periplogenin is an orally active cardiac glycoside found in Cortex periplocae. Periplogenin can induce ROS production and necroptosis and cause G0/G1 phase arrest. Periplogenin can inhibit pyroptosis by regulating the NLRP3/Caspase-1/GSDMD signaling. Periplogenin suppresses growth of prostate carcinoma cells by docking to an ATP1A1 protein pocket and forming a hydrogen bond with T804. Periplogenin can be used for the researches of cancer, inflammation and immunology, such as prostate carcinoma, rheumatoid arthritis and psoriasis .

HY-153128

DOCK2-IN-1	DOCK Drug Derivative	Inflammation/Immunology
DOCK2-IN-1 (Compound 3) is an analog of CPYPP (HY-110100) and a *DOCK2* inhibitor (IC₅₀ = 19.1 μM). DOCK2-IN-1 binds to the DHR-2 domain of DOCK2 and inhibits its mediated Rac guanine nucleotide exchange factor activity. DOCK2-IN-1 blocks chemokine receptor- and antigen receptor-mediated activation of Rac in lymphocytes. DOCK2-IN-1 significantly inhibits chemotaxis and T cell activation. DOCK2-IN-1 can be used in the research of transplant rejection and organ-specific autoimmune diseases .

HY-N2025

Oroxin A 4 Publications Verification	PPAR Glycosidase	Metabolic Disease
Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE). Oroxin A acts as a partial PPARγ agonist that can activate PPARγ transcriptional activation. Oroxin A activates PPARγ by docking into the PPARγ protein ligand-binding domain. Oroxin A also exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity . Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence .

HY-N4294

Arjungenin	FXR Insecticide	Infection Metabolic Disease Inflammation/Immunology
Arjungenin, a pentacyclic triterpenoid compound, is a FXR agonist. Arjungenin can improve insulin sensitivity by regulating the function of fat cells. Arjungenin exhibits moderate free radical scavenging activity. Arjungenin has growth inhibitory activity against the insect Spilarctia obliqua. Arjungenin has significant antiviral activity against a series of viruses such as chikungunya Virus (CHIKV) .

HY-123035

Gamendazole	HSP Akt EGFR	Endocrinology
Gamendazole, an indazole carboxylic acid (ICA), is an orally active, selective HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A) inhibitor. Gamendazole binds to the C-terminal nucleotide binding pocket of HSP90 and cause downregulation of clients AKT1 and ERBB2, but stabilizes the HSP90 heterocomplex. Gamendazole specifically inhibits the actin bundling function of EEF1A1, but does not bind to the nucleotide docking pocket nor inhibits the ribosome charging or protein translation functions of EEF1A1. Gamendazole, an antispermatogenic compound with antifertility effects, has the potential for reversible non-hormonal male contraceptive agent research .

HY-124711

TBOPP 1 Publications Verification	DOCK	Cancer
TBOPP is a selective inhibitor of *DOCK1* with an IC₅₀ of 8.4 μM. TBOPP binds to the *DOCK1* DHR-2 domain with high affinity (K_d of 7.1 μM), has anti-tumor activity for broader types of tumors .

HY-N16395

Jensenone	SARS-CoV Virus Protease	Infection
Jensenone is an acylphloroglucinol derivative. Jensenone binds to COVID-19 proteinase in molecular docking studies. Jensenone can be used as a COVID-19 Mpro inhibitor .

HY-114645

PDK1-IN-RS2	PDK-1	Cancer
PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a K_d of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1 .

HY-102078

ZINC69391 1 Publications Verification	Ras Apoptosis	Cancer
ZINC69391, a specific Rac1 inhibitor, interferes with Rac1-GEF interaction by masking Trp56 residue on Rac1 surface. ZINC69391 interferes with the interaction of Rac1 with Dock180 and reduces Rac1-GTP levels. ZINC69391 induces apoptosis, and shows antiproliferative and antimetastatic effects .

HY-124858

SC99	STAT JAK Apoptosis	Cardiovascular Disease Cancer
SC99 is an orally active, selective STAT3 inhibitor targeting JAK2-STAT3 pathway. SC99 docks into the ATP-binding pocket of JAK2. SC99 inhibits phosphorylation of JAK2 and STAT3 with no effects on the other kinases associated with STAT3 signaling. SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activities .

HY-171274

DOCK5-IN-1	DOCK	Metabolic Disease
DOCK5-IN-1 (Compound 14) is the inhibitor for *DOCK5* and exhibits no toxicity (100 μM) in cell RAW264.7 .

HY-N10336

Notoginsenoside R4	VEGFR STAT Akt Ras	Others
Notoginsenoside R4 is a ginsenoside that can be isolated from ginseng roots. In the molecular docking results, Notoginsenoside R4 can target STAT3, AKT1, HRAS, VEGFA and CASP3 .

HY-163109

Carbonic anhydrase inhibitor 16	Carbonic Anhydrase	Infection
Carbonic anhydrase inhibitor 16 (compound 1) is a dengue protease inhibitor with inhibitory activity against carbonic anhydrase hCA I and hCA II (K_i: 28.5 nM, 2.2 nM) .

