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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
103 Results for "
Eph
" in MedChemExpress (MCE) Product Catalog:
Products (103)
103 Results for "Eph" in MCE Product Catalog:
32
32 Cited Publications
Cat. No.: HY-18007
CAS No.: 1186206-79-0
Synonyms: Eph receptor tyrosine kinase inhibitor
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ALW-II-41-27 is a Eph family tyrosine kinase inhibitor with an IC50 of 11 nM for Eph2.
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1 Cited Publications
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Eph inhibitor 1 is a potent Eph inhibitor. Eph inhibitor 1 has the potential for the research of neurological disorders .
Synonyms: Eph 116 hydrochloride
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SI-2 (EPH 116 hydrochloride) is a highly promising SRC-3 inhibitor (PPI). SI-2 (EPH 116 hydrochloride) has a much improved toxicity and pharmacokinetic profile, with acceptable oral availability .
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UniPR129 is a potent and orally active Eph/ephrin antagonist. UniPR129 can inhibit EphA2-ephrin-A1 interaction with an IC50 of 945 nM and a Ki of 370 nM. UniPR129 can inhibit angiogenesis and show antitumor and neuroprotective effect. UniPR129 can be used for the researches of cancer and neurological disease, such as colorectal cancer and optic neuropathy .
Cat. No.: HY-131005
CAS No.: 861249-59-4
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Eph inhibitor 2 (Example 35) is a Eph family tyrosine kinase inhibitor.
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UniPR1331 is an orally active 3β-hydroxy-Δ5-choline acid derivative that inhibits Eph-ephrin interactions. UniPR1331 blocks the interaction of VEGFR2 with its natural ligand vascular endothelial growth factor and inhibits subsequent autophosphorylation, signaling, and pro-angiogenic activation of endothelial cells. UniPR1331 exhibits anti-angiogenesis, anti-cancer and anti-inflammation effects. UniPR1331 can be used for the researches of cancer and inflammation, such as glioma and colitis .
Cat. No.: HY-101447
CAS No.: 223788-33-8
Synonyms: Eph 116
SI-2 (EPH 116) is an inhibitor for steroid receptor coactivator-3 (SRC-3), which reduces the transcriptional activity and protein concentration of SRC-3 in cells, exhibits cytotoxicity in cancer cell, inhibits migration of MDA-MB-468, induces apoptosis of MDA-MB-468. SI-2 inhibits the tumor growth in mouse models, without significant toxicity for heart and other major organs (20 mg/kg) .
Cat. No.: HY-107144
CAS No.: 908265-94-1
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LY2457546 is a potent and orally active multi-targeted anti-angiogenic tyrosine kinases inhibitor. LY2457546 demonstrates potent activity against targets that include VEGFR2, PDGFRβ, FLT-3, Tie-2 and members of the Eph family of receptors. LY2457546 can be used for the research of cancer, such as leukemia .
Cat. No.: HY-RS04424
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EPHA1 Human Pre-designed siRNA Set A contains three designed siRNAs for EPHA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-121582
CAS No.: 380537-35-9
Synonyms: (E)-Eph 116
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(E)-SI-2 is an isomer of SI-2, an inhibitor of the steroid receptor coactivator SRC-3. SI-2 has anticancer activity and increases the number of cytotoxic immune cells in mice with breast cancer .
Cat. No.: HY-101447AR
CAS No.: 1992052-49-9
Synonyms: Eph 116 hydrochloride (Standard)
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SI-2 (hydrochloride) (Standard) is the analytical standard of SI-2 (hydrochloride) (HY-101447A). This product is intended for research and analytical applications. SI-2 (EPH 116 hydrochloride) is a highly promising SRC-3 inhibitor (PPI). SI-2 (EPH 116 hydrochloride) has a much improved toxicity and pharmacokinetic profile, with acceptable oral availability .
Cat. No.: HY-P70321
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHuEphrin type-A receptor 1/EphA1, His; Ephrin type-A receptor 1; hEpha1; Eph tyrosine kinase; Eph tyrosine kinase 1; Erythropoietin-producing hepatoma receptor; Tyrosine-protein kinase receptor Eph; EphA1; Eph; EphT; EphT1
Cat. No.: HY-P702706
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: EphA1; Eph receptor A1; Ephrin type-A receptor 1; mEpha1; embryonic stem cell kinase; tyrosine-protein kinase receptor ESK; Eph; Esk; AL033318; 5730453L17Rik
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Cat. No.: HY-10654
CAS No.: 1192216-03-7
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EphB4-IN-2 is a tyrosine kinase inhibitor targeting the Eph family and Src family. EphB4-IN-2 binds to the ATP-binding site of the kinase domain of EphB4, and exhibits high affinity for tyrosine kinases with threonine as the gatekeeper residue, such as Abl, Lck and Src. EphB4-IN-2 can be used in research related to tumor-associated angiogenesis .
Cat. No.: HY-RS19190
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Epha1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Epha1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
