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Guluronic acid

" in MedChemExpress (MCE) Product Catalog:

標的別:	Biochemical Assay Reagents (1) COX (2) Drug Intermediate (1) Factor Xa (1) Fungal (3) MMP (2) NF-κB (2) NO Synthase (2) Toll-like Receptor (TLR) (2) VEGFR (2)
研究分野別:	Cancer (2) Cardiovascular Disease (1) Infection (6) Inflammation/Immunology (3)

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天然物

製品番号	製品名	Target	研究分野	構造式

HY-N7700C

*L-Guluronic* acid sodium salt**	Drug Intermediate	Inflammation/Immunology
L-Guluronic acid sodium salt is an uronic acid that can produce D-glucosaccharic acid on oxidation .

HY-N7700A

Guluronic acid sodium 1 Publications Verification G2013 sodium	VEGFR Toll-like Receptor (TLR) COX NO Synthase NF-κB MMP	Inflammation/Immunology Cancer
Guluronic acid (G2013) sodium is an orally active oxidative stress regulator and anti-inflammatory agent that exerts pharmacological effects by down-regulating various pro-inflammatory and oxidative stress-related genes (such as TLR4, NF-κB, iNOS, etc.) and inhibiting the activities of COX-2, MMPs and VEGF. Low-dose Guluronic acid sodium up-regulates the expression of immunoregulatory genes SHIP1 and SOCS1, thereby effectively inhibiting cancer-related inflammation, tumor angiogenesis, cell adhesion and metastasis, while reducing the accumulation of immunosuppressive cells. Guluronic acid sodium significantly prolongs the survival time of tumor-bearing hosts within a concentration range without direct cytotoxicity, demonstrating favorable safety. Guluronic acid sodium has involved in the research of multiple sclerosis, ankylosing spondylitis, breast cancer and other inflammatory diseases .

HY-N7700

Guluronic acid G2013	MMP COX VEGFR Toll-like Receptor (TLR) NF-κB NO Synthase	Inflammation/Immunology Cancer
Guluronic acid (G2013) is an orally active oxidative stress regulator and anti-inflammatory agent that exerts pharmacological effects by down-regulating various pro-inflammatory and oxidative stress-related genes (such as TLR4, NF-κB, iNOS, etc.) and inhibiting the activities of COX-2, MMPs and VEGF. Low-dose Guluronic acid up-regulates the expression of immunoregulatory genes SHIP1 and SOCS1, thereby effectively inhibiting cancer-related inflammation, tumor angiogenesis, cell adhesion and metastasis, while reducing the accumulation of immunosuppressive cells. Guluronic acid significantly prolongs the survival time of tumor-bearing hosts within a concentration range without direct cytotoxicity, demonstrating favorable safety. Guluronic acid has involved in the research of multiple sclerosis, ankylosing spondylitis, breast cancer and other inflammatory diseases .

HY-N7701B

L-Tetraguluronic acid	Biochemical Assay Reagents	Infection
L-Tetraguluronic acid is a linear polysaccharide copolymer composed of four L-guluronic acid (G) .

HY-N7701A

L-Triguluronic acid	Fungal	Infection
L-Triguluronic acid is a linear polysaccharide copolymer composed of three L-guluronic acid (G) and can be used to from Alginate . Alginate is a generic name of unbranched polyanionic polysaccharides and can be used for the research of anti-fungal agents delivery carries .

HY-N7701D

L-Hexaguluronic acid	Others	Infection
L-Hexaguluronic acid is a linear polysaccharide copolymer composed of six L-guluronic acid (G) .

HY-N7701E

L-Diguluronic acid disodium	Fungal	Infection
L-Diguluronic acid disodium is a linear polysaccharide copolymer composed of two L-guluronic acid. L-Diguluronic acid disodium can be used to form Alginate. L-Diguluronic acid disodium is a generic name of unbranched polyanionic polysaccharides and it can be used for the research of antifungal agents delivery carries .

HY-N7701C

L-Pentaguluronic acid	Others	Infection
L-Pentaguluronic acid is a linear polysaccharide copolymer composed of four L-guluronic acid (G) .

HY-N7701

L-Diguluronic acid	Fungal	Infection
L-Diguluronic acid is a linear polysaccharide copolymer composed of two L-guluronic acid (G) and can be used to from Alginate . Alginate is a generic name of unbranched polyanionic polysaccharides and can be used for the research of antifungal agents delivery carries .

HY-N7700B

*L-Guluronic* acid**	Factor Xa	Cardiovascular Disease
L-Guluronic acid is a coagulation factor X inhibitor. L-Guluronic acid can replace L-Iduronic acid (HY-135197) in the anticoagulant pentasaccharide of heparin-like substances, while retaining the inhibitory activity against factor Xa. L-Guluronic acid can be used in the research of diseases with coagulation disorders such as deep vein thrombosis and pulmonary embolism .

Guluronic acid sodium 1 Publications Verification G2013 sodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	VEGFR Toll-like Receptor (TLR) COX NO Synthase NF-κB MMP
Guluronic acid (G2013) sodium is an orally active oxidative stress regulator and anti-inflammatory agent that exerts pharmacological effects by down-regulating various pro-inflammatory and oxidative stress-related genes (such as TLR4, NF-κB, iNOS, etc.) and inhibiting the activities of COX-2, MMPs and VEGF. Low-dose Guluronic acid sodium up-regulates the expression of immunoregulatory genes SHIP1 and SOCS1, thereby effectively inhibiting cancer-related inflammation, tumor angiogenesis, cell adhesion and metastasis, while reducing the accumulation of immunosuppressive cells. Guluronic acid sodium significantly prolongs the survival time of tumor-bearing hosts within a concentration range without direct cytotoxicity, demonstrating favorable safety. Guluronic acid sodium has involved in the research of multiple sclerosis, ankylosing spondylitis, breast cancer and other inflammatory diseases .

L-Hexaguluronic acid	Infection Classification of Application Fields Disease Research Fields	Others
L-Hexaguluronic acid is a linear polysaccharide copolymer composed of six L-guluronic acid (G) .

L-Pentaguluronic acid	Infection Classification of Application Fields Disease Research Fields	Others
L-Pentaguluronic acid is a linear polysaccharide copolymer composed of four L-guluronic acid (G) .

L-Diguluronic acid	Infection Polysaccharides other families Classification of Application Fields Plants Disease Research Fields Saccharides Source Classification	Fungal
L-Diguluronic acid is a linear polysaccharide copolymer composed of two L-guluronic acid (G) and can be used to from Alginate . Alginate is a generic name of unbranched polyanionic polysaccharides and can be used for the research of antifungal agents delivery carries .

*L-Guluronic* acid**	Structural Classification 天然物 Microorganisms Source Classification	Factor Xa
L-Guluronic acid is a coagulation factor X inhibitor. L-Guluronic acid can replace L-Iduronic acid (HY-135197) in the anticoagulant pentasaccharide of heparin-like substances, while retaining the inhibitory activity against factor Xa. L-Guluronic acid can be used in the research of diseases with coagulation disorders such as deep vein thrombosis and pulmonary embolism .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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