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Gram-negative bacteria,

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Ampicillin Maximum Cited Publications 80 Publications Verification D-(-)-α-Aminobenzylpenicillin	Bacterial Antibiotic	Infection
Ampicillin is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria.

Ampicillin sodium Maximum Cited Publications 80 Publications Verification D-(-)-α-Aminobenzylpenicillin sodium salt	Bacterial Antibiotic	Infection
Ampicillin sodium (D-(-)-α-Aminobenzylpenicillin sodium salt) is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative *bacteria* .

Colistin sulfate 25+ Cited Publications Polymyxin E sulfate	Bacterial Autophagy Antibiotic	Infection
Colistin sulfate is a polypeptide antibiotic which inhibits **gram-negative bacteria** by binding to lipopolysaccharides and phospholipids in the outer cell membrane of gram-negative bacteria.

4-Hydroxybenzoic acid	Endogenous Metabolite Bacterial	Infection
4-Hydroxybenzoic acid, a phenolic derivative of benzoic acid, could inhibit most gram-positive and some gram-negative bacteria, with an IC₅₀ of 160 μg/mL.

Colistin Polymyxin E	Antibiotic Bacterial	Infection
Colistin is an orally active polypeptide antibiotic. Colistin has excellent activity against various Gram-negative rod-shaped bacteria, including multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae. Colistin is associated with nephrotoxicity. Colistin can be used for the research of infections caused by Gram-negative bacilli .

Ampicillin trihydrate Maximum Cited Publications 80 Publications Verification D-(-)-α-Aminobenzylpenicillin trihydrate	Bacterial Antibiotic	Infection
Ampicillin trihydrate (D-(-)-α-Aminobenzylpenicillin trihydrate) is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative *bacteria*.

Flucloxacillin sodium 1 Publications Verification	Bacterial Antibiotic	Infection
Flucloxacillin sodium is an active antibiotic against gram-positive and gram-negative bacteria .

SPR741 3 Publications Verification NAB741	Bacterial Antibiotic	Infection
SPR741 (NAB741) is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 increases the permeability of the outer membrane of Gram-negative *bacteria* and is used to treat severe Gram-negative *bacteria* infections. SPR741 inhibits multidrug-resistant Gram-negative *bacteria*. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741 .

Fosmidomycin sodium salt 2 Publications Verification FR-31564	Bacterial Antibiotic	Infection
Fosmidomycin sodium salt is a phosphonic acid antibiotic and a antimalarial agent, which is active against both Gram-negative and Gram-positive bacteria.

SPR741 acetate 3 Publications Verification NAB741 acetate	Bacterial Antibiotic	Infection
SPR741 acetate (NAB741 acetate) is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 acetate increases the permeability of the outer membrane of Gram-negative *bacteria* and is used to treat severe Gram-negative *bacteria* infections. SPR741 acetate inhibits multidrug-resistant Gram-negative *bacteria*. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741 acetate .

Colistin sulfate (Standard) Polymyxin E sulfate (Standard)	Reference Standards Bacterial Autophagy Antibiotic	Infection
Colistin (sulfate) (Standard) is the analytical standard of Colistin (sulfate). This product is intended for research and analytical applications. Colistin sulfate is a polypeptide antibiotic which inhibits gram-negative bacteria by binding to lipopolysaccharides and phospholipids in the outer cell membrane of gram-negative bacteria.

Midecamycin 2 Publications Verification SF-837; Antibiotic SF-837	Bacterial Antibiotic	Infection
Midecamycin, an acetoxy-substituted macrolide antibiotic, is tested against gram-positive and gram-negative bacteria.

Bicyclomycin benzoate 2 Publications Verification FR2054	Bacterial Antibiotic	Infection
Bicyclomycin benzoate is an antibiotic exhibiting activity against a broad spectrum of Gram-negative bacteria and against the Gram-positive bacterium.

Azomycin 2-Nitroimidazole	MOFs Bacterial Antibiotic	Infection
Azomycin (2-Nitroimidazole) is an antibiotic which can be active against aerobic Gram-positive and Gram-negative bacteria.

Flucloxacillin 1 Publications Verification	Antibiotic Bacterial	Infection
Flucloxacillin is an active antibiotic against gram-positive and gram-negative bacteria .

Cefazedone Refosporen	Antibiotic Bacterial	Infection
Cefazedone (Refosporen) is a first-generation cephalosporin antibiotic. Cefazedone is active against both Gram-positive and Gram-negative bacteria .

Arbekacin	Antibiotic Bacterial	Infection
Arbekacin, an aminoglycoside antibiotic, exhibits broad antimicrobial activities against not only Gram-positive bacteria but also Gram-negative bacteria .

Temporin L	Bacterial Fungal	Infection
Temporin L is a potent antimicrobial peptide and is active against **Gram-negative bacteria and yeast strains**. Temporin L also has antiendotoxin properties .

Fabimycin	Antibiotic Bacterial	Infection
Fabimycin is a FabI inhibitor with potent antibacterial activity against gram-negative bacteria. Fabimycin is effective against drug-resistant gram-negative Infections in vivo .

Fluoroquinolonic acid	Antibiotic Bacterial	Infection
Fluoroquinolonic acid is a bacteriostatic antibiotic. Fluoroquinolonic acid has broad-spectrum activity against Gram-positive and Gram-negative bacteria .

Pyrrhocoricin	Bacterial	Others
Pyrrhocoricin is a biological active peptide. (Antimicrobial activity against Gram-negative bacteria)

Temporin B acetate	Bacterial	Infection
Temporin B acetate is an antimicrobial peptide against Gram-positive bacteria. Temporin B acetate is less active against Gram-negative bacteria .

Dienone B Dibromoverongiaquinol	Bacterial	Infection
Dienone B is a marine algicide with antibiotic activity against both Gram-positive and Gram-negative marine bacteria .

OGDA	Fluorescent Dye	Infection
OGDA is a green fluorescent D-amino acid. OGDA is suitable for labeling peptidoglycan in Gram-positive and Gram-negative bacteria .

Temporin B	Bacterial	Infection
Temporin B is an antimicrobial peptide against Gram-positive bacteria. Temporin B is less active against Gram-negative bacteria .

Meridinol (-)-Meridinol	Bacterial Fungal	Inflammation/Immunology
Meridinol ((-)-Meridinol) shows antimicrobial activity against a wide range of gram-positive and gram-negative bacteria and fungi.

The K4 peptide	Bacterial	Infection
The K4 peptide is an antimicrobial peptide with strong activity against Gram-positive and Gram-negative bacteria, including human pathogenic bacteria, such as Staphylococcus aureus and Marine Vibrio bacteria .

Polymyxin A1	Antibiotic Bacterial	Infection
Polymyxin A1 is a heteropeptide antibiotic found in different strains of Bacillus polymyxa, and its effect against Gram-negative bacteria is greater than that against Gram-positive bacteria .

Colistin A sulfate hydrate	Bacterial Antibiotic	Infection
Colistin A sulfate hydrate is a major component of Colistin. Colistin is a polymyxin antibiotic and can be used to combat infections caused by problematic gram-negative bacteria .

