Art. -Nr.: HY-N3617

Coniferin

(Synonyms: Laricin)

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Coniferin (Laricin) is a glucoside of coniferyl alcohol. Coniferin inhibits fungal melanization. Coniferin inhibits the release of certain hormones from cells, including Prostaglandin E2 and Thromboxane B2.

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Reinheit: 98.84%
CAS. Nr.: 531-29-3
Formel: C₁₆H₂₂O₈
Molecular Weight:342.34

Speicherung:

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Coniferin Chemical Structure

CAS. Nr.: 531-29-3

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (2)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Fungal^[1]

Alle Prostaglandin Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

Coniferin (100 μM) inhibits melanization of Verticillium longisporum in vitro^[1].
Coniferin (100 μM; 1 h) significantly reduces the release of Prostaglandin E2 (HY-101952) (IC₅₀ value: 75.2 μM) from ionophore-stimulated mouse peritoneal macrophages^[2].
Coniferin (100 μM) significantly reduces the release of Thromboxane B2 (HY-113331) (IC₅₀ value: 619 μM) from ionophore-stimulated human platelets^[2].
Coniferin (50 μM; 20 min) shows strong ATP-dependent transport activity in membrane vesicles prepared from differentiating xylem tissues of hybrid poplar, poplar, Japanese cypress and pine^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 531-29-3
Appearance Solid
Molecular Weight 342.34
Formel C₁₆H₂₂O₈
Color White to off-white
SMILES

COC(C=C(/C=C/CO)C=C1)=C1O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)CO
Synonyms

Laricin
Structure Classification
- Phenylpropanoids
- Simple Phenylpropanols
Initial Source
- Plants
- other families
- Microorganisms
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (2)

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Journal Impact Factor

Int J Biol Macromol

Integrative bioinformatics analysis reveals CGAS as a ferroptosis-related signature gene in sepsis and screens the potential natural inhibitors of CGAS. [Abstract]

2025 Mar:297:139778. PMID: 39805448
Molecules

Seed Watermelon (Citrullus mucosospermus (Fursa))-Derived Coniferyl Alcohol as a Functional Ingredient in Remedies for Dry Skin: Evidence of Facilitated Lipogenesis in Human Sebocytes. [Abstract]

2025 Aug 13;30(16):3360. PMID: 40871513

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (292.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.9211 mL

14.6054 mL

29.2107 mL

5 mM

0.5842 mL

2.9211 mL

5.8421 mL

10 mM

0.2921 mL

1.4605 mL

2.9211 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (7.30 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (7.30 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (7.30 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. König S, et al. Soluble phenylpropanoids are involved in the defense response of Arabidopsis against Verticillium longisporum. New Phytol. 2014 May;202(3):823-37. [Content Brief]

[2]. Díaz Lanza AM, et al. Lignan and phenylpropanoid glycosides from Phillyrea latifolia and their in vitro anti-inflammatory activity. Planta Med. 2001 Apr;67(3):219-23. [Content Brief]

[3]. Tsuyama T, et al. Proton-dependent coniferin transport, a common major transport event in differentiating xylem tissue of woody plants. Plant Physiol. 2013 Jun;162(2):918-26. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.9211 mL	14.6054 mL	29.2107 mL	73.0268 mL
	5 mM	0.5842 mL	2.9211 mL	5.8421 mL	14.6054 mL
	10 mM	0.2921 mL	1.4605 mL	2.9211 mL	7.3027 mL
	15 mM	0.1947 mL	0.9737 mL	1.9474 mL	4.8685 mL
	20 mM	0.1461 mL	0.7303 mL	1.4605 mL	3.6513 mL
	25 mM	0.1168 mL	0.5842 mL	1.1684 mL	2.9211 mL
	30 mM	0.0974 mL	0.4868 mL	0.9737 mL	2.4342 mL
	40 mM	0.0730 mL	0.3651 mL	0.7303 mL	1.8257 mL
	50 mM	0.0584 mL	0.2921 mL	0.5842 mL	1.4605 mL
	60 mM	0.0487 mL	0.2434 mL	0.4868 mL	1.2171 mL
	80 mM	0.0365 mL	0.1826 mL	0.3651 mL	0.9128 mL
	100 mM	0.0292 mL	0.1461 mL	0.2921 mL	0.7303 mL

Keywords

Coniferin

2 Cited Publications

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Publications Citing Use of MedChemExpress (MCE) Coniferin

Alle Prostaglandin Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (2)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Coniferin Related Classifications

HY-N3617 Related Classifications