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Eos

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (3) Biochemical Assay Reagents (1) Drug Derivative (1) Endogenous Metabolite (3) IKZF Family (2) Indoleamine 2,3-Dioxygenase (IDO) (2) Integrin (1) Isotope-Labeled Compounds (1) Molecular Glues (2) Platelet-activating Factor Receptor (PAFR) (1) Reference Standards (1) Small Interfering RNA (siRNA) (4) Sodium Phosphate Cotransporter (1) Transmembrane Glycoprotein (1) TREM receptor (1)
By Research Areas:	Cancer (10) Cardiovascular Disease (2) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (3) Cholesterol (1) siRNAs (4)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101111

PF-06840003 1 Publications Verification Eos200271	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
PF-06840003 (EOS200271) is a highly selective, orally active and brain-penetrant IDO-1 inhibitor with IC₅₀s of 0.41 μM, 0.59 μM, and 1.5 μM for hIDO-1, dIDO-1, and mIDO-1, respectively .

HY-P99333

Volociximab 2 Publications Verification M200; Eos 200-4	Integrin	Cardiovascular Disease Cancer
Volociximab (M200) is a chimeric human/murine IgG4 antibody IIA1 targeting integrin α5β1 (EC₅₀=0.2 nM). Integrin α5β1 is a major fibronectin receptor involved in angiogenesis. Volociximab has antiangiogenic and antitumor activities and inhibits the proliferation of human umbilical vein vascular endothelial cells (HUVECs) .

HY-P991621

EOS006215 Eos-215	TREM receptor	Cancer
EOS006215 (EOS-215) is a humanized monoclonal antibody targeting TREM-2. EOS006215 competes with TREM2 ligands, prevents TREM2 multimerization, and blocks downstream signaling. EOS006215 inhibits efferocytosis, reprograms transcriptomic profiles of monocyte-derived macrophages, alters metabolism and immune response genes, and increases pro-inflammatory marker secretion. EOS006215 reduces metastasis burden, delays tumor growth, and reprograms the tumor microenvironment to overcome anti-PD-1 resistance. EOS006215 can be used for the research of triple negative breast cancer and colorectal cancer .

HY-173630

BMS-986449	Molecular Glues IKZF Family	Cancer
BMS-986449 is a potent and orally active CELMoD molecular glue and an IKZF2/IKZF4 degrader. BMS-986449 targets the degradation of transcription factors Helios (IKZF2) and Eos (IKZF4) in regulatory T (Treg) cells. BMS-986449 redirects the E3 ubiquitin ligase Cereblon to induce the degradation of Helios and Eos, reprogramming Treg cells and enhancing antitumor immunity. BMS-986449 is promising for research of advanced solid tumors .

HY-159650

EOS-984	Adenosine Receptor	Cancer
EOS-984 is a highly potent and selective ENT1 (equilibrative nucleoside transporter 1) inhibitor. EOS-984 is designed to inhibit the immunosuppressive activity of adenosine and restore immune cell proliferation .

HY-107823

Cholesteryl acetate Cholesterol 3-acetate; Cholesterin acetate; Cholesterol 3β-acetate	Endogenous Metabolite	Others
Cholesteryl acetate (Cholesterol 3-acetate) is a cholesterol ester that is exported from Saccharomyces cerevisiae via a Pry1-dependent mechanism. Cholesteryl acetate binds to the CAP superfamily protein Pry1 via interactions dependent on Pry1’s caveolin-binding motif .

HY-137442

Inupadenant 1 Publications Verification Eos-850	Adenosine Receptor	Cancer
Inupadenant is an orally active, highly selective A_2A receptor antagonist. Inupadenant can not cross BBB. Inupadenant can enhance the humoral immune response and has anti-tumor activity .

HY-P990032

Belrestotug Eos-448; Eos884448; GSK4428859A	Transmembrane Glycoprotein	Inflammation/Immunology Cancer
Belrestotug (EOS-448) is an antagonistic anti-TIGIT (VSIG9, VSTM3) human immunoglobulin G1 kappa (hIgG1 kappa) antibody. Belrestotug shows antineoplastic activity. Belrestotug can be used for cancer and immunological research such as colon cancer .