Pillaromycin A	Bacterial	Infection Cancer
Pillaromycin A has anti-mycobacteria, Gram-positive bacteria and Gram-negative bacteria effects, but the effect of anti-Gram-negative bacteria is weak. Pillaromycin A also has antitumor activity .

SPR741 TFA NAB741 TFA	Bacterial Antibiotic	Infection
SPR741 TFA (NAB741 TFA) is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 TFA increases the permeability of the outer membrane of Gram-negative *bacteria* and is used to treat severe Gram-negative *bacteria* infections. SPR741 TFA inhibits multidrug-resistant Gram-negative *bacteria*. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741 TFA .

Saframycin Mx2	Bacterial	Infection
Saframycin Mx2 has anti-Gram-positive bacteria and Gram-negative bacteria effects .

Juvenimicin A2	Bacterial	Infection
Juvenimicin A2 can resist Gram-positive bacteria and individual Gram-negative bacteria .

Cirramycin B1	Bacterial	Infection
Cirramycin B1 has the activity against Gram-positive bacteria, Gram-negative bacteria and mycoplasmas .

Amythiamicin D	Antibiotic Bacterial	Infection
Amythiamicin D is a thiopeptide antibiotic that inhibits the growth of many Gram-positive bacteria, but not Gram-negative bacteria such as E.coli .

Sannamycin L	Antibiotic Bacterial	Infection
Sannamycin L is an aminoglycoside antibiotic. Sannamycin L has weak antibacterial activity against Gram-positive bacteria and Gram-negative bacteria .

Olivomycin D	Bacterial	Infection
Olivomycin D has strong activity against Gram-positive bacteria and weak activity against Gram-negative bacteria .

Olivomycin B	Bacterial	Infection
Olivomycin B has strong activity against Gram-positive bacteria and weak activity against Gram-negative bacteria .

Pluracidomycin D	Antibiotic Bacterial	Infection
Pluracidomycin D is a carbapenem antibiotic. Pluracidomycin D has anti-Gram-positive bacteria and Gram-negative bacteria activities .

Nemotinic acid	Bacterial Fungal	Infection
Nemotinic acid has the activity against Gram-positive bacteria, mycobacterium and fungus, and also against Gram-negative bacteria, but the activity is weak .

Nemotin	Bacterial Fungal	Infection
Nemotin has the activity against Gram-positive bacteria, mycobacterium and fungus, and also against Gram-negative bacteria, but the activity is weak .

Aerocavin	Antibiotic Bacterial	Infection
Aerocavin is an antibiotic that is active against both Gram-positive and Gram-negative bacteria in vitro .

Oryzoxymycin	Antibiotic Bacterial	Infection
Oryzoxymycin is an aromatic derivative antibiotic. Oryzoxymycin has anti - Gram-negative bacteria activity .

Sannamycin F	Antibiotic Bacterial	Infection
Sannamycin F is an aminoglycoside antibiotic. Sannamycin F has weak antibacterial activity against Gram-positive bacteria and Gram-negative bacteria .

Pluracidomycin A2 PLM A2	Antibiotic Bacterial	Infection
Pluracidomycin A2 (PLM A2) is a carbapenem antibiotic and has anti-Gram-positive bacteria and Gram-negative bacteria activities .

Sannamycin K	Antibiotic Bacterial	Infection
Sannamycin K is an aminoglycoside antibiotic. Sannamycin K has weak antibacterial activity against Gram-positive bacteria and Gram-negative bacteria .

Cat. No.	Product Name	Type

HY-W009756

N-Phenylnaphthalen-1-amine

3 Publications Verification

Fluorescent Dyes

N-Phenyl-1-naphthylamine is a dye that fluoresces strongly when bound to the inner phospholipid bilayer of Gram-negative bacteria. N-Phenyl-1-naphthylamine can be used to measure outer membrane permeability. N-Phenylnaphthalen-1-amine is a fluorescence probe for odorant-binding proteins (OBP) with a dissociation constant of 1.67 μM. N-Phenylnaphthalen-1-amine exhibits an excitation wavelength of 337 nM and an emission wavelength of 407 nM .

HY-D2208

SYTM Green 1 Publications Verification	Fluorescent Dyes
SYTM Green is a cell impermeant DNA dye that fluoresces green by binding to dsDNA (Ex/Em=503/530 nm). SYTM Green can also be used to stain bacteria, including Gram-positive and Gram-negative bacteria. Note: SYTM Green cannot penetrate living cells, and this product is equivalent to (Ex/Em=488/530 nm) .

HY-D3389

sCy5DL-amide

Fluorescent Dyes

sCy5DL-amide is an amidated fluorescent D-amino acid conjugated to Sulfo-Cyanine 5, and a peptidoglycan labeling agent. sCy5DL-amide incorporates into bacterial peptidoglycan cell wall via transpeptidase-mediated reactions, replacing the fourth or fifth D-amino acid of the peptidoglycan stem peptide for visualization of nascent peptidoglycan biosynthesis. sCy5DL-amide produces clear cell outline, septum labeling, and high localization density in Bacillus subtilis, including a 'V-shape' pattern at cell-cell contact areas. sCy5DL-amide exhibits robust incorporation into Gram-positive bacteria and mycobacteria, with reduced incorporation into Gram-negative bacteria (Ex/Em = 646/666 nm) .

Cat. No.	Product Name	Type

HY-W012669

Phthalaldehyde

Phthaldialdehyde

Biochemical Assay Reagents

Phthalaldehyde (Phthaldialdehyde) reacts with proteins containing primary amines and blocked amino-terminal peptides of amino acids. Phthalaldehyde stabilizes bacterial outer membranes and cell walls, increases the optical density of bacterial cell suspensions, and inhibits bacterial lysis induced by ethylenediaminetetraacetic acid and sodium dodecyl sulfate. Phthalaldehyde exhibits bactericidal activity against Gram-negative vegetative bacteria .

HY-W250308A

ε-Poly-L-lysine hydrochloride (MV 2000-5000)

Epsilon-polylysine hydrochloride (MV 2000-5000); ε-Polylysine hydrochloride (MV 2000-5000); ε-PL hydrochloride (MV 2000-5000)

Biochemical Assay Reagents

ε-Poly-L-lysine (Epsilon-polylysine; ε-Polylysine) hydrochloride (MV 2000-5000) is a polycationic antibacterial agent with broad-spectrum activity against Gram-positive bacteria, Gram-negative bacteria, fungi, yeasts and specific bacteriophages. ε-Poly-L-lysine hydrochloride (MV 2000-5000) exerts bactericidal effects through mechanisms such as disrupting microbial membranes, inducing ROS production, inhibiting metabolism and spore germination. ε-Poly-L-lysine hydrochloride (MV 2000-5000) also regulates the expression of multiple key genes including sodA, oxyR and recA. ε-Poly-L-lysine hydrochloride (MV 2000-5000) exhibits properties such as low eukaryotic cytotoxicity, thermal stability and pH stability, and supports tissue regeneration and anti-tumor applications. ε-Poly-L-lysine hydrochloride (MV 2000-5000) can be applied in research fields including bacterial and fungal infections, diabetic ulcers, and methicillin-resistant Staphylococcus aureus infections .

