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HPAC

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Complement System (1) Drug Metabolite (1) Endogenous Metabolite (2) Environmental Pollutants (1) Epigenetic Reader Domain (1) ERK (1) IAP (1) Keap1-Nrf2 (2) Mucin (1) PERK (1) RAD51 (1) Ras (4) Reference Standards (1) Small Interfering RNA (siRNA) (1) Src (1)
By Research Areas:	Cancer (12) Inflammation/Immunology (2) Metabolic Disease (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148439

Daraxonrasib Maximum Cited Publications 10 Publications Verification RMC-6236; RAS-IN-2	Ras PERK	Cancer
Daraxonrasib (RMC-6236) is an orally active, non-covalent RAS (ON) inhibitor. Daraxonrasib disrupts the interaction of wild-type or mutant RAS proteins with the RAS binding domain of BRAF, with EC₅₀ values ranging from 28-220 nM for wild-type KRAS, NRAS, HRAS, and multiple oncogenic RAS variants. Daraxonrasib inhibits pERK. Daraxonrasib has anti-tumor activity against KRAS mutant tumors .

HY-N0326

L-Methionine 5+ Cited Publications	Environmental Pollutants Endogenous Metabolite Apoptosis Keap1-Nrf2	Inflammation/Immunology Cancer
L-Methionine is an L-isomer of orally active Methionine, an essential amino acid. Methionine is a strong liver antidote that acts as a liver protector. L-Methionine can inhibit cell proliferation and induce cell apoptosis. L-Methionine has antitumor and antioxidant activity .

HY-153723

BI-2493 4 Publications Verification	Ras	Cancer
BI-2493 is a structural analogue of BI-2865 and a highly selective and orally active pan-KRAS inhibitor. BI-2493 can attenuate tumor growth. BI-2493 can be used for cancer iseases research .

HY-P99237

Sofituzumab MMUC 1206A	Mucin	Cancer
Sofituzumab (MMUC 1206A) is an anti-MUC16 antibody with a K_d of 0.3-0.9 nM. Sofituzumab can bind multiple adjacent antibody molecules to the repeat sequences of the same MUC16 molecule. Sofituzumab exhibits no anti-tumor activity in the HPAC pancreatic adenocarcinoma xenograft model .

HY-N6678

Zearalanone 2 Publications Verification	Drug Metabolite	Metabolic Disease
Zearalanone is a reductive metabolite of Zearalenone (HY-103447). Zearalanone binds to serum albumin across multiple species. Zearalanone enhances the binding affinity of Warfarin (HY-B0687) to serum albumin .

HY-N0326R

L-Methionine (Standard)	Reference Standards Endogenous Metabolite Keap1-Nrf2 Apoptosis	Inflammation/Immunology Cancer
L-Methionine (Standard) is the analytical standard of L-Methionine. This product is intended for research and analytical applications. L-Methionine is an L-isomer of orally active Methionine, an essential amino acid. Methionine is a strong liver antidote that acts as a liver protector. L-Methionine can inhibit cell proliferation and induce cell apoptosis. L-Methionine has antitumor and antioxidant activity .

HY-P991229

MK-4721 AGS-1C4D4; AGS-PSCA	Complement System	Cancer
AGS-1C4D4 is a fully human IgG1κ monoclonal antibody targeting PSCA, with a K_a value of 0.2 nM. AGS-1C4D4 mediates antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) against PSCA-expressing cells. AGS-1C4D4 can be used for the research of pancreatic cancer .

HY-158703

KRAS G12D inhibitor 24	Ras	Cancer
KRAS G12D inhibitor 24 (compound 103) is a potent inhibitor of KRAS G12D, with the IC₅₀ of 0.004 μM. KRAS G12D inhibitor 24 has oral bioactivity .

HY-163468

SRC-3-IN-1	Src	Cancer
SRC-3-IN-1 (compound SI-10) is a steroid receptor coactivator 3 (SRC-3) inhibitor (IC₅₀=3.3 μM). SRC-3-IN-1 has good water solubility, oral bioavailability, and improved selectivity profile. SRC-3-IN-1 can be used in prostate cancer research .