HY-173630A

(Rac)-BMS-986449	Molecular Glues IKZF Family	Cancer
(R)-BMS-986449 is the racemic mixture of BMS-986449 (HY-173630). BMS-986449 is a CELMoD molecular glue and an IKZF2/IKZF4 degrader. BMS-986449 targets the degradation of transcription factors Helios (IKZF2) and Eos (IKZF4) in regulatory T (Treg) cells. BMS-986449 redirects the E3 ubiquitin ligase Cereblon to induce the degradation of Helios and Eos, reprogramming Treg cells and enhancing antitumor immunity. BMS-986449 is promising for research of advanced solid tumors .

HY-136066

Tauro-ω-muricholic acid sodium 1 Publications Verification TωMCA sodium	Endogenous Metabolite	Metabolic Disease
Tauro-ω-muricholic acid sodium (TωMCA sodium) is a bile acid released by the liver and an analog of tauro-α-muricholic acid. Tauro-ω-muricholic acid sodium is investigated as a potential marker in plasma for early-onset neonatal sepsis (EOS) and cholestasis studies

HY-137442A

Inupadenant hydrochloride 1 Publications Verification Eos-850 hydrochloride	Adenosine Receptor	Cancer
Inupadenant (EOS-850) hydrochloride is an orally active, highly selective A_2A receptor antagonist. Inupadenant hydrochloride can not cross BBB. Inupadenant hydrochloride can enhance the humoral immune response and has anti-tumor activity .

HY-165066

EOS (d18:1/30:0/18:2) N-(30-Linoleoyloxy-triacontanoyl)-sphingosine	Endogenous Metabolite	Neurological Disease
EOS (d18:1/30:0/18:2) is a kind ceramide in the outer epidermis .

HY-139393

EOS (d18:1/32:1/18:2) C52:3 Eos (18:1/32:1(22 Z)w18:2(9Z,12Z); Esterified ω-hydroxyacyl sphingosine	Biochemical Assay Reagents	Others
EOS (d18:1/32:1/18:2) is a biochemical reagent.

HY-152022S

EOS (d18:1/32:0/18:2)-d9 N-(32-lioleoyloxy-dotiacotaoyl)-sphigosie-d₉	Isotope-Labeled Compounds	Others
EOS (d18:1/32:0/18:2)-d₉ is the deuterium labeled EOS (d18:1/32:1/18:2) (HY-139393). EOS (d18:1/32:1/18:2) is a kind ceramide in the outer epidermis .

HY-175088

EOP (t18:0/30:0/18:2) C48:2 EOP (t18:0/30:0w18:2 (9Z,12Z)); N-(30-Linoleoyloxy-triacontanoyl)-phytosphingosine	Drug Derivative	Others
EOP (t18:0/30:0/18:2) (C48:2 EOP (t18:0/30:0w18:2 (9Z,12Z)); N-(30-Linoleoyloxy-triacontanoyl)-phytosphingosine) is a plant ceramide-based EOS analog. EOP (t18:0/30:0/18:2) is formed by esterifying an ω-hydroxy very long chain ceramide (C28-36) with the essential fatty acid linoleic acid. EOP (t18:0/30:0/18:2) has been used as a component of a model stratum corneum lipid mixture .

HY-RS11254

PRSS33 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PRSS33 Human Pre-designed siRNA Set A contains three designed siRNAs for PRSS33 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRSS33 Human Pre-designed siRNA Set A PRSS33 Human Pre-designed siRNA Set A

HY-RS06668

IKZF4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IKZF4 Human Pre-designed siRNA Set A contains three designed siRNAs for IKZF4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IKZF4 Human Pre-designed siRNA Set A IKZF4 Human Pre-designed siRNA Set A

HY-113635

ONO-6240	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease Inflammation/Immunology
ONO-6240 is a platelet-activating factor antagonist. ONO-6240 prevents EOS infiltration into airway. ONO-6240 can be used in the study of asthmatic .

HY-159978

EOS789	Sodium Phosphate Cotransporter	Metabolic Disease Inflammation/Immunology
EOS789 is an orally active sodium-dependent phosphate transporter inhibitor, with IC₅₀ values of 6.8, 1.5, and 1.7 μM against human NaPi-IIb, PiT-1, PiT-2, respectively; and IC₅₀ values of 3.9, 1.9, and 1.7 μM against rat NaPi-IIb, PiT-1, PiT-2, respectively. EOS789 inhibits intestinal phosphate absorption, increases fecal phosphate excretion, reduces urinary phosphate excretion, and decreases the levels of serum phosphate, FGF23, and adult parathyroid hormone. EOS789 ameliorates ectopic thoracic aortic calcification, renal injury and hyperphosphatemia, and inhibits the expression of fibrosis markers. EOS789 can be used for the research of hyperphosphatemia and chronic kidney disease-mineral and bone disorder (CKD-MBD) .