HY-Y1106

Tripotassium phosphate	Biochemical Assay Reagents
Tripotassium phosphate is a Bactericid with bactericidal activity primarily against Gram-negative bacteria. Tripotassium phosphate reduces the population counts of Enterobacteriaceae and Campylobacter in poultry skin rinsates. Tripotassium phosphate fails to reduce the population count of Enterococcus in poultry skin rinsates .

HY-W016473

Adamantane-carboxylic acid

Biochemical Assay Reagents

Adamantane-carboxylic acid is a compound with inhibitory activity against microorganisms. Although its specific target has not been clearly defined, it can inhibit Gram-positive bacteria and some Gram-negative bacteria. It forms a 1-monoacylglycerol derivative through a direct reaction with glycidol, and exerts its antibacterial effect by mechanisms such as altering the permeability of the bacterial cell membrane. This compound can be used in the research of antibacterial agents in the food and cosmetic industries to reduce harmful microbial flora and extend the shelf life of products .

HY-Y1329

Trisodium phosphate	Biochemical Assay Reagents
Trisodium phosphate is a food additive. Trisodium phosphate affects the growth parameters (lag phase, maximum growth rate) of Listeria monocytogenes and increases the sensitivity of Gram-negative bacteria to Lysozyme (HY-P1068) and Nisin (HY-P1607) .

HY-Y0850U5

PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization)

Polyvinyl alcohol (Mw 27000, 98-99% hydrolyzed, ~600 polymerization); Poly(Ethenol) (Mw 27000, 98-99% hydrolyzed, ~600 polymerization)

Biochemical Assay Reagents

PVA (Polyvinyl alcohol) (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) is a nonionic ethanol homopolymer with hydrophilicity, water solubility and biodegradability. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) exhibits biocompatibility, non-toxicity and non-carcinogenicity, as well as antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and fungal strains. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) can serve as a solubilizer, stabilizer, mucoadhesive agent and sustained-release agent, and has a synergistic solubilizing effect on voriconazole/sulfobutyl ether β-cyclodextrin complexes. By stabilizing such complexes, PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) forms freeze-thaw hydrogels with high mucoadhesion, sustained drug release and ex vivo corneal permeability. When compounded with hyaluronic acid hydrogels, PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) supports chondrocyte growth in vitro, and also forms complexes with Cu ²⁺, Co ²⁺, Ni ²⁺ and Zn ²⁺ ions. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) can be used in studies related to fungal keratitis, bacterial infections and fungal infections .

HY-W354851

Pisiferic acid	Biochemical Assay Reagents
Pisiferic acid is an antibacterial agent with inhibitory activity against Gram-negative/positive bacteria such as P. vulgaris, S. aureus and B. subtilis. Pisiferic acid can be used to study bacterial infections .

HY-60325

2-Amino-4-chloropyridine	Biochemical Assay Reagents
2-Amino-4-chloropyridine is a key intermediate. 2-Amino-4-chloropyridine derivatives exhibit antibacterial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi .

HY-W353258R

Moxifloxacin hydrochloride monohydrate (Standard)

BAY 12-8039 monohydrate (Standard)

Biochemical Assay Reagents

Moxifloxacin hydrochloride (BAY 12-8039) monohydrate (Standard) is the analytical standard of Moxifloxacin hydrochloride monohydrate. This product is intended for research and analytical applications. Moxifloxacin hydrochloride monohydrate is a blood-brain barrier-permeable, orally active topoisomerase II/IV inhibitor and a fluoroquinolone antibiotic. Moxifloxacin hydrochloride monohydrate disrupts bacterial DNA replication, transcription, repair and chromosome segregation processes. Moxifloxacin hydrochloride monohydrate exhibits activity against Gram-positive bacteria, Gram-negative bacteria, anaerobes, atypical pathogens, drug-resistant respiratory pathogens, Mycobacterium tuberculosis, mycoplasmas and Ureaplasma urealyticum.

Cat. No.	Product Name	Target	Research Area

HY-N6708

Alamethicin 2 Publications Verification	Antibiotic Bacterial	Infection
Alamethicin is a linear 20-amino acid antibiotic, which can induce voltage-gated conductance in model and cell membranes. Alamethicin exhibits antimicrobial activity against Gram-positive bacteria, but not Gram-negative bacteria. Alamethicin can form an amphipathic α-helical structure in biological membranes .

HY-106783

Polymyxin B nonapeptide 2 Publications Verification	Bacterial Antibiotic	Infection
Polymyxin B nonapeptide is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes .

HY-P4855

CRAMP (mouse) 1 Publications Verification	Bacterial TNF Receptor	Infection Inflammation/Immunology
CRAMP (mouse) is an antibacterial peptide and a functional homolog of LL-37 . CRAMP (mouse) exhibits potent antibacterial activity against Gram-negative bacteria . The complex formed by CRAMP (mouse) and CpG can activate macrophages to secrete TNF-α . CRAMP (mouse) plays a key role in wound healing, immune regulation and maintenance of intestinal homeostasis .

HY-P1649

SPR741 3 Publications Verification NAB741	Bacterial Antibiotic	Infection
SPR741 (NAB741) is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 increases the permeability of the outer membrane of Gram-negative *bacteria* and is used to treat severe Gram-negative *bacteria* infections. SPR741 inhibits multidrug-resistant Gram-negative *bacteria*. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741 .

HY-P0270

Magainin 2 Magainin II	Bacterial Antibiotic Fungal	Infection
Magainin 2 (Magainin II) is an antimicrobial peptide (AMP) isolated from the skin of the African clawed frog Xenopus laevis. Magainin 2 displays antibiotic activity against numerous gram-negative and gram-positive bacteria. Magainin 2 also is active against protozoa . Magainin 2 exerts its cytotoxicity effects by preferential interactions with anionic phospholipids abundant in bacterial membranes .

HY-P10352A

Pediocin PA 1 TFA	Bacterial	Infection
Pediocin PA-1 TFA is a class IIa bacteriocin that specifically binds to membrane proteins of susceptible Gram-positive bacteria (such as Listeria monocytogenes) to form voltage-independent hydrophilic pores, leading to dissipation of proton motive force, ATP depletion and cell death. Pediocin PA-1 TFA shows no significant activity against intact Gram-negative bacteria, strains carrying immunity genes and obligate anaerobic commensal gut microbiota, and its bactericidal function depends on the integrity of disulfide bonds, with activity lost upon reduction. Pediocin PA-1 TFA can be used not only as a food biopreservative but also for research on listeriosis .

HY-P1649B

SPR741 acetate 3 Publications Verification NAB741 acetate	Bacterial Antibiotic	Infection
SPR741 acetate (NAB741 acetate) is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 acetate increases the permeability of the outer membrane of Gram-negative *bacteria* and is used to treat severe Gram-negative *bacteria* infections. SPR741 acetate inhibits multidrug-resistant Gram-negative *bacteria*. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741 acetate .

HY-105048

Omiganan 2 Publications Verification	Bacterial	Infection
Omiganan is a cationic antimicrobial peptide. Omiganan as an analogue of indolicidin shows activity against gram-positive and gram-negative bacteria but also Candida spp. isolates. Omiganan can be used for the research of alcohol nose and acne .