HY-155465

HPPD-IN-2	HPPD	Others
HPPD-IN-2 (compound 28) is a herbicide based on HPPD inhibitors. HPPD-IN-2 potently targets AtHPPD and exhibits enhanced safety in canola crops .

HY-75637

3-Amino-5-methylpyrazole	Drug Intermediate	Others
5-Methyl-1H-pyrazol-3-amine is a pyrazole heterocyclic compound and can be used as a key intermediate for the synthesis of pyrazolylamide derivatives.

HY-162520

DJ-1-IN-1	Wnt	Cancer
DJ-1-IN-1 (compound 797780-71-3) is a DJ-1 inhibitor. DJ-1-IN-1 exhibits antiproliferative activity in ACHN cells with an IC50 value of 12.18 μM and can inhibit the Wnt signaling pathway. DJ-1-IN-1 can be used in cancer research .

HY-P10424

OPBP-1	PD-1/PD-L1	Cancer
OPBP-1 is a D-peptide obtained by phage display screening, molecular docking and molecular dynamics simulation. OPBP-1 has high stability and strong antitumor and oral activity. OPBP-1 can selectively bind PD-L1 protein, significantly block the interaction between PD-1 and PD-L1, and this blocking effect helps to restore and improve the function of T lymphocytes and reduce the proportion of bone marrow derived suppressor cells (MDSCs) to combat tumor-induced immune escape. OPBP-1 can be used in cancer immunotherapy research .

HY-RS03924

DOCK2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DOCK2 Human Pre-designed siRNA Set A contains three designed siRNAs for DOCK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DOCK2 Human Pre-designed siRNA Set A DOCK2 Human Pre-designed siRNA Set A

HY-W087058

1,4-Di-tert-butylbenzene	Topoisomerase	Infection
1,4-Di-tert-butylbenzene is a volatile compound identified in the hexane extracts of corn cob and green millet. 1,4-Di-tert-butylbenzene shows potent inhibition against receptor proteins of Bacterial type II topoisomerase (4PLB and LpxC) in docking analysis .

HY-RS18172

Dock2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dock2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dock2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dock2 Mouse Pre-designed siRNA Set A Dock2 Mouse Pre-designed siRNA Set A

HY-136177R

Tris(2,4-di-tert-butylphenyl)phosphate (Standard)	Reference Standards Phospholipase	Inflammation/Immunology
Tris(2,4-di-tert-butylphenyl)phosphate (Standard) is the analytical standard of Tris(2,4-di-tert-butylphenyl)phosphate. This product is intended for research and analytical applications. Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A2 (sPLA2) through molecular docking .

HY-164587

E197	DOCK	Metabolic Disease
E197 is the inhibitor for *DOCK5* that destroys the podosome belt structure of osteoclasts, thereby inhibiting the bone resorption (IC₅₀=3.44 μM in human osteoclast). E197 inhibits the Rac in DOCK5 expressing HEK293 cell with an IC₅₀ of 36 μM. E197 prevents the bone loss in mouse ovariectomized models .

HY-B1349

Mepiroxol	Biochemical Assay Reagents	Others
Mepiroxol can form various interactions with key residues of specific proteins. It establishes salt bridges with Arg-153 and Arg-74, and forms two hydrogen bonds with Asp-50 and Gly-96 through its terminal hydroxyl group, these interactions help enhance its binding affinity and lead to a higher docking score .

HY-Y1013

5-Bromonicotinic acid	Drug Intermediate	Others
5-Bromonicotinic acid can be used as a pharmaceutical intermediate to synthesize 5-aryloyl nicotinic acid compounds. 5-Bromonicotinic acid has the characteristics of good drug similarity, high oral bioavailability, and low toxicity through molecular docking prediction. 5-Bromonicotinic acid has good binding ability with hepatitis virus proteins (binding energy: -4.7 to -5.3 kcal/mol) .

HY-P1906

[pThr3]-CDK5 Substrate	CDK	Neurological Disease
[pThr3]-CDK5 Substrate is an effective Phospho-Thr3CDK5 Substrate. [pThr3]-CDK5 Substrate is derived from the sequence of the histone H1 peptide that docks in the active site of CDK5. [pThr3]-CDK5 Substrate is phosphorylated by CDK5 with a K_m value of 6 µM .

HY-N0451R

Acacetin (Standard) Maximum Cited Publications 13 Publications Verification 5,7-Dihydroxy-4'-methoxyflavone (Standard)	Reference Standards Apoptosis Autophagy	Neurological Disease Inflammation/Immunology Cancer
Acacetin (Standard) is the analytical standard of Acacetin. This product is intended for research and analytical applications. Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an orally active flavonoid derived from Dendranthema morifolium. Acacetin docks in the ATP binding pocket of PI3Kγ. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory activity and has the potential for pain-related diseases research .

HY-32806

2-Chloro-4-methyl-3-nitropyridine	Drug Intermediate	Infection
2-Chloro-4-methyl-3-nitropyridine is a pyridine derivative that can be used to synthesize 2-methoxypyridine derivatives with antibacterial and antituberculosis activities .

