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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
KL 2
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "KL 2" in MCE Product Catalog:
1
Target:
Research Areas:
SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 μM .
Cat. No.: HY-172825
Target:
Research Areas:
KL4‑219A is a more durable MYC degrader derived from structural optimization of KL2‑236, with its inactive diastereomer being KL4‑219B. KL4‑219A induces destabilization and degradation of MYC protein in a proteasome-dependent manner. KL4‑219A is applicable to the research of pancreatic cancer .
Cat. No.: HY-155972A
CAS No.: 3032506-81-0
CRM1-IN-2 (Compound KL2) is a noncovalent CRM1 inhibitor. CRM1-IN-2 localizes CRM1 in the nuclear periphery, depletes nuclear CRM1, and inhibits CRM1-mediated nuclear export. CRM1-IN-2 inhibits growth of colorectal cancer cells, and induces apoptosis .
Cat. No.: HY-RS07383
Target:
Research Areas:
KLK5 Human Pre-designed siRNA Set A contains three designed siRNAs for KLK5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-188012
CAS No.: 2975602-21-0
Synonyms: dMGer
Desmethyl germinone (dMGer) is a KL signaling pathway activator that binds to the human HTL/KAI2 receptor with an IC50 of 46.4 nM. Desmethyl germinone induces conformational changes of the receptor by directly binding to the ligand-binding pocket of KAI2/D14L, promotes the interaction of KAI2/D14L with D3/MAX2 and SMAX1, and leads to SMAX1 degradation. Desmethyl germinone induces seed germination and inhibits hypocotyl elongation in an abscisic acid-independent manner in Arabidopsis thaliana, and inhibits mesocotyl elongation and induces the expression of KL-responsive genes in rice. Desmethyl germinone can be used in studies related to seed germination, dormancy, and the KAI2/KL signaling pathway .
Cat. No.: HY-P77731
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: KLK5; KLKL2; Kallikrein Related Peptidase 5; Kallikrein-Related Peptidase 5 Transcript Variant 5; KLK-L2; Kallikrein-Related Peptidase 5 Transcript Variant 6; SCTE; Kallikrein 5 Isoform 3 Preproprotein; Stratum Corneum Tryptic Enzyme; Kallikrein 5, Isofor
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P77731A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KLK5; KLKL2; Kallikrein Related Peptidase 5; Kallikrein-Related Peptidase 5 Transcript Variant 5; KLK-L2; Kallikrein-Related Peptidase 5 Transcript Variant 6; SCTE; Kallikrein 5 Isoform 3 Preproprotein; Stratum Corneum Tryptic Enzyme; Kallikrein 5, Isofor
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P70939A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KLK5; KLKL2; Kallikrein Related Peptidase 5; Kallikrein-Related Peptidase 5 Transcript Variant 5; KLK-L2; Kallikrein-Related Peptidase 5 Transcript Variant 6; SCTE; Kallikrein 5 Isoform 3 Preproprotein; Stratum Corneum Tryptic Enzyme; Kallikrein 5, Isofor
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
