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Fungal Inhibitor

" in MedChemExpress (MCE) Product Catalog:

390

Inhibitors & Agonists

1

Fluorescent Dyes

5

Biochemical Assay Reagents

5

Peptides

1

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1

Inhibitory Antibodies

154

Natural
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30

Isotope-Labeled Compounds

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0105
    Ketoconazole
    25+ Cited Publications

    Ketoconazol; R 41400

    		 Fungal Cytochrome P450 Ras Bacterial Infection Cancer
    Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
    Ketoconazole
  • HY-76200
    Voriconazole
    10+ Cited Publications

    UK-109496

    		 Fungal Bacterial Infection Neurological Disease Cancer
    Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes. Voriconazole can penetrate the blood brain barrier (BBB) .
    Voriconazole
  • HY-119976
    Boscalid
    1 Publications Verification

    		 Environmental Pollutants Apoptosis Fungal Mitochondrial Metabolism Succinate Dehydrogenase Infection
    Boscalid is a succinate dehydrogenase (SDHI) inhibitor with antifungal activity. Boscalid binds to the ubiquinone-binding site of fungal mitochondrial complex II, blocks ATP production and aerobic respiration, exhibits good control efficacy against a variety of plant fungal diseases including gray mold, sclerotinia rot and powdery mildew, and is widely used for disease control in agriculture. Boscalid induces apoptosis, altered lipid metabolism, mitochondrial dysfunction, respiratory impairment, oxidative stress, ROS accumulation and neurodevelopmental disorders in zebrafish. Boscalid reduces foraging ability, shortens median death time and causes chronic toxicity in exposed honeybees. Boscalid also possesses genotoxicity, cytotoxicity, elevated mitochondrial superoxide levels and early-stage apoptosis .
    Boscalid
  • HY-17006A
    Caspofungin
    5+ Cited Publications

    MK-0991; L-743872

    		 Antibiotic Fungal Bacterial Infection Cancer
    Caspofungin is a potent antifungal agent. Caspofungin inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan .
    Caspofungin
  • HY-B0105A
    (+)-Ketoconazole

    (+)-Ketoconazol; (+)-R 41400

    		 Fungal Cytochrome P450 Infection
    (+)-Ketoconazole ((+)-R 41400) is an imidazole anti-fungal agent, a CYP3A4 inhibitor.
    (+)-Ketoconazole
  • HY-B0850
    Difenoconazole
    3 Publications Verification

    		 Environmental Pollutants Fungal Infection
    Difenoconazole is a sterol demethylation inhibitor, as a fungicide. Difenoconazole binds the heme portion of the fungal cytochrome P450 51, interferes the mycelial growth and inhibits the spore germination of pathogens, suppressing fungal growth .
    Difenoconazole
  • HY-119847
    Abafungin

    BAY-W-6341

    		 Fungal Infection
    Abafungin (BAY-W-6341) is a broad-spectrum fungicidal arylguanidine compound and a selective inhibitor of sterol-C-24-methyltransferase. Abafungin blocks the transmethylation reaction at the C-24 position of the sterol side chain during the ergosterol biosynthesis pathway. Abafungin directly disrupts fungal cell membrane integrity, and diminishes fungal viability independent of the fungal growth state. Abafungin can be applied to the research of fungal infections, particularly dermatomycoses .
    Abafungin
  • HY-77995
    2-Methoxybenzaldehyde

    o-Anisaldehyde

    		 Bacterial Fungal Infection
    2-Methoxybenzaldehyde (o-Anisaldehyde) is a bacterial/fungal inhibitor with a BA50 value of 0.19 for Salmonella. 2-Methoxybenzaldehyde can be used for the study of bacterial and fungal infectious diseases .
    2-Methoxybenzaldehyde
  • HY-B0848
    Tricyclazole
    2 Publications Verification

    		 Environmental Pollutants Bacterial Infection Metabolic Disease
    Tricyclazole is a pentaketone melanin biosynthesis inhibitor and a unique fungicide for controlling rice blast. Tricyclazole alters the structure and function of fungal cell walls, reduces fungal pathogenicity and penetration, and causes dose-dependent liver damage in animals .
    Tricyclazole
  • HY-116290
    Zaragozic acid A
    1 Publications Verification

    Squalestatin S1

    		 Endogenous Metabolite Metabolic Disease
    Zaragozic acid A is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase. Zaragozic acid A is an inhibitor of acute hepatic cholesterol synthesis in mouse (IC50 = 6 μM) .
    Zaragozic acid A
  • HY-N1633
    1-Methoxycarbonyl-β-carboline

