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Results for "

FOXA1

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

3

Antibodies

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-168534
    WX-02-23

    		SF3B1 Apoptosis Cancer
    WX-02-23 is a small-molecule probe that stereoselectively and site-specifically binds to C258 of FOXA1 and C1111 of SF3B1. WX-02-23 remodels FOXA1's chromatin binding and pioneer activity in a DNA-dependent manner, disrupts spliceosome assembly, and enhances the thermal stability of SF3B1. WX-02-23 inhibits tumor cell proliferation and induces apoptosis. WX-02-23 can be used for research on cancers such as prostate cancer [1] .
    WX-02-23
  • HY-156190A
    NR2F2-IN-1 free base

    		Orphan Nuclear Receptor Cancer
    NR2F2-IN-1 (free base) is a potent and selective orphan nuclear receptor COUP-TFII (NR2F2) inhibitor. NR2F2-IN-1 (free base) substantially inhibits COUP-TFII–driven NGFIA reporter expression. NR2F2-IN-1 (free base) directly binds to the COUP-TFII ligand-binding domain and disrupts COUP-TFII interaction with transcription regulators, including FOXA1, thus repressing COUP-TFII activity on target gene regulation [1].
    NR2F2-IN-1 free base
  • HY-RS05036
    FOXA1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    FOXA1 Human Pre-designed siRNA Set A contains three designed siRNAs for FOXA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    FOXA1 Human Pre-designed siRNA Set A
    FOXA1 Human Pre-designed siRNA Set A
  • HY-RS23794
    Foxa1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Foxa1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Foxa1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Foxa1 Rat Pre-designed siRNA Set A
    Foxa1 Rat Pre-designed siRNA Set A
  • HY-156190
    NR2F2-IN-1

    		Orphan Nuclear Receptor Cancer
    NR2F2-IN-1 (CIA1) is a potent and selective orphan nuclear receptor COUP-TFII (NR2F2) inhibitor. NR2F2-IN-1 substantially inhibits COUP-TFII-driven NGFIA reporter expression. NR2F2-IN-1 directly binds to the COUP-TFII ligand-binding domain and disrupts COUP-TFII interaction with transcription regulators, including FOXA1, thus repressing COUP-TFII activity on target gene regulation [1].
    NR2F2-IN-1
  • HY-179433
    PROTAC AR Degrader-12

    		PROTACs Androgen Receptor Estrogen Receptor/ERR Src Cancer
    PROTAC AR Degrader-12 is a highly efficient PROTAC targeting AR coactivator binding site (AR-CBS). PROTAC AR Degrader-12 induces AR degradation in a ubiquitin proteasome system (UPS) pathway-dependent manner. PROTAC AR Degrader-12 inhibits tumor cell growth by affecting DNA replication and cell division PROTAC AR Degrader-12 could not only effectively degrade AR, but also potently inhibit the proliferation of MCF-7 and multiple mutant or resistant BC cells. PROTAC AR Degrader-12 effectively blocked estrogen receptor α (ERα) signaling through a dual mechanism involving ERα protein downregulation and suppression of its transcriptional activity. PROTAC AR Degrader-12 significantly inhibits the mRNA expression of FOXA1, GREB1, SRC, and PELP1. PROTAC AR Degrader-12 can be used for the study of breast cancer [1].
    PROTAC AR Degrader-12
  • HY-174681
    Human FOXA1 mRNA

    		mRNA Cancer
    Human FOXA1 mRNA encodes the human forkhead box A1 (FOXA1) protein, a member of the forkhead class of DNA-binding proteins. FOXA1 is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues.
    Human FOXA1 mRNA
  • HY-RS17339
    Foxa1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Foxa1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Foxa1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Foxa1 Mouse Pre-designed siRNA Set A
    Foxa1 Mouse Pre-designed siRNA Set A
  • HY-181421
    WX-02-43

    		SF3B1 Cancer
    WX-02-43 is a weak covalent inhibitor of SF3B1, and is the (1S,3R) enantiomer of WX-02-23 (HY-168534). WX-02-43 cannot effectively covalently modify the C258 site in the DNA-binding domain of FOXA1, and its inhibitory activity against SF3B1 is also weaker than that of WX-02-23. WX-02-43 serves as a negative control probe that fails to remodel the chromatin binding pattern and transcriptional activity of FOXA1. WX-02-43 can be used in studies on cancers such as prostate cancer to verify the specific effects of WX-02-23 on FOXA1 and SF3B1 targets [1] .
    WX-02-43

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