109 Results for "

Indole Alkaloid

" in MedChemExpress (MCE) Product Catalog:
Products (109)

109 Results for "Indole Alkaloid" in MCE Product Catalog:

14
14 Publications Verification
Cat. No.: HY-N0117
CAS No.: 479-41-4
Synonyms: Couroupitine B; Indigo red; Indigopurpurin
Indirubin (Couroupitine B) is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia .
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11
11 Cited Publications
Cat. No.: HY-N6778
CAS No.: 57186-25-1
Paxilline is an indole alkaloid mycotoxin derived from Penicillium paxilli, which effectively inhibits the BK channel through a channel-blocking mechanism. Paxilline also inhibits sarco/endoplasmic reticulum Ca 2+-stimulated ATPase (SERCA), with IC50 values ranging from 5 μM to 50 μM for different SERCA isoforms. Paxilline exhibits significant anticonvulsant and neuroprotective effects, as well as certain antioxidant activity .
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8
8 Cited Publications
Cat. No.: HY-N6607
CAS No.: 13220-57-0
Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α .
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2
2 Cited Publications
Cat. No.: HY-W014971
CAS No.: 343-94-2
Tryptamine hydrochloride belongs to the class of indole alkaloids and is a derivative of the amino acid tryptophan. Tryptamine hydrochloride is psychoactive and acts as a neurotransmitter in the body, affecting mood, perception and cognition. In its hydrochloride form, Tryptamine hydrochloride hydrochloride, it is commonly used as a research chemical and as a starting material for the synthesis of other organic compounds. It can also occur naturally in certain plants and animals, including fungi and mammals. Due to the psychoactive properties of Tryptamine hydrochloride and its derivatives, its use and possession are controlled substances in many countries.
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2
2 Cited Publications
Cat. No.: HY-N2197
CAS No.: 35467-43-7
Hirsuteine is an indole alkaloid extracted from Uncaria rhynchophylla. Hirsuteine non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes .
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1
1 Cited Publications
Cat. No.: HY-N2193
CAS No.: 7729-23-9
Hirsutine, an indole alkaloid of Uncaria rhynchophylla, exhibits anti-cancer activity. Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity .
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1
1 Cited Publications
Cat. No.: HY-B1021
CAS No.: 1617-90-9
Vincamine is a monoterpenoid indole alkaloid extracted from the Madagascar periwinkle. Vincamine is a peripheral vasodilator and exerts a selective vasoregulator action on the brain microcapilar circulation . Vincamine is a GPR40 agonist and acts as a β-cell protector by ameliorating β-cell dysfunction and promoting glucose-stimulated insulin secretion (GSIS). Vincamine improves glucose homeostasis in vivo, and has the potential for the type 2 diabetes mellitus (T2DM) research .
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1
1 Cited Publications
Cat. No.: HY-20897A
CAS No.: 25197-99-3
5-Bromo-L-tryptophan is a substrate of PLP-dependent enzyme AetE, as well as an indole alkaloid and Amino acid derivative. 5-Bromo-L-tryptophan can be isolated from Semenospongia sp. 5-Bromo-L-tryptophan can be converted into 5-bromoindole (HY-30236) via AetE-mediated catalysis. 5-Bromo-L-tryptophan is applicable to colon cancer research .
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1
1 Cited Publications
Cat. No.: HY-A0220
CAS No.: 24815-24-5
Synonyms: Reserpinine
Rescinnamine is a derivative of the indole alkaloid reserpine. Rescinnamine shows sedative effects. Rescinnamine can be used for hypertension research .
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1
1 Cited Publications
Cat. No.: HY-N6932
CAS No.: 3371-85-5
Voacamine is an indole alkaloid with cannabinoid 1 (CB1) antagonistic activity. Voacamine can inhibit nuclear translocation. Voacamine is effective in enhancing the effect of Doxorubicin (HY-15142A) as it interferes with the P-glycoprotein (P-gp) function. Voacamine promotes apoptosis-independent autophagic cell death in human osteosarcoma cells. Voacamine activates mitochondrial-associated apoptosis signaling pathway and inhibition of PI3K/Akt/mTOR signaling pathway to suppress breast cancer progression. Voacamine inhibits EGFR to exert oncogenic activity against colorectal cancer .
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Cat. No.: HY-N1163
CAS No.: 6474-90-4
Synonyms: (-)-Tetrahydroalstonine
Tetrahydroalstonine ((-)-Tetrahydroalstonine) is an indole alkaloid and a selective α₂-adrenergic receptor antagonist. Tetrahydroalstonine exhibits certain neuroprotective effects. Tetrahydroalstonine can regulate autophagy-lysosomal function by activating the Akt/mTOR pathway, significantly reducing OGD/R-induced primary cortical neuronal injury .
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Cat. No.: HY-N3536
CAS No.: 479-43-6
Canthin-6-one is an indole alkaloid, displays antibacterial and anti-inflammatory activities .
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Cat. No.: HY-N0275
CAS No.: 64439-81-2
Synonyms: (±)-10-HCPT
(±)-10-Hydroxycamptothecin is an indole alkaloid that inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity.
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Cat. No.: HY-N11478
CAS No.: 1319743-81-1
Villocarine A is a natural vasorelaxant indole alkaloid .
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Cat. No.: HY-N0117A
CAS No.: 906748-38-7
Synonyms: (Z)-Couroupitine B; (Z)-Indigo red; (Z)-Indigopurpurin
Target:  

Apoptosis

Research Areas:  

Cancer

(Z)-Indirubin is an isomer of Indirubin (HY-N0117). Indirubin is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia .
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Cat. No.: HY-N6776
CAS No.: 12627-35-9
Penitrem A is an indole diterpene neurotoxic alkaloid produced by Penicillium, acts as a selective BK channel antagonist with antiproliferative and anti-invasive activities against multiple malignancies. Penitrem A increases the spontaneous release of endogenous glutamate, gamma-aminobutyric acid (GABA) and aspartate from cerebrocortical synaptosomes, and induces tremorgenic syndromes in animals .
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Cat. No.: HY-N10379
CAS No.: 132923-06-9
19-epi-Scholaricine is an orally active indole alkaloid. 19-epi-Scholaricine downregulates the expression of profibrotic/apoptotic proteins (HRAS, HSP90AA1, KDR) and upregulates the expression of cell cycle-related protein (CDK2). 19-epi-Scholaricine suppresses ROS production and reduces the release of inflammatory mediators, thereby attenuating podocyte apoptosis, renal inflammation and oxidative stress by inhibiting AKT/mTOR. 19-epi-Scholaricine can be used in the research of chronic glomerulonephritis and membranous nephropathy .
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Cat. No.: HY-121002
CAS No.: 642-18-2
Alstonine is a major indole alkaloid compound of a plant-based remedy. Alstonine has antipsychotic, anxiolytic, anticancer and antimalarial properties .
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Cat. No.: HY-N4012
CAS No.: 5548-10-7
Synonyms: 3-Indoleglyoxamide
Indole-3-glyoxylamide (Compound 4) is a type of indole alkaloid. Indole-3-glyoxylamide shows no significant cytotoxic activity against Hela, Ishikawa, and MGC-803 cells .
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Cat. No.: HY-N3797A
CAS No.: 6878-36-0
Synonyms: Ditaine chloride
Echitamine (Ditaine) chloride is the major monoterpene indole alkaloid present in Alstonia scholaris with potent anti-tumour activity. Echitamine chloride induces DNA fragmentation and cells apoptosis. Echitamine chloride inhibits pancreatic lipase with an IC50 of 10.92 μM .
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