HY-P1630

Buforin II	Bacterial	Infection
Buforin II, derived from buforin I, a protein isolated from the stomach of the Asian toad Bufo bufo gargarizans, is a potent antimicrobial peptide. Buforin II has antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria .

HY-P5601

Thanatin	Bacterial Fungal	Infection
Thanatin is an inducible cationic antimicrobial peptide. Thanatin is a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption .

HY-P5601A

Thanatin TFA	Bacterial Fungal	Infection
Thanatin TFA is an inducible cationic antimicrobial peptide. Thanatin TFA s a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin TFA displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin TFA has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption .

HY-P0230

Teixobactin	Antibiotic Bacterial	Infection
Teixobactin is a potent antibiotic. Teixobactin shows antibacterial activity for gram-negative bacteria. Teixobactin inhibits cell wall synthesis by binding to a highly conserved motif of lipid II and lipid III .

HY-P0269

Magainin 1 Magainin I	Bacterial Fungal Antibiotic	Infection
Magainin 1 (Magainin I) is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis. Magainin 1 exhibits antibiotic activity against numerous Gram-negative and Gram-positive *bacteria* .

HY-A0248B

Polymyxin B2	Antibiotic Bacterial	Infection
Polymyxin B2 is a polypeptide antibiotic that has antibacterial activity, particularly against gram-negative bacteria. Polymyxin B2 kills the bacteria by binding to lipopolysaccharide molecules on the bacterial cell membrane, disrupting the integrity of the cell membrane and causing the cell contents to leak. Polymyxin B2 can be used in antibiotic development and treatment of drug-resistant strains .

HY-125576

Griselimycin	Bacterial	Infection
Griselimycin is a cyclic lipopeptide produced by Streptomyces. Griselimycin specifically binds to the sliding clamp of bacterial DNA polymerase and does not interact with human PCNA. Griselimycin exhibits potent antibacterial activity against Mycobacterium tuberculosis (including drug-resistant strains) and a variety of Gram-negative bacteria .

HY-P10257

KR-12 (human)	Bacterial	Infection
KR-12 (human) is an active segment of LL-37 (HY-P4744). KR-12 (human) exhibits antimicrobial activity against gram-negative bacteria. KR-12 (human) inhibits E. coli K-12 with a MIC of 66 μM. KR-12 human can be used for the research of infection, such as E. coli infection .

HY-P10352

Pediocin PA 1	Bacterial	Infection
Pediocin PA 1 is a class IIa bacteriocin that specifically binds to membrane proteins of susceptible Gram-positive bacteria (such as Listeria monocytogenes) to form voltage-independent hydrophilic pores, leading to dissipation of proton motive force, ATP depletion and cell death. Pediocin PA 1 shows no significant activity against intact Gram-negative bacteria, strains carrying immunity genes and obligate anaerobic commensal gut microbiota, and its bactericidal function depends on the integrity of disulfide bonds, with activity lost upon reduction. Pediocin PA 1 can be used not only as a food biopreservative but also for research on listeriosis .

HY-P2523

Temporin L	Bacterial Fungal	Infection
Temporin L is a potent antimicrobial peptide and is active against **Gram-negative bacteria and yeast strains**. Temporin L also has antiendotoxin properties .

HY-P3512

Iseganan IB-367	Bacterial Fungal Parasite	Infection Cancer
Iseganan is an anti-microbial peptide that is active against both *Gram-positive* and **Gram-negative bacteria and fungi*. Iseganan kills a broad-spectrum of bacteria* and fungi by attaching to and destroying the integrity of the lipid cell membranes. Iseganan can be used for oral mucositis research .

HY-P3914

Cecropin A (1-7)-Melittin A (2-9) Oct-CA(1-7)M(2-9)	Bacterial	Infection
Cecropin A (1-7)-Melittin A (2-9) is an antimicrobial peptide with antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative aerobic bacteria, as well as antimalarial activity, without the adverse hemolytic properties of bee venom peptides .

HY-106783A

Polymyxin B nonapeptide TFA 2 Publications Verification	Bacterial Antibiotic	Infection
Polymyxin B nonapeptide TFA is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide TFA is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes .

HY-P2317

Cecropin P1, porcine	Bacterial Endogenous Metabolite	Infection
Cecropin P1, porcine is an antibacterial peptide that can be isolated from the upper part of the small intestine of the pig. Cecropin P1, porcine shows antibacterial activity against Gram-negative bacteria. Cecropin P1, porcine shows antiviral activity and inhibits PRRSV infection .

HY-P3328A

MDP1 acetate	Bacterial	Infection
MDP1 acetate, a Melittin-derived peptide, alters the integrity of both Gram-positive and Gram-negative bacterial membranes and kills the bacteria via membrane damages. MDP1 acetate has a high-antibacterial activity against multidrug resistant (MDR) and reference strains of S. aureus, E. coli, and P. aeruginosa .

HY-P10913

HYNIC-UBI29-41	Bacterial	Infection
HYNIC-UBI29-41 is composed of a bifunctional chelator HYNIC and an antimicrobial peptide UBI 29-41 (HY-P10364) (HY-P10364). HYNIC-UBI29-41 retains the antibacterial properties of UBI 29-41, and exhibits good affinity to Gram-positive and Gram-negative bacteria. HYNIC-UBI29-41 can be used as an imaging agent for bacterial infection detection in mouse models, when labeled with the radioactive element technetium (99mTc) .

HY-P11142

Jelleine-I	Bacterial Fungal	Infection
Jelleine-I is an antimicrobial peptide. Jelleine-I can be purified from royal jelly of honeybees. Jelleine-I exhibits antimicrobial activities against yeast, fungi, Gram-positive and Gram-negative bacteria .

HY-P3979

Defensin HNP 4 HNP 4	Bacterial Melanocortin Receptor	Infection
Defensin HNP 4 (HNP 4) is a host-defense peptide that has antimicrobial activity against Gram-negative bacteria. Defensin HNP 4 inhibits ACTH stimulated synthesis of Corticosterone (HY-B1618) in rat adrenal cell suspensions .

HY-P5016A

CRAMP-18 (mouse) acetate	Antibiotic Fungal Bacterial	Infection Cancer
CRAMP-18 (mouse) acetate is an antibiotic peptide without hemolytic activity. CRAMP-18 (mouse) acetate has good inhibitory activity against Gram-negative bacteria, such as S. typhimurium and P. aeruginosa. CRAMP-18 (mouse) acetate has the potential to study antifungal, antibacterial and antitumor .

HY-P5443

Pyrrhocoricin	Bacterial	Others
Pyrrhocoricin is a biological active peptide. (Antimicrobial activity against Gram-negative bacteria)

HY-P5592A

Temporin B acetate	Bacterial	Infection
Temporin B acetate is an antimicrobial peptide against Gram-positive bacteria. Temporin B acetate is less active against Gram-negative bacteria .

HY-P10518

Anoplin	Bacterial	Infection
Anoplin is an antimicrobial peptide found in the venom of the solitary wasp (Anoplius samariensis). Anoplin exhibits antimicrobial activity against a wide range of bacteria, including both gram-positive and gram-negative bacteria. Anoplin can be used in the development of antibiotics .