HY-178923

NNRT-IN-14	HIV Reverse Transcriptase	Infection
NNRT-IN-14 is an HIV-1 reverse transcriptase inhibitor (IC₅₀ = 0.175 µM). NNRT-IN-14 can form hydrogen bonds with LYS101, PRO225, and PHE227, and π–π stacking with TYR181 and TRP229. NNRT-IN-14 can be used for the study of HIV .

HY-15350

Trovirdine hydrochloride LY 300046 hydrochloride	Reverse Transcriptase	Others
Trovirdine hydrochloride, a phenethylthiazolylthiourea (PETT) derivative, is an HIV reverse transcriptase (RT) non-nucleoside inhibitor (NNI). A novel computer model of the RT/NNI binding pocket revealed spatial gaps around Trovirdine hydrochloride's pyridyl ring. Docking studies suggested that replacing this planar ring with a nonplanar piperidinyl or piperazinyl ring could better occupy the binding pocket, enhancing anti-HIV activity. Synthesized heterocyclic compounds based on this modification demonstrated greater potency than Trovirdine hydrochloride, effectively inhibiting HIV replication at nanomolar concentrations without cytotoxicity in infected peripheral blood mononuclear cells .

HY-172264

XT17	Antibiotic Bacterial DNA/RNA Synthesis	Infection
XT17 is an anthrone compound with broad-spectrum antibacterial activity. It exerts its antibacterial effect by disrupting the cell wall and inhibiting DNA synthesis. XT17 exhibits weak hemolytic activity, low cytotoxicity against mammalian cell lines, and a low frequency of drug resistance. Meanwhile, XT17 shows in vivo efficacy in a mouse corneal infection model induced by Staphylococcus aureus or Pseudomonas aeruginosa. Further docking studies have confirmed that XT17 can form a stable complex with bacterial gyrase. XT17 can be used in the research of the anti - infection field .

HY-156332

TNKS-2-IN-2	PARP	Cancer
TNKS-2-IN-2 is a potent and selective inhibitor of TNKS2 with an IC₅₀ of 22 nM .

HY-176744

HER2-IN-22	EGFR Apoptosis	Cancer
HER2-IN-22 is a potent and selective HER2 inhibitor with an IC₅₀ of 215 μM. HER2-IN-22 possesses killing activity against various tumor cells and can induce cell apoptosis. HER2-IN-22 significantly inhibits tumor growth. HER2-IN-22 can be used in the study for tumors such as HER2+ breast cancer .

HY-179039

EGFR-IN-183	EGFR	Cancer
EGFR-IN-183 (Compound 5q) is an EGFR inhibitor. EGFR-IN-183 strongly binds to EGFR (T790M/L858R) mutants. EGFR-IN-183 exhibits anti-proliferative activity against MDA-MB-231, with an IC₅₀ value of 16.4 μM. EGFR-IN-183 can be used for research on triple-negative breast cancer .

HY-175540

PDGFRα kinase-IN-2	PDGFR	Cardiovascular Disease Cancer
PDGFRα kinase-IN-2 is a potent PDGFR-α inhibitor with an IC₅₀ of 2.1 nM. PDGFRα kinase-IN-2 exhibits anticancer activity against human colon cancer HT-29 cell with an IC₅₀ of 1.48 μM. PDGFRα kinase-IN-2 has anti-angiogenic activity in zebrafish models and low embryonic lethality. PDGFRα kinase-IN-2 can used for the studies of colon cancer and anti-angiogenesis .

HY-157170

CYP450-IN-1	Cytochrome P450	Cancer
CYP450-IN-1 (compound 2e) is a potent inhibitor of CYP450 .

HY-178380

HDAC8-IN-14	HDAC Reactive Oxygen Species (ROS) Apoptosis Necroptosis Biochemical Assay Reagents Caspase Bcl-2 Family	Inflammation/Immunology Cancer
HDAC8-IN-14, a curcuminoid derivative, is a selective HDAC8 inhibitor with a Ki of 9 nM. HDAC8-IN-14 induces the production of reactive oxygen species (ROS), disrupts mitochondrial membrane potential, and promotes apoptosis. HDAC8-IN-14 can significantly promote the accumulation of cells in the sub-G0/G1 phase, consistent with apoptotic or necrotic cell death. HDAC8-IN-14 induces upregulation of cytochrome c, cleaved caspase-3, and the pro-apoptotic protein Bak while leaving the anti-apoptotic Bcl-2 levels unaltered. HDAC8-IN-14 can be used for the study of leukemia .