HY-RS09953

PACC1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PACC1 Human Pre-designed siRNA Set A contains three designed siRNAs for PACC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PACC1 Human Pre-designed siRNA Set A PACC1 Human Pre-designed siRNA Set A

HY-172210

DDO-8958	Epigenetic Reader Domain Apoptosis	Cancer
DDO-8958 is an orally active and selective BET BD1 inhibitor with a K_D of 5.6 nM for BRD4 BD1. DDO-8958 exhibits low nanomolar inhibitory activity against all BET BD1 bromodomains except for BRDT BD1. DDO-8958 can inhibit the proliferation and migration, induce apoptosis and cell cycle arrest of tumor cells. DDO-8958 has anti-tumor activity .

HY-158076

S2/IAPinh	IAP	Cancer
S2/IAPinh is a conjugate, which consist of an inhibitor for the apoptosis protein inhibitor (IAPinh) and a ligand for sigma 2 SW43. S2/IAPinh exhibits an anti-proliferative and apoptotic-inducing effect through degradation of the cellular inhibitor for apoptosis protein (clAP-1) .

HY-180885S

KRAS G12D-IN-35	Ras ERK	Cancer
KRAS G12D-IN-35 (example 7) is a potent and orally active KRAS G12D inhibitor. KRAS G12D-IN-35 suppresses p-ERK in AGS cells and potently inhibits the proliferation of various KRAS G12D-mutant cancer cell lines. KRAS G12D-IN-35 inhibits tumor growth in HPAC and GP2D mouse models. KRAS G12D-IN-35 can be used for cancer research, such as pancreatic and colorectal cancer .

HY-181561

BRCA2-RAD51-IN-3	RAD51	Cancer
BRCA2-RAD51-IN-3 is a RAD51-BRCA2 protein-protein interaction inhibitor with an EC₅₀ of 29.35 μM and a K_d of 75.14 μM. BRCA2-RAD51-IN-3 blocks RAD51-BRCA2 binding, impairs homologous recombination in cancer cells, and induces synthetic lethality. BRCA2-RAD51-IN-3 acts in human pancreatic cancer cells and shows no activity in normal pancreatic cells. BRCA2-RAD51-IN-3 can be used for the research of pancreatic cancer .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99237

Sofituzumab MMUC 1206A	Mucin	Cancer
Sofituzumab (MMUC 1206A) is an anti-MUC16 antibody with a K_d of 0.3-0.9 nM. Sofituzumab can bind multiple adjacent antibody molecules to the repeat sequences of the same MUC16 molecule. Sofituzumab exhibits no anti-tumor activity in the HPAC pancreatic adenocarcinoma xenograft model .

HY-P991229

MK-4721 AGS-1C4D4; AGS-PSCA	Complement System	Cancer
AGS-1C4D4 is a fully human IgG1κ monoclonal antibody targeting PSCA, with a K_a value of 0.2 nM. AGS-1C4D4 mediates antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) against PSCA-expressing cells. AGS-1C4D4 can be used for the research of pancreatic cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0326

L-Methionine 5+ Cited Publications	Structural Classification Classification of Application Fields Anti-aging Endocrine diseases Amino acids Endogenous metabolite Research on Agricultural Breeding Agricultural Research Microorganisms Disease markers Other Diseases Nervous System Disorder Disease Research Fields Cardiovascular System Disorder Source Classification	Environmental Pollutants Endogenous Metabolite Apoptosis Keap1-Nrf2
L-Methionine is an L-isomer of orally active Methionine, an essential amino acid. Methionine is a strong liver antidote that acts as a liver protector. L-Methionine can inhibit cell proliferation and induce cell apoptosis. L-Methionine has antitumor and antioxidant activity .