HY-P4816

Pseudin-2	Bacterial Fungal	Infection Inflammation/Immunology
Pseudin-2, an AMP thast could be isolated from the skin of the South American paradoxical frog Pseudis paradoxa, exert a potent growth inhibitory effect against Gram-negative bacteria .

HY-P11189

Astacidin 1	Bacterial	Infection
Astacidin 1 is an antibacterial peptide. Astacidin 1 can be produced by a proteolytic cleavage from hemocyanin under acidic conditions. Astacidin 1 has broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria .

HY-101399R

γ-Glu-Phe (Standard) H-γ-Glu-Phe-OH (Standard); γ-Glutamylphenylalanine (Standard)	Reference Standards Endogenous Metabolite	Others
Ceftezole (sodium) (Standard) is the analytical standard of Ceftezole (sodium). This product is intended for research and analytical applications. Ceftezole sodium (CTZ sodium) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole sodium (CTZ sodium) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .

HY-P11074

Sakacin P	Bacterial	Infection
Sakacin P is an antimicrobial peptide that targets Gram-positive bacteria (such as Listeria monocytogenes) and belongs to Class IIa bacteriocin. Sakacin P has almost no antimicrobial activity against Gram-negative bacteria. Sakacin P exerts its antimicrobial activity by interacting with bacterial cell membranes and destroying membrane integrity. Sakacin P can be used for the study of Listeria contamination and antimicrobial drugs in the food industry.

HY-P11080

Oncocin	Bacterial	Infection
Oncocin is an antibacterial peptide. It belongs to proline-rich antimicrobial peptides (PrAMPs). Oncocin works against Gram-negative bacteria. It has MIC values of 0.125-8 μg/mL for 34 strains and clinical isolates of Enterobacteriaceae and nonfermenters. Oncocin binds to the substrate-binding domain of the chaperone DnaK. The binding has dissociation constants in the micromolar range. This binding causes protein misfolding and aggregation and the bacteria death .

HY-P1978

CysHHC10	Bacterial	Infection
CysHHC10 is a synthetic antimicrobial peptide (AMP), and exhibits strong anti-microbial properties against both Gram-positive and Gram-negative *bacteria. The MIC values of CysHHC10 against E. coli, P. aeruginosa, S. aureus* and *S. epidermidis* are 10.1 mM, 20.2 mM, 2.5 mM and 1.3 mM, respectively .

HY-P2313

Human β-defensin-2 HβD-2	Antibiotic Bacterial	Infection
Human β-defensin-2 (HβD-2) is a small cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by a number of epithelial cells.Human β-defensin-2 has antimicrobial activity against gram-negative bacteria and Candida, but not gram-positive Staphylococcus aureus . Human β-defensin-2 can be used for the study of colitis .

HY-P5592

Temporin B	Bacterial	Infection
Temporin B is an antimicrobial peptide against Gram-positive bacteria. Temporin B is less active against Gram-negative bacteria .

HY-P5600

The K4 peptide	Bacterial	Infection
The K4 peptide is an antimicrobial peptide with strong activity against Gram-positive and Gram-negative bacteria, including human pathogenic bacteria, such as Staphylococcus aureus and Marine Vibrio bacteria .

HY-P2123A

Colistin A sulfate hydrate	Bacterial Antibiotic	Infection
Colistin A sulfate hydrate is a major component of Colistin. Colistin is a polymyxin antibiotic and can be used to combat infections caused by problematic gram-negative bacteria .

HY-P11006

Onc112	Bacterial	Infection
Onc112 is a proline-rich antimicrobial peptide that displays potent activity against Gram-negative bacteria. Onc112 inhibits translation by blocking and destabilizing the initiation complex .

HY-P5486A

Tet-20 acetate	Bacterial	Infection
Tet-20 acetate is a broad-spectrum antimicrobial peptide. Tet-20 acetate is promising for research of Gram-negative and Gram-positive bacteria (e.g., P. aeruginosa, S. aureus) .

HY-122494

Bilanafos SF-1293	Bacterial	Infection
Bilanafos is a natural organic phosphine tripeptide antibiotic metabolized by Streptomyces hydroscopius or Streptomyces viridochromeogenes. Bialaphos has antimicrobial activity aganist Gram-negative and positive bacteria as well as some fungal plant diseases .

HY-P3365

Cecropin D	Bacterial	Inflammation/Immunology Cancer
Cecropin D is an antimicrobial peptide with a MIC of 4.55 μg/mL. Cecropin D is effective against both Gram-negative and Gram-positive bacteria. Cecropin D has antiviral, antifungal, antitumor, and immunomodulatory .

HY-P5708

Adenoregulin Dermaseptin b2	Antibiotic Fungal Bacterial	Infection
Adenoregulin (Dermaseptin b2) is an antimicrobial peptide antibiotic. Adenoregulin is active against Gram-negative and Gram-positive bacteria, yeast and fungi. Adenoregulin also enhances the binding of agonists to the A1 adenosine receptor .

HY-P11547

Plantaricin F	Bacterial	Infection
Plantaricin F is an antibacterial peptide. Plantaricin F strongly inhibits several gram-negative bacteria including the foodbome pathogens Salmonella enteritidis and Pseudomonas aeruginosa. Plantaricin F inhibits several Lactobacillus, Pediococcus and Leuconostoc species .

HY-P1631

Polyphemusin I	Bacterial	Infection
Polyphemusin I is a natural antimicrobial peptide with excellent antimicrobial activity against *Gram-negative* and **Gram-positive bacteria**. Polyphemusin I contains 18 amino acids and is stabilized into an amphiphilic, antiparallel β-hairpin by two disulfide bridges .

HY-P10618

BTM-P1	Bacterial	Infection
BTM-P1 is a polycationic peptide that exhibits antibacterial activity against both Gram-positive and Gram-negative bacteria. BTM-P1 can form ion-permeable channels in the inner mitochondrial membrane to interfere with mitochondrial energy processes .

HY-P10695

Bac8c	Bacterial Antibiotic	Infection
Bac8c is an antimicrobial peptide with strong antibacterial activity against Gram-negative and Gram-positive bacteria. The MIC of Bac8c against S. aureus, MRSA, S. epidermidis, E. coli, and P. aeruginosa are 2, 8, 4, 4, and 4 μg/mL, respectively .

HY-P10508

Pantinin-1	Bacterial Apoptosis	Infection Cancer
Pantinin-1 is an antimicrobial peptide found in the venom of the Pandinus imperator scorpion. Pantinin-1 has potent antimicrobial activity against Gram-positive bacteria and fungi, weak antimicrobial activity against Gram-negative bacteria, and very low hemolytic activity against human erythrocytes. Pantinin-1 also has anticancer activity and can induce apoptosis in tumor cells .

Cat. No.	Product Name

HY-K1097

Gram Stain Kit
MCE Gram Stain Kit can be used to differentiate between Gram-negative and Gram-positive bacteria.

HY-K1044

Polymyxin B (1,000×), Sterile

Polymixin B is a mixture of B1 and B2 polypeptides obtained from different strains of Bacillus polymyxa, with antibacterial activity against gram-negative bacteria. It can bind lipopolysaccharide (LPS) of the outer membrane of gram-negative bacteria and disrupts the cytoplasmic membrane by inducing large pores to allow nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.