HY-RS20911

Dock1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dock1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dock1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dock1 Mouse Pre-designed siRNA Set A Dock1 Mouse Pre-designed siRNA Set A

HY-RS03928

DOCK6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DOCK6 Human Pre-designed siRNA Set A contains three designed siRNAs for DOCK6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DOCK6 Human Pre-designed siRNA Set A DOCK6 Human Pre-designed siRNA Set A

HY-RS03922

DOCK10 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DOCK10 Human Pre-designed siRNA Set A contains three designed siRNAs for DOCK10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DOCK10 Human Pre-designed siRNA Set A DOCK10 Human Pre-designed siRNA Set A

HY-RS03930

DOCK8 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DOCK8 Human Pre-designed siRNA Set A contains three designed siRNAs for DOCK8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DOCK8 Human Pre-designed siRNA Set A DOCK8 Human Pre-designed siRNA Set A

HY-RS03921

DOCK1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DOCK1 Human Pre-designed siRNA Set A contains three designed siRNAs for DOCK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DOCK1 Human Pre-designed siRNA Set A DOCK1 Human Pre-designed siRNA Set A

HY-RS28076

Dock7 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dock7 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dock7 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dock7 Rat Pre-designed siRNA Set A Dock7 Rat Pre-designed siRNA Set A

HY-RS03931

DOCK9 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DOCK9 Human Pre-designed siRNA Set A contains three designed siRNAs for DOCK9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DOCK9 Human Pre-designed siRNA Set A DOCK9 Human Pre-designed siRNA Set A

HY-RS03929

DOCK7 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DOCK7 Human Pre-designed siRNA Set A contains three designed siRNAs for DOCK7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DOCK7 Human Pre-designed siRNA Set A DOCK7 Human Pre-designed siRNA Set A

HY-RS03927

DOCK5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DOCK5 Human Pre-designed siRNA Set A contains three designed siRNAs for DOCK5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DOCK5 Human Pre-designed siRNA Set A DOCK5 Human Pre-designed siRNA Set A

Cat. No.	Product Name

HY-L907

MCE Kinase Hinge Binder Fragment Library

12,417 compounds

The most prominent mechanism of action of kinase inhibitors is their competition with ATP by binding to the hinge region of the kinase protein. Once the kinase is blocked by an inhibitor, it loses the ability to transfer phosphate groups from ATP to other molecules, resulting in the loss of kinase activity.

The hinge-binding region of kinase inhibitors mimics the interaction pattern between the ATP nucleobase and the kinase. MCE extracted thousands of kinase inhibitors from the ChEMBL database and isolated their molecular fragments. In certain cases, the amino and amide groups on the molecular fragments are crucial for binding in the hinge region. Therefore, we enhanced the diversity of the collected results by adding these two groups to unoccupied positions on the ring system. Subsequently, the fragments were assessed for their hinge region binding ability via docking at distinct kinases, we also applied pharmacophore constraints to ensure interactions with key amino acids in the kinase hinge region, ultimately obtaining kinase-related molecular fragments.

MCE provides over 12,417 kinase fragment molecules that meet the above requirements and are available off the shelf, serving as an effective tool for screening and developing drugs targeting kinases.

HY-L918

Molecular Glue-like Compound Library

317 compounds

Targeted Protein Degradation (TPD) is a novel and promising approach to drug development. It shows great potential for targeting proteins traditionally considered "undruggable" due to the lack of enzymatic function and absence of binding sites by tagging them for degradation or recruiting natural degradation mechanisms.

Molecular glues are a type of small-molecule degraders that primarily induce novel interactions between E3 ubiquitin ligases and target proteins, forming ternary complexes that lead to protein ubiquitination and subsequent proteasomal degradation. Compared with PROTACs, molecular glues generally have lower molecular weights, higher cell permeability, and better drug-like properties. Additionally, the design of molecular glues is relatively simple, without the requirements for complex linkers and ligand optimization. As a result, molecular glues have gradually emerged as a promising therapeutic approach for various diseases.

Multiple types of molecular glues have been reported previously. Analysis of co-crystal complex structures reveals that CRBN-related molecular glues are more versatile. Therefore, MCE researchers select active molecules related to these targets as probes for artificial intelligence (AI) screening.Subsequently, molecular docking technology was used to verify whether the screened molecules retained the key pharmacophore features. Ultimately, we obtained 317 molecular glue analogs, and these compounds serve as powerful tools for the research of molecular glues.

HY-L906

Norepinephrine Transporter (NET) Compound Library

647 compounds

On May 15, 2024, "Dimerization and antidepressant recognition at noradrenaline transporter" was published online by Nature. The research findings were an effort from Shanghai Institute of Materia Medica, Chinese Academy of Sciences. This study unraveled the important neural system target - the noradrenaline transporter (NET), obtaining the binding modes of human NET homodimers with the natural substrate norepinephrine (NE) and six selective antidepressants. It laid an important theoretical foundation for understanding the physiological regulation mechanisms of NET and other monoamine transporters.

The Norepinephrine Transporter (NET) Compound Library is obtained by computer-aided virtual screening based on the HY-L901 compound library . The specific screening process includes molecular docking screening, key pharmacophore screening, and CNS-MPO screening, which can be used for new drug discovery targeting the noradrenaline transporter.

Cat. No.	Product Name	Type

HY-Y0775

1-Bromo-2,5-pyrrolidinedione	Biochemical Assay Reagents
1-Bromo-2,5-pyrrolidinedione is a collagen protein ligand in docking experiments. 1-Bromo-2,5-pyrrolidinedione can be used to study wound healing-related diseases .

