Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
IP6K
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "IP6K" in MCE Product Catalog:
製品番号: HY-171099
CAS 番号: 2245949-62-4
別名: LI-2124
Target:
SC-919 is an orally active IP6K inhibitor, with an IC50 of < 5.2 nM against IP6K1, < 3.8 nM against IP6K2, and 0.65 nM against IP6K3. By inhibiting the activity of IP6K, SC-919 reduces intracellular IP7 levels, thereby suppressing XPR1-mediated cellular phosphate efflux. SC-919 increases intracellular phosphate and ATP levels while reducing phosphate entry into the bloodstream, thus decreasing plasma phosphate levels. SC-919 can be used in research related to chronic kidney disease and hyperphosphatemia .
Target:
研究分野:
TNP is a competitive, reversible inhibitor of IP6K1 and IP3K, with IC50s of 0.55 μM and 10.2 μM for IP6K1 and IP3K, respectively. TNP competitively binds to the ATP binding site of IP6K, inhibits the generation of 5-IP7, and thus relieves the inhibition of 5-IP7 on the AKT signaling pathway. TNP can enhance insulin sensitivity and promote thermogenesis in adipose tissue. TNP cannot effectively pass through the blood-brain barrier and is mainly used in the study of obesity, type 2 diabetes, and metabolic syndrome. However, TNP also inhibits CYP3A4 and may need further optimization[1][2][3].
Target:
研究分野:
UNC7467 is a potent IP6K inhibitor with values of 4.9, 8.9 and 1320 nM for IP6K2, IP6K1 and IP6K6, respectively. UNC7467 reduces levels of inositol pyrophosphates. UNC7467 can be used for obesity research .
Target:
LI-2242 is an inositol hexakisphosphate kinase (IP6K) inhibitor. LI-2242 has inhibition effect for IP6K1, IP6K2, IP6K3 and IPMK with IC50 values of 31 nM, 42 nM, 8.7 nM and 1944 nM, respectively. LI-2242 can be used for thew research of type II diabetes, obesity, metabolic complications, venous thrombosis, and psychiatric disorders .
製品番号: HY-162016
CAS 番号: 3055440-67-7
Target:
研究分野:
IP6K-IN-1 (compound 24) is a potent and selective inhibitor of IP6K with an IC50 of 0.896 μM. IP6K-IN-1 can used in study metabolic disease .
Target:
研究分野:
IP6K2-IN-2 (Compound 6) is an IP6K2 inhibitor, with IC50 values of 0.58 μM (IP6K2), 0.86 μM (IP6K1) and 3.08 μM (IP6K3). IP6K2-IN-2 can be used in research of obesity .
製品番号: HY-185141
CAS 番号: 3024590-83-5
Target:
研究分野:
IP6K-IN-2 is an inositol hexakisphosphate kinase (IP6K1) inhibitor that inhibits IP6K1 enzyme activity with an IC50 value of 110 nM. IP6K-IN-2 can be used for the research of neurological disease and CNS disorders .
製品番号: HY-RS06861
Target:
研究分野:
IP6K1 Human Pre-designed siRNA Set A contains three designed siRNAs for IP6K1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-RS06862
Target:
研究分野:
IP6K2 Human Pre-designed siRNA Set A contains three designed siRNAs for IP6K2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-RS06863
Target:
研究分野:
IP6K3 Human Pre-designed siRNA Set A contains three designed siRNAs for IP6K3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-RS19698
Target:
研究分野:
Ip6k1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ip6k1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-RS26193
Target:
研究分野:
Ip6k1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ip6k1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-175477
CAS 番号: 2967648-29-7
Target:
研究分野:
UNC9750 is an inositol phosphate multikinase (IPMK) inhibitor with IC50 values of 31.6 and 374 nM for IPMK and IP6K2, respectively.. UNC9750 inhibits cellular accumulation of InsP5, the direct product of IPMK kinase activity, while having no effect on either InsP6 or InsP7 levels. UNC9750 has ≥ 75% inhibition of four kinases (DAPK1, DYRK1B, PDGFR, and KDR). UNC9750 can be used for the study of glioblastoma .
製品番号: HY-161032
CAS 番号: 2926679-10-7
Target:
研究分野:
IP6K2-IN-1 is a selective flavonoid-based IP6K2 inhibitor with an IC50 value of 0.55 μM . IP6K2-IN-1 shows higher inhibitory potency against IP6K2 than IP6K1 and IP6K3. IP6K2-IN-1 can be utilised as a hit compound for further structural modifications of IP6K2 inhibitors .
製品番号: HY-110079R
CAS 番号: 519178-28-0
Target:
研究分野:
TNP (Standard) is the analytical standard of TNP (HY-110079). This product is intended for research and analytical applications. TNP is a competitive, reversible inhibitor of IP6K1 and IP3K, with IC50s of 0.55 μM and 10.2 μM for IP6K1 and IP3K, respectively. TNP competitively binds to the ATP binding site of IP6K, inhibits the generation of 5-IP7, and thus relieves the inhibition of 5-IP7 on the AKT signaling pathway. TNP can enhance insulin sensitivity and promote thermogenesis in adipose tissue. TNP cannot effectively pass through the blood-brain barrier and is mainly used in the study of obesity, type 2 diabetes, and metabolic syndrome. However, TNP also inhibits CYP3A4 and may need further optimization .
製品番号: HY-162821
CAS 番号: 3024591-38-3
Target:
研究分野:
LI-3948 is a blood-brain barrier-penetrant IP6K1 inhibitor with an IC50 of 16 nM. LI-3948 reduces locomotor activity and grooming behavior in mice and induces hypothermia. LI-3948 is a moderate P-glycoprotein efflux substrate, with low clearance in rodents and high plasma protein binding. LI-3948 can be used for central nervous system-related research .
製品番号: HY-P77427
純度: ≥ 85%, as determined by reducing SDS-PAGE.
別名: IP6K1; ATP:1D-Myo-Inositol-Hexakisphosphate Phosphotransferase; Prev. IHPK1; Pi Uptake Stimulator; Inositol Hexaphosphate Kinase 1; Kinase; KIAA0263; PiUS; InsP6 Kinase 1; Inositol Hexakisphosphate Kinase 1; Alternative Protein IP6K1
Species:
Human
Source:
Sf9 insect cells
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