HY-K1008

Gentamicin-Amphotericin B (500×), Sterile 1 Publications Verification
MCE Gentamicin-Amphotericin B (500×), sterile is used to prevent contamination of cell culture due to their effective combined action against gram-positive bacteria, gram-negative bacteria, fungi and yeasts, which contains 5 mg/mL of gentamicin, and 125 μg/mL of amphotericin.

HY-K1050

Gentamicin, Sterile 3 Publications Verification
MCE Gentamicin, Sterile (10 mg/mL) is a filtered and sterilized antibiotic solution that can be used directly in cell culture. Gentamicin acts by binding to the 30S subunit of the bacterial ribosome leading to inhibition of protein synthesis and death in susceptible bacteria, mainly for gram-negative and gram-positive bacteria.

HY-K1006

Penicillin-Streptomycin (100×), Sterile Maximum Cited Publications 92 Publications Verification
MCE Penicillin-Streptomycin (100×), Sterile is used to prevent bacterial contamination of cell culture due to their effective combined action against gram-positive and gram-negative bacteria, which contains 10,000 units/mL of penicillin and 10 mg/mL of streptomycin.

HY-K1010

Penicillin-Streptomycin-Glutamine (100×), Sterile 1 Publications Verification
MCE Penicillin-Streptomycin-Glutamine (100×), sterile is used to prevent bacterial contamination of cell culture due to their effective combined action against gram-positive and gram-negative bacteria, which contains 10,000 units/mL of penicillin, 10 mg/mL of streptomycin, and 29.2 mg/mL of Glutamine.

HY-K0014

Penicillin-Streptomycin-Neomycin (PSN) (100×), Sterile
MCE Penicillin-Streptomycin-Neomycin (PSN) (100×), Sterile is used to prevent bacterial contamination of cell culture due to their effective combined action against gram-positive and gram-negative bacteria, which contains 5,000 units/mL of penicillin, 5 mg/mL of streptomycin, and 10 mg/mL of Neomycin.

Cat. No.	Product Name	Chemical Structure

HY-A0107S

Tetracycline-d6
Tetracycline-d₆ is the deuterium labeled Tetracycline. Tetracycline is a broad-spectrum antibiotic, exhibiting activity against a wide range of gram-positive and gram-negative bacteria.

HY-B0510S

Trimethoprim-d9
Trimethoprim-d₉ is the deuterium labeled Trimethoprim. Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for urinary tract infections, Shigellosis and Pneumocystis pneumonia treatment .

HY-B0522S

Ampicillin-d5
Ampicillin-d₅ is the deuterium labeled Ampicillin. Ampicillin is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria .

HY-B1923S

Piperacillin-d5
Piperacillin-d₅ is deuterium labeled Piperacillin. Piperacillin is kind of semisynthetic penicillins. Piperacillin has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. Piperacillin has shown greater activity against β-lactamase-producing organisms than the other penicillins .

HY-B0132S

Norfloxacin-d5
Norfloxacin-d₅ is the deuterium labeled Norfloxacin. Norfloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase .

HY-143831S

Cefepime-d8 sulfate

Cefepime-d₈ (BMY-28142-d₈) sulfate is deuterium labeled Cefepime sulfate. Cefepime sulfate is a broad-spectrum, blood-brain barrier-permeable cephalosporin antibiotic with hPON1 inhibitory activity, with an IC₅₀ of 21.115 mM and a K_i of 35.092 mM. Cefepime sulfate inhibits hPON1 via a non-competitive mechanism and blocks GABA_A receptors. Cefepime sulfate penetrates the outer membrane of Gram-negative bacteria, inhibits the growth of Gram-positive and Gram-negative bacteria, and does not induce the production of β-lactamase.

HY-Y0264S1

4-Hydroxybenzoic acid-d4
4-Hydroxybenzoic acid-d₄ is the deuterium labeled 4-Hydroxybenzoic acid. 4-Hydroxybenzoic acid, a phenolic derivative of benzoic acid, could inhibit most gram-positive and some gram-negative bacteria, with an IC50 of 160 μg/mL.

HY-B0479S

Thiamphenicol-d3
Thiamphenicol-d₃ is a deuterium labeled Thiamphenicol. Thiamphenicol, a methyl-sulfonyl derivative of Chloramphenicol, is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit, leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative, Gram-positive aerobic and anaerobic bacteria) .

HY-W654100

Cefepime-d3 sulfate

Cefepime-d₃ (BMY-28142-d₃) sulfate is deuterium labeled Cefepime sulfate. Cefepime sulfate is a broad-spectrum, blood-brain barrier-permeable cephalosporin antibiotic with hPON1 inhibitory activity, with an IC₅₀ of 21.115 mM and a K_i of 35.092 mM. Cefepime sulfate inhibits hPON1 via a non-competitive mechanism and blocks GABA_A receptors. Cefepime sulfate penetrates the outer membrane of Gram-negative bacteria, inhibits the growth of Gram-positive and Gram-negative bacteria, and does not induce the production of β-lactamase.

HY-Y0264S

4-Hydroxybenzoic acid-13C6
4-Hydroxybenzoic acid- ¹³C6 is the ¹³C labeled isotope of 4-Hydroxybenzoic acid- ¹³C6.4-Hydroxybenzoic acid is a phenolic derivative of benzoic acid, which can inhibit most Gram-positive bacteria and some Gram-negative bacteria with an IC50 value of 160 μg/mL.

HY-B0510S2

Trimethoprim-d3
Trimethoprim-d₃is the deuterium labeled Trimethoprim. Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for urinary tract infections, Shigellosis and Pneumocystis pneumonia treatment .

HY-B0275S

Oxytetracycline-d6
Oxytetracycline-d₆ is deuterium labeled Oxytetracycline. Oxytetracycline is an antibiotic belonging to the tetracycline class. Oxytetracycline potent inhibits **Gram-negative and Gram-positive bacteria. Oxytetracycline is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline also possesses anti-HSV-1** activity .

HY-B0593S

Ceftazidime-d5
Ceftazidime-d₅ (GR20263-d₅) is the deuterium labeled Ceftazidime (HY-B0593). Ceftazidime (GR20263), an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .

HY-Y0264S2

4-Hydroxybenzoic acid-13c
4-Hydroxybenzoic acid- ¹³C is the ¹³C labeled 4-Hydroxybenzoic acid . 4-Hydroxybenzoic acid, a phenolic derivative of benzoic acid, could inhibit most gram-positive and some gram-negative bacteria, with an IC₅₀ of 160 μg/mL .

HY-17395S

Terbinafine-d3 hydrochloride

Terbinafine-d₃ hydrochloride is the deuterium labeled Terbinafine hydrochloride. Terbinafine hydrochloride (TDT 067 hydrochloride) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a K_i of 30 nM . Terbinafine hydrochloride also antibacterial activity against certain Gram-positive and Gram-negative bacteria .

HY-B0275S1

Oxytetracycline-d3

Oxytetracycline-d₃ is the deuterium labeled Oxytetracycline (HY-B0275). Oxytetracycline is an antibiotic belonging to the tetracycline class. Oxytetracycline potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline also possesses anti-HSV-1 activity .