HY-75637

3-Amino-5-methylpyrazole	Biochemical Assay Reagents
5-Methyl-1H-pyrazol-3-amine is a pyrazole heterocyclic compound and can be used as a key intermediate for the synthesis of pyrazolylamide derivatives.

HY-Y1013

5-Bromonicotinic acid	Biochemical Assay Reagents
5-Bromonicotinic acid can be used as a pharmaceutical intermediate to synthesize 5-aryloyl nicotinic acid compounds. 5-Bromonicotinic acid has the characteristics of good drug similarity, high oral bioavailability, and low toxicity through molecular docking prediction. 5-Bromonicotinic acid has good binding ability with hepatitis virus proteins (binding energy: -4.7 to -5.3 kcal/mol) .

HY-32806

2-Chloro-4-methyl-3-nitropyridine	Biochemical Assay Reagents
2-Chloro-4-methyl-3-nitropyridine is a pyridine derivative that can be used to synthesize 2-methoxypyridine derivatives with antibacterial and antituberculosis activities .

HY-Y0775R

1-Bromo-2,5-pyrrolidinedione (Standard)	Biochemical Assay Reagents
1-Bromo-2,5-pyrrolidinedione (Standard) is the analytical standard of 1-Bromo-2,5-pyrrolidinedione (HY-Y0775). This product is intended for research and analytical applications. 1-Bromo-2,5-pyrrolidinedione is a collagen protein ligand in docking experiments. 1-Bromo-2,5-pyrrolidinedione can be used to study wound healing-related diseases .

HY-Y1013R

5-Bromonicotinic acid (Standard)

Biochemical Assay Reagents

5-Bromonicotinic acid (Standard) is the analytical standard of 5-Bromonicotinic acid. This product is intended for research and analytical applications. 5-Bromonicotinic acid can be used as a pharmaceutical intermediate to synthesize 5-aryloyl nicotinic acid compounds. 5-Bromonicotinic acid has the characteristics of good drug similarity, high oral bioavailability, and low toxicity through molecular docking prediction. 5-Bromonicotinic acid has good binding ability with hepatitis virus proteins (binding energy: -4.7 to -5.3 kcal/mol) .

Cat. No.	Product Name	Target	Research Area

HY-P10424

OPBP-1	PD-1/PD-L1	Cancer
OPBP-1 is a D-peptide obtained by phage display screening, molecular docking and molecular dynamics simulation. OPBP-1 has high stability and strong antitumor and oral activity. OPBP-1 can selectively bind PD-L1 protein, significantly block the interaction between PD-1 and PD-L1, and this blocking effect helps to restore and improve the function of T lymphocytes and reduce the proportion of bone marrow derived suppressor cells (MDSCs) to combat tumor-induced immune escape. OPBP-1 can be used in cancer immunotherapy research .

HY-P10053

sPLA2-IIA Inhibitor	Phospholipase	Metabolic Disease
sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK (cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2)), that binds to hGIIA (human IIA phospholipase A2) and inhibits its hydrolytic ability. sPLA2 is a member of the esterase superfamily that catalyzes the hydrolysis of the ester bond at the sn-2 position of glycerophospholipids, releasing free fatty acids such as arachidonic acid and lysophospholipids .

HY-P1906

[pThr3]-CDK5 Substrate	CDK	Neurological Disease
[pThr3]-CDK5 Substrate is an effective Phospho-Thr3CDK5 Substrate. [pThr3]-CDK5 Substrate is derived from the sequence of the histone H1 peptide that docks in the active site of CDK5. [pThr3]-CDK5 Substrate is phosphorylated by CDK5 with a K_m value of 6 µM .

HY-P1906A

[pThr3]-CDK5 Substrate TFA	CDK	Neurological Disease
[pThr3]-CDK5 Substrate TFA is an effective Phospho-Thr3CDK5 Substrate. [pThr3]-CDK5 Substrate is derived from the sequence of the histone H1 peptide that docks in the active site of CDK5. [pThr3]-CDK5 Substrate is phosphorylated by CDK5 with a K_m value of 6 µM .

HY-P11266

Phakellistatin 13	Peptides	Cancer
Phakellistatin 13 is a natural cycloheptapeptide with anti-tumor activity. Phakellistatin 13 exhibits a potent inhibitory effect on liver cancer cells BEL-7404 (ED₅₀0 < 0.01 μg/mL). Phakellistatin 13 can be used for research on liver cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0451

Acacetin Maximum Cited Publications 13 Publications Verification 5,7-Dihydroxy-4'-methoxyflavone	Neurological Disease Classification of Application Fields Flavones Anti-aging Dendranthema morifolium (Ramat.) Tzvel. Plants Compositae Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Phenols Polyphenols Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis Autophagy
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an orally active flavonoid derived from Dendranthema morifolium. Acacetin docks in the ATP binding pocket of PI3Kγ. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory activity and has the potential for pain-related diseases research .