    		Fungal Infection
    1-Methoxycarbonyl-β-carboline is a phytopathogenic fungal growth inhibitor with moderate to weak in vitro antifungal activity. 1-Methoxycarbonyl-β-carboline can be used for the research of phytopathogenic fungal infections .
    1-Methoxycarbonyl-β-carboline
  • HY-100527
    AN2718

    		Fungal Infection
    AN2718 inhibits fungal growth by blocking protein synthesis using the oxaborole tRNA trapping (OBORT) mechanism.
    AN2718
  • HY-B0843A
    Metalaxyl-M

    (R)-Metalaxyl

    		 Environmental Pollutants Fungal DNA/RNA Synthesis Infection Inflammation/Immunology
    Metalaxyl-M ((R)-Metalaxyl) is an orally active and selective inhibitor of fungal RNA polymerase, which exerts fungicidal activity by selectively interfering with the synthesis of fungal ribosomal RNA. Metalaxyl-M can also be used to induce inflammation in hepatocytes and regulate tryptophan metabolism. Metalaxyl-M can be used in ecotoxicology studies .
    Metalaxyl-M
  • HY-76200S
    Voriconazole-d3
    2 Publications Verification

    UK-109496-d3

    		 Fungal Infection
    Voriconazole-d3 is the deuterium labeled Voriconazole. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes .
    Voriconazole-d3
  • HY-123777
    VT-1598

    		Fungal Infection Inflammation/Immunology
    VT-1598 is an orally active and selective fungal inhibitor targeting CYP51. VT-1598 shows anti-fungal activity against Candida auris . VT-1598 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    VT-1598
  • HY-109040
    Quilseconazole

    VT-1129

    		 Fungal Cytochrome P450 Infection Inflammation/Immunology
    Quilseconazole (VT-1129) is an orally active, highly selective fungal cytochrome P450 enzyme Cyp51 inhibitor that can cross the blood-brain barrier. Quilseconazole prevents the synthesis of ergosterol, an important component of the fungal cell membrane, by inhibiting Cyp51. Quilseconazole has minimal effects on human CYP enzymes. Quilseconazole has antifungal activity and can be used in the study of cryptococcal meningitis and other diseases .
    Quilseconazole
  • HY-121721
    Inz-5

    		Fungal Infection
    Inz-5 is a fungal-selective mitochondrial cytochrome bc1 inhibitor. Inz-5 impairs fungal virulence and prevents the evolution of agent resistance .
    Inz-5
  • HY-N2519
    (E)-Coniferin

    (E)-Laricin

    		 Fungal Infection
    (E)-Coniferin is the isomer of Coniferin. Coniferin is a glucoside of coniferyl alcohol. Coniferin inhibits fungal growth and melanization .
    (E)-Coniferin
  • HY-B0850R
    Difenoconazole (Standard)

    		Reference Standards Fungal Infection
    Difenoconazole (Standard) is the analytical standard of Difenoconazole. This product is intended for research and analytical applications. Difenoconazole is a sterol demethylation inhibitor, as a fungicide. Difenoconazole binds the heme portion of the fungal cytochrome P450 51, interferes the mycelial growth and inhibits the spore germination of pathogens, suppressing fungal growth .
    Difenoconazole (Standard)
  • HY-W775091
    Isofetamid

    IKF-5411

    		 Fungal Succinate Dehydrogenase Infection
    Isofetamid (IKF-5411) is a succinate dehydrogenase inhibitor and a fungicide. Isofetamid exhibits good control effects against various fungal diseases such as gray mold, white mold, and powdery mildew. Isofetamid is promising for research of plant fungal diseases .
    Isofetamid
  • HY-126765
    Territrem B

    		Cholinesterase (ChE) Infection Neurological Disease
    Territrem B is an irreversible inhibitor of Acetylcholinesterase (AChE) inhibitor. Territrem B is also a fungal meroterpenoid that can be isolated from Aspergillus terreus .
    Territrem B
  • HY-139161
    Penflufen

    		Environmental Pollutants Fungal Infection
    Penflufen is a highly efficient, broad-spectrum succinate dehydrogenase inhibitor (SDHI). Penflufen can be used as a fungicide and has broad bioactivity against many fungal diseases, including potato black scurf, wheat sharp eyespot, rice sheath blight, and root rot in peanut and other similar fungal diseases .
    Penflufen
  • HY-123779
    RWJ-49815

    		Bacterial Fungal Infection
    RWJ-49815 is a histidine kinase inhibitor. RWJ-49815 inhibits the autokinase activity of purified GST-Sln1 and the autophosphorylation of KinA in vitro. RWJ-49815 acts as a fungal growth inhibitor . RWJ-49815 serves as a bactericide against Gram-positive pathogenic bacteria. RWJ-49815 is applicable to research related to fungal infections and Gram-positive bacterial infections .
    RWJ-49815
  • HY-W516735
    Sedaxane