HY-W653936

Cephalexin-d5 hydrate

Cephalexin-d₅ (hydrate) is deuterium labeled Cephalexin (monohydrate). Cephalexin (Cefalexin) monohydrate is a potent, orally active new semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin (Cefalexin) monohydrate has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin (Cefalexin) monohydrate targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin (Cefalexin) monohydrate is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al .

HY-B1145S

Chlorhexidine-d8 dihydrochloride

Chlorhexidine-d₈ (dihydrochloride) is the deuterium labeled Chlorhexidine dihydrochloride (HY-B1145). Chlorhexidine dihydrochloride is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine dihydrochloride binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine dihydrochloride has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine dihydrochloride can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) .

HY-B0200S

Cephalexin-d5
Cephalexin-d₅ is deuterium labeled Cephalexin. Cephalexin (Cefalexin; Cephacillin) is a potent, orally active and the first-generation?cephalosporin antibiotic. Cephalexin kills?gram-positive?and some?gram-negative bacteria?by disrupting the growth of the bacterial cell wall. Cephalexin monohydrate is used for the research of?pneumonia,?strep throat, and bacterial endocarditis, et al .

HY-136382S

Sulfachloropyridazine-d4
Sulfachloropyridazine-d₄ is the deuterium labeled Sulfachloropyridazine. Sulfachloropyridazine is a broad spectrum sulfonamide used against both Gram-positive and Gram-negative aerobic bacteria .

HY-B1256S

Cefuroxime-d3
Cefuroxime-d₃ is deuterium labeled Cefuroxime (sodium). Cefuroxime sodium is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime sodium has a broad spectrum activity against Gram-positive and Gram-negative bacteria .

HY-W654101

Cefotaxime-d3
Cefotaxime-d3 is the deuterium labeled Cefotaxime (HY-A0088A). Cefotaxime is the β-lactamase stable cephalosporin and the third-generation cephalosporin antibiotic. Cefotaxime possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria .

HY-17395AS

Terbinafine-d7
Terbinafine-d₇ is the deuterium labeled Terbinafine. Terbinafine (TDT 067) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a K_i of 30 nM . Terbinafine also antibacterial activity against certain Gram-positive and Gram-negative bacteria .

HY-B1282S

Sulfaquinoxaline-d4
Sulfaquinoxaline-d₄ is the deuterium labeled Sulfaquinoxaline. Sulfaquinoxaline is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections .

HY-B0398S

Nalidixic Acid-d5

Nalidixic Acid-d₅ is the deuterium labeled Nalidixic acid. Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria .

HY-A0088S

Cefotaxime-d3 sodium
Cefotaxime-d₃ (sodium) is the deuterium labeled Cefotaxime (sodium salt). Cefotaxime sodium salt, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria .

HY-B1002S

Oxolinic acid-d5
Oxolinic acid-d₅ is the deuterium labeled Oxolinic acid. Oxolinic acid is an antibiotic against both Gram-negative and Gram-positive bacteria. Oxolinic acid can be used for the research of acute and chronic urinary tract infections. Oxolinic acid is a DNA/RNA synthesis inhibitor. Oxolinic acid acts a dopamine uptake inhibitor and stimulants locomotor effect in mice .

HY-B0510S3

Trimethoprim-13C3

Trimethoprim- ¹³C₃ is the deuterium labeled Trimethoprim (HY-B0510) . Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim can inhibit infection of Influenza A virus in chick embryo when combinated with zinc .

HY-B0724BS

Pazufloxacin-d4

Pazufloxacin-d₄ is deuterium labeled Pazufloxacin (HY-B0724B). Pazufloxacin is an orally active fluoroquinolone antimicrobial agent. Pazufloxacin inhibits DNA gyrase with IC₅₀ values of 0.88 μg/mL (E. coli) and 1.9 μg/mL (P. aeruginosa). Pazufloxacin exhibits broad-spectrum antimicrobial activity, with MIC₉₀ values ranging from 0.025 to 100 μg/mL against Gram-positive and Gram-negative bacteria, non-fermenting bacteria, Legionella spp., and anaerobic bacteria. Pazufloxacin is indicated for research on systemic infections, lung infections, urinary tract infections, and Legionella pneumonia .

HY-B1190S

Cefadroxil-d4 hydrate

Cefadroxil-d₄ (hydrate) is the deuterium labeled Cefadroxil hydrate (HY-B1190A). Cefadroxil hydrate is an orally active broad-spectrum cephalosporin antibiotic. Cefadroxil hydrate inhibits bacterial cell wall synthesis and enhances the expression of glutamate transporter-1. Cefadroxil hydrate is dependent on the intestinal peptide transporter PepT1 for small intestinal absorption. Cefadroxil hydrate has inhibitory and bactericidal activity against a variety of Gram-positive and Gram-negative bacteria and has analgesic effects on neuropathic pain .

HY-W743473

Cefetamet-d3

Cefetamet-d₃ (Ro 15-8074-d₃; Deacetoxycefotaxime-d₃) is the deuterium labeled Cefetamet (HY-A0111). Cefetamet (Ro 15-8074) is a cephalosporin antibiotic and the active metabolite of Cefetamet pivoxil (HY-B1894A). Cefetamet binds to bacterial penicillin-binding protein (PBP) (IC₅₀ for PBP3 in Escherichia coli W3110 is 2.5 μg/mL). Cefetamet has significant activity against Gram-negative bacteria such as Enterobacteriaceae, Neisseria species, and Haemophilus influenzae, as well as Gram-positive bacteria such as Streptococcus. Cefetamet kills and lyses Treponema pallidum. Cefetamet can be used in the research of respiratory tract, urinary tract, ear, nose and throat infections, and syphilis .

HY-B0712S1

Ceftriaxone-13C2,d3 triethylammonium salt

Ceftriaxone-13C2,d3 triethylammonium salt is 13C and deuterated labeled Ceftriaxone (HY-B0712). Ceftriaxone (Ro 13-9904 free acid) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone is a covalent inhibitor of GSK3β with IC₅₀ value of 0.78 mM. Ceftriaxone is an inhibitor of Aurora B. Ceftriaxone has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone can be used in the study of bacterial infections and meningitis .

HY-B0200BS

Cephalexin-d5 monohydrate

Cephalexin-d₅ (monohydrate) is the deuterium labeled Cephalexin monohydrate. Cephalexin monohydrate is a potent, orally active and the first-generation?cephalosporin antibiotic. Cephalexin monohydrate kills?gram-positive?and some?gram-negative bacteria?by disrupting the growth of the bacterial cell wall. Cephalexin monohydrate is used for the research of?pneumonia,?strep throat, and bacterial endocarditis, et al .

HY-B1781S

Sulfachloropyridazine-13C6
Sulfachloropyridazine- ¹³C₆ is the ¹³C₆ labeled Sulfachloropyridazine. Sulfachloropyridazine is a broad spectrum sulfonamide used against both Gram-positive and Gram-negative aerobic bacteria.

HY-B0132S1

Norfloxacin-d8
Norfloxacin-d₈ is the deuterium labeled Norfloxacin. Norfloxacin (MK-0366) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase.