HY-N6678

Zearalanone 2 Publications Verification	Structural Classification Classification of Application Fields Antibacterial Disease Research Microorganisms Macrolide Antibiotics Antibiotics Phenols Polyphenols Anticancer Disease Research Fields Endocrinology Source Classification	Drug Metabolite
Zearalanone is a reductive metabolite of Zearalenone (HY-103447). Zearalanone binds to serum albumin across multiple species. Zearalanone enhances the binding affinity of Warfarin (HY-B0687) to serum albumin .

HY-N0326R

L-Methionine (Standard)	Structural Classification Microorganisms Disease markers Endocrine diseases Amino acids Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder Source Classification	Reference Standards Endogenous Metabolite Keap1-Nrf2 Apoptosis
L-Methionine (Standard) is the analytical standard of L-Methionine. This product is intended for research and analytical applications. L-Methionine is an L-isomer of orally active Methionine, an essential amino acid. Methionine is a strong liver antidote that acts as a liver protector. L-Methionine can inhibit cell proliferation and induce cell apoptosis. L-Methionine has antitumor and antioxidant activity .

Species:	Human (4)
Tag:	His (2) Strep (2) Tag Free (2)
Source:	E. coli (4)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701388

	PSMG3 Protein, Human PSMG3; Proteasome assembly chaperone 3; PAC-3; HPAC3	Human	E. coli
	The PSMG3 protein acts as a chaperone and actively promotes the assembly of the 20S proteasome. It involves potential cooperation with the PSMG1-PSMG2 heterodimer to ensure precise assembly of the proteasome. PSMG3 Protein, Human is the recombinant human-derived PSMG3 protein, expressed by E. coli , with tag free.

HY-P701390

	PSMG4 Protein, Human PSMG4; Proteasome assembly chaperone 4; PAC-4; HPAC4	Human	E. coli
	PSMG4 protein functions as a chaperone, facilitating the assembly of the 20S proteasome. In its role as a chaperone, PSMG4 interacts with PSMG3, forming a functional complex that contributes to the proper assembly of the 20S proteasome. Notably, PSMG4 associates specifically with the alpha subunits of the 20S proteasome, highlighting its involvement in the intricate process of proteasomal maturation and functionality. PSMG4 Protein, Human is the recombinant human-derived PSMG4 protein, expressed by E. coli , with tag free.

HY-P701389

	PSMG3 Protein, Human (His, StrepⅡ) PSMG3; Proteasome assembly chaperone 3; PAC-3; HPAC3	Human	E. coli
	The PSMG3 protein acts as a chaperone and actively promotes the assembly of the 20S proteasome. It involves potential cooperation with the PSMG1-PSMG2 heterodimer to ensure precise assembly of the proteasome. PSMG3 Protein, Human (His, Strep) is the recombinant human-derived PSMG3 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag.

HY-P701391

	PSMG4 Protein, Human (His, StrepⅡ) PSMG4; Proteasome assembly chaperone 4; PAC-4; HPAC4	Human	E. coli
	PSMG4 protein functions as a chaperone, facilitating the assembly of the 20S proteasome. In its role as a chaperone, PSMG4 interacts with PSMG3, forming a functional complex that contributes to the proper assembly of the 20S proteasome. Notably, PSMG4 associates specifically with the alpha subunits of the 20S proteasome, highlighting its involvement in the intricate process of proteasomal maturation and functionality. PSMG4 Protein, Human (His, Strep) is the recombinant human-derived PSMG4 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-180885S

KRAS G12D-IN-35
KRAS G12D-IN-35 (example 7) is a potent and orally active KRAS G12D inhibitor. KRAS G12D-IN-35 suppresses p-ERK in AGS cells and potently inhibits the proliferation of various KRAS G12D-mutant cancer cell lines. KRAS G12D-IN-35 inhibits tumor growth in HPAC and GP2D mouse models. KRAS G12D-IN-35 can be used for cancer research, such as pancreatic and colorectal cancer .

PACC1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PACC1 Human Pre-designed siRNA Set A contains three designed siRNAs for PACC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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HPAC

Inhibitors & Agonists

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Oligonucleotides

Natural
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