HY-RS16338

EOS Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EOS Human Pre-designed siRNA Set A contains three designed siRNAs for EOS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EOS Human Pre-designed siRNA Set A EOS Human Pre-designed siRNA Set A

HY-101111R

PF-06840003 (Standard) Eos200271 (Standard)	Indoleamine 2,3-Dioxygenase (IDO) Reference Standards	Cancer
PF-06840003 (Standard) is the analytical standard of PF-06840003 (HY-101111). This product is intended for research and analytical applications. PF-06840003 (EOS200271) is a highly selective, orally active and brain-penetrant IDO-1 inhibitor with IC50s of 0.41 μM, 0.59 μM, and 1.5 μM for hIDO-1, dIDO-1, and mIDO-1, respectively .

HY-RS21602

Ikzf4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ikzf4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ikzf4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ikzf4 Mouse Pre-designed siRNA Set A Ikzf4 Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area	Image

HY-P99333

Volociximab 2 Publications Verification M200; Eos 200-4	Integrin	Cardiovascular Disease Cancer
Volociximab (M200) is a chimeric human/murine IgG4 antibody IIA1 targeting integrin α5β1 (EC₅₀=0.2 nM). Integrin α5β1 is a major fibronectin receptor involved in angiogenesis. Volociximab has antiangiogenic and antitumor activities and inhibits the proliferation of human umbilical vein vascular endothelial cells (HUVECs) .

HY-P991621

EOS006215 Eos-215	TREM receptor	Cancer
EOS006215 (EOS-215) is a humanized monoclonal antibody targeting TREM-2. EOS006215 competes with TREM2 ligands, prevents TREM2 multimerization, and blocks downstream signaling. EOS006215 inhibits efferocytosis, reprograms transcriptomic profiles of monocyte-derived macrophages, alters metabolism and immune response genes, and increases pro-inflammatory marker secretion. EOS006215 reduces metastasis burden, delays tumor growth, and reprograms the tumor microenvironment to overcome anti-PD-1 resistance. EOS006215 can be used for the research of triple negative breast cancer and colorectal cancer .

HY-P990032

Belrestotug Eos-448; Eos884448; GSK4428859A	Transmembrane Glycoprotein	Inflammation/Immunology Cancer
Belrestotug (EOS-448) is an antagonistic anti-TIGIT (VSIG9, VSTM3) human immunoglobulin G1 kappa (hIgG1 kappa) antibody. Belrestotug shows antineoplastic activity. Belrestotug can be used for cancer and immunological research such as colon cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-107823

Cholesteryl acetate Cholesterol 3-acetate; Cholesterin acetate; Cholesterol 3β-acetate	Structural Classification Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite
Cholesteryl acetate (Cholesterol 3-acetate) is a cholesterol ester that is exported from Saccharomyces cerevisiae via a Pry1-dependent mechanism. Cholesteryl acetate binds to the CAP superfamily protein Pry1 via interactions dependent on Pry1’s caveolin-binding motif .

Cat. No.	Product Name	Chemical Structure

HY-152022S

EOS (d18:1/32:0/18:2)-d9
EOS (d18:1/32:0/18:2)-d₉ is the deuterium labeled EOS (d18:1/32:1/18:2) (HY-139393). EOS (d18:1/32:1/18:2) is a kind ceramide in the outer epidermis .

Cat. No.	Product Name		Classification

HY-107823

Cholesteryl acetate Cholesterol 3-acetate; Cholesterin acetate; Cholesterol 3β-acetate		Cholesterol
Cholesteryl acetate (Cholesterol 3-acetate) is a cholesterol ester that is exported from Saccharomyces cerevisiae via a Pry1-dependent mechanism. Cholesteryl acetate binds to the CAP superfamily protein Pry1 via interactions dependent on Pry1’s caveolin-binding motif .

HY-RS11254

PRSS33 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PRSS33 Human Pre-designed siRNA Set A contains three designed siRNAs for PRSS33 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06668

IKZF4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IKZF4 Human Pre-designed siRNA Set A contains three designed siRNAs for IKZF4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16338

EOS Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
EOS Human Pre-designed siRNA Set A contains three designed siRNAs for EOS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS21602

Ikzf4 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ikzf4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ikzf4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Eos

Inhibitors & Agonists

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products