    		Fungal Succinate Dehydrogenase Infection
    Sedaxane is a new broad-spectrum seed treatment fungicide. Sedaxane inhibits fungal respiration by binding to the succinate dehydrogenase complex in fungal mitochondria. Sedaxane has broad-spectrum activity against a variety of seed-borne and soil-borne fungi. Sedaxane can be used in the study of barley loose smut and barley stripe disease .
    Sedaxane
  • HY-76200R
    Voriconazole (Standard)

    UK-109496 (Standard)

    		 Reference Standards Fungal Bacterial Infection Cancer
    Voriconazole (Standard) is the analytical standard of Voriconazole. This product is intended for research and analytical applications. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes .
    Voriconazole (Standard)
  • HY-N8541
    Endocrocin

    		Endogenous Metabolite Inflammation/Immunology
    Endocrocin, an anthraquinone, is a fungal secondary metabolite. Endocrocin is a potent chemotaxis inhibitor with immunosuppressive properties .
    Endocrocin
  • HY-177246A
    Mitotic kinesin-IN-1 hydrochloride

    		Kinesin Infection Cardiovascular Disease Inflammation/Immunology Cancer
    Mitotic kinesin-IN-1 (Example 80) hydrochloride is a Mitotic kinesin inhibitor. Mitotic kinesin-IN-1 hydrochloride inhibits cell proliferation by suppressing mitosis. Mitotic kinesin-IN-1 hydrochloride can be used for cancer, cardiac hypertrophy, immune and inflammatory disorders, fungal infections research .
    Mitotic kinesin-IN-1 hydrochloride
  • HY-125319
    Amidepsine A

    		Acyltransferase Metabolic Disease
    Amidepsine A is a fungal metabolite isolated from the culture broth of Humicola sp. FO-2942 that inhibits Diacylglycerol acyltransferases (DGAT) activity .
    Amidepsine A
  • HY-W1127089
    Antifungal agent 136

    		Fungal Cytochrome P450 Interleukin Related Infection Inflammation/Immunology
    Antifungal agent 136 (Compound M-15) is an irreversible fungal lanosterol 14α-demethylase (CYP51) inhibitor. Antifungal agent 136 exhibits potent antifungal activity against drug-resistant Candida albicans and downregulates IL-6 expression. Antifungal agent 136 is promising for research of fungal infection and inflammatory disease .
    Antifungal agent 136
  • HY-N8331
    Terpendole I

    		Endogenous Metabolite Acyltransferase Metabolic Disease
    Terpendole I is a fungal indole diterpenoid and an ACAT inhibitor (IC50 = 145 µM). Terpendole I can be used in studies related to lipid metabolism .
    Terpendole I
  • HY-N10227
    Geodin

    		PAI-1 Antibiotic Infection Inflammation/Immunology
    Geodin, a fungal metabolite, shows antibacterial activity. Geodin also is an inhibitor of plasminogen activator inhibitor- 1 (PAI-1) .
    Geodin
  • HY-177247A
    Mitotic kinesin-IN-2 hydrochloride

    		Kinesin Infection Cardiovascular Disease Inflammation/Immunology Cancer
    Mitotic kinesin-IN-2 (Page 135, fifteenth) hydrochloride is a Mitotic kinesin inhibitor. Mitotic kinesin-IN-2 hydrochloride inhibits cell proliferation by suppressing mitosis. Mitotic kinesin-IN-2 hydrochloride can be used for cancer, cardiac hypertrophy, immune and inflammatory disorders, fungal infections research .
    Mitotic kinesin-IN-2 hydrochloride
  • HY-177248A
    Mitotic kinesin-IN-3 hydrochloride

    		Kinesin Infection Cardiovascular Disease Inflammation/Immunology Cancer
    Mitotic kinesin-IN-3 (Page 135, fourteenth) hydrochloride is a Mitotic kinesin inhibitor. Mitotic kinesin-IN-3 hydrochloride inhibits cell proliferation by suppressing mitosis. Mitotic kinesin-IN-3 hydrochloride can be used for cancer, cardiac hypertrophy, immune and inflammatory disorders, fungal infections research .
    Mitotic kinesin-IN-3 hydrochloride
  • HY-118330
    Apigeninidin chloride

    Gesneridin chloride; Apigenidin chloride

    		 Fungal Infection
    Apigeninidin (Gesneridin) chloride, a 3‐deoxyanthocyanidin, is a fungal growth inhibitor. Apigeninidin chloride is a bioactive red biocolorant .
    Apigeninidin chloride
  • HY-114518
    Butenafine