HY-103248

Toyocamycin 5+ Cited Publications Vengicide	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	IRE1 Fungal Antibiotic Apoptosis CDK
Toyocamycin (Vengicide) is an adenosine analog produced by Streptomyces diastatochromogenes, acts as an XBP1 inhibitor. Toyocamycin blocks RNA synthesis and ribosome function, and induces apoptosis. Toyocamycin affects IRE1α-XBP1 pathway, and inhibits XBP1 mRNA cleavage with an IC₅₀ value of 80 nM with affecting IRE1α auto-phosphorylation. Toyocamycin specifically inhibits CDK9 with an IC₅₀ value of 79 nM .

HY-111355B

Cholesteryl sulfate sodium	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Sirtuin Endogenous Metabolite PKC AMPK DOCK
Cholesterol sulfate sodium is a naturally occurring, orally active cholesterol derivative that is widely distributed in various tissues and body fluids. Cholesterol sulfate sodium acts as a *DOCK2* inhibitor, with IC₅₀ values of 2 μM and 2.9 μM against mouse and human targets, respectively. Cholesterol sulfate sodium restricts excessive neutrophil infiltration and alleviates intestinal inflammation and damage. Cholesterol sulfate sodium serves as an activator of protein kinase C (PKC), which promotes squamous cell differentiation and inhibits skin carcinogenesis. Cholesterol sulfate sodium regulates cholesterol homeostasis and cellular metabolism by activating the AMPK-Sirt1 pathway. Cholesterol sulfate sodium can be used in research related to actinic keratitis, ulcerative colitis, skin cancer, and other conditions .

HY-136177

Tris(2,4-di-tert-butylphenyl)phosphate	Natural Products Verbenaceae Plants Inflammation/Immunology Disease Research Fields Source Classification Vitex negundo Linn.	Phospholipase
Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A₂ (sPLA₂) through molecular docking .

HY-N2414

Periplogenin 1 Publications Verification	Structural Classification other families Classification of Application Fields Plants Inflammation/Immunology Disease Research Fields Steroids Source Classification	Reactive Oxygen Species (ROS) Necroptosis Pyroptosis Interleukin Related Caspase NOD-like Receptor (NLR)
Periplogenin is an orally active cardiac glycoside found in Cortex periplocae. Periplogenin can induce ROS production and necroptosis and cause G0/G1 phase arrest. Periplogenin can inhibit pyroptosis by regulating the NLRP3/Caspase-1/GSDMD signaling. Periplogenin suppresses growth of prostate carcinoma cells by docking to an ATP1A1 protein pocket and forming a hydrogen bond with T804. Periplogenin can be used for the researches of cancer, inflammation and immunology, such as prostate carcinoma, rheumatoid arthritis and psoriasis .

HY-N2025

Oroxin A 4 Publications Verification	Flavonoids Classification of Application Fields Flavones Metabolic Disease Bignoniaceae Plants Oroxylum indicum (Linn.) Bentham ex Kurz Disease Research Fields Source Classification	PPAR Glycosidase
Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE). Oroxin A acts as a partial PPARγ agonist that can activate PPARγ transcriptional activation. Oroxin A activates PPARγ by docking into the PPARγ protein ligand-binding domain. Oroxin A also exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity . Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence .

HY-111355

Cholesterol sulfate	Structural Classification Animals Steroids Source Classification	Endogenous Metabolite DOCK PKC AMPK Sirtuin
Cholesterol sulfate is a naturally occurring, orally active cholesterol derivative that is widely distributed in various tissues and body fluids. Cholesterol sulfate acts as a *DOCK2* inhibitor, with IC₅₀ values of 2 μM and 2.9 μM against mouse and human targets, respectively. Cholesterol sulfate restricts excessive neutrophil infiltration and alleviates intestinal inflammation and damage. Cholesterol sulfate serves as an activator of protein kinase C (PKC), which promotes squamous cell differentiation and inhibits skin carcinogenesis. Cholesterol sulfate regulates cholesterol homeostasis and cellular metabolism by activating the AMPK-Sirt1 pathway. Cholesterol sulfate can be used in research related to actinic keratitis, ulcerative colitis, skin cancer, and other conditions .

HY-N4294

Arjungenin	Triterpenes Classification of Application Fields Terpenoids Combretaceae Metabolic Disease Terminalia chebula Retz. Plants Disease Research Fields Source Classification	FXR Insecticide
Arjungenin, a pentacyclic triterpenoid compound, is a FXR agonist. Arjungenin can improve insulin sensitivity by regulating the function of fat cells. Arjungenin exhibits moderate free radical scavenging activity. Arjungenin has growth inhibitory activity against the insect Spilarctia obliqua. Arjungenin has significant antiviral activity against a series of viruses such as chikungunya Virus (CHIKV) .

HY-N16395

Jensenone	Phenols Polyphenols Myrtaceae Eucalyptus jensenii Maiden Plants Source Classification	SARS-CoV Virus Protease
Jensenone is an acylphloroglucinol derivative. Jensenone binds to COVID-19 proteinase in molecular docking studies. Jensenone can be used as a COVID-19 Mpro inhibitor .

