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Results for "

DUSP6

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

2

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-115502
    BCI
    Maximum Cited Publications
    17 Publications Verification

    (E)-BCI

    		 Phosphatase Inflammation/Immunology
    BCI ((E)-BCI) is a DUSP6 (dual specificity phosphatase 6) inhibitor. BCI shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI can be used in inflammatory disease research .
    BCI
  • HY-115502A
    BCI hydrochloride
    Maximum Cited Publications
    17 Publications Verification

    (E)-BCI hydrochloride

    		 Phosphatase Inflammation/Immunology
    BCI ((E)-BCI) hydrochloride is a DUSP6 (dual specificity phosphatase 6) inhibitor. BCI hydrochloride shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI hydrochloride can be used in inflammatory disease research .
    BCI hydrochloride
  • HY-RS04067
    DUSP6 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    DUSP6 Human Pre-designed siRNA Set A contains three designed siRNAs for DUSP6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    DUSP6 Human Pre-designed siRNA Set A
    DUSP6 Human Pre-designed siRNA Set A
  • HY-126390
    (E/Z)-BCI
    1 Publications Verification

    NSC 150117

    		 Phosphatase Apoptosis Inflammation/Immunology Cancer
    (E/Z)-BCI (NSC 150117) is a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory activities. (E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB pathway .
    (E/Z)-BCI
  • HY-RS23450
    Dusp6 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Dusp6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dusp6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Dusp6 Rat Pre-designed siRNA Set A
    Dusp6 Rat Pre-designed siRNA Set A
  • HY-RS17007
    Dusp6 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Dusp6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dusp6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Dusp6 Mouse Pre-designed siRNA Set A
    Dusp6 Mouse Pre-designed siRNA Set A
  • HY-168012
    Pan-RAS-IN-6

    		Ras Phosphatase Cancer
    Pan-RAS-IN-6 (compound 24) is an inhibitor targeting DUSP6, which reduces MAPK activation in the brain of the NCI-H1373-Luc model (DUSP6), at the same time, it shows significant tumor growth inhibition and tumor regression effects in the NSCLC brain metastasis mouse model. Pan-RAS-IN-6 shows high selectivity and strong inhibitory effects, especially in KRAS mutation-related signaling pathways, demonstrating varying inhibitory activity against different KRAS mutants and interacting proteins. The IC50 values for KRAS G12C, G12D, and G12V are 1.3 nM, 4.7 nM, and 0.3 nM, respectively .
    Pan-RAS-IN-6
  • HY-181889
    KRAS G12C-IN-75

    		Ras Cancer
    KRAS G12C-IN-75 is an orally active, blood-brain barrier penetrant KRAS G12C inhibitor with an IC50 of 0.53 nM. KRAS G12C-IN-75 attenuates active transport mediated by P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP). KRAS G12C-IN-75 inhibits tumor growth, regulates the expression of downstream MAPK target genes DUSP6 and SPRY4, and exhibits dose-dependent KRAS G12C alkylation in KRAS G12C-positive xenograft models. KRAS G12C-IN-75 can be used for research related to non-small cell lung cancer .
    KRAS G12C-IN-75

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