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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
Eos
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "Eos" in MCE Product Catalog:
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PF-06840003 (EOS200271) is a highly selective, orally active and brain-penetrant IDO-1 inhibitor with IC50s of 0.41 μM, 0.59 μM, and 1.5 μM for hIDO-1, dIDO-1, and mIDO-1, respectively .
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Inupadenant is an orally active, highly selective A2A receptor antagonist. Inupadenant can not cross BBB. Inupadenant can enhance the humoral immune response and has anti-tumor activity .
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1 Cited Publications
Synonyms: TωMCA sodium
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Tauro-ω-muricholic acid sodium (TωMCA sodium) is a bile acid released by the liver and an analog of tauro-α-muricholic acid. Tauro-ω-muricholic acid sodium is investigated as a potential marker in plasma for early-onset neonatal sepsis (EOS) and cholestasis studies
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1 Cited Publications
Synonyms: Eos-850 hydrochloride
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Inupadenant (EOS-850) hydrochloride is an orally active, highly selective A2A receptor antagonist. Inupadenant hydrochloride can not cross BBB. Inupadenant hydrochloride can enhance the humoral immune response and has anti-tumor activity .
Cat. No.: HY-P991621
Synonyms: Eos-215
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EOS006215 (EOS-215) is a humanized monoclonal antibody targeting TREM-2. EOS006215 competes with TREM2 ligands, prevents TREM2 multimerization, and blocks downstream signaling. EOS006215 inhibits efferocytosis, reprograms transcriptomic profiles of monocyte-derived macrophages, alters metabolism and immune response genes, and increases pro-inflammatory marker secretion. EOS006215 reduces metastasis burden, delays tumor growth, and reprograms the tumor microenvironment to overcome anti-PD-1 resistance. EOS006215 can be used for the research of triple negative breast cancer and colorectal cancer .
Cat. No.: HY-173630
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BMS-986449 is a potent and orally active CELMoD molecular glue and an IKZF2/IKZF4 degrader. BMS-986449 targets the degradation of transcription factors Helios (IKZF2) and Eos (IKZF4) in regulatory T (Treg) cells. BMS-986449 redirects the E3 ubiquitin ligase Cereblon to induce the degradation of Helios and Eos, reprogramming Treg cells and enhancing antitumor immunity. BMS-986449 is promising for research of advanced solid tumors .
Cat. No.: HY-159650
CAS No.: 2724937-55-5
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EOS-984 is a macrocyclic diamine equilibrative nucleoside transporter 1 (ENT1) inhibitor. EOS984 inhibits ENT1 and ENT1-mediated nucleoside transport, restricting adenosine entry into cells via ENT1, thereby attenuating ATP-derived adenosine-mediated T cell immunosuppression and restoring primary human T cell proliferation. EOS984 can be used in research related to ENT1-mediated nucleoside transport, adenosine-related immunosuppression, and tumor immunity .
Cat. No.: HY-P990032
CAS No.: 2574438-65-4
Synonyms: Eos-448; Eos884448; GSK4428859A
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Cat. No.: HY-173630A
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(R)-BMS-986449 is the racemic mixture of BMS-986449 (HY-173630). BMS-986449 is a CELMoD molecular glue and an IKZF2/IKZF4 degrader. BMS-986449 targets the degradation of transcription factors Helios (IKZF2) and Eos (IKZF4) in regulatory T (Treg) cells. BMS-986449 redirects the E3 ubiquitin ligase Cereblon to induce the degradation of Helios and Eos, reprogramming Treg cells and enhancing antitumor immunity. BMS-986449 is promising for research of advanced solid tumors .
Cat. No.: HY-165066
CAS No.: 97040-38-5
Synonyms: N-(30-Linoleoyloxy-triacontanoyl)-sphingosine
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EOS (d18:1/30:0/18:2) is a kind ceramide in the outer epidermis .
Cat. No.: HY-139393
CAS No.: 1318771-31-1
Synonyms: C52:3 Eos (18:1/32:1(22 Z)w18:2(9Z,12Z); Esterified ω-hydroxyacyl sphingosine
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EOS (d18:1/32:1/18:2) is a biochemical reagent.
Cat. No.: HY-152022S
CAS No.: 2692624-26-1
Synonyms: N-(32-lioleoyloxy-dotiacotaoyl)-sphigosie-d9
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EOS (d18:1/32:0/18:2)-d9 is the deuterium labeled EOS (d18:1/32:1/18:2) (HY-139393). EOS (d18:1/32:1/18:2) is a kind ceramide in the outer epidermis .
Cat. No.: HY-RS11254
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PRSS33 Human Pre-designed siRNA Set A contains three designed siRNAs for PRSS33 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS06668
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IKZF4 Human Pre-designed siRNA Set A contains three designed siRNAs for IKZF4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-113635
CAS No.: 99659-62-8
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ONO-6240 is a platelet-activating factor antagonist. ONO-6240 prevents EOS infiltration into airway. ONO-6240 can be used in the study of asthmatic .
Cat. No.: HY-189613
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EOS34295 is a dipeptidyl peptidase-IV (DPP-IV) inhibitor predicted to have oral activity. EOS34295 competitively binds to key residues in the active site of DPP-IV, inhibiting its enzymatic activity and blocking the degradation of incretins such as GLP-1/GIP, ultimately promoting insulin release to improve glycemic control. EOS34295 can be used in the study of type 2 diabetes .
Cat. No.: HY-175088
Synonyms: C48:2 EOP (t18:0/30:0w18:2 (9Z,12Z)); N-(30-Linoleoyloxy-triacontanoyl)-phytosphingosine
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EOP (t18:0/30:0/18:2) (C48:2 EOP (t18:0/30:0w18:2 (9Z,12Z)); N-(30-Linoleoyloxy-triacontanoyl)-phytosphingosine) is a plant ceramide-based EOS analog. EOP (t18:0/30:0/18:2) is formed by esterifying an ω-hydroxy very long chain ceramide (C28-36) with the essential fatty acid linoleic acid. EOP (t18:0/30:0/18:2) has been used as a component of a model stratum corneum lipid mixture .
Cat. No.: HY-RS16338
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EOS Human Pre-designed siRNA Set A contains three designed siRNAs for EOS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-101111R
CAS No.: 198474-05-4
Synonyms: Eos200271 (Standard)
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PF-06840003 (Standard) is the analytical standard of PF-06840003 (HY-101111). This product is intended for research and analytical applications. PF-06840003 (EOS200271) is a highly selective, orally active and brain-penetrant IDO-1 inhibitor with IC50s of 0.41 μM, 0.59 μM, and 1.5 μM for hIDO-1, dIDO-1, and mIDO-1, respectively .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