HY-W750848

Raja 42-d10
Raja 42-d₁₀ is the deuterium labeled Raja 42 (HY-W749146). Raja 42 is a gamma lactam antibiotic. Raja 42 is effective against a variety of different bacterias, including Gram-positive and Gram-negative bacteria, such as C. difficile strains .

HY-19581S

Baquiloprim-d6
Baquiloprim-d₆ is deuterium labeled Baquiloprim. Baquiloprim, an antibiotic, is a selective inhibitor of bacterial dihydrofolate reductases. Baquiloprim possesses in vitro bacteriostatic activity against both Gram-negative and Gram-positive bacteria .

HY-N0285S

Imperatorin-d6
Imperatorin-d6 (Ammidin-d6) is the deuterium labeled Imperatorin. Imperatorin is a BChE inhibitor and HIV-1 replication inhibitor. Imperatorin shows mild activity against Gram-negative bacteria .

HY-A0107S2

Tetracycline-d6-1
Tetracycline-d₆-1 is deuterated labeled Tetracycline (HY-A0107). Tetracycline is a broad-spectrum antibiotic with oral activity. Tetracycline exhibits activity against a wide range of bacteria including gram-positive, gram-negative bacteria, chlamydiae, mycoplasmas and rickettsiae. Tetracycline can be used for the research of infections .

HY-121341S

Brodimoprim-d6
Brodimoprim-d₆ (Ro 10-5970-d₆) is a deuterium labeled Brodimoprim. Brodimoprim, a trimethoprim analogue, is an orally active dihydrofolate reductase inhibitor. Brodimoprim is highly active against a broad spectrum of gram-negative and gram-positive bacteria .

HY-B1217S

Bronopol-d4
Bronopol-d₄ is deuterium labeled Bronopol. Bronopol is an antibacterial agent with low toxicity (to mammals) and high activity (especially against Gram-negative bacteria). Bronopol oxidizes protein thiols, inhibits enzymatic activity, and exhibits antibacterial activity. Bronopol is also a formaldehyde releaser ^.

HY-B0126S

Marbofloxacin-d8
Marbofloxacin-d₈ is the deuterium labeled Marbofloxacin. Marbofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent, which has a broad spectrum bactericidal activity and good efficacy. Marbofloxacin can be used for the research of infections by Gram-positive and Gram-negative bacteria and Mycoplasma .

HY-B0126AS

Marbofloxacin-d8 hydrochloride
Marbofloxacin-d₈ (hydrochloride) is deuterium labeled Marbofloxacin (hydrochloride). Marbofloxacin hydrochloride is a third generation fluoroquinolone and orally active antimicrobial agent, which has a broad spectrum bactericidal activity and good efficacy. Marbofloxacin hydrochloride can be used for the research of infections by Gram-positive and Gram-negative bacteria and Mycoplasma .

HY-B0213S

Sulfameter-d4
Sulfameter-d₄ (Sulfametoxydiazine-d₄) is the deuterium labeled Sulfameter (HY-B0213) . Sulfameter (Sulfametoxydiazine) is an orally active long-acting sulfonamide antibiotic. Sulfameter is active against both Gram-positive and Gram-negative bacteria. Sulfameter can be used for the research of diseases such as respiratory and urinary tract infections .

HY-B0395S

Sitafloxacin-d4

Sitafloxacin-d₄ (DU6859a-d₄) is deuterium labeled Sitafloxacin. Sitafloxacin (DU6859a) is a potent, orally active fluoroquinolone antibiotic. Sitafloxacin shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin can be used for the research of respiratory tract infection and urinary tract infection .

HY-W770956

Cefotiam-13C,15N2
Cefotiam- ¹³C, ¹⁵N₂ (SCE-963- ¹³C, ¹⁵N₂) is the ¹³C- and ¹⁵N-labeled Cefotiam (HY-B0734). Cefotiam (SCE-963) is a parenteral cephalosporin antibiotic. Cefotiam has broad-spectrum activity against Gram-positive and Gram-negative bacteria .

HY-B0213S1

Sulfameter-13C6
Sulfameter- ¹³C₆ (Sulfametoxydiazine- ¹³C₆) is the ¹³C₆ labeled Sulfameter (HY-B0213). Sulfameter (Sulfametoxydiazine) is an orally active long-acting sulfonamide antibiotic. Sulfameter is active against both Gram-positive and Gram-negative bacteria. Sulfameter can be used for the research of diseases such as respiratory and urinary tract infections .

HY-B0885S

Econazole-d6

Econazole-d₆ ((±)-Econazol-d₆) is the deuterium labeled Econazole (HY-B0885). Econazole is an orally active imidazole antifungal agent, as well as a cytochrome P-450 inhibitor and a blocker of calcium and manganese ion uptake. Econazole is active against a variety of fungi and some Gram-positive bacteria, but has no significant activity against Gram-negative bacteria. Econazole can inhibit the synthesis of prostaglandins and can also induce liver damage .

HY-B1085S

Cinoxacin-d5

Cinoxacin-d₅ is the deuterium-labeled Cinoxacin (HY-B1085) . Cinoxacin (Compound 64716)，a synthetic antimicrobial related to the quinolone class of orally active antibacterial agent. Cinoxacin has antibacterial activity against many gram-negative aerobic bacteria and inhibits bacterial DNA synthesis. Cinoxacin can be used for the research of urinary tract infections and bacterial prostatitis .

HY-130187S

Sapienic acid-d19

Sapienic acid-d19 is a deuterated labeled Sapienic acid . Sapienic acid is a fatty acid commonly found on the skin and in mucosa. Sapienic acid has variable antimicrobial activities against Gram-positive and Gram-negative bacteria found on the skin and in the oral cavity. Sapienic acid is active against Streptococcus sanguinis, Streptococcus mitis and Fusobacterium nucleatum with MBC values of 31.3 μg/mL, 375.0 μg/mL and 93.8 μg/mL, respectively .

Cat. No.	Product Name		Classification

HY-130379

Propargyl-PEG8-acid		ADC Synthesis PROTAC Synthesis Alkynes
Propargyl-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). The ADCs can be used in bacterial infections caused by Gram-negative bacteria . Propargyl-PEG8-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N16526

Juncatrin B		Alkynes
Juncatrin B is a type of dihydrophenanthrene compound. Juncatrin B exhibits inhibitory activity against both Methicillin (HY-121544)-sensitive Staphylococcus aureus (MSSA) and Methicillin-resistant Staphylococcus aureus (MRSA). Juncatrin B can inhibit the formation of biofilms in MSSA and MRSA. Juncatrin B has no significant activity against Gram-negative bacteria. Juncatrin B can be used in the research of anti-Staphylococcus aureus .

Cat. No.	Product Name		Classification

HY-W089856

Chlorobutanol hemihydrate		Preservatives
Chlorobutanol hemihydrate is an antimicrobial agent with oral activity, also possessing preservative effects. Chlorobutanol hemihydrate exhibits resistance to a variety of Gram-positive and Gram-negative *bacteria, as well as several fungal* spores and fungi, and is widely used in the food and cosmetics industries .

HY-174524

Human TLR4 mRNA		mRNA
Human TLR4 mRNA encodes the human toll like receptor 4 (TLR4) protein, a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR4 has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria.

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