HY-N10336

Notoginsenoside R4	Panax ginseng C. A. Meyer Triterpenes Terpenoids Plants Araliaceae Source Classification	VEGFR STAT Akt Ras
Notoginsenoside R4 is a ginsenoside that can be isolated from ginseng roots. In the molecular docking results, Notoginsenoside R4 can target STAT3, AKT1, HRAS, VEGFA and CASP3 .

HY-120294

Chrysin 6-C-glucoside 8-C-arabinoside	Flavonoids Rheum palmatum L. Flavones Polygonaceae Plants Source Classification	CGRP Receptor TRP Channel
Chrysin 6-C-glucoside 8-C-arabinoside can inhibit the CGRP releasing and the activation of TRPV1 channel. Chrysin 6-C-glucoside 8-C-arabinoside can be used for anti-migraine research .

HY-N17254

Onjisaponin R	Triterpenes Structural Classification Terpenoids Polygalaceae Plants Polygala tenuifolia Willd. Source Classification	Amylases
Onjisaponin R is an α-amylase inhibitor. Onjisaponin R can be used in diabetes research .

HY-136177R

Tris(2,4-di-tert-butylphenyl)phosphate (Standard)	Natural Products Verbenaceae Plants Source Classification Vitex negundo Linn.	Reference Standards Phospholipase
Tris(2,4-di-tert-butylphenyl)phosphate (Standard) is the analytical standard of Tris(2,4-di-tert-butylphenyl)phosphate. This product is intended for research and analytical applications. Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A2 (sPLA2) through molecular docking .

HY-N0451R

Acacetin (Standard) Maximum Cited Publications 13 Publications Verification 5,7-Dihydroxy-4'-methoxyflavone (Standard)	Neurological Disease Classification of Application Fields Anti-aging Dendranthema morifolium (Ramat.) Tzvel. Plants Compositae Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Phenols Inflammation/Immunology Disease Research Fields Source Classification	Reference Standards Apoptosis Autophagy
Acacetin (Standard) is the analytical standard of Acacetin. This product is intended for research and analytical applications. Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an orally active flavonoid derived from Dendranthema morifolium. Acacetin docks in the ATP binding pocket of PI3Kγ. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory activity and has the potential for pain-related diseases research .

HY-N9922

Alashinol G Carinol	Apocynaceae Phenols Polyphenols Plants Carissa carandas Linn. Source Classification	Others
Alashinol G (Carinol) (compound 1) is a compound with antioxidant and anti-tyrosinase activities. Through affinity ultrafiltration and related experimental screening and identification, it can effectively dock with tyrosinase molecules and inhibit its activity.

HY-114604

Propioxatin B	Natural Products Microorganisms Source Classification	Bacterial
Propioxatin B is a tricyclic sesquiterpenoid compound isolated from the root of vetiver grass. It has anti-tuberculosis activity and inhibitory effects on a variety of drug-resistant mutants of Mycobacterium tuberculosis. In computer simulation docking studies, it showed binding affinity with bacterial DNA gyrase and has a certain safety in vivo.

HY-N2025R

Oroxin A (Standard)	Structural Classification Flavonoids Flavones Bignoniaceae Plants Oroxylum indicum (Linn.) Bentham ex Kurz Source Classification	Reference Standards PPAR Glycosidase
Oroxin A (Standard) is the analytical standard of Oroxin A. This product is intended for research and analytical applications. Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE). Oroxin A acts as a partial PPARγ agonist that can activate PPARγ transcriptional activation. Oroxin A activates PPARγ by docking into the PPARγ protein ligand-binding domain. Oroxin A also exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity . Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence .

HY-N2414R

Periplogenin (Standard)	Structural Classification other families Plants Steroids Source Classification	Reference Standards Reactive Oxygen Species (ROS) Necroptosis Pyroptosis Interleukin Related Caspase NOD-like Receptor (NLR)
Periplogenin (Standard) is the analytical standard of Periplogenin (HY-N2414). Periplogenin is an orally active cardiac glycoside found in Cortex periplocae. Periplogenin can induce ROS production and necroptosis and cause G0/G1 phase arrest. Periplogenin can inhibit pyroptosis by regulating the NLRP3/Caspase-1/GSDMD signaling. Periplogenin suppresses growth of prostate carcinoma cells by docking to an ATP1A1 protein pocket and forming a hydrogen bond with T804. Periplogenin can be used for the researches of cancer, inflammation and immunology, such as prostate carcinoma, rheumatoid arthritis and psoriasis .

HY-103248R

Toyocamycin (Standard) Vengicide (Standard)	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards IRE1 Fungal Antibiotic Apoptosis CDK
DL-Aspartic acid (Standard) is the analytical standard of DL-Aspartic acid. This product is intended for research and analytical applications. DL-Aspartic acid (DL-Asp-OH) is a kind of biological materials or organic compounds that are widely used in life science research .