    KP363

    		 Fungal Infection
    Butenafine (KP363) is a potent and broad spectrum benzylamine antifungal agent . Butenafine inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation, leading to a deficiency of the fungal cell membranes. Butenafine is effective against dermatophytes infections, such as  tinea pedis,  tinea cruris, tinea versicolor .
    Butenafine
  • HY-B2048S
    Pencycuron-d5

    		Isotope-Labeled Compounds Others
    Pencycuron-d5 is the deuterium labeled Pencycuron (HY-B2048). Pencycuron is a benzoylurea fungicide. Pencycuron kills fungi by inhibiting the synthesis of fungal cell walls.Pencycuron can be used in research on the control of fungal diseases on crops, such as sheath blight, powdery mildew and late blight .
    Pencycuron-d5
  • HY-175198
    Cs-2d

    		Acyltransferase Fungal Infection
    Cs-2d is a selective ceramide synthases Cer1 inhibitor. Cs-2d has potent inhibitory activity toward C. neoformans Cer1, while maintaining a low off-target effect on human hCerS1. Cs-2d has potent antifungal activity with the significant growth inhibition. Cs-2d can be used for invasive fungal infections research .
    Cs-2d
  • HY-171796
    Bromomonilicin

    		Fungal Infection
    Bromomonilicin is a selective fungal cell membrane inhibitor. Bromomonilicin exerts antifungal activity by disrupting fungal cell membrane integrity. Bromomonilicin is promising for research of plant pathogenic fungal infections (e.g., Monilinia fructicola-induced brown rot) and superficial mycoses (e.g., dermatophyte infections) .
    Bromomonilicin
  • HY-116290A
    Zaragozic acid A trisodium

    Squalestatin S1 trisodium

    		 Farnesyl Transferase Fungal Endogenous Metabolite Others
    Zaragozic acid A trisodium is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase .
    Zaragozic acid A trisodium
  • HY-76200B
    Voriconazole camphorsulfonate

    UK-109496 camphorsulfonate

    		 Fungal Bacterial Infection Cancer
    Voriconazole (UK-109496) camphorsulfonate is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole camphorsulfonate exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes .
    Voriconazole camphorsulfonate
  • HY-111357
    Antifungal agent 2

    		Fungal Infection
    Antifungal agent 2 is a broad-spectrum fungal inhibitor which inhibits growth of pertinent species of Candida, Cryptococcus, and Aspergillus at a concentration as low as 0.5 μg/mL.
    Antifungal agent 2
  • HY-123777A
    VT-1598 tosylate

    		Cytochrome P450 Infection
    VT-1598 tosylate is an orally active and selective fungal inhibitor targeting CYP51. VT-1598 tosylate shows anti-fungal activity against C. auris . VT-1598 (tosylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    VT-1598 tosylate
  • HY-N8287
    Oxaline

    		Microtubule/Tubulin Cancer
    Oxaline is a fungal alkaloid that can be isolated from Penicillium oxalicum. Oxaline inhibits tubulin polymerization, resulting in cell cycle arrest at the M phase .
    Oxaline
  • HY-125344
    Fusarisetin A

    		Endogenous Metabolite Infection
    Fusarisetin A, a pentacyclic fungal metabolite, is an acinar morphogenesis inhibitor .
    Fusarisetin A
  • HY-N10234
    Phenylpyropene A

    		Acyltransferase Infection
    Phenylpyropene A, a fungal metabolite, is a potent acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor with an IC50 of 0.8 μM .
    Phenylpyropene A
  • HY-117424
    Inz-4

    		Fungal Infection
    Inz-4 is a fungal-selective inhibitor of mitochondrial cytochrome bc1, with the IC50 of 0.026 μM .
    Inz-4
  • HY-W714655
    Becliconazole

    		Fungal Cytochrome P450 Infection
    Becliconazole is a fungal CYP51A1 inhibitor. Becliconazole can be used in research on fungal infections .
    Becliconazole
  • HY-125705
    Herquline A

    Herqueline A

    		 Influenza Virus Infection Cardiovascular Disease
    Herquline A (Herqueline A) is a fungal piperazine alkaloid. Herquline A is a fungal metabolite that inhibits platelet aggregation and replication of the influenza virus .
    Herquline A
  • HY-121051
    Aleurodiscal

    		Fungal Antibiotic Infection
    Aleurodiscal is an fungal inhibitor that can be obtained from cultures of Aleurodiscus mirabilis. Aleurodiscal can be used in the study of fungal infections .
    Aleurodiscal
  • HY-121633
    Kayahope

    		Fungal Infection
    Kayahope is a fungal inhibitor .
    Kayahope

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