HY-N8075

Artonin U	Structural Classification Flavonoids Flavones Plants Moraceae Source Classification	Estrogen Receptor/ERR
Artonin U is an artonin. Artonin U can be isolated from Artocarpus species. Artonin U binds to hERα, as measured by docking score and Prime MM-GBSA binding free energy evaluation. Artonin U can be used in breast cancer research .

HY-N16855

Tinoscorside D	Structural Classification Simple Phenylpropanols Phenylpropanoids Plants Menispermaceae Source Classification	Drug Derivative
Tinoscorside D is a natural phenylacetylene.

HY-N9664

Crepidiaside B	Structural Classification Terpenoids Sesquiterpenes Plants Compositae Sophora tomentosa L. Source Classification	SARS-CoV Virus Protease
Crepidiaside B is a plant-derived active component that can be found in Cichorium intybus. Crepidiaside B acts as a SARS-CoV-2 spike glycoprotein inhibitor and is used in research related to coronavirus disease 2019 (COVID-19) .

Cat. No.	Product Name	Chemical Structure

HY-111355S

Cholesterol sulfate-d7 sodium

Cholesterol sulfate sodium-d₇ is the deuterium labeled Cholesterol sulfate sodium. Cholesterol sulfate sodium is a naturally occurring, orally active cholesterol derivative that is widely distributed in various tissues and body fluids. Cholesterol sulfate sodium acts as a DOCK2 inhibitor, with IC₅₀ values of 2 μM and 2.9 μM against mouse and human targets, respectively. Cholesterol sulfate sodium restricts excessive neutrophil infiltration and alleviates intestinal inflammation and damage. Cholesterol sulfate sodium serves as an activator of protein kinase C (PKC), which promotes squamous cell differentiation and inhibits skin carcinogenesis. Cholesterol sulfate sodium regulates cholesterol homeostasis and cellular metabolism by activating the AMPK-Sirt1 pathway. Cholesterol sulfate sodium can be used in research related to actinic keratitis, ulcerative colitis, skin cancer, and other conditions.

Host:	Mouse (3) Rabbit (4)
Reactivity:	Human (6) mouse (1) Rat (2) Mouse (2) rat (1) human (1)
Application:	IHC-P (2) ICC/IF (4) IF-Tissue (1) IP (1) WB (5) FC (1) ELISA (1)
Isotype:	IgG (4) IgG1 (1) IgG2a (2)
Conjugation:	Non-conjugated (7)
Clonality:	Monoclonal (4) Recombinant (2)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82965

	DOCK2 Antibody (YA2710) DOCK 2; IMD40	WB	Human
	DOCK2 Antibody (YA2710) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DOCK2.

HY-P82965A

	DOCK2 Antibody (YA2710)(PBS only) DOCK 2; IMD40	WB	Human
	DOCK2 Antibody (YA2710) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DOCK2.

HY-P89558

	DOCK 7 Antibody (YA8902)	WB, ICC/IF, IF-Tissue, IP, ELISA	human, mouse, rat
	DOCK 7 Antibody (YA8902) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DOCK 7.

HY-P88929

	DOCK2 Antibody (YA8613) FLJ46592; KIAA0209	IHC-P, ICC/IF	Human, Mouse, Rat
	DOCK2 Antibody (YA8613) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to DOCK2.

HY-P82968

	DOCK8 Antibody (YA2713) MRD2; ZIR8; HEL-205	WB	Human
	DOCK8 Antibody (YA2713) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DOCK8.

HY-P88929A

	DOCK2 Antibody (YA8613)(PBS only) FLJ46592; KIAA0209	IHC-P, ICC/IF	Human, Mouse, Rat
	DOCK2 Antibody (YA8613) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to DOCK2.

HY-P810485

	DOCK8 Antibody (YA9782) MRD2, ZIR8, HEL-205, Dedicator of cytokinesis protein 8	WB, ICC/IF, FC	Human
	DOCK8 Antibody (YA9782) is a Rabbit-derived and non-conjugated IgG Monoclonal antibody, targeting to DOCK8.

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Cat. No.	Product Name		Classification

HY-179232

ERα antagonist 2		Tetrazine
ERα antagonist 2 (Compound 5b) is an ER-α antagonist with an IC₅₀ value of 1729 nM. ERα antagonist 2 exhibits significant inhibitory activity against breast cancer cell lines, and is still effective against ER-negative cells (MDA-MB-231), suggesting the existence of ER-independent pathways. ERα antagonist 2 can be used for the study of breast cancer .

HY-180114

NSS-18		Alkynes
NSS-18 is a potent and reversible inhibitor of AChE and MAO-B, with IC₅₀ values of 1.53 and 1.51 μM respectively. NSS-18 can inhibit the self-aggregation of Aβ. NSS-18 inhibits the intracellular generation of ROS induced by Aβ. NSS-18 shows a moderate neuroprotective effect against 6-OHDA (HY-B1081)-induced neurotoxicity. NSS-18 can form chelates with metal ions such as Cu²⁺, Fe³⁺, and Zn²⁺, with the strongest chelation being with Cu²⁺. NSS-18 can be used for the study of Alzheimer's